scholarly journals The Effect of 17β-Estradiol Administration on Cutaneous Wound Healing in 24-Week Ovariectomized Female Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Kanae Mukai ◽  
Yukari Nakajima ◽  
Tamae Urai ◽  
Emi Komatsu ◽  
Kana Takata ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Estrogen Replacement ◽  
Wound Area ◽  
Cutaneous Wound ◽  
Female Mice ◽  
Exogenous Estrogen ◽  
17Β Estradiol

Estrogen replacement promotes cutaneous wound healing in 8–10-week young ovariectomized female mice. However, research using aged ovariectomized female mice has not been reported, to the best of our knowledge. Therefore, we investigated the effect of 17β-estradiol on cutaneous wound healing using 24-week middle-aged ovariectomized female mice. Twenty-week-old female mice were divided into three groups: medication with 17β-estradiol after ovariectomy (OVX + 17β-estradiol), ovariectomy (OVX), and sham (SHAM). After 4 weeks, the mice received two full-thickness wounds. Then, the OVX + 17β-estradiol group was administered 17β-estradiol at 0.01 g/day until healing. The ratio of wound area in the OVX + 17β-estradiol group was significantly decreased compared with that in the OVX group. The numbers of neutrophils and macrophages in the OVX + 17β-estradiol group were significantly smaller than those in the OVX group. In addition, the ratio of myofibroblasts in the OVX + 17β-estradiol group was significantly higher than that in the OVX group. These data suggested that exogenous continuous 17β-estradiol administration promotes cutaneous wound healing in 24-week OVX female mice by reducing wound area, shortening inflammatory response, and promoting wound contraction. However, it is unclear whether the effect of exogenous estrogen on wound healing outweighs the delay of wound healing due to advanced age.

scholarly journals Comparison of the Cutaneous Wound Healing of Ovariectomized Mouse at 12 Weeks with That of SHAM and Estrogen-Administered Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Kanae Mukai ◽  
Yuriko Miyasaka ◽  
Kana Takata ◽  
Tamae Urai ◽  
Yukari Nakajima ◽  
...  
Keyword(s):  
Wound Healing ◽  
Estradiol Level ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Wound Area ◽  
Cutaneous Wound ◽  
Cutaneous Wounds ◽  
Female Mice ◽  
Ovariectomized Mouse ◽  
Significant Difference

The aim of this experiment was to investigate the effect of 17β-estradiol on cutaneous wound healing in 12-week ovariectomized (OVX) female mice. Eight-week-old female mice were divided into three groups: administration of 17β-estradiol after OVX (OVX + 17β-estradiol), OVX, and sham (SHAM). Four weeks after surgery, the mice received two full-thickness cutaneous wounds. 17β-Estradiol at 0.01 g/day was administered on the backs of mice in the OVX + 17β-estradiol group every day. Plasma 17β-estradiol level in the OVX + 17β-estradiol group was thus significantly higher than in the SHAM and OVX groups, but there was no significant difference between SHAM and OVX groups. The ratio of wound area was not significantly different among the three groups. However, the period required to reach a ratio of wound area of 0.15 in the OVX + 17β-estradiol group was significantly shorter than in the SHAM and OVX groups. These results indicate that cutaneous wound healing in young OVX mice was promoted by the administration of 17β-estradiol compared with that in SHAM and OVX mice without such administration, but there was no difference between the latter two groups that did not differ in 17β-estradiol level.

scholarly journals 17β-Estradiol administration promotes delayed cutaneous wound healing in 40-week ovariectomised female mice

2014 ◽  
Vol 13 (5) ◽  
pp. 636-644 ◽  
Author(s):  
Kanae Mukai ◽  
Yukari Nakajima ◽  
Tamae Urai ◽  
Emi Komatsu ◽  
Nasruddin ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Female Mice ◽  
17Β Estradiol

Study on the Effect of Cerium Oxide Nanocubes on Full-Thickness Cutaneous Wound Healing of Type 2 Diabetic Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cerium Oxide ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Type 2 Diabetic

scholarly journals The Effect of 17β-Estradiol on Cutaneous Wound Healing in Protein-Malnourished Ovariectomized Female Mouse Model

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115564 ◽  
Author(s):  
Kanae Mukai ◽  
Emi Komatsu ◽  
Yukari Nakajima ◽  
Tamae Urai ◽  
Nasruddin ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mouse Model ◽  
Female Mouse ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
17Β Estradiol

scholarly journals Hyaluronidase Modulates Inflammatory Response and Accelerates the Cutaneous Wound Healing

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112297 ◽  
Author(s):  
Marcio Fronza ◽  
Guilherme F. Caetano ◽  
Marcel N. Leite ◽  
Claudia S. Bitencourt ◽  
Francisco W. G. Paula-Silva ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

scholarly journals The Effect of Aloe vera (Linn) On Cutaneous Wound Healing and Wound Contraction Rate in Adult Rabbits

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Martha Orendu Attah ◽  
Tonye Watson Jacks ◽  
Attah Jacob ◽  
Otong Eduitem ◽  
Barnabas John
Keyword(s):  
Wound Healing ◽  
Aloe Vera ◽  
Wound Contraction ◽  
Control Group ◽  
Cutaneous Wound Healing ◽  
Contraction Rate ◽  
Wound Area ◽  
Cutaneous Wound ◽  
Cutaneous Wounds ◽  
Aloe Vera Gel

Background: In the present research study, the rate of cutaneous wound healing and contraction rate in healthy rabbits using Aloe vera pulp was studied.Methods: Ten healthy rabbits were used for the study. They were divided into two groups consisting of five rabbits each. Cutaneous wounds were made on the lumbar region of each rabbit using a template which ensured that the wounds were of the same size in all the rabbits. 5ml of Aloe vera gel was applied to the wounds of the animals in the test group, while nothing was applied to the wound area of the animals in the control group. The wound area in each group was measured for a period of 21 days, using a venire caliper and tracing paper which was used to trace the wound area. Tissue samples were removed from the wound area in both experimental and control groups and subjected to routine histological analysis, also, morphometric analysis was performed.Results: The rate of wound contraction and mean centripetal contraction was calculated in both groups and graphically represented using Microsoft Excel. The results showed that animals who were treated with Aloe vera gel had a greater wound contraction rate, as well as rapid wound closure. The micrographs showed a thicker epithelial layer, with thinner collagen fibers in the dermis of experimental animals compared to the control group. There was also an abundant capillary bed at the dermal-epidermal junction in the experimental group, compared to the control group.Conclusion:  Aloe vera may increase the rate of wound healing by accelerating epithelial migration, and may also play a role in neo-vascularization of the newly healed area.Keywords: Aloe vera, Cutaneous Wounds, Rabbits, Wound Contraction, Wound Healing

Cutaneous wound healing in the EpiDerm-FT full thickness in vitro human skin model

2010 ◽  
Vol 196 ◽  
pp. S152
Author(s):  
S. Letasiova ◽  
P. Hayden ◽  
G. Stolper ◽  
A. Armento ◽  
C. Cooney ◽  
...  
Keyword(s):  
Wound Healing ◽  
Human Skin ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Skin Model ◽  
Cutaneous Wound
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