scholarly journals Aloe vera: An Ancient Herb for Modern Dentistry—A Literature Review

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Arbaz Sajjad ◽  
Samia Subhani Sajjad
Keyword(s):  
Aloe Vera ◽  
Clinical Applications ◽  
In Vivo Studies ◽  
Cochrane Central Register ◽  
Patient Centered ◽  
Aphthous Ulcers ◽  
Central Register ◽  
Dental Diseases

Objectives. To review composition, actions, and clinical applications of Aloe vera plant in dentistry and to establish its effectiveness as an invaluable adjunct in the treatment of dental diseases. Method. A manual and electronic literature (MEDLINE, Cochrane Central Register of Controlled Trials, and Google Scholar) search was performed up to July 2013 for in vitro and in vivo studies and research presenting clinical, microbiological, immunological, and patient-centered data to validate the efficacy of Aloe vera gel in dentistry. A total of 38 titles, abstracts, and full-text studies were selected and reviewed. Aloe vera has various medicinal properties like anti-inflammatory, antibacterial, antiviral, and antitumor which accelerates wound healing and helps in treating various lesions in oral cavity. Benefits associated with Aloe vera have been attributed to the polysaccharides contained in the gel of the leaves. Conclusion. The pharmacological attributes of Aloe vera have been revalidated in modern sciences through various in vivo and in vitro studies. The herb has immense potential as a dental therapeutic. Even though Aloe vera is a promising herb with various clinical applications in medicine and dentistry, more clinical research needs to be undertaken especially to validate and explain the action of acemannan hydrogel in accelerating the healing of aphthous ulcers and to validate the efficacy of Aloe gel on plaque and gingivitis, so that it can be established in the field of dentistry.

Evaluation of Isolated Fractions of Aloe vera Gel Materials on Indinavir Pharmacokinetics: In vitro and in vivo Studies

2016 ◽  
Vol 13 (3) ◽  
pp. 471-480 ◽  
Author(s):  
Lonette Wallis ◽  
Maides Malan ◽  
Chrisna Gouws ◽  
Dewald Steyn ◽  
Suria Ellis ◽  
...  
Keyword(s):  
Aloe Vera ◽  
In Vivo Studies ◽  
Aloe Vera Gel

Erythropoietin/aloe vera-releasing wet-electrospun polyvinyl alcohol/chitosan sponge-like wound dressing: In vitro and in vivo studies

2017 ◽  
Vol 33 (3) ◽  
pp. 269-281 ◽  
Author(s):  
Mahdi Naseri-Nosar ◽  
Saeed Farzamfar ◽  
Majid Salehi ◽  
Ahmad Vaez ◽  
Roksana Tajerian ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Wound Dressing ◽  
Aloe Vera ◽  
In Vivo Studies

Quantitative Lung Ultrasound: Technical Aspects and Clinical Applications

2021 ◽  
Author(s):  
Silvia Mongodi ◽  
Daniele De Luca ◽  
Andrea Colombo ◽  
Andrea Stella ◽  
Erminio Santangelo ◽  
...  
Keyword(s):  
Lung Ultrasound ◽  
Scoring Systems ◽  
Clinical Applications ◽  
In Vivo Studies ◽  
Technical Aspects ◽  
Critical Care Units ◽  
Medical Wards ◽  
Opening Up

Lung ultrasound is increasingly used in emergency departments, medical wards, and critical care units—adult, pediatric, and neonatal. In vitro and in vivo studies show that the number and type of artifacts visualized change with lung density. This has led to the idea of a quantitative lung ultrasound approach, opening up new prospects for use not only as a diagnostic but also as a monitoring tool. Consequently, the multiple scoring systems proposed in the last few years have different technical approaches and specific clinical indications, adaptable for more or less time-dependent patients. However, multiple scoring systems may generate confusion among physicians aiming at introducing lung ultrasound in their clinical practice. This review describes the various lung ultrasound scoring systems and aims to clarify their use in different settings, focusing on technical aspects, validation with reference techniques, and clinical applications.

Sodium 3-mercaptopropanesulphonate substituted phthalocyanine: Synthesis, photophysical properties, in vitro and in vivo PDT efficacy

2020 ◽  
pp. A-E
Author(s):  
Mack Biyiklioglu
Keyword(s):  
Tumor Growth ◽  
Singlet Oxygen ◽  
Hepg2 Cells ◽  
Photophysical Properties ◽  
Clinical Applications ◽  
In Vivo Studies ◽  
Cremophor El ◽  
Photochemical Properties

A new sulfonic zinc(II) phthalocyanine bearing sodium 3-mercaptopropanesulphonate (Pc) was synthesized and characterized, as to its photophysical and photochemical properties, in vitro and in vivo. Pc remain non-aggregated in [Formula: see text],[Formula: see text]-dimethylformamide and in water containing 0.1% Cremophor EL, with high singlet oxygen efficacy. In vitro studies showed that the IC[Formula: see text] value of Pc on HepG2 cells was 1.3 [Formula: see text]M. In addition, in vivo studies showed that Pc mainly accumulated in tumor sites and showed an obvious PDT effect, and ca.97% of tumor growth was inhibited. Therefore, the Pc could be applied as a very promising photosensitizer for PDT in future clinical applications.

scholarly journals Inhaled Nitric Oxide for postexposure chemoprophylaxis of COVID-19

2021 ◽  
Author(s):  
Antoine AbdelMassih ◽  
Rafeef Hozaien ◽  
Meryam El Shershaby ◽  
Aya Kamel ◽  
Habiba-Allah Ismail ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Systematic Review ◽  
Viral Replication ◽  
Medical Personnel ◽  
Inhaled Nitric Oxide ◽  
Cochrane Central Register ◽  
Central Register ◽  
Antiviral Role

Abstract Background: Postexposure prophylaxis has been an overlooked strategy in the context of COVID-19. Inhaled Nitric Oxide offers itself as a potential tool in this context. The aim of this systematic review was to depict previous in vivo and in vitro studies demonstrating an antiviral role for NO Methodology:Embase, Medline and the Cochrane Central Register were used to search for specific keywords such as “Nitric oxide” AND “Antiviral activity” for relevant publications up to 1st of June 2021. The systematic review was performed using PRISMA protocolResults:Twenty-one studies were identified depicting an antiviral role for Nitric Oxide. Those studies involved sixteen viruses. Only four of the depicted studies were clinical trials, while three were performed on a murine model. The remainder of the studies involved in vitro experimentation of the role of NO in halting viral replication of several viruses including SARS-CoV-2Conclusion: While early reports of NO role in the treatment of COVID-19 suggested its use for the treatment of established ARDS, NO seems to have a much earlier and more efficient prophylactic role. It inhibits a protease needed for canonical viral replication of SARS-CoV-2, namely Furin, by decreasing calcium's cytosolic levels. This might add a significant tool for postexposure chemoprophylaxis in the at-risk group, especially medical personnel.

Treatment of Skin Disorders with Aloe Materials

2019 ◽  
Vol 25 (20) ◽  
pp. 2208-2240 ◽  
Author(s):  
Hanna Svitina ◽  
Roan Swanepoel ◽  
Jacques Rossouw ◽  
Happiness Netshimbupfe ◽  
Chrisna Gouws ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Water Loss ◽  
Aloe Vera ◽  
In Vivo Studies ◽  
Skin Disorders ◽  
Prevention And Treatment ◽  
Ancient Times ◽  
Excessive Water

The skin is the largest organ and functions as a barrier to protect the underlying tissues against the elements and pathogens, while also fulfilling many physiological roles and biochemical functions such as preventing excessive water loss. Skin disorders vary greatly in terms of origin, severity, symptoms and affect persons of all ages. Many plants have been used for medicinal purposes since ancient times including the treatment of skin disorders and diseases. Aloe represents one of the earliest medicinal plant species mentioned in antique scriptures and even in rock art dating back thousands of years. Different Aloe species and materials have been used in the prevention and treatment of skin related disorders. Aloe vera is the most commonly used Aloe species for medicinal purposes. Some of the most prominent skin related applications and disorders that Aloe materials have been investigated for are discussed in this paper, which include cosmetic, radiation, cancer, wound and antimicrobial applications. Both in vitro and in vivo studies are included in the discussions of this paper and comprehensive summaries of all these studies are given in tables in each section. Although some contradictory results were obtained among studies, certain Aloe materials have shown excellent efficacy and exhibited potential for the treatment of skin related disorders and cosmetic applications.

Synthesis, characterization and evaluation of collagen scaffolds crosslinked with aminosilane functionalized silver nanoparticles: in vitro and in vivo studies

2015 ◽  
Vol 3 (15) ◽  
pp. 3032-3043 ◽  
Author(s):  
Abhishek Mandal ◽  
Santhanam Sekar ◽  
N. Chandrasekaran ◽  
Amitava Mukherjee ◽  
Thotapalli P. Sastry
Keyword(s):  
Silver Nanoparticles ◽  
Clinical Applications ◽  
In Vivo Studies ◽  
Cross Linking ◽  
Collagen Scaffolds ◽  
Novel Approach

This work presents a novel approach for functionalization of silver nanoparticles and cross-linking them with collagen to form FSCSC scaffolds suitable for clinical applications.

BODIPYS and aza-BODIPY derivatives as promising fluorophores for in vivo molecular imaging and theranostic applications

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1159-1183 ◽  
Author(s):  
Ewen Bodio ◽  
Franck Denat ◽  
Christine Goze
Keyword(s):  
Molecular Imaging ◽  
Cyanine Dyes ◽  
Clinical Applications ◽  
In Vivo Studies ◽  
Optical Molecular Imaging ◽  
Theranostic Applications ◽  
Scientific Fields

Since their discovery in 1968, the BODIPYs dyes (4,4-difluoro-4-bora-3a, 4a diaza-s-indacene) have found an exponentially increasing number of applications in a large variety of scientific fields. In particular, studies reporting bioapplications of BODIPYs have increased dramatically. However, most of the time, only in vitro investigations have been reported. The in vivo potential of BODIPYs and aza-BODIPYs is more recent, but considering the number of in vivo studies with BODIPY and aza-BODIPY which have been reported in the last five years, we can now affirm that this family of fluorophores can be considered important as cyanine dyes for future in vivo and even clinical applications. This review aims to present representative examples of recent in vivo applications of BODIPYs or aza-BODIPYs, and to highlight the potential of these dyes for optical molecular imaging.

scholarly journals Effect of Different Laser Wavelengths on Periodontopathogens in Peri-Implantitis: A Review of In Vivo Studies

2019 ◽  
Vol 7 (7) ◽  
pp. 189 ◽  
Author(s):  
Katarzyna Świder ◽  
Marzena Dominiak ◽  
Kinga Grzech-Leśniak ◽  
Jacek Matys
Keyword(s):  
Er:Yag Laser ◽  
Oral Bacteria ◽  
In Vivo Studies ◽  
Cochrane Central Register ◽  
Bacterial Strains ◽  
Search Terms ◽  
Central Register ◽  
Dental Lasers ◽  
Power Diode

Nowadays, many studies are examining the effectiveness of dental lasers in the treatment of peri-implantitis; however, most of them only report periodontal parameter changes. The authors of this review tried to address the question: “What is the effect of different laser wavelengths on oral bacteria that cause peri-implantitis?” An electronic search of PubMed and Cochrane Central Register of Controlled Trials was performed. The following search terms were used: (peri-implantitis OR periimplantitis) OR/AND (microbial OR microbiologic) AND (laser OR Er:YAG OR erbium OR diode OR Nd:YAG OR neodymium-doped OR Er,Cr:YSGG OR chromium-doped). Initially, 212 studies were identified. After screening the titles and abstracts and excluding studies according to predefined inclusion criteria, seven publications were included in the review. Three studies about the effect of aPDT (antimicrobial photodynamic therapy) reported a decrease in the different bacterial strains associated with peri-implantitis, e.g., A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. denticola, T. forsythia, F. nucleatum, and C. rectus. Two studies showed that the high-power diode laser may have some effect on peri-implant pathogens. Two articles about the Er:YAG laser reported a lowering in the count of oral pathogens; however, it was hard to determine if this was due to the use of the laser. aPDT has the ability to decrease the count of peri-implant pathogens, whereas Er:YAG laser application shows no significant effect on oral bacteria in the long term.

scholarly journals Statins Against Drug-Induced Nephrotoxicity

2013 ◽  
Vol 16 (4) ◽  
pp. 588 ◽  
Author(s):  
Simin Dashti-Khavidaki ◽  
Azadeh Moghaddas ◽  
Behrooz Heydari ◽  
Hossein Khalili ◽  
Mahboob Lessan-Pezeshki ◽  
...  
Keyword(s):  
In Vivo Studies ◽  
Renal Diseases ◽  
Statin User ◽  
High Dose ◽  
Cochrane Central Register ◽  
Contrast Induced Nephropathy ◽  
Drug Induced ◽  
Reductase Inhibitors

Drug-induced nephrotoxicity (DIN) accounts for up to 60% of hospital acquired acute kidney injury with considerable morbidity and mortality. Several efforts have been made to reduce drug-induced nephrotoxicity; however, DIN remains a matter of concern. Statins with their antioxidant, anti-inflammatory and anti-apoptotic effects may have the potential to protect kidney against DIN. The present review evaluated all of the available in vitro and in vivo studies that examined the use of statins as renoprotective agents against nephrotoxic drugs. Materials for this review were obtained by searching Medline, PubMed, Scopus, Cochrane central register of controlled trials, and Cochrane database of systematic reviews. Key words used as search terms included “statin”, “3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, “HMG-CoA reductase inhibitors”, “nephroprotective”, “renoprotective”, “drug-induced renal diseases”, “drug-induced nephrotoxicity”, “drug-induced renal toxicity”, “drug-induced nephropathy”, “drug-induced renal side effects”, and “contrast-induced nephropathy”. This search was performed without time limitation. Only English language articles were included in this review. This review concluded that chronic statin user may be less prone to contrast-induced nephropathy (CIN) compared with statin non-users. Short-term high dose statin administration may also reduce the incidence of CIN in statin naïve patients. This renoprotective effect of statins against CIN is seen in low risk patients with normal kidney function or mild kidney dysfunction, but probably not in patients with moderate to severe renal dysfunction.  Based on available animal data, statins may protect kidney against gentamicin-, cisplatin- and cyclosporine-induced nephrotoxicity, however, theses animal results have not yet been confirmed by human data. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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