scholarly journals Anti-Inflammatory, Anticholinesterase, and Antioxidant Potential of Scopoletin Isolated fromCanarium patentinerviumMiq. (Burseraceae Kunth)

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
R. Mogana ◽  
K. Teng-Jin ◽  
C. Wiart
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Enzymatic Activity ◽  
Neurodegenerative Diseases ◽  
Ethanol Extract ◽  
Antioxidant Potential ◽  
Spectroscopic Methods ◽  
Acetyl Cholinesterase ◽  
Bioassay Guided Fractionation

Bioassay guided fractionation of an ethanol extract of leaves ofCanarium patentinerviumMiq. (Burseraceae Kunth.) led to the isolation of scopoletin. The structure of this coumarin was elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D) and mass spectrometry. Scopoletin inhibited the enzymatic activity of 5-lipoxygenase and acetyl cholinesterase with an IC50equal to1.76±0.01 μM and0.27±0.02 mM, respectively, and confronted oxidation in the ABTS, DPPH, FRAP, andβ-carotene bleaching assay with EC50values equal to5.62±0.03 μM,0.19±0.01 mM,0.25±0.03 mM and0.65±0.07 mM, respectively. Given the aforementioned evidence, it is tempting to speculate that scopoletin represents an exciting scaffold from which to develop leads for treatment of neurodegenerative diseases.

scholarly journals Dudley Howard Williams. 25 May 1937 — 3 November 2010

2017 ◽  
Vol 63 ◽  
pp. 567-583
Author(s):  
Jeremy K. M. Sanders ◽  
Dame Carol V. Robinson
Keyword(s):  
Organic Chemistry ◽  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Nmr Spectroscopy ◽  
Magnetic Resonance ◽  
Molecular Recognition ◽  
Mode Of Action ◽  
Academic Research ◽  
Spectroscopic Methods ◽  
Structural Problems

Dudley Williams was a pioneer in using nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) to solve important structural problems in Chemistry and Biology. His 35-year quest to understand the structure and mode of action of the vancomycin antibiotics led him to fundamental thinking about the nature and thermodynamics of molecular recognition, in particular the roles of solvation, flexibility, entropy, enthalpy and cooperativity. He was always keen that his expertise be used for practical benefit through his academic research and industrial consulting. His legacy also includes a set of textbooks that transformed the use of spectroscopic methods in organic chemistry, and a school of former PhD students and postdoctoral colleagues who have themselves made major contributions across a broad swathe of science.

Identification of benzisoquinolinone derivatives with cytotoxicities from the leaves of Portulaca oleracea

2019 ◽  
Vol 74 (5-6) ◽  
pp. 139-144
Author(s):  
Rong-Rui Wei ◽  
Qin-Ge Ma ◽  
Guo-Yue Zhong ◽  
Ming Yang ◽  
Zhi-Pei Sang
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
A549 Cell ◽  
Positive Control ◽  
Portulaca Oleracea ◽  
Spectroscopic Methods ◽  
First Time ◽  
Mcf 7

Abstract Three new benzisoquinolinones (1–3), together with seven known benzisoquinolinone derivatives (4–10), were isolated from Portulaca oleracea for the first time. The structures of the isolated compounds (1–10) had been elucidated on the basis of extensive spectroscopic methods including ultraviolet, infrared, mass spectrometry, and nuclear magnetic resonance techniques and by comparison with data reported in the references. All isolated compounds were assayed for cytotoxicities against selected human lines in vitro by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay. Compounds 1, 2, 4, and 7 showed important cytotoxicities against HCT116, MCF-7, U87, and A549 cell lines with IC50 values in the range of 11.62–84.45 μM, which compared with positive control doxorubicin.

scholarly journals Urobilinogenic chlorophyll catabolite behaviuor in oxygen-containing moiety

2014 ◽  
Vol 68 (1) ◽  
pp. 77-82
Author(s):  
Nina Djapic
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Liquid Chromatography ◽  
Reaction Mechanism ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Spectroscopic Methods ◽  
Liquid Chromatography Mass Spectrometry ◽  
Chlorophyll Catabolite

The urobilinogenic chlorophyll catabolite upon standing in oxygen-containing moiety, after three months, forms the C-82-hydroxy urobilinogenic chlorophyll catabolite. The chromatographic and spectroscopic methods have been used to study the hydroxylated urobilinogenic chlorophyll catabolite product formed. Using liquid chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy identified was the C-82 hydroxylated urobilinogenic chlorophyll catabolite. Analysis of the results obtained enables the propositions of the reaction mechanism.

Botryane Sesquiterpenoids, Cyclopentadepsipeptides, Xanthones, and Trichothecenes from Trichoderma oligosporum

Planta Medica ◽  
2018 ◽  
Vol 84 (14) ◽  
pp. 1055-1063 ◽  
Author(s):  
Baosong Chen ◽  
Erwei Li ◽  
Li Liu ◽  
Mingfang Liao ◽  
Zhaoxiang Zhu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Cell Line ◽  
A549 Cell ◽  
Spectroscopic Methods ◽  
A549 Cell Line ◽  
K562 Cell Line ◽  
New Compounds ◽  
Line Compound

AbstractFive new botryane sesquiterpenes (1–5), one new cyclopentadepsipeptide (9), and two new xanthones (11 – 12), together with 11 known compounds, were isolated from Trichoderma oligosporum. The structures of the new compounds were identified by comprehensive spectroscopic methods including nuclear magnetic resonance and mass spectrometry. The cytotoxicity of 1–19 was evaluated against K562, A549, and ASPC cell lines. Compounds 5, 8, 11, 17, and 18 showed cytotoxicity against the K562 cell line with more than 50% inhibition at 12.5 µM. As to A549 cell line, compound 8 showed the strongest cytotoxicity with approximately 50% inhibition at 25.0 µM. No compounds showed cytotoxicity against the ASPC cell line.

scholarly journals Triterpenoid Saponins From the Root Bark of Haplocoelum congolanum

2019 ◽  
Vol 14 (5) ◽  
pp. 1934578X1985136 ◽  
Author(s):  
David Pertuit ◽  
Anne-Claire Mitaine-Offer ◽  
Tomofumi Miyamoto ◽  
Chiaki Tanaka ◽  
Duy Khang Tran ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Spectroscopic Methods ◽  
Root Bark ◽  
Two Dimensional ◽  
Triterpenoid Saponins ◽  
One Dimensional ◽  
Nuclear Magnetic

Two undescribed triterpenoid saponins together with 5 known ones were isolated from the root bark of Haplocoelum congolanum Hauman. Their structures were elucidated by spectroscopic methods including one-dimensional and two-dimensional nuclear magnetic resonance experiments in combination with mass spectrometry as 3- O-(4- O-[3-hydroxy-3-methylglutaryl])-α-l-arabinopyranosyl-(1→3)-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)]-α-l-arabinopyranosyloleanolic acid and 3- O-α-l-arabinofuranosyl-(1→3)-α-l-rhamnopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→4)]-α-l-arabinopyranosyloleanolic acid.

Methods to Determine Phytopharmaceuticals in Tobacco and Tobacco Products. 4th Report: A Procedure to Determine Vamidothion and its Metabolites/Methoden zur Bestimmung von Phytopharmaka in Tabak und Tabakerzeugnissen: IV. Mitteilung: Ein Bestimmungsverfahren fuer Vamidothion und seine Metaboliten

1977 ◽  
Vol 9 (2) ◽  
Author(s):  
A.N. Sagredos ◽  
R. Moser
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Acetic Acid ◽  
Magnetic Resonance ◽  
Aluminium Oxide ◽  
Nuclear Magnetic Resonance Data ◽  
Gas Chromatograph ◽  
Tobacco Products ◽  
Magnetic Resonance Data ◽  
Resonance Data

AbstractBased on previous work (7) a method to simultaneously determine vamidothion [I], vamidothion-sulfoxide [II] and vamidothion sulfone [III] in tobacco has been developed. The compounds are extracted with water/acetone/acetic acid from the tobacco, cleansed over an aluminium oxide column and then determined on the gas chromatograph with the specific sulphur detector. Rates of recovery are 70 % - 92 %, the determination level is 0.1 ppm. Mass spectrometry and nuclear magnetic resonance data of vamidothion [I], vamidothion-sulfoxide [ II ] and vamidothion-sulfone [III] are given.

scholarly journals N,N-Bis(Hexyl α-d-Acetylmannosyl) Acrylamide

Molbank ◽  
10.3390/m1255 ◽  
2021 ◽  
Vol 2021 (3) ◽  
pp. M1255
Author(s):  
Atsushi Miyagawa ◽  
Shinya Ohno ◽  
Hatsuo Yamamura
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Nuclear Magnetic Resonance Spectroscopy ◽  
Side Reaction ◽  
Resonance Spectroscopy ◽  
Biological Functions ◽  
Unknown Compound ◽  
Acrylamide Monomer

Glycosyl monomers for the assembly of multivalent ligands are typically synthesized using carbohydrates with biological functions and polymerizable functional groups such as acrylamide or styrene introduced into the carbohydrate aglycon, and monomers polymerized using a radical initiator. Herein, we report the acryloylation of 6-aminohexyl α-mannoside and its conversion into the glycosyl monomer bearing an acrylamide group. The general acryloylation procedure afforded the desired N-hexyl acetylmannosyl acrylamide monomer as well as an unexpected compound with a close Rf value. The compounds were separated and analyzed by nuclear magnetic resonance spectroscopy and mass spectrometry, which revealed the unknown compound to be the bivalent N,N-bis(hexyl α-d-acetylmannosyl) acrylamide monomer, which contains two hexyl mannose units and one acrylamide group. To the best of our knowledge, this side reaction has not previously been disclosed, and may be useful for the construction of multivalent sugar ligands.

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