Kimura Disease Manifesting as Synchronous Bilateral Parotid Swelling in a Young Middle-Eastern Patient

Abstract Kimura disease is a benign rare chronic inflammatory disorder of unknown etiology that involves the lymph nodes and subcutaneous tissue of the head and neck regions. Elevated serum immunoglobulin E levels and peripheral blood eosinophilia are also common. This disease is most common in middle-aged Asian men. Although the etiology is unknown, it most probably represents an aberrant chronic immune response. Treatment for Kimura disease includes surgical resection and regional or systemic steroid therapy. Cytotoxic therapy and radiation have also been utilized. The disease has an excellent prognosis, although it may recur locally.

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Kimura Disease of Parotid Gland

International Journal of Human and Health Sciences (IJHHS) ◽

10.31344/ijhhs.v4i1.122 ◽

2019 ◽

Vol 4 (1) ◽

pp. 63

Author(s):

Muhammad Hazim Abdul Ghafar ◽

Amy Oon ◽

Nik Mohd Yunus Mohammad ◽

Irfan Mohamad

Keyword(s):

Immunoglobulin E ◽

Elevated Serum ◽

Neck Region ◽

Oral Prednisolone ◽

High Dose ◽

Inflammatory Disorder ◽

Kimura Disease ◽

Chronic Inflammatory Disorder ◽

Dose Oral ◽

Characteristic Features

Kimura disease is a rare, benign, chronic inflammatory disorder. Characteristic features of the disease include painless subcutaneous mass in the head and neck region, elevated serum eosinophilia and markedly raised serum immunoglobulin E. Herein, we report a case of Kimura disease in a patient who presented with a parotid mass and received both medical and surgical management. A course of high dose oral prednisolone and subsequently parotidectomy were the important elements of the management.International Journal of Human and Health Sciences Vol. 04 No. 01 January’20 Page : 63-66

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Challenging Presentations of Seven Cases of Gastrointestinal Basidiobolomycosis in Sudan: Clinical Features, Histology, Imaging, and Recommendations

Journal of Laboratory Physicians ◽

10.1055/s-0040-1721149 ◽

2020 ◽

Vol 12 (04) ◽

pp. 281-284

Author(s):

Sawsan A. Mohammed ◽

Azza A. Abdelsatir ◽

Mohamed Abdellatif ◽

Suliman Hussein Suliman ◽

Omer Mohammed Ibrahim Elbasheer ◽

...

Keyword(s):

Gastrointestinal Tract ◽

Fungal Infection ◽

Clinical Features ◽

Subcutaneous Tissue ◽

Case Series ◽

First Case

AbstractsBasidiobolomycosis is a fungal infection caused by Basidiobolus ranarum which affects the skin and subcutaneous tissue and rarely the gastrointestinal tract. We report seven cases of gastrointestinal basidiobolomycosis with interesting clinical, radiological, and histological presentations. To our knowledge, this is the first case series of abdominal basidiobolomycosis to be reported from Sudan.

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Spontaneous cervical surgical emphysema following childbirth

The Journal of Laryngology & Otology ◽

10.1017/s0022215107001089 ◽

2007 ◽

Vol 121 (12) ◽

Cited By ~ 1

Author(s):

S Mylvaganam ◽

C G L Hobbs

Keyword(s):

Case Report ◽

Complete Resolution ◽

Post Partum ◽

Neck Swelling ◽

First Case ◽

Increased Risk ◽

Surgical Emphysema

AbstractObjective:We report a case of post-partum surgical cervical emphysema, which is a rare but well recognised complication of labour. By reporting the first case in the ENT literature, we aim to raise awareness of this complication, particularly amongst trainees, to ensure that patients are managed most appropriately.Case report:A 36-year-old, primigravida woman developed neck swelling and odynophagia post-partum. Surgical cervical emphysema was palpated, with further examination excluding pneumomediastinum and pneumothorax. The patient was managed conservatively, with complete resolution of symptoms within a week.Conclusions:Surgical cervical emphysema, pneumothorax and pneumomediastinum are all well recognised post-partum complications. The vast majority of cases do not present with respiratory or cardiac compromise and can be appropriately managed conservatively, with expectation of resolution in a fortnight. There is no evidence that such patients are at increased risk during subsequent pregnancies.

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Benign Cutaneous Tumors

10.2310/tywc.1227 ◽

2018 ◽

Author(s):

Elizabeth A Abel

Keyword(s):

Connective Tissue ◽

Subcutaneous Tissue ◽

Cell Types ◽

Kimura Disease ◽

Epithelial Tumors ◽

Melanocytic Tumors ◽

Lymphangioma Circumscriptum ◽

Familial Tumor ◽

Vascular Birthmarks ◽

Nevus Cell

Tumors of the cutaneous surface may arise from the epidermis, dermis, or subcutaneous tissue or from any of the specialized cell types in the skin or its appendages. Broad categories include tumors derived from epithelial, melanocytic, or connective tissue structures. Within each location or cell type, lesions are classified as benign, malignant, or, in certain cases, premalignant. Benign epithelial tumors include tumors of the surface epidermis that form keratin, tumors of the epidermal appendages, and cysts of the skin. Melanocytic (pigment-forming) lesions are very common. One of the most frequently encountered forms is the nevus cell nevus. Tumors that are derived from connective tissue include fibromas, histiocytomas, lipomas, leiomyomas, and hemangiomas. This chapter provides an overview of each type of tumor, including sections on epithelial tumors, tumors of the epidermal appendages, familial tumor syndromes, melanocytic tumors, neural tumors, connective tissue tumors, vascular birthmarks, acquired vascular disorders, Kimura disease, lipoma, leiomyoma, and lymphangioma circumscriptum. The sections discuss various forms and their diagnosis, differential diagnosis, and treatment. Figures accompany the descriptions. This chapter contains 83 references, 26 highly rendered figures, and 5 MCQs.

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Benign Cutaneous Tumors

10.2310/im.1227 ◽

2014 ◽

Author(s):

Elizabeth A Abel

Keyword(s):

Connective Tissue ◽

Subcutaneous Tissue ◽

Cell Types ◽

Kimura Disease ◽

Epithelial Tumors ◽

Melanocytic Tumors ◽

Lymphangioma Circumscriptum ◽

Familial Tumor ◽

Vascular Birthmarks ◽

Nevus Cell

Tumors of the cutaneous surface may arise from the epidermis, dermis, or subcutaneous tissue or from any of the specialized cell types in the skin or its appendages. Broad categories include tumors derived from epithelial, melanocytic, or connective tissue structures. Within each location or cell type, lesions are classified as benign, malignant, or, in certain cases, premalignant. Benign epithelial tumors include tumors of the surface epidermis that form keratin, tumors of the epidermal appendages, and cysts of the skin. Melanocytic (pigment-forming) lesions are very common. One of the most frequently encountered forms is the nevus cell nevus. Tumors that are derived from connective tissue include fibromas, histiocytomas, lipomas, leiomyomas, and hemangiomas. This chapter provides an overview of each type of tumor, including sections on epithelial tumors, tumors of the epidermal appendages, familial tumor syndromes, melanocytic tumors, neural tumors, connective tissue tumors, vascular birthmarks, acquired vascular disorders, Kimura disease, lipoma, leiomyoma, and lymphangioma circumscriptum. The sections discuss various forms and their diagnosis, differential diagnosis, and treatment. Figures accompany the descriptions. This chapter contains 83 references, 26 highly rendered figures, and 5 MCQs.

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Life-threating complication of parapharyngeal abscess and mediastinitis in a 10-year-old otherwise healthy girl following elective tonsillectomy – first reported paediatric case

The Journal of Laryngology & Otology ◽

10.1017/s0022215119000021 ◽

2019 ◽

Vol 133 (2) ◽

pp. 161-163 ◽

Cited By ~ 2

Author(s):

C C Holm-Hansen ◽

E Thisted ◽

M Kaltoft

Keyword(s):

Paediatric Population ◽

Neck Swelling ◽

Resonance Imaging ◽

Thoracic Pain ◽

Intravenous Antibiotic ◽

Parapharyngeal Abscess ◽

First Case ◽

Operative Complications ◽

Paediatric Case ◽

Life Threatening

AbstractBackgroundParapharyngeal abscess and mediastinitis are rare but very severe post-operative complications following an elective tonsillectomy. Parapharyngeal abscess as a complication to tonsilectomy is very seldom described in the literature and no cases in the paediatric population have been described.Case reportThis paper presents, to our knowledge, the first case of life-threatening parapharyngeal abscess and mediastinitis following elective adenotonsillectomy in an otherwise healthy, fully vaccinated 10-year-old girl.ConclusionDiagnosing parapharyngeal abscess and mediastinitis can be challenging, but should be suspected and ruled out in cases of post-operative odynophagia, fever, and/or neck swelling and thoracic pain. Diagnosis is made based on magnetic resonance imaging and computed tomography findings. Prompt broad-spectrum intravenous antibiotic treatment and surgical drainage should be initiated. Other severe complications such as meningitis should also be considered.

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A case series of Kimura’s disease: a diagnostic challenge

Therapeutic Advances in Hematology ◽

10.1177/2040620718780370 ◽

2018 ◽

Vol 9 (7) ◽

pp. 207-211 ◽

Cited By ~ 5

Author(s):

Vivek Kumar ◽

Navneet Mittal ◽

Yiwu Huang ◽

Jasminka Balderracchi ◽

Huo Xiang Zheng ◽

...

Keyword(s):

Lymph Node ◽

Lymph Nodes ◽

Hodgkin's Disease ◽

Immunoglobulin E ◽

Hodgkin’S Disease ◽

Case Series ◽

Kimura’S Disease ◽

Pathological Features ◽

Diagnostic Challenge ◽

First Case

Kimura’s disease (KD) is a rare, benign disorder characterized by subcutaneous masses with regional lymph-node enlargement. It is considered to be due to chronic inflammation of unclear etiology. Most cases have been reported in young, 20–30-year-old men of Asian descent. The diagnosis of KD is based on pathological features and elevated immunoglobulin E levels. Characteristic pathological features include intact lymph-node architecture, florid germinal center hyperplasia, extensive eosinophilic infiltrates, and proliferation of postcapillary venules. However, these features can also be seen in Hodgkin’s disease or T-cell lymphoma, therefore, cases presenting as KD pose a diagnostic challenge. We report a case series of two cases with suspected KD at initial presentation, with one patient eventually diagnosed with Hodgkin’s disease after clinical progression. The first case was a 45-year-old Asian man who presented with bilateral thigh masses and significantly enlarged inguinal lymph nodes. The histopathology was characteristic and the patient had stable disease on treatment with cetirizine for 20 months. The second case was a 29-year-old African-American man who had progressive enlargement of the right neck lymph nodes extending into the mediastinum, with the original biopsy suggestive of KD. An initial search for Reed–Sternberg cells using immunohistochemical staining for CD15 and CD30 was negative. However, the patient developed neurological symptoms corresponding to tumor extension to the cervical and thoracic neural foramina. A repeat biopsy showed a lack of nodal structure and atypical large cells that were positive for CD30 staining. The patient was treated with chemotherapy with good response. We emphasize the importance of following the clinical course to render an accurate diagnosis. Both cases showed extensive eosinophilic infiltration and other KD-like pathological features. However, KD is rare; not missing a malignant diagnosis lies in high clinical suspicion and repeated exhaustive work up.

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The first case of autochthonous subcutaneous dirofilariasis (Dirofilaria repens) in a dog from Białowieża (NE Poland) and possible threat posed to inhabitants of Białowieża Primeval Forest area

Parasitology Research ◽

10.1007/s00436-020-06955-2 ◽

2020 ◽

Author(s):

Marta Kołodziej-Sobocińska ◽

Mariusz Miniuk ◽

Małgorzata Tokarska

Keyword(s):

Subcutaneous Tissue ◽

Domestic Animals ◽

Dirofilaria Repens ◽

Primeval Forest ◽

Adult Nematode ◽

Ne Poland ◽

First Case ◽

Diverse Community ◽

European Forest ◽

Białowieża Primeval Forest

AbstractWe present the first case of dirofilariasis in a dog from Białowieża village located in the primeval European forest—Białowieża Primeval Forest (NE Poland). Molecular analysis of adult nematode specimens isolated from subcutaneous tissue confirmed the infection with Dirofilaria repens. An adult male dog has not travelled out of the Białowieża village for at least five years; therefore, we assume this is the autochthonous case of the disease. We discuss possible inter- and intra-species transmission routes of dirofilariasis on this territory, which is inhabited by diverse community of wild carnivores, domestic animals, and humans. We also discuss the likely sources of the disease in this, highly biodiverse unique European forest complex. We underline the lack of attention to this problem and its importance for veterinary, wildlife, and human health safety.

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Bilateral basal-cell adenomas in the parotid glands

The Journal of Laryngology & Otology ◽

10.1258/0022215001903780 ◽

2000 ◽

Vol 114 (1) ◽

pp. 83-85 ◽

Cited By ~ 8

Author(s):

Satoshi Katsuno ◽

Keiko Ishii ◽

Akihiro Otsuka ◽

Susumu Ezawa ◽

Shin-Ichi Usami

Keyword(s):

Adenoid Cystic Carcinoma ◽

Basal Cell ◽

English Literature ◽

Parotid Glands ◽

Cystic Change ◽

Cell Adenoma ◽

Adenoid Cystic ◽

First Case ◽

Appropriate Treatment ◽

Dermal Cylindroma

A rare case of bilateral basal-cell adenomas in the parotid glands of a 65-year-old woman is reported. There have been only four previous reported cases of bilateral parotid basal-cell adenomas, all of which occurred synchronously with dermal cylindromas. The present lesion is the first case reported in the English literature of bilateral parotid basal-cell adenoma without coexisting dermal cylindroma. Histological examination revealed that the left tumour had adenoid cystic change, which closely resembled adenoid cystic carcinoma. This case is of interest not only because of the raity of bilateral parotid basal-cell adenomas, but also because of the necessity for differentiation from adenoid cystic carcinoma in order to plan appropriate treatment.

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