scholarly journals Comparison of Different Measures of Fat Mass and Their Association with Serum Cystatin C Levels

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Boon Wee Teo ◽  
Jonathan J. H. Soon ◽  
Qi Chun Toh ◽  
Hui Xu ◽  
Jialiang Li ◽  
...  
Keyword(s):  
Cystatin C ◽  
Information Criterion ◽  
C Reactive Protein ◽  
Multivariate Models ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Percentage Body Fat ◽  
Reactive Protein ◽  
Skin Fold ◽  
Triceps Skin Fold

Introduction. Cystatin C (CysC) is a glomerular filtration rate (GFR) marker affected by GFR and obesity. Because percentage body fat (%BF) distribution is affected by ethnicity, different measures of %BF may improve CysC prediction. This study aims to create multivariate models that predict serum CysC and determine which %BF metric gives the best prediction. Methods. Serum CysC was measured by nephelometric assay. We estimated %BF by considering weight, body mass index, waist-hip ratio, triceps skin fold, bioimpedance, and Deurenberg and Yap %BF equations. A base multivariate model for CysC was created with a %BF metric added in turn. The best model is considered by comparing P values, R2, Akaike information criterion (AIC), and Bayesian information criterion (BIC). Results. There were 335 participants. Mean serum CysC and creatinine were 1.27 mg/L and 1.44 mg/dL, respectively. Variables for the base model were age, gender, ethnicity, creatinine, serum urea, c-reactive protein, log GFR, and serum albumin. %BF had a positive correlation with CysC. The best model for predicting CysC included bioimpedance-derived %BF (P=0.0011), with the highest R2 (0.917) and the lowest AIC and BIC (−371, −323). Conclusion. Obesity is associated with CysC, and the best predictive model for CysC includes bioimpedance-derived %BF.

scholarly journals Serum Cystatin C Levels in COPD: Potential Diagnostic Value and Relation Between Respiratory Functions

2018 ◽  
Vol 37 (4) ◽  
pp. 434-440 ◽  
Author(s):  
Selda Telo ◽  
Mutlu Kuluöztürk ◽  
Figen Deveci ◽  
Gamze Kırkıl ◽  
Önsel Öner ◽  
...  
Keyword(s):  
Cystatin C ◽  
Diagnostic Value ◽  
Serum Urea ◽  
C Reactive Protein ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Positive Correlation ◽  
Reactive Protein ◽  
Cell Counts ◽  
Significant Difference

SummaryBackground:The aim of this study was to determine the level of serum cystatin C (CysC) in patients with Chronic Obstructive Pulmonary Disease (COPD) during exacerbation and stable periods and to investigate its potential diagnostic value and the relationship between CysC levels and the pulmonary function test (PFT).Methods:One hundred twenty-six patients with COPD (68 in stable periods, 58 during exacerbation periods) and 50 healthy subjects were included in the study. PFT, body mass index (BMI), white blood cell counts, C-reactive protein (CRP), serum urea and creatinine levels were evaluated in both groups of patients. CysC levels were measured in all participants.Results:Serum CysC levels were statistically higher in both COPD groups than the control group (p<0.001 for both) although there was no statistically significant difference between COPD groups (p>0.05). CysC levels showed negative correlation with forced expiratory volume in 1 second (FEV1) and a positive correlation with C-reactive protein (CRP) levels in patients with stable COPD. There was a positive correlation between serum CysC levels and serum urea, creatinine, CRP levels in patients with COPD exacerbation (r=0.333, p=0.011; r=0.260, p=0.049; r=0.414, p<0.01 respectively). When stable COPD and control groups were evaluated, serum CysC had an area under the curve (AUC) in the receiver operating characteristic (ROC) curve of 0.951 (0.909–0.994 95% CI: p<0.001).Conclusions:Our results showed that CysC levels increased in both COPD groups. Increased CysC levels may be related with lung function decline and inflammation in COPD patients. In addition, CysC levels may be a potential indicator for the diagnosis of COPD.

Changes in serum cystatin C, creatinine, and C-reactive protein after cardiopulmonary bypass in patients with normal preoperative kidney function

Nephrology ◽  
2016 ◽  
Vol 21 (6) ◽  
pp. 519-525 ◽  
Author(s):  
Anders S. Svensson ◽  
John-Peder Escobar Kvitting ◽  
Csaba P. Kovesdy ◽  
Ingemar Cederholm ◽  
Zoltán Szabó
Keyword(s):  
Cardiopulmonary Bypass ◽  
Kidney Function ◽  
Cystatin C ◽  
C Reactive Protein ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Reactive Protein

509-P: Utility of Serum Cystatin C in Early Kidney Dysfunction in Prediabetics

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 509-P
Author(s):  
JULIA I.F. BRANDA ◽  
BIANCA ALMEIDA ◽  
SANDRA R.G. VIVOLO
Keyword(s):  
Cystatin C ◽  
Kidney Dysfunction ◽  
Serum Cystatin C ◽  
Serum Cystatin

scholarly journals Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Bertille Elodie Edinga-Melenge ◽  
Adrienne Tchapmi Yakam ◽  
Jobert Richie Nansseu ◽  
Catherine Bilong ◽  
Suzanne Belinga ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Cystatin C ◽  
Reference Intervals ◽  
African Population ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Sub Saharan

scholarly journals Assessment of Subclinical Renal Glomerular and Tubular Dysfunction in Children with Beta Thalassemia Major

Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 100
Author(s):  
Asmaa A. Mahmoud ◽  
Doaa M. Elian ◽  
Nahla MS. Abd El Hady ◽  
Heba M. Abdallah ◽  
Shimaa Abdelsattar ◽  
...  
Keyword(s):  
Cystatin C ◽  
Kidney Injury ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Good Survival ◽  
Control Group ◽  
Healthy Children ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Beta Thalassemia Major

Background: A good survival rate among patients with beta thalassemia major (beta-TM) has led to the appearance of an unrecognized renal disease. Therefore, we aimed to assess the role of serum cystatin-C as a promising marker for the detection of renal glomerular dysfunction and N-acetyl beta-D-glucosaminidase (NAG) and kidney injury molecule 1 (KIM-1) as potential markers for the detection of renal tubular injury in beta-TM children. Methods: This case-control study was implemented on 100 beta-TM children receiving regular blood transfusions and undergoing iron chelation therapy and 100 healthy children as a control group. Detailed histories of complete physical and clinical examinations were recorded. All subjected children underwent blood and urinary investigations. Results: There was a significant increase in serum cystatin-C (p < 0.001) and a significant decrease in eGFR in patients with beta-TM compared with controls (p = 0.01). There was a significant increase in urinary NAG, KIM-1, UNAG/Cr, and UKIM-1/Cr (p < 0.001) among thalassemic children, with a significant positive correlation between serum cystatin-C, NAG and KIM-1 as regards serum ferritin, creatinine, and urea among thalassemic patients. A negative correlation between serum cystatin-C and urinary markers with eGFR was noted. Conclusion: Serum cystatin-C is a good marker for detection of glomerular dysfunction. NAG and KIM-1 may have a predictive role in the detection of kidney injury in beta-TM children.

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