Synthesis, Characterization, Mössbauer Parameters, and Antitumor Activity of Fe(III) Curcumin Complex

Curcumin-Fe(III) complex was prepared from Fe(NO3)3·9H2O precursor and curcumin by refluxing a slightly basic methanolic solution of their mixture with the objective of investigating its cytotoxicity. The enol form of curcumin ligand was established by FTIR, UV/Vis,1H NMR, and13C NMR spectroscopy. The as-prepared product was characterized by elemental analysis, FTIR, UV, and Mössbauer spectroscopic techniques. An octahedral high-spin Fe(III) complex was obtained,δ, 0.37 mms−1; Q.S., 0.79 mms−1; no magnetic relaxation was observed at liquid N2temperature, neither reduction of Fe(III). The tested cytotoxicity of the as-prepared complex on four cancer cell lines indicated inhibition of the curcumin activity upon complexing with iron.

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[Zn(phen)2(CX3COO)]+, X = H orCl; Influence of X on the Coordination Mode of the Carboxylate Group (phen = 1,10-Phenanthroline)

Zeitschrift für Naturforschung B ◽

10.1515/znb-2005-1005 ◽

2005 ◽

Vol 60 (10) ◽

pp. 1049-1053 ◽

Cited By ~ 1

Author(s):

Zeanab Talaei ◽

Ali Morsali ◽

Ali R. Mahjoub

Keyword(s):

Nmr Spectroscopy ◽

Elemental Analysis ◽

Coordination Mode ◽

Bidentate Ligand ◽

Carboxylate Group ◽

X Ray ◽

X Ray Crystallography ◽

H Nmr ◽

Coordinate Geometry ◽

C Nmr

Two new ZnII(phen)2 complexes with trichloroacetate and acetate anions, [Zn(phen)2(CCl3COO)- (H2O)](ClO4) and [Zn(phen)2(CH3COO)](ClO4), have been synthesized and characterized by elemental analysis, IR, 1H NMR, 13C NMR spectroscopy. The single crystal X-ray data of these compounds show the Zn atoms to have six-coordinate geometry. From IR spectra and X-ray crystallography it is established that the coordination of the COO− group is different for trichloroacetate and acetate. The former acts as a monodentate whereas the latter acts as a bidentate ligand.

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Synthesis and Pharmacological Activities of Some New 2-[1-Heptyl-3-(4- methoxybenzyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]acetohydrazide Derivatives

Zeitschrift für Naturforschung B ◽

10.5560/znb.2014-4126 ◽

2014 ◽

Vol 69 (9-10) ◽

pp. 969-981 ◽

Cited By ~ 6

Author(s):

Olcay Bekircan ◽

Emre Mentese ◽

Serdar Ulker

Keyword(s):

Nmr Spectroscopy ◽

Elemental Analysis ◽

Lipase Activity ◽

Spectral Studies ◽

Antituberculosis Activity ◽

Pharmacological Activities ◽

Mass Spectral ◽

H Nmr ◽

Acetohydrazide Derivative ◽

C Nmr

Abstract In the present investigation, the key intermediate acetohydrazide derivative 5 was synthesized starting from 3-(4-methoxybenzyl)-4-amino-4,5-dihydro-1,2,4-triazol-5-one (1) by a four-step reaction. Thiosemicarbazides 6a-f and arylidenehydrazide derivatives 8a-d were obtained from compound 5. The cyclization of compounds 6a-f in the presence of NaOH resulted in the formation of compounds 7a-f. The compounds were characterized by IR, 1H NMR, 13C NMR spectroscopy, elemental analysis and mass spectral studies. The compounds were tested for their anti-lipase, anti-α-glucosidase and anti-mycobacterial activities. Compounds 6b and 8c exhibited excellent anti-lipase activity, and compound 8d showed excellent anti-a-glucosidase activity. Compounds 3 and 4 exhibited good antituberculosis activity

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Synthesis of cis, cis-1,3,5-trisubstituted cyclohexane based chelators with polyfunctional pendant arms

Journal of Chemical Research ◽

10.3184/0308234053431149 ◽

2005 ◽

Vol 2005 (1) ◽

pp. 43-45 ◽

Cited By ~ 3

Author(s):

Minati Baral ◽

B.K. Kanungo ◽

Peter Moore

Keyword(s):

Schiff Base ◽

Nmr Spectroscopy ◽

Organic Compounds ◽

Elemental Analysis ◽

H Nmr ◽

Benzenetricarboxylic Acid ◽

New Compounds ◽

Pendant Arms ◽

C Nmr

Some novel organic compounds of the type: cis, cis-1,3,5-tris(X)cyclohexane, where X= –CONH(CH2)2NH2, –CONH(CH2)3NH2, –CONH(CH2)2NCH –C6H4OH, CONH(CH2)3NCHC6H4OH, which are expected to function as potential polydentate chelators have been synthesised from 1,3,5-benzenetricarboxylic acid through multi-steps reactions. 1,3,5-benzenetricarboxylic acid was reduced to cis, cis-1,3,5-tris(ethylcarboxylate)cyclohexane, which on reaction with excess of 1,2-diaminoethane and 1,2-diaminopropane afforded two new compounds. Condensation of the obtained derivatives with three equivalents of salicylaldehyde resulted the formation of two new Schiff base compounds. All the compounds were characterised by a combination of elemental analysis, mass, IR, UV-Vis, 1H NMR and 13C NMR spectroscopy.

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Synthesis, biological evaluation, and molecular docking of ((4-([1,2,4]triazolo[4,3-b][1,2,4,5]tetrazin-6-yl) piperazin-1-yl)methyl) benzohydrazide derivatives

Journal of Chemical Research ◽

10.1177/1747519820911278 ◽

2020 ◽

Vol 44 (9-10) ◽

pp. 543-550

Author(s):

Xiaoyu Wu ◽

Feng Xu ◽

Zhenzhen Yang ◽

Zhonglu Ke ◽

Lei Shi ◽

...

Keyword(s):

Molecular Docking ◽

Antitumor Activity ◽

Tumor Cells ◽

Elemental Analysis ◽

Biological Evaluation ◽

Significant Inhibition ◽

Antitumor Activities ◽

H Nmr ◽

C Nmr

A series of ((4-([1,2,4]triazolo[4,3- b][1,2,4,5] methyl) benzo-hydrazide derivatives was designed, synthesized, and evaluated for their inhibition activities against five tumor cells and c-Met kinase in vitro. These compounds were fully characterized by 1H NMR, 13C NMR, MS, and elemental analysis. Antitumor experiments indicated that some compounds exhibited significant inhibition activities against A549 and Bewo. Especially, the IC50 values of 5f (12 μM), 5h (7.1 μM), 6a (8.4 μM), and 6d (9.2 μM) demonstrated better antitumor activities against A549 than the positive agent cisplatin (13.3 μM), and the IC50 value of 6a (5.2 μM) exhibited better antitumor activity against Bewo than cisplatin (7.7 μM).

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2,9-Dimethyl-1,10-phenanthroline as Ligand in the Holo- and Hemidirected 1:1 and 1:2 Lead(II) Complexes

Zeitschrift für Naturforschung B ◽

10.1515/znb-2005-0204 ◽

2005 ◽

Vol 60 (2) ◽

pp. 149-154 ◽

Cited By ~ 3

Author(s):

Ali Morsali

Keyword(s):

Nmr Spectroscopy ◽

Single Crystal ◽

Elemental Analysis ◽

X Ray ◽

X Ray Crystallography ◽

H Nmr ◽

Coordinate Geometry ◽

C Nmr

1:1 and 1:2 lead(II) complexes with 2,9-dimethyl-1,10-phenanthroline (Dmphen), {[Pb(Dmphen)(NO3)n] and [Pb(Dmphen)2(ClO4)2]} have been synthesized and characterized by CHN elemental analysis, IR, 1H NMR, 13C NMR and 207Pb NMR spectroscopy. The structure of these complexes was confirmed by X-ray crystallography. The single crystal X-ray data of [Pb(Dmphen)(NO3)n] show the complex to be polymeric and the Pb atom to have an unsymmetrical eight-coordinate geometry, the coordination being holodirected, whereas the [Pb(Dmphen)2(ClO4)2] complex is monomeric and the Pb atom has an unsymmetrical eight-coordinate geometry with the coordination hemidirected.

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The Preparation of Some Mono-and Bis(thiolate)-2-butyne Complexes of Tungsten(II) of the Types [WI(SR)(CO)(dppm )(η2-MeC2Me)] {dppm = Ph2P(CH2)PPh2; R = Et, But, Ph or CH2Ph} and [W (SR)2(CO)(dppm)(η2-MeC2Me)]

Zeitschrift für Naturforschung B ◽

10.1515/znb-1994-1115 ◽

1994 ◽

Vol 49 (11) ◽

pp. 1544-1548 ◽

Cited By ~ 2

Author(s):

Paul K. Baker ◽

Kevin R. Flower

Keyword(s):

Nmr Spectroscopy ◽

Elemental Analysis ◽

Good Yield ◽

Nmr Spectra ◽

Room Temperature ◽

H Nmr ◽

Thiolate Complexes ◽

C Nmr

Equimolar quantities of [WI(CO)(NCMe)(dppm)(η2-MeC2Me)][BF4] {dppm = Ph2P(CH2)PPh2) and NaSR (R = Et. But ,Ph or CH2Ph) react in CH2Cl2 at room temperature to give the neutral thiolate complexes [WI(SR)(CO)(dppm)(η2-MeC2Me)] (1 → 4) in good yield. The complex [WI(CO)(NCMe)(dppm)(η2-MeC2Me)][BF4] also reacts with two equivalents of NaSR (R = Et. But, Ph or CH2Ph) in CH2Cl2 at room temperature to afford the bis(thiolate) complexes [W(SR)2(CO)(dppm)(η2-MeC2Me)] (5 → 8), in good yield. Complexes 1→8 have been characterized by elemental analysis (C, H and N), IR and 1H NMR spectroscopy. 13C NMR spectra of selected complexes indicate that the 2-butyne ligand is donating four electrons to the metal in both [WI(SR)(CO)(dppm)(η2-MeC2Me)] and [W(SR)2(CO)(dppm)(η2-MeC2Me)] type complexes.

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An Efficient One Pot Synthesis of some New 1,4-Dihydropyridine Derivatives Using Multicomponent Reaction

International Letters of Chemistry Physics and Astronomy ◽

10.18052/www.scipress.com/ilcpa.57.45 ◽

2015 ◽

Vol 57 ◽

pp. 45-50

Author(s):

Devang R. Prajapati ◽

Hardik K. Senjani ◽

Yogesh T. Naliapara

Keyword(s):

Nmr Spectroscopy ◽

Multicomponent Reaction ◽

Elemental Analysis ◽

One Pot ◽

H Nmr ◽

One Pot Synthesis ◽

Target Molecules ◽

Dihydropyridine Derivatives ◽

C Nmr

Synthesize target molecules, multicomponent reaction of 4-(4-aminophenyl) morpholin-3-one with various pyrazole aldehydes and ethylacetoacetate or methylacetoacetate afforded various 1,4-dihydropyridines derivatives. The newly synthesized compounds were characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis.

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Thallium(I) Salicylate and Phthalate: Syntheses and Structural Characterization

Zeitschrift für Naturforschung B ◽

10.1515/znb-2006-0510 ◽

2006 ◽

Vol 61 (5) ◽

pp. 565-569 ◽

Cited By ~ 9

Author(s):

Azadeh Askarinejad ◽

Ali Asgar Torabi ◽

Ali Morsali

Keyword(s):

Nmr Spectroscopy ◽

Elemental Analysis ◽

Structural Characterization ◽

Lone Pair ◽

Coordination Geometry ◽

X Ray ◽

H Nmr ◽

2D Polymers ◽

Active Electron ◽

C Nmr

Two new 2D polymers, thallium(I) hydrogensalicylate (1) and hydrogenphthalate (2), have been synthesized and characterized by elemental analysis, IR, 1H NMR and 13C NMR spectroscopy. The single-crystal X-ray data show the coordination number of the TlI ions of compounds 1 and 2 to be four and six with the environment TlO4 and TlO6, respectively. The arrangement of the O atoms suggests a gap in the coordination geometry around the thallium atoms in both compounds, due to a stereo-chemically ‘active’ electron lone pair of TlI. There is another interaction between the thallium atom and the carbon atoms of an aromatic ring in compound 1, giving a total hapticity of ten with the environment C6O4Tl.

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Synthesis, Characterization and Complexation Studies with K + and Ca2+ Cations of trans-1.2-Cyclohexanedioxydiacetamides

Zeitschrift für Naturforschung B ◽

10.1515/znb-1988-0206 ◽

1988 ◽

Vol 43 (2) ◽

pp. 165-170 ◽

Cited By ~ 2

Author(s):

Whei Oh Lin ◽

Maria C. B. V. de Souza ◽

Helmut G. Alt

Keyword(s):

Nmr Spectroscopy ◽

Mass Spectroscopy ◽

H Nmr ◽

Coordination Sites ◽

Complexation Studies ◽

Ir And Nmr Spectroscopy ◽

Elemental Analyses ◽

C Nmr

The synthesis of trans-1.2-cyclohexanedioxydiacetamides starting with trans-1.2-cyclohexane-diol is described. Eleven of these compounds are characterized by IR, 1H NMR, 13C NMR and mass spectroscopy as well as elemental analyses. Most of these compounds are suitable ionophors for the cations K+ and Ca2+. The coordination sites of these ligands in the 1:2 complexes were determined by IR and NMR spectroscopy

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SYNTHESIS AND STRUCTURAL ELUCIDATION OF AMINO ACETYLENIC AND THIOCARBAMATES DERIVATIVES FOR 2-MERCAPTOBENZOTHIAZOLE AS ANTIMICROBIAL AGENTS

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i2.15760 ◽

2017 ◽

Vol 9 (2) ◽

pp. 192

Author(s):

Aseel Alsarahni ◽

Zuhair Muhi Eldeen ◽

Elham Al-kaissi ◽

Ibrahim Al- Adham ◽

Najah Al-muhtaseb

Keyword(s):

Antimicrobial Activity ◽

Elemental Analysis ◽

Antimicrobial Agents ◽

Diffusion Method ◽

Benzothiazole Derivatives ◽

H Nmr ◽

Ft Ir ◽

Potential Antimicrobial Activity ◽

C Nmr

Objective: To design and synthesize amino acetylenic and thiocarbonate of 2-mercapto-1,3-benthiazoles as potential antimicrobial agents.Methods: A new series of 2-{[4-(t-amino-1-yl) but-2-yn-1-yl] sulfanyl}-1,3-benzothiazole derivatives (AZ1-AZ6), and S-1,3-benzothiazol-2-yl-O-alkyl carbonothioate derivatives were synthesised, with the aim that the target compounds show new and potential antimicrobial activity. The elemental analysis was indicated by the EuroEA elemental analyzer, and biological characterization was via IR, 1H-NMR, [13]C-NMR, DSC were determined with the aid of Bruker FT-IR and Varian 300 MHz spectrometer using DMSO-d6 as a solvent. In vitro antimicrobial activity, evaluation was done for the synthesised compounds, by agar diffusion method and broth dilution test. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined. Results: The IR, 1H-NMR, 13C-NMR, DSC and elemental analysis were consistent with the assigned structures. Compound of 2-{[4-(4-methylpiperazin-1-yl)but-2-yn-1-yl] sulfanyl}-1,3-benzothiazole (AZ1), 2-{[4-(2-methylpiperidin-1-yl)but-2-yn-1-yl]sulfanyl}-1,3-benzothiazole (AZ2), 2-{[4-(piperidin-1-yl) but-2-yn-1-yl]sulfanyl}-1, 3-benzothiazole (AZ6), S-1,3-benzothiazol-2-yl-O-ethyl carbonothioate (AZ7), and S-1,3-benzothiazol-2-yl-O-(2-methylpropyl) carbonothioate (AZ9) showed the highest antimicrobial activity against Pseudomonas aeruginosa (P. aeruginosa), AZ-9 demonstrated the highest antifungal activity against Candida albicans (C. albicans), with MIC of 31.25 µg/ml.Conclusion: These promising results promoted our interest to investigate other structural analogues for their antimicrobial activity further.

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