Solid Lipid Nanoparticles: A Promising Drug Delivery Technology

One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticle represents an important particulate carrier system, developed accordingly. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles (SLNs) are important advancement in this area. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their preparation, advantages, characterization and special features.

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Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs

Nanomaterials ◽

10.3390/nano9030474 ◽

2019 ◽

Vol 9 (3) ◽

pp. 474 ◽

Cited By ~ 29

Author(s):

Laura Bayón-Cordero ◽

Itziar Alkorta ◽

Lide Arana

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Large Scale ◽

Lipid Nanoparticles ◽

Resistance Mechanisms ◽

Target Cells ◽

Therapeutic Effects ◽

Scale Production ◽

Solid Lipid ◽

Large Scale Production

Drug delivery systems have opened new avenues to improve the therapeutic effects of already-efficient molecules. Particularly, Solid Lipid Nanoparticles (SLNs) have emerged as promising nanocarriers in cancer therapy. SLNs offer remarkable advantages such as low toxicity, high bioavailability of drugs, versatility of incorporation of hydrophilic and lipophilic drugs, and feasibility of large-scale production. Their molecular structure is crucial to obtain high quality SLN preparations and it is determined by the relationship between the composition and preparation method. Additionally, SLNs allow overcoming several physiological barriers that hinder drug delivery to tumors and are also able to escape multidrug resistance mechanisms, characteristic of cancer cells. Focusing on cell delivery, SLNs can improve drug delivery to target cells by different mechanisms, such as passive mechanisms that take advantage of the tumor microenvironment, active mechanisms by surface modification of SLNs, and codelivery mechanisms. SLNs can incorporate many different drugs and have proven to be effective in different types of tumors (i.e., breast, lung, colon, liver, and brain), corroborating their potential. Finally, it has to be taken into account that there are still some challenges to face in the application of SLNs in anticancer treatments but their possibilities seem to be high.

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A Technical Review: Solid- Lipid Nanoparticle (SLN), Their Characteristics and Their Preparation

Asian Journal of Pharmaceutical Research and Development ◽

10.22270/ajprd.v8i3.764 ◽

2020 ◽

Vol 8 (3) ◽

pp. 185-189

Author(s):

Sunirmal Bhattacharjee ◽

Rabindra Debnath ◽

Sinha Ashutosh Kumar ◽

Arpan Saha ◽

Surajit Saha ◽

...

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Large Scale ◽

Clinical Medicine ◽

Lipid Nanoparticles ◽

Correlation Spectroscopy ◽

Great Promise ◽

Scale Production ◽

Scanning Calorimetry ◽

Solid Lipid

Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their advantages, limitations and their possible remedies. The different types of nanocarriers which were based on solid lipid like solid lipid nanoparticles, nanostructured lipid carriers, lipid drug conjugates are discussed with their structural differences. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are described. Appropriate analytical techniques for characterization of solid lipid nanoparticles like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. Aspects of solid lipid nanoparticles route of administration and their biodistribution are also incorporated. If appropriately investigated,solid lipid nanoparticles may open new vistas in therapy of complex diseases.

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Solid Lipid Nanoparticles: A Brief Review

International Journal of Advanced Research in Science, Communication and Technology ◽

10.48175/ijarsct-1759 ◽

2021 ◽

pp. 368-385

Author(s):

Amol Giri ◽

Aijaz Sheikh ◽

P R Tathe ◽

G R Sitaphale ◽

K R Biyani

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Surfactant Solution ◽

Lipid Nanoparticles ◽

Drug Bioavailability ◽

New Approach ◽

Pharmaceutical Ingredients ◽

Advantages And Disadvantages ◽

Solid Lipid ◽

Novel Drug

In this present review this new approach of solid lipid Nanoparticles (SLNs) is discussed in terms of their aims, advantages, and disadvantages, methods of preparation, characterization and special features. In the state of developments in the research and development of new drug delivery systems have been made in Last decade by resolving various disorders, such as Low Drug Bioavailability and unpredictable gastric emptying era. Most of the active pharmaceutical ingredients are under poor bioavailability and also their solubility. By using the nanotechnology to overcome this problems of novel drug delivery system. The main advantage of nanotechnology i.e. solid lipid Nanoparticles increases the bioavailability and elimination biological half-life of the drugs. Solid lipid Nanoparticles are spherical lipid particles ranging in size from 1 to 1000 nm and are dispersed in water or in aqueous surfactant solution.

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Solid Lipid Nanoparticles for Topical Drug Delivery: Mechanisms, Dosage Form Perspectives, and Translational Status

Current Pharmaceutical Design ◽

10.2174/1381612826666200526145706 ◽

2020 ◽

Vol 26 (27) ◽

pp. 3203-3217

Author(s):

Mengyang Liu ◽

Jingyuan Wen ◽

Manisha Sharma

Keyword(s):

Drug Delivery ◽

Cellular Uptake ◽

Solid Lipid Nanoparticles ◽

Dosage Form ◽

Scale Up ◽

Form Factors ◽

Skin Penetration ◽

Lipid Nanoparticles ◽

Solid Lipid ◽

Topical Applications

Solid lipid nanoparticles (SLNs) have shown potential as a novel lipid-based drug delivery system for the topical applications of innumerable therapeutic compounds. However, the mechanisms governing the absorption and cellular uptake of SLNs through topical route, along with the mechanism of drug release from SLNs are still ambiguous, and require further investigation. In addition, the selection of an appropriate dosage form/formulation base is essential for ease of application of SLNs and to enhance dermal and transdermal delivery. Upscaling and regulatory approvals are other challenges that may impede the clinical translation of SLNs. Therefore, this review focusses on different mechanisms involved in skin penetration and cellular uptake of SLNs. This is followed by a comprehensive discussion on the physicochemical properties of SLNs including various formulation and dosage form factors, which might influence the absorption of SLNs through the skin. Finally, translational status with respect to scale-up and regulatory aspects are also discussed. This review will be useful to researchers with an interest in topical applications of SLNs for the efficient delivery of drugs and cosmetics.

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Large-Scale Production of Solid Lipid Nanoparticles (SLN) and Nanosuspensions (DissoCubes)

Handbook of Pharmaceutical Controlled Release Technology ◽

10.1201/9781482289985-23 ◽

2000 ◽

pp. 371-388

Keyword(s):

Solid Lipid Nanoparticles ◽

Large Scale ◽

Lipid Nanoparticles ◽

Scale Production ◽

Solid Lipid ◽

Large Scale Production

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SOLID LIPID NANOPARTICLES (SLNs) AS NANO DRUG DELIVERY CARRIERS: PREPARATION, CHARACTERIZATION AND APPLICATION

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2020v12i1.35312 ◽

2019 ◽

pp. 1-9

Author(s):

MONA QUSHAWY ◽

ALI NASR

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Colloidal Particles ◽

Drug Carrier ◽

Physical Stability ◽

Controlled Drug Release ◽

Drug Carriers ◽

Colloidal Dispersion ◽

Lipid Nanoparticles ◽

Solid Lipid

Over the last few years, there has been a significant consideration of solid lipid nanoparticles (SLNs) as an alternative method to other colloidal dispersion methods for drug delivery. Special consideration has been given to the use of SLNs as a drug carrier in recent years. SLNs are aqueous dispersions in which the colloidal particles consist of solid lipids that are biodegradable. As a result of their physical stability, the protection of the entrapped drug from decomposition, the provision of controlled drug release, and the exceptional acceptability, SLNs have several advantages over other drug carriers. This article focuses on the techniques of SLNs preparation and characterization, the effect of formulation variables on SLNs properties, the routes of administration, and the pharmaceutical applications. The data used for this review was collected by searching on Google Scholar and PubMed using the following keywords during the period from 2010 to date.

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Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v1i1.8837 ◽

2009 ◽

Vol 1 (1) ◽

Cited By ~ 1

Author(s):

Pravin Patil ◽

Anil Sharma ◽

Subhash Dadarwal ◽

Vijay Sharma

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Solid Lipid Nanoparticles ◽

Rotation Speed ◽

Lipid Nanoparticles ◽

Brain Targeting ◽

Brain Penetration ◽

Solid Lipid ◽

Diffusion Technique

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

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