scholarly journals Kikuchi-Fujimoto Disease Associated with Symptomatic CD4 Lymphocytopenia

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Meera Yogarajah ◽  
Bhradeev Sivasambu
Keyword(s):  
Oral Candidiasis ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Cd4 Count ◽  
African American Female ◽  
Retroviral Infection ◽  
Benign Condition ◽  
Hiv Rna ◽  
Node Biopsy ◽  
First Case

Kikuchi-Fujimoto disease is a rare benign condition of necrotising histiocytic lymphadenitis with unknown aetiology. We describe here a 30-year-old African American female who presented with fever, generalized rash, cervical lymphadenopathy, and oral candidiasis and was found to have Kikuchi-Fujimoto disease on lymph node biopsy with low CD4 count. The initial presentation was concerning for acute retroviral infection. Her HIV serology and HIV RNA PCR were negative however she had low CD4 count with reversal of CD4/CD8 ratio. Although low CD4 count has been associated with autoimmune disease, it has not been described with Kikuchi-Fujimoto disease. We report the first case of Kikuchi-Fujimoto disease associated with symptomatic CD4 lymphocytopenia.

scholarly journals Kikuchi necrotizing lymphadenopathy: a tip of the iceberg disease?

2021 ◽  
Vol 8 (9) ◽  
pp. 1602
Author(s):  
Sushil Singla ◽  
Mohitesh Kumar ◽  
Vinod Kumar Jat ◽  
Deepika Parwan
Keyword(s):  
Lymph Node ◽  
Laboratory Test ◽  
Young Patient ◽  
Healthy Individual ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Benign Condition ◽  
Node Biopsy ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto disease (KFD) is a rare benign condition also called histiocytic necrotizing lymphadenitis, which typically presented as fever with cervical lymphadenopathy in previously healthy individual. We presented a case of 11 year old boy with fever and cervical lymphadenopathy since 2 months. Lymph node biopsy was performed which suggested of KFD and was treated symptomatically. KFD incidence is rare but clinicians should be alert if young patient comes with fever and cervical lymphadenopathy to lower the chance of unwanted laboratory test and harmful treatment. 

Baffled with fever and lymphadenopathy: neither infection nor malignancy, think Kikuchi disease

2021 ◽  
Vol 14 (1) ◽  
pp. e238914
Author(s):  
Ali Hussain ◽  
Mohsin Gondal ◽  
Hira Yousuf ◽  
Mubashar Iqbal
Keyword(s):  
Young Women ◽  
Cervical Lymphadenopathy ◽  
Complete Recovery ◽  
Symptomatic Treatment ◽  
Lymph Node Biopsy ◽  
Asian Woman ◽  
Unknown Aetiology ◽  
Benign Condition ◽  
Node Biopsy ◽  
Clinical Investigations

Kikuchi disease is a rare, benign condition of unknown aetiology, which usually involves young women and is characterised by cervical lymphadenopathy and fever. Herein, we are reporting a case of a young Asian woman, who presented with fever and lymphadenopathy raising possibility of either infection or malignancy but after appropriate clinical investigations including lymph node biopsy, it turned out to be Kikuchi disease. She made an uneventful complete recovery with only symptomatic treatment.

scholarly journals Kikuchi's Disease: A Rare Cause of Fever and Lymphadenopathy

2012 ◽  
Vol 5 ◽  
pp. CPath.S8685 ◽  
Author(s):  
A Vivekanandarajah ◽  
B Krishnarasa ◽  
M Hurford ◽  
S Gupta
Keyword(s):  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Imaging Studies ◽  
Benign Condition ◽  
Kikuchi’S Disease ◽  
Node Biopsy ◽  
Cervical Lymph Node Biopsy ◽  
Necrotizing Lymphadenitis ◽  
Work Up ◽  
Kikuchi's Disease

Kikuchi's disease is a benign condition that occurs in women. A young woman presented to the hospital with fevers and cervical lymphadenopathy. Infectious work-up was negative except for streptococcus pharyngitis. Imaging studies revealed the presence of diffuse cervical and axillary lymphadenopathy. The fevers persisted and she underwent excisional cervical lymph node biopsy that revealed histiocytic necrotizing lymphadenitis corresponding to a benign diagnosis of Kikuchi's disease. Three months later, the patient was afebrile and there was complete resolution of the cervical lymphadenopathy.

scholarly journals Kikuchi-Fujimoto Disease: A Study Of 67 Cases From Coastal South India 

2020 ◽  
Author(s):  
Basavaprabhu Achappa ◽  
Nipuni Chamathka Herath ◽  
Jyoti Ramanath Kini ◽  
Ramesh Holla ◽  
Bodhi Sebastian ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Histopathological Examination ◽  
Cervical Lymphadenopathy ◽  
Symptomatic Treatment ◽  
Lymph Node Biopsy ◽  
Unknown Etiology ◽  
Extensive Literature ◽  
Cervical Lymphadenitis ◽  
Benign Condition ◽  
The Mean

Abstract Background Kikuchi-Fujimoto disease is a rare, benign condition, of unknown etiology, presenting as cervical lymphadenitis, usually tender and maybe associated with systemic symptoms. Despite the extensive literature on this disease, it continues to be misdiagnosed owing to its misleading clinical presentation. Results The mean age in our study was 26.9 (±11.3) years with a female majority of 65.7%. The clinical presentation of most cases was, tender swelling over the side of the neck ( n =50, 74.6%). On local examination, the mean length and width were 2.3 (±1.0) cm and 2.2 (±0.7) cm respectively. Histopathological examination revealed that most patients presented in the proliferative stage ( n =40, 59.7%). In 83.6% of the patients lymphadenopathy resolved in less than 2 months. Follow up of these patients over 9 months revealed that a vast majority of the patients underwent full recovery with symptomatic treatment ( n =42, 62.7%). Conclusions The disease is prevalent in young, female patients of Asian descent and often presents as cervical lymphadenopathy. Early diagnosis with excisional lymph node biopsy is crucial to avoid unnecessary investigations and treatment. Treatment is only symptomatic unless complicated, where steroid therapy is considered. Kikuchi’s disease has an excellent prognosis with almost no risk of fatality.

scholarly journals Kikuchi-Fujimoto Disease: A Report of 3 Cases

2007 ◽  
Vol 86 (7) ◽  
pp. 412-413 ◽  
Author(s):  
Eimear Phelan ◽  
Emer Lang ◽  
Peter Gormley ◽  
John Lang
Keyword(s):  
Weight Loss ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Accurate Diagnosis ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Kikuchi’S Disease ◽  
Node Biopsy ◽  
Night Sweats ◽  
Necrotizing Lymphadenitis ◽  
Kikuchi's Disease

Cervical lymphadenopathy has many underlying etiologies. One of its rare causes is Kikuchi-Fujimoto disease (Kikuchi's disease, histiocytic necrotizing lymphadenitis). We discovered such a cause in a 37-year-old woman who had presented with malaise, night sweats, and weight loss in addition to cervical lymphadenopathy. We based our diagnosis on excisional lymph node biopsy. We also review 2 other cases of Kikuchi's disease that were diagnosed by others at our institution. Clinically and histologically, Kikuchi's disease is very similar to lymphoma, and distinguishing the two is difficult. However, despite the fact that Kikuchi's disease is benign, an accurate diagnosis is important because misdiagnosis might lead to unnecessary surgery and/or chemotherapy.

Predictors of the necessity for lymph node biopsy of cervical lymphadenopathy

2015 ◽  
Vol 43 (10) ◽  
pp. 2200-2204 ◽  
Author(s):  
Tadataka Tsuji ◽  
Koichi Satoh ◽  
Hiroshi Nakano ◽  
Yoshiya Nishide ◽  
Yasuhiro Uemura ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Node Biopsy

scholarly journals A young woman presenting a kikuchi-fujimoto’s disease associated with induced lupus

2018 ◽  
Author(s):  
Galith Kalmi
Keyword(s):  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Screening Tests ◽  
Unknown Etiology ◽  
Caucasian Woman ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Drug Induced ◽  
First Case ◽  
Necrotizing Lymphadenitis

Introduction: Kikuchi-Fujimoto’s disease (KFD) or histiocytic necrotizing lymphadenitis is a benign and self-limited disease of unknown etiology mainly affecting young women. Although the association with systemic lupus erythematosus (SLE) is well described, no case of drug-induced lupus erythematosus (DILE) associated KFD has not been reported so far. Case report: We herein report a 25-year old Caucasian woman, with no medical history and no medication except for oral estrogen-progestin contraception (levonorgestrel-ethinylestradiol), who presented with cervical lymphadenopathy, fever and arthralgia without weight loss, night sweats or skin involvement. An exhaustive infectious disease screening was negative and lymph node biopsy revealed histiocytic necrotizing lymphadenitis suggesting KFD. Autoimmune screening tests evidenced high titers of anti-histone antibodies suggesting DILE induced by estrogen-progestin medication. The patient received a short course of non-steroidal anti-inflammatory treatment for painful lymphadenitis and arthralgia. Oral levonorgestrel-ethinylestradiol contraceptive medication was stopped and KFD and DILE completely recovered with a long-term disappearance of anti-histone antibodies. Conclusion: We report the first case of KFD associated-DILE following oral levonorgestrel-ethinylestradiol medication. Even though levonorgestrel-ethinylestradiol induced lupus is well known, the association with KFD has never been reported and the physiopathology remained unknown. Keywords: Kikuchi-Fujimoto disease, Lupus, Levonorgestrel-ethinylestradiol

scholarly journals Case Report: Kikuchi: The great mimicker

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 520
Author(s):  
Kevin Bryan Lo ◽  
Anna Papazoglou ◽  
Lorayne Chua ◽  
Nellowe Candelario
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Disease Patient ◽  
Cervical Lymphadenopathy ◽  
Hematologic Malignancies ◽  
Lymph Node Biopsy ◽  
Benign Disease ◽  
Node Biopsy ◽  
Necrotizing Lymphadenitis ◽  
Serious Disease

Kikuchi-Fujimoto disease is a form of a benign necrotizing lymphadenitis which is most commonly misdiagnosed as tuberculosis and or lymphoma, usually more common among young adults in Asia. It is a benign disease but can mimic a lot of other disease processes spanning infectious, rheumatologic and even hematologic malignancies. Our patient presented with prolonged fever and lymphadenopathy. Initial considerations were lymphoma and a nonspecific viral infection. A CT scan showed diffuse cervical lymphadenopathy with lacrimal gland involvement. An excisional lymph node biopsy was done which revealed Kikuchi disease. Patient was given steroids with immediate response with defervescence. Kikuchi is a disease with many mimics and a complete workup is needed to exclude serious disease like malignancy.

scholarly journals Disseminated cat-scratch disease: a case report

2015 ◽  
Vol 22 (2) ◽  
pp. 229-231
Author(s):  
Faizul Islam Chowdhury ◽  
MA Kashem ◽  
Md Anwar Hossain ◽  
Imran Munadil Ahsan ◽  
Avijit Pandit ◽  
...  
Keyword(s):  
Bartonella Henselae ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Cat Scratch Disease ◽  
Gram Negative ◽  
Systemic Involvement ◽  
Medical College ◽  
Negative Bacillus ◽  
Node Biopsy ◽  
Gram Negative Bacillus

Cat-scratch disease is an infectious disease caused by Bartonella henselae, a gram-negative bacillus. The disease is usually transmitted to the human being by cat scratches. Cat-scratch disease typically presents with painful regional lymphadenopathy. Systemic involvement is unusual. A 35 years old lady, came with the complaints of fever, abdominal pain along with nausea, anorexia & difficulties of swallowing for 6 months. She has painful cervical lymphadenopathy. Histopathology of her lymph node biopsy shows features of cat-scratch disease. DOI: http://dx.doi.org/10.3329/jdmc.v22i2.21550 J Dhaka Medical College, Vol. 22, No.2, October, 2013, Page 229-231

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