scholarly journals Protective Effect of Danhong Injection on Acute Hepatic Failure Induced by Lipopolysaccharide and D-Galactosamine in Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Ying Wang ◽  
Li-Na Gao ◽  
Yuan-Lu Cui ◽  
Heng-Li Jiang
Keyword(s):  
Protective Effect ◽  
Hepatic Failure ◽  
Interleukin 1 ◽  
Acute Hepatic Failure ◽  
Serum Levels ◽  
Histopathological Analysis ◽  
Potential Candidate ◽  
Glutathione S Transferase ◽  
Danhong Injection ◽  
Hepatic Lipid Peroxidation

Acute hepatic failure (AHF), which leads to an extremely high mortality rate, has become the focus of attention in clinic. In this study, Danhong injection (DHI) was investigated to evaluate the preventive and protective effect on AHF induced by lipopolysaccharide (LPS) and D-galactosamine (GalN) in mice. For AHF induction, ICR mice were intraperitoneally injected with D-GalN (700 mg/kg) and LPS (20 μg/kg). DHI was administrated twice, at 12 and 1 h, respectively, before D-GalN/LPS injection. After stimulation with D-GalN/LPS for 1 and 6 h, serum and livers were collected for analysis. We found that mice administrated with DHI displayed a higher survival rate, lower serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), glutathione S-transferase (GST), and tumor necrosis factor (TNF)-α. DHI inhibited the elevations of hepatic lipid peroxidation (malondialdehyde), caspase-8 activity, and mRNA expression levels of inflammatory cytokines (interleukin-1βand interleukin-6) increased by D-GalN/LPS in the liver. Furthermore, liver histopathological analysis indicated that the DHI group showed markedly fewer apoptotic (TUNEL positive) cells and less pathological changes than those in the AHF model group. These results provide a novel insight into the pharmacological actions of DHI as a potential candidate for treating AHF.

Lipocalin-2 Serum Levels Are Increased in Acute Hepatic Failure

2013 ◽  
Vol 45 (1) ◽  
pp. 241-244 ◽  
Author(s):  
G.A. Roth ◽  
S. Nickl ◽  
D. Lebherz-Eichinger ◽  
E.M. Schmidt ◽  
H.J. Ankersmit ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Serum Levels ◽  
Lipocalin 2

scholarly journals Protective Effect ofBaccharis trimeraExtract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Bruno da Cruz Pádua ◽  
Joamyr Victor Rossoni Júnior ◽  
Cíntia Lopes de Brito Magalhães ◽  
Míriam Martins Chaves ◽  
Marcelo Eustáquio Silva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Clinical Problem ◽  
Hepatic Damage ◽  
Histopathological Analysis ◽  
Potential Candidate ◽  
Apap Overdose ◽  
Candidate Drug ◽  
Antioxidant Parameters ◽  
High Doses

Background. Acetaminophen (APAP) is a commonly used analgesic and antipyretic. When administered in high doses, APAP is a clinical problem in the US and Europe, often resulting in severe liver injury and potentially acute liver failure. Studies have demonstrated that antioxidants and anti-inflammatory agents effectively protect against the acute hepatotoxicity induced by APAP overdose.Methods. The present study attempted to investigate the protective effect ofB. trimeraagainst APAP-induced hepatic damage in rats. The liver-function markers ALT and AST, biomarkers of oxidative stress, antioxidant parameters, and histopathological changes were examined.Results. The pretreatment withB. trimeraattenuated serum activities of ALT and AST that were enhanced by administration of APAP. Furthermore, pretreatment with the extract decreases the activity of the enzyme SOD and increases the activity of catalase and the concentration of total glutathione. Histopathological analysis confirmed the alleviation of liver damage and reduced lesions caused by APAP.Conclusions. The hepatoprotective action ofB. trimeraextract may rely on its effect on reducing the oxidative stress caused by APAP-induced hepatic damage in a rat model.General Significance. These results make the extract ofB. trimeraa potential candidate drug capable of protecting the liver against damage caused by APAP overdose.

Nucleosome Serum Levels in Acute Hepatic Failure and MARS Treatment

2009 ◽  
Vol 41 (10) ◽  
pp. 4207-4210 ◽  
Author(s):  
G.A. Roth ◽  
B.A. Lubsczyk ◽  
J. Pilz ◽  
P. Faybik ◽  
H. Hetz ◽  
...  
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Serum Levels

scholarly journals The protective effect of prostaglandin E1 on experimentally-induced acute hepatic failure.

Kanzo ◽  
1987 ◽  
Vol 28 (4) ◽  
pp. 433-438
Author(s):  
Yasuhiro MIZOGUCHI ◽  
Hiroko TSUTSUI ◽  
Hiroshi KUBOI ◽  
Jae-Dam LEE ◽  
Yumiko FUJINOBU ◽  
...  
Keyword(s):  
Protective Effect ◽  
Hepatic Failure ◽  
Prostaglandin E1 ◽  
Acute Hepatic Failure ◽  
Experimentally Induced

Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats

2004 ◽  
Vol 32 (10) ◽  
pp. 2079-2083 ◽  
Author(s):  
Cristiane Ritter ◽  
Adalisa Reinke ◽  
Michael Andrades ◽  
Márcio Rodrigo Martins ◽  
João Rocha ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Hepatic Failure ◽  
Acute Hepatic Failure

REPRODUCTIVE TOXICITY OF CHLORPYRIFOS, CYPERMETHRIN AND THEIR INTERACTION IN MALE ALBINO RATS

2018 ◽  
pp. 69-86
Author(s):  
Asmaa ELnamaky ◽  
Amal Halawa ◽  
Mamdouh Abouelmaged
Keyword(s):  
Reproductive Toxicity ◽  
Prostatic Acid Phosphatase ◽  
Serum Levels ◽  
Reproductive Organs ◽  
Male Rats ◽  
Albino Rats ◽  
Glutathione S Transferase ◽  
Significant Drop ◽  
Sperm Abnormalities ◽  
Pituitary Glands

he present work was designed to investigate the reproductive toxicity induced by oral administration of chlorpyrifos (CPF), cypermethrin (CYP) and their combination in adult male albino rats. Forty mature male albino rats were separated into four groups (10 each), the first group was used as control, while second, third and fourth groups received orally 1/20 LD50 of CPF (10 mg/kg b.wt), 1/20 LD50 of CYP (17.22 mg/kg b.wt) and 1/40 LD50 of CPF plus 1/40 LD50 of CYP (5 mg/kg b.wt CPF plus 8.61 mg/kg b.wt CYP) respectively for 26 days. The results revealed that exposure to CPF and/or CYP induced a significant decrease in the reproductive organs weight. Moreover, a significant decrease in spermatic picture (sperm cell concentration and viability) was observed with high percent of sperm abnormalities. Serum levels of testosterone and pituitary gonadotropins (FSH and LH) have been declined significantly in all treated groups. Significant elevations were observed in malondialdehyde and nitric oxide concentrations, while antioxidant enzymes superoxide dismutase and glutathione-S-transferase activities were decreased significantly as a result of induced oxidative stress. A significant drop in prostatic acid phosphatase activity was observed. Additionally, the results showed some histopathological alterations in the reproductive organs as well as neurological lesions in brain and pituitary glands. In conclusion, CPF and CYP induce deleterious effects on reproductive efficiency of male rats which reflect more obvious impacts when both combined

Applying the Principles of Bridging Therapy at Concomitant Acute Hepatic Failure

2016 ◽  
Vol 0 (3.74) ◽  
pp. 112
Author(s):  
I.A. Kuchinskaya ◽  
M.V. Bondar ◽  
D.B. Areshnikov ◽  
S.S. Shapoval ◽  
R.D. Dobush
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Bridging Therapy
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