Green Synthesized Nanomaterials as Theranostic Platforms for Cancer Treatment: Principles, Challenges and the Road Ahead

2019 ◽  
Vol 26 (8) ◽  
pp. 1311-1327 ◽  
Author(s):  
Pala Rajasekharreddy ◽  
Chao Huang ◽  
Siddhardha Busi ◽  
Jobina Rajkumari ◽  
Ming-Hong Tai ◽  
...  
Keyword(s):  
Nanoparticle Synthesis ◽  
Research Field ◽  
Synthesis Methods ◽  
Synthetic Approach ◽  
Future Directions ◽  
The Road ◽  
New Methods ◽  
Recent Developments ◽  
Theranostic Applications ◽  
Insight Into

With the emergence of nanotechnology, new methods have been developed for engineering various nanoparticles for biomedical applications. Nanotheranostics is a burgeoning research field with tremendous prospects for the improvement of diagnosis and treatment of various cancers. However, the development of biocompatible and efficient drug/gene delivery theranostic systems still remains a challenge. Green synthetic approach of nanoparticles with low capital and operating expenses, reduced environmental pollution and better biocompatibility and stability is a latest and novel field, which is advantageous over chemical or physical nanoparticle synthesis methods. In this article, we summarize the recent research progresses related to green synthesized nanoparticles for cancer theranostic applications, and we also conclude with a look at the current challenges and insight into the future directions based on recent developments in these areas.

scholarly journals Recent developments in sustainably sourced protein-based biomaterials

2021 ◽  
Author(s):  
H. Agnieray ◽  
J.L. Glasson ◽  
Q. Chen ◽  
M. Kaur ◽  
L.J. Domigan
Keyword(s):  
Environmental Impact ◽  
Renewable Resources ◽  
Research Field ◽  
Future Directions ◽  
Recent Developments ◽  
Innovative Biomaterials ◽  
Increasing Demand ◽  
Definition Of ◽  
Advanced Biomaterials ◽  
Insight Into

Research into the development of sustainable biomaterials is increasing in both interest and global importance due to the increasing demand for materials with decreased environmental impact. This research field utilises natural, renewable resources to develop innovative biomaterials. The development of sustainable biomaterials encompasses the entire material life cycle, from desirable traits, and environmental impact from production through to recycling or disposal. The main objective of this review is to provide a comprehensive definition of sustainable biomaterials and to give an overview of the use of natural proteins in biomaterial development. Proteins such as collagen, gelatin, keratin, and silk, are biocompatible, biodegradable, and may form materials with varying properties. Proteins, therefore, provide an intriguing source of biomaterials for numerous applications, including additive manufacturing, nanotechnology, and tissue engineering. We give an insight into current research and future directions in each of these areas, to expand knowledge on the capabilities of sustainably sourced proteins as advanced biomaterials.

British Library document supply – a fork in the road

2010 ◽  
Vol 38 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Andy Appleyard
Keyword(s):  
Design Methodology ◽  
British Library ◽  
Improvement Strategy ◽  
Content Type ◽  
The Road ◽  
Current Thinking ◽  
Recent Developments ◽  
Insight Into ◽  
Future Plans

PurposeThis paper seeks to provide an overview of recent developments within the British Library's document supply service and offer an insight into future plans.Design/methodology/approachThe paper takes the form of a general review.FindingsThe British Library Document Supply Centre (BLDSC) has made tremendous gains in optimising the service in its current guise. As with similar organisations, challenges are presenting themselves that require a completely new look at the way the business model is designed. Although the long‐term plan is not completely formed, this paper aims to give an insight into current thinking.Originality/valueThe paper spells out the improvement strategy that the BL has adopted for document supply in the light of the worldwide decline.

scholarly journals Wavefront manipulation by acoustic metasurfaces: from physics and applications

Nanophotonics ◽  
2018 ◽  
Vol 7 (6) ◽  
pp. 1191-1205 ◽  
Author(s):  
Bin Liang ◽  
Jian-chun Cheng ◽  
Cheng-Wei Qiu
Keyword(s):  
Acoustic Waves ◽  
Review Paper ◽  
Three Dimensional ◽  
New Physics ◽  
Research Field ◽  
Acoustic Metamaterials ◽  
Future Directions ◽  
Practical Applications ◽  
The Past ◽  
Recent Developments

AbstractMolding the wavefront of acoustic waves into the desired shape is of paramount significance in acoustics, which however are usually constrained by the acoustical response of naturally available materials. The emergence of acoustic metamaterials built by assembling artificial subwavelength elements provides distinct response to acoustic waves unattainable in nature. More recently, acoustic metasurfaces, a class of metamaterials with a reduced dimensionality, empower new physics and lead to extended functionalities different from their three-dimensional counterparts, enabling controlling, transmitted or reflected acoustic waves in ways that were not possible before. In this review paper, we present a comprehensive view of this rapidly growing research field by introducing the basic concepts of acoustic metasurfaces and the recent developments that have occurred over the past few years. We review the interesting properties of acoustic metasurfaces and their important functionalities of wavefront manipulation, followed by an outlook for promising future directions and potential practical applications.

scholarly journals A Perspective on Reversibility in Controlled Polymerization Systems: Recent Progress and New Opportunities

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2870 ◽  
Author(s):  
Houliang Tang ◽  
Yi Luan ◽  
Lu Yang ◽  
Hao Sun
Keyword(s):  
Environmental Sustainability ◽  
Polymer Materials ◽  
Controlled Polymerization ◽  
Future Directions ◽  
Structure And Property ◽  
Vinyl Polymers ◽  
Recent Developments ◽  
General Concern ◽  
Insight Into ◽  
Significant Effort

The field of controlled polymerization is growing and evolving at unprecedented rates, facilitating polymer scientists to engineer the structure and property of polymer materials for a variety of applications. However, the lack of degradability, particularly in vinyl polymers, is a general concern not only for environmental sustainability, but also for biomedical applications. In recent years, there has been a significant effort to develop reversible polymerization approaches in those well-established controlled polymerization systems. Reversible polymerization typically involves two steps, including (i) forward polymerization, which converts small monomers into macromolecule; and (ii) depolymerization, which is capable of regenerating original monomers. Furthermore, recycled monomers can be repolymerized into new polymers. In this perspective, we highlight recent developments of reversible polymerization in those controlled polymerization systems and offer insight into the promise and utility of reversible polymerization systems. More importantly, the current challenges and future directions to solve those problems are discussed. We hope this perspective can serve as an “initiator” to promote continuing innovations in this fairly new area.

scholarly journals Recent Advances in Colloidal Photonic Crystal-Based Anti-Counterfeiting Materials

Crystals ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 417 ◽  
Author(s):  
Pan ◽  
Wang ◽  
Dou ◽  
Zhao ◽  
Xu ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Research Field ◽  
Band Gaps ◽  
Synthesis Methods ◽  
Security Level ◽  
Identification Methods ◽  
Structural Colors ◽  
Recent Developments ◽  
Photonic Band ◽  
Development Prospects

Colloidal photonic crystal (PC)-based anti-counterfeiting materials have been widely studied due to their inimitable structural colors and tunable photonic band gaps (PBGs) as well as their convenient identification methods. In this review, we summarize recent developments of colloidal PCs in the field of anti-counterfeiting from aspects of security strategies, design, and fabrication principles, and identification means. Firstly, an overview of the strategies for constructing PC anti-counterfeiting materials composed of variable color PC patterns, invisible PC prints, and several other PC anti-counterfeiting materials is presented. Then, the synthesis methods, working principles, security level, and specific identification means of these three types of PC materials are discussed in detail. Finally, the summary of strengths and challenges, as well as development prospects in the attractive research field, are presented.

scholarly journals The Role of Protein Persulfidation in Brain Aging and Neurodegeneration

2021 ◽  
Vol 13 ◽  
Author(s):  
Dunja Petrovic ◽  
Emilia Kouroussis ◽  
Thibaut Vignane ◽  
Milos R. Filipovic
Keyword(s):  
Brain Aging ◽  
Chemical Reactivity ◽  
Underlying Mechanism ◽  
Research Field ◽  
Future Directions ◽  
Link Protein ◽  
Cellular Defense ◽  
Recent Developments ◽  
Cysteine Thiols

Hydrogen sulfide (H2S), originally considered a toxic gas, is now a recognized gasotransmitter. Numerous studies have revealed the role of H2S as a redox signaling molecule that controls important physiological/pathophysiological functions. The underlying mechanism postulated to serve as an explanation of these effects is protein persulfidation (P-SSH, also known as S-sulfhydration), an oxidative posttranslational modification of cysteine thiols. Protein persulfidation has remained understudied due to its instability and chemical reactivity similar to other cysteine modifications, making it very difficult to selectively label. Recent developments of persulfide labeling techniques have started unraveling the role of this modification in (patho)physiology. PSSH levels are important for the cellular defense against oxidative injury, albeit they decrease with aging, leaving proteins vulnerable to oxidative damage. Aging is one of the main risk factors for many neurodegenerative diseases. Persulfidation has been shown to be dysregulated in Parkinson's, Alzheimer's, Huntington's disease, and Spinocerebellar ataxia 3. This article reviews the latest discoveries that link protein persulfidation, aging and neurodegeneration, and provides future directions for this research field that could result in development of targeted drug design.

scholarly journals Graphene-Based Magnetic Nanoparticles for Theranostics: An Overview for Their Potential in Clinical Application

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1073
Author(s):  
Teresa Lage ◽  
Raquel O. Rodrigues ◽  
Susana Catarino ◽  
Juan Gallo ◽  
Manuel Bañobre-López ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Clinical Application ◽  
Carrier Mobility ◽  
Charge Carrier Mobility ◽  
High Chemical ◽  
Future Directions ◽  
Magnetic Performance ◽  
Recent Developments ◽  
Theranostic Applications ◽  
High Charge Carrier Mobility

The combination of diagnostics and therapy (theranostic) is one of the most complex, yet promising strategies envisioned for nanoengineered multifunctional systems in nanomedicine. From the various multimodal nanosystems proposed, a number of works have established the potential of Graphene-based Magnetic Nanoparticles (GbMNPs) as theranostic platforms. This magnetic nanosystem combines the excellent magnetic performance of magnetic nanoparticles with the unique properties of graphene-based materials, such as large surface area for functionalization, high charge carrier mobility and high chemical and thermal stability. This hybrid nanosystems aims toward a synergistic theranostic effect. Here, we focus on the most recent developments in GbMNPs for theranostic applications. Particular attention is given to the synergistic effect of these composites, as well as to the limitations and possible future directions towards a potential clinical application.

scholarly journals Sulvanites: The Promise at the Nanoscale

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 823
Author(s):  
Roberto Prado-Rivera ◽  
Chen-Yu Chang ◽  
Mimi Liu ◽  
Cheng-Yu Lai ◽  
Daniela R. Radu
Keyword(s):  
Optoelectronic Devices ◽  
Synthesis Methods ◽  
Theoretical Studies ◽  
Printable Electronics ◽  
Solar Photovoltaics ◽  
Copper Chalcogenides ◽  
The Past ◽  
Recent Developments ◽  
Experimental And Theoretical Studies ◽  
Insight Into

The class of ternary copper chalcogenides Cu3MX4 (M = V, Nb, Ta; X = S, Se, Te), also known as the sulvanite family, has attracted attention in the past decade as featuring promising materials for optoelectronic devices, including solar photovoltaics. Experimental and theoretical studies of these semiconductors have provided much insight into their properties, both in bulk and at the nanoscale. The recent realization of sulvanites at the nanoscale opens new avenues for the compounds toward printable electronics. This review is aimed at the consideration of synthesis methods, relevant properties and the recent developments of the most important sulvanites.

scholarly journals Reversibility in Controlled Polymerization Systems: Recent Progress and New Opportunities

2018 ◽  
Author(s):  
Houliang Tang ◽  
Yi Luan ◽  
Lu Yang ◽  
Hao Sun
Keyword(s):  
Environmental Sustainability ◽  
Polymer Materials ◽  
Controlled Polymerization ◽  
Future Directions ◽  
Structure And Property ◽  
Vinyl Polymers ◽  
Recent Developments ◽  
General Concern ◽  
Insight Into ◽  
Significant Effort

The field of controlled polymerization is growing and evolving at unprecedented rates, facilitating polymer scientists to engineer the structure and property of polymer materials for a variety of applications. However, the lack of degradability, particularly in vinyl polymers, is a general concern for not only environmental sustainability but also biomedical applications. In recent years, there has been a significant effort to develop reversible polymerization approaches in those well-established controlled polymerization systems. Reversible polymerization typically involves two steps including (i) forward polymerization which converts small monomers into macromolecules, and (ii) depolymerization capable of regenerating original monomers. Furthermore, recycled monomers can be repolymerized into new polymers. In this perspective, we highlight recent developments of reversible polymerization in those controlled polymerization systems and offer insight into the promise and utility of reversible polymerization systems. More importantly, the current challenges and future directions to solve those problems are discussed. We hope this perspective can serve as an “initiator” to promote continuing innovations in this fairly new area.

No fear of George Kingsley Zipf

10.1558/37291 ◽  
2018 ◽  
Vol 2 (2) ◽  
pp. 242-263
Author(s):  
Stefano Rastelli ◽  
Kook-Hee Gil
Keyword(s):  
Minimalist Program ◽  
Classroom Research ◽  
Language Design ◽  
Efficient Computation ◽  
Generative Linguistics ◽  
The Third ◽  
Factor Effect ◽  
Language Classroom ◽  
Recent Developments ◽  
Insight Into

This paper offers a new insight into GenSLA classroom research in light of recent developments in the Minimalist Program (MP). Recent research in GenSLA has shown how generative linguistics and acquisition studies can inform the language classroom, mostly focusing on what linguistic aspects of target properties should be integrated as a part of the classroom input. Based on insights from Chomsky’s ‘three factors for language design’ – which bring together the Faculty of Language, input and general principles of economy and efficient computation (the third factor effect) for language development – we put forward a theoretical rationale for how classroom research can offer a unique environment to test the learnability in L2 through the statistical enhancement of the input to which learners are exposed.

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