scholarly journals Insight into the Willgerodt-Kindler Reaction of ω-Haloacetophenone Derivatives: Mechanistic Implication

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Urbain C. Kasséhin ◽  
Fernand A. Gbaguidi ◽  
Coco N. Kapanda ◽  
Christopher R. McCurdy ◽  
Jacques H. Poupaert
Keyword(s):  
Practical Method ◽  
Synthetic Approach ◽  
Compound Library ◽  
One Pot ◽  
Insight Into

This paper reports efforts aimed at tuning up the synthesis of a compound library centered on the general template 2-amino-1-phenyl-2-thioxoethanone taking the condensation of ω-haloacetophenone, octasulfur, and morpholine as pilot reaction. Considerations about atomic economy were found extremely precious in selecting the best starting halo-reagent. A one-pot practical method based on use of 2-bromo-1-phenylethanone as substrate and N,N-dimethylformamide as solvent can be easily scaled up to gram amounts (72% yield). Based on this synthetic approach, some more specific examples are reported.

Green Synthesized Nanomaterials as Theranostic Platforms for Cancer Treatment: Principles, Challenges and the Road Ahead

2019 ◽  
Vol 26 (8) ◽  
pp. 1311-1327 ◽  
Author(s):  
Pala Rajasekharreddy ◽  
Chao Huang ◽  
Siddhardha Busi ◽  
Jobina Rajkumari ◽  
Ming-Hong Tai ◽  
...  
Keyword(s):  
Nanoparticle Synthesis ◽  
Research Field ◽  
Synthesis Methods ◽  
Synthetic Approach ◽  
Future Directions ◽  
The Road ◽  
New Methods ◽  
Recent Developments ◽  
Theranostic Applications ◽  
Insight Into

With the emergence of nanotechnology, new methods have been developed for engineering various nanoparticles for biomedical applications. Nanotheranostics is a burgeoning research field with tremendous prospects for the improvement of diagnosis and treatment of various cancers. However, the development of biocompatible and efficient drug/gene delivery theranostic systems still remains a challenge. Green synthetic approach of nanoparticles with low capital and operating expenses, reduced environmental pollution and better biocompatibility and stability is a latest and novel field, which is advantageous over chemical or physical nanoparticle synthesis methods. In this article, we summarize the recent research progresses related to green synthesized nanoparticles for cancer theranostic applications, and we also conclude with a look at the current challenges and insight into the future directions based on recent developments in these areas.

ChemInform Abstract: A New Synthetic Approach to Functionalize Pyrimido[4,5-b]quinoline-2,4(1H,3H)-diones via a Three-Component One-Pot Reaction.

ChemInform ◽  
2010 ◽  
Vol 41 (29) ◽  
pp. no-no
Author(s):  
Karen Aknin ◽  
Stephanie Desbene-Finck ◽  
Philippe Helissey ◽  
Sylviane Giorgi-Renault
Keyword(s):  
Synthetic Approach ◽  
One Pot

Direct insight into crystallization and stability of hybrid perovskite CH3NH3PbI3via solvothermal synthesis

2015 ◽  
Vol 3 (31) ◽  
pp. 15854-15857 ◽  
Author(s):  
Ying Chen ◽  
Shuang Yang ◽  
Xiao Chen ◽  
Yi Chu Zheng ◽  
Yu Hou ◽  
...  
Keyword(s):  
Single Crystals ◽  
Solvothermal Synthesis ◽  
One Pot ◽  
Hybrid Perovskite ◽  
First Time ◽  
Solvothermal Conditions ◽  
Insight Into

We report a one-pot solvothermal approach to synthesize cuboid shaped CH3NH3PbI3 single crystals. Growth and dissolution phenomena of perovskite crystals were discovered for the first time under solvothermal conditions.

Highly bright and stable white-light-emitting cadmium-free Ag,Mn co-doped Zn–In–S/ZnS quantum dots and their electroluminescence

2018 ◽  
Vol 6 (38) ◽  
pp. 10233-10240 ◽  
Author(s):  
Wen-Jin Zhang ◽  
Chun-Yang Pan ◽  
Fan Cao ◽  
Haoran Wang ◽  
Xuyong Yang
Keyword(s):  
Quantum Dots ◽  
White Light ◽  
Low Cost ◽  
Synthetic Approach ◽  
One Pot ◽  
Light Emitting ◽  
Co Doped

Optimized white light emitting Ag,Mn:Zn–In–S quantum dots (QDs) were synthesized via a simple, scalable, reproducible, and low-cost one-pot non-injection synthetic approach.

scholarly journals A synthetic approach to ‘click’ neoglycoprotein analogues of EPO employing one-pot native chemical ligation and CuAAC chemistry

2019 ◽  
Vol 10 (3) ◽  
pp. 815-828 ◽  
Author(s):  
D. J. Lee ◽  
A. J. Cameron ◽  
T. H. Wright ◽  
P. W. R. Harris ◽  
M. A. Brimble
Keyword(s):  
Native Chemical Ligation ◽  
Synthetic Approach ◽  
One Pot ◽  
Chemical Ligation ◽  
Synthetic Methodologies

The batch-wise variability of commercial erythropoietin (EPO) preparations warrants development of more advanced synthetic methodologies. We have developed a diverse chemical toolkit to prepare ‘click’ neoglycoprotein variants of EPO.

Synthetic Approach to Fused Azasultams with 1,2,4-Thiadiazepine Framework

Synthesis ◽  
2020 ◽  
Vol 52 (19) ◽  
pp. 2857-2869
Author(s):  
Demyd S. Milokhov ◽  
Vasyl Y. Hys ◽  
Olesya B. Volovenko ◽  
Irina S. Konovalova ◽  
Svitlana V. Shishkina ◽  
...  
Keyword(s):  
Building Blocks ◽  
Synthetic Approach ◽  
Chemical Behavior ◽  
One Pot ◽  
Enamino Ketone ◽  
The One

Synthetic approach to fused azasultams with 1,2,4-thiadi­azepine framework via base promoted protocols has been developed. 1H-Azole-2-carboxylates and N-(chloromethyl)-N-methylmethanesulfonamide were used as ambiphilic building blocks in the one-pot and two-step reaction sequences. Chemical behavior of the obtained azasultams in reactions with amines, hydrazine, DMFDMA, and NaBH4 was investigated. An enamino ketone derived from an azasultam was exploited in the synthesis of new pyrazole and pyrimidine heterocycles.

scholarly journals Practical Synthesis of Precursors of Cyclohexyne and 1,2-Cyclohexadiene

Synthesis ◽  
2019 ◽  
Vol 51 (07) ◽  
pp. 1561-1564 ◽  
Author(s):  
Kentaro Okano ◽  
Ryo Nakura ◽  
Kazuki Inoue ◽  
Atsunori Mori
Keyword(s):  
Room Temperature ◽  
Practical Method ◽  
Enol Ether ◽  
One Pot ◽  
Subsequent Formation ◽  
Silyl Group ◽  
Stoichiometric Amount ◽  
Lithium Enolate ◽  
Silyl Enol Ether ◽  
Practical Synthesis

This study investigated a practical method for regiocontrolled synthesis of precursors of strained cyclohexynes and 1,2-cyclohexadienes, which is a one-pot procedure consisting of a rearrangement of silyl enol ether and subsequent formation of the enol triflates. Triethylsilyl enol ether, derived from cyclohexanone, was treated with a combination of LDA and t-BuOK in n-hexane/THF to encourage the migration of the silyl group to generate an α-silyl enolate. Subsequently, the α-silyl enolate was reacted with Comins’ reagent to yield the corresponding enol triflate. Finally, the α-silylated trisubstituted lithium enolate for the synthesis of 1,2-cyclohexadiene precursor was isomerized in the presence of a stoichiometric amount of water for one hour at room temperature to exclusively provide tetrasubstituted lithium enolate for the synthesis of cyclohexyne precursor in one pot.

scholarly journals A facile one pot synthetic approach for C3N4–ZnS composite interfaces as heterojunctions for sunlight-induced multifunctional photocatalytic applications

RSC Advances ◽  
2016 ◽  
Vol 6 (22) ◽  
pp. 17800-17809 ◽  
Author(s):  
P. Suyana ◽  
Sneha K. R. ◽  
Balagopal N. Nair ◽  
Venugopal Karunakaran ◽  
A. Peer Mohamed ◽  
...  
Keyword(s):  
Zinc Nitrate ◽  
Synthetic Approach ◽  
One Pot ◽  
The Creation ◽  
Composite Interfaces ◽  
Photocatalytic Applications

Herein, we report a facile one pot synthetic protocol for the creation of C3N4–ZnS composite interfaces by the co-pyrolysis of a precursor mix containing zinc nitrate, melamine, and thiourea at 550 °C in air.

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