Early Preinvasive Lesions in Ovarian Cancer

Faced with the catastrophic prognosis for ovarian cancer due to the fact that it is most often diagnosed late at the peritoneal carcinomatosis stage, screening and early detection could probably reduce the mortality rate. A better understanding of the molecular characteristics of the different ovarian cancer subtypes and their specific molecular signatures is indispensable prior to development of new screening strategies. We discuss here the early natural history of ovarian cancer and its origins.

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The Preclinical Natural History of Serous Ovarian Cancer: Defining the Target for Early Detection

PLoS Medicine ◽

10.1371/journal.pmed.1000114 ◽

2009 ◽

Vol 6 (7) ◽

pp. e1000114 ◽

Cited By ~ 161

Author(s):

Patrick O. Brown ◽

Chana Palmer

Keyword(s):

Ovarian Cancer ◽

Natural History ◽

Early Detection ◽

Serous Ovarian Cancer ◽

History Of

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Optimal scheduling of post-therapeutic follow-up of patients treated for cancer for early detection of relapses

Statistical Methods in Medical Research ◽

10.1177/0962280214524178 ◽

2016 ◽

Vol 25 (6) ◽

pp. 2457-2471 ◽

Cited By ~ 2

Author(s):

Serge MA Somda ◽

Eve Leconte ◽

Jean-Marie Boher ◽

Bernard Asselain ◽

Andrew Kramar ◽

...

Keyword(s):

Natural History ◽

Early Detection ◽

Clinical Stage ◽

Optimal Schedule ◽

Optimal Scheduling ◽

Evidence Based ◽

Scientific Societies ◽

Different Types ◽

History Of

Post-therapeutic surveillance is one important component of cancer care. However, there still is no evidence-based strategies to schedule patients’ follow-up examinations. Our approach is based on the modeling of the probability of the onset of relapse at an early asymptotic or preclinical stage and its transition to a clinical stage. For that we consider a multistate homogeneous Markov model, which includes the natural history of relapse. The model also handles separately the different types of possible relapses. The optimal schedule is provided by the calendar visit that maximizes a utility function. The methodology has been applied to laryngeal cancer. The different follow-up strategies revealed to be more efficient than those proposed by different scientific societies.

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Screening for the early detection of cancer— II. The impact of screening on the natural history of the disease

Mathematical Biosciences ◽

10.1016/0025-5564(78)90075-5 ◽

1978 ◽

Vol 40 (1-2) ◽

pp. 61-109 ◽

Cited By ~ 40

Author(s):

Arthur Albert ◽

Paul M. Gertman ◽

Thomas A. Louis ◽

Shu-ing Liu

Keyword(s):

Natural History ◽

Early Detection ◽

Early Detection Of Cancer ◽

History Of ◽

The Impact

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Natural History of Diabetic Complications: Early Detection and Progression

Diabetic Medicine ◽

10.1111/j.1464-5491.1991.tb02153.x ◽

1991 ◽

Vol 8 (S2) ◽

pp. S33-S37 ◽

Cited By ~ 9

Author(s):

T. Deckert ◽

B. Feldt-Rasmussen ◽

K. Borch-Johnsen ◽

T. Jensen ◽

A. Kofoed-Enevoldsen ◽

...

Keyword(s):

Natural History ◽

Early Detection ◽

Diabetic Complications ◽

History Of

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The Importance of Screening for Early Detection of Ovarian Cancer: Epidemiological Review

10.20944/preprints202110.0434.v1 ◽

2021 ◽

Author(s):

Navneetha Hardikar

Keyword(s):

Risk Factors ◽

Ovarian Cancer ◽

Mortality Rate ◽

Early Detection ◽

Transvaginal Ultrasound ◽

Screening Methods ◽

Ovarian Cancers ◽

Nutrition And Diet ◽

Incidence And Mortality ◽

Common Diagnosis

Abstract – Objective: Ovarian cancer, although not possessing a high incidence, is still the most common cancer-related deaths among women diagnosed with a gynecologic malignancy. The present study aims to highlight the epidemiology, risk factors of this disease and the significance of development of improved early detection strategies. Materials and Methods: This study was conducted using current published English studies by searching PubMed and Google Scholar. The search strategy included the keywords “ovarian cancer”, “diagnosis”, “risk factors”, “screening”, “epidemiology”. Studies on incidence and mortality were also considered. Case reports were excluded.Results: The highest incidence and mortality rates are observed in Central and Eastern Europe, while rates are relatively low in Asia and Africa. These rates are highest among the white population (14.3 per 100,000) and lowest among blacks (10 per 100,000) and Asians (9.7 per 100,000). The risk factors for this disease includes a family history, hormonal factors, nutrition and diet and physical activity, with some of them playing protective roles in reducing risk of ovarian cancers. There are no reliable screening methods for ovarian cancers. The most common diagnosis methods include a transvaginal ultrasound and a blood test to detect CA125 markers.Conclusions: The mortality rate of ovarian cancer is gradually increasing; thus, preventative measures are required to reduce lifetime risk of ovarian cancers and improve mortality rate.

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Appendiceal Rupture: A Continuing Diagnostic Problem

PEDIATRICS ◽

10.1542/peds.63.1.37 ◽

1979 ◽

Vol 63 (1) ◽

pp. 37-43

Author(s):

Ronald A. Savrin ◽

H. William Clatworthy

Keyword(s):

Mortality Rate ◽

Natural History ◽

Physical Examination ◽

Early Recognition ◽

Correct Diagnosis ◽

Diagnostic Problem ◽

Children's Hospital ◽

Primary Physician ◽

History Of ◽

Physical Findings

The mortality rate for appendicitis in children has remained relatively unchanged since the 1940s, when antibiotics were introduced in the treatment of appendiceal peritonitis. However, since this time the incidence of appendiceal rupture has increased appreciably, presumably owing to a failure of early recognition and treatment. At Columbus Children's Hospital, one half of all patients undergoing appendectomy for ruptured appendix in 1975 had been seen by another physician before admission, but the correct diagnosis had not been made. The history obtained by the primary physician and that given on admission were similar, yet differed from the histories given by patients whose disease had been correctly diagnosed. Findings on in-hospital physical examination of incorrectly diagnosed patients differed from those recorded by the primary physician, but were similar to those of patients whose disease had been correctly diagnosed. Since it is unlikely that the natural history of the disease has changed, the increased incidence of rupture must result either from early misinterpretation of physical findings or from greater delay by parents in responding to the child's illness. Physicians and parents must share the responsibility equally for the increasing incidence of appendiceal rupture in children.

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