scholarly journals Nanoparticle-Based Drug Delivery for Therapy of Lung Cancer: Progress and Challenges

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Anish Babu ◽  
Amanda K. Templeton ◽  
Anupama Munshi ◽  
Rajagopal Ramesh
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Detection ◽  
Large Scale ◽  
Three Dimensional ◽  
National Institutes Of Health ◽  
Innovative Strategies ◽  
Gene Therapies ◽  
Cancer Nanomedicine ◽  
Target Disease

The last decade has witnessed enormous advances in the development and application of nanotechnology in cancer detection, diagnosis, and therapy culminating in the development of the nascent field of “cancer nanomedicine.” A nanoparticle as per the National Institutes of Health (NIH) guidelines is any material that is used in the formulation of a drug resulting in a final product smaller than 1 micron in size. Nanoparticle-based therapeutic systems have gained immense popularity due to their ability to overcome biological barriers, effectively deliver hydrophobic therapies, and preferentially target disease sites. Currently, many formulations of nanocarriers are utilized including lipid-based, polymeric and branched polymeric, metal-based, magnetic, and mesoporous silica. Innovative strategies have been employed to exploit the multicomponent, three-dimensional constructs imparting multifunctional capabilities. Engineering such designs allows simultaneous drug delivery of chemotherapeutics and anticancer gene therapies to site-specific targets. In lung cancer, nanoparticle-based therapeutics is paving the way in the diagnosis, imaging, screening, and treatment of primary and metastatic tumors. However, translating such advances from the bench to the bedside has been severely hampered by challenges encountered in the areas of pharmacology, toxicology, immunology, large-scale manufacturing, and regulatory issues. This review summarizes current progress and challenges in nanoparticle-based drug delivery systems, citing recent examples targeted at lung cancer treatment.

scholarly journals Virus Nanoparticles & Different Nanoparticles Affect Lung Cancer- A New Approach

2021 ◽  
pp. 867-884
Author(s):  
Ranajit Nath ◽  
Ratna Roy ◽  
Soubhik bhattacharyya ◽  
Sourav Datta
Keyword(s):  
Lung Cancer ◽  
Three Dimensional ◽  
The Body ◽  
Dimensional Structure ◽  
Innovative Strategies ◽  
Lung Cancer Patients ◽  
Gene Therapies ◽  
Structure Of Nanoparticles ◽  
Life Threatening ◽  
Cancer Types

In the past, few decades cancer has become a worldwide problem to mankind. Lung cancer is the most life-threatening among all cancer types. Non-small cell lung cancer (NSCLC) is the main reason for approximately 80% to 90% of deaths. Lack of early detection and incompetent conventional therapies is the leading cause for poor prognosis and overall survival rate of lung cancer patients. Immense progress in the field of nanotechnology and nanomedicine has given inspiration to the development of an alternative strategy in the treatment of lung cancer. The unique physicochemical properties of the nanoparticles likeability to cross the different biological barriers, effectiveness in delivering hydrophobic drugs which are difficult to incorporate in the body, and targeting in the particular disease sites have given rise to enormous advantages for nanoparticulate systems for the early diagnosis and active delivery of drugs for a better treatment for lung cancer. Recently, many formulations of nanocarriers like lipid-based, polymeric and branched polymeric, metal-based, magnetic, and mesoporous silica are being used in this treatment. Innovative strategies have been employed to utilize the multicomponent, three-dimensional structure of nanoparticles and modify it and construct a new structure moiety that has multifunctional capabilities. Developing such designs permits simultaneous drug delivery of chemotherapeutics as well as anticancer gene therapies to site-specific targets. In lung cancer, nanoparticle-based therapeutics is now breaking the ground in the diagnosis, imaging, screening, and treatment of primary and metastatic tumors. This review emphasizes the pathogenesis of lung cancer and its treatment by nanotechnology.

Three-dimensional visualization system as an aid for lung cancer detection

2000 ◽  
Author(s):  
Andrzej Delegacz ◽  
Shih-Chung B. Lo ◽  
Huchen Xie ◽  
Matthew T. Freedman ◽  
Jae Jeong Choi
Keyword(s):  
Lung Cancer ◽  
Cancer Detection ◽  
Three Dimensional ◽  
Visualization System ◽  
Lung Cancer Detection

Green synthesis of nanomaterials for early lung cancer detection

2018 ◽  
pp. 1-1
Keyword(s):  
Lung Cancer ◽  
Green Synthesis ◽  
Cancer Detection ◽  
World Wide ◽  
Early Stage ◽  
Age Groups ◽  
Early Lung Cancer ◽  
Lung Cancer Detection ◽  
Synthesis Of Nanomaterials

Lung cancer is the foremost cause of cancer-related deaths world-wide [1]. It affects 100,000 Americans of the smoking population every year of all age groups, particularly those above 50 years of the smoking population [2]. In India, 51,000 lung cancer deaths were reported in 2012, which include 41,000 men and 10,000 women [3]. It is the leading cause of cancer deaths in men; however, in women, it ranked ninth among all cancerous deaths [4]. It is possible to detect the lung cancer at a very early stage, providing a much higher chance of survival for the patients.

Solid Lipid Nanoparticles: A Promising Drug Delivery Technology

2009 ◽  
Vol 2 (2) ◽  
pp. 509-516
Author(s):  
S. Pragati ◽  
S. Kuldeep ◽  
S. Ashok ◽  
M. Satheesh
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Large Scale ◽  
Colloidal Particles ◽  
Scale Up ◽  
Lipid Nanoparticles ◽  
Scale Production ◽  
Research Activity ◽  
New Approach ◽  
Solid Lipid

One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticle represents an important particulate carrier system, developed accordingly. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles (SLNs) are important advancement in this area. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their preparation, advantages, characterization and special features.

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