scholarly journals Kikuchi-Fujimoto Disease: A Study Of 67 Cases From Coastal South India 

2020 ◽  
Author(s):  
Basavaprabhu Achappa ◽  
Nipuni Chamathka Herath ◽  
Jyoti Ramanath Kini ◽  
Ramesh Holla ◽  
Bodhi Sebastian ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Histopathological Examination ◽  
Cervical Lymphadenopathy ◽  
Symptomatic Treatment ◽  
Lymph Node Biopsy ◽  
Unknown Etiology ◽  
Extensive Literature ◽  
Cervical Lymphadenitis ◽  
Benign Condition ◽  
The Mean

Abstract Background Kikuchi-Fujimoto disease is a rare, benign condition, of unknown etiology, presenting as cervical lymphadenitis, usually tender and maybe associated with systemic symptoms. Despite the extensive literature on this disease, it continues to be misdiagnosed owing to its misleading clinical presentation. Results The mean age in our study was 26.9 (±11.3) years with a female majority of 65.7%. The clinical presentation of most cases was, tender swelling over the side of the neck ( n =50, 74.6%). On local examination, the mean length and width were 2.3 (±1.0) cm and 2.2 (±0.7) cm respectively. Histopathological examination revealed that most patients presented in the proliferative stage ( n =40, 59.7%). In 83.6% of the patients lymphadenopathy resolved in less than 2 months. Follow up of these patients over 9 months revealed that a vast majority of the patients underwent full recovery with symptomatic treatment ( n =42, 62.7%). Conclusions The disease is prevalent in young, female patients of Asian descent and often presents as cervical lymphadenopathy. Early diagnosis with excisional lymph node biopsy is crucial to avoid unnecessary investigations and treatment. Treatment is only symptomatic unless complicated, where steroid therapy is considered. Kikuchi’s disease has an excellent prognosis with almost no risk of fatality.

Baffled with fever and lymphadenopathy: neither infection nor malignancy, think Kikuchi disease

2021 ◽  
Vol 14 (1) ◽  
pp. e238914
Author(s):  
Ali Hussain ◽  
Mohsin Gondal ◽  
Hira Yousuf ◽  
Mubashar Iqbal
Keyword(s):  
Young Women ◽  
Cervical Lymphadenopathy ◽  
Complete Recovery ◽  
Symptomatic Treatment ◽  
Lymph Node Biopsy ◽  
Asian Woman ◽  
Unknown Aetiology ◽  
Benign Condition ◽  
Node Biopsy ◽  
Clinical Investigations

Kikuchi disease is a rare, benign condition of unknown aetiology, which usually involves young women and is characterised by cervical lymphadenopathy and fever. Herein, we are reporting a case of a young Asian woman, who presented with fever and lymphadenopathy raising possibility of either infection or malignancy but after appropriate clinical investigations including lymph node biopsy, it turned out to be Kikuchi disease. She made an uneventful complete recovery with only symptomatic treatment.

scholarly journals Sarcoidosis - A Case Report

2019 ◽  
Vol 10 (1) ◽  
pp. 92-95
Author(s):  
Md Safiqul Islam ◽  
Md Mahmudur Rahman Siddiqui
Keyword(s):  
Cervical Lymphadenopathy ◽  
Symptomatic Treatment ◽  
Lymph Node Biopsy ◽  
Unknown Etiology ◽  
Healthy Life ◽  
X Ray ◽  
Medical College ◽  
Node Biopsy ◽  
Chest X Ray ◽  
Granulomatous Disorder

Sarcoidosis is a chronic granulomatous disorder of unknown etiology, commonly affecting the lungs, skin and eyes. Although lungs and lymph nodes are involved in more than 90% of patients, virtually any organ can be involved. We describe a 36 years old lady presented with fever, skin rashes, cough, polyarthralgia, bodyache, wt. loss for 3 months. Examination revealed Fever, Erythema Nodosum, Cervical Lymphadenopathy. Investigations revealed high ESR (80 mm in 1st hour), high CRP, Hilar Lymphadenopathy on Chest X ray, Non-caseous Granuloma, Giant cell and Asteroid body on Lymph node Biopsy. All of her history, clinical examinations and Investigations are suggestive of Sarcoidosis. With symptomatic treatment and watchful observation, now she is completely symptoms free and leaving a healthy life. Anwer Khan Modern Medical College Journal Vol. 10, No. 1: Jan 2019, P 92-95

scholarly journals Kikuchi's Disease: A Case Report

2014 ◽  
Vol 8 (2) ◽  
pp. 96-98
Author(s):  
Md Shafiq-Ur Rahman ◽  
Golam Muktadir ◽  
SK Abdul Momen Ahmed
Keyword(s):  
Early Recognition ◽  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Lymph Node Biopsy ◽  
Unknown Etiology ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Cervical Lymphadenitis ◽  
Kikuchi’S Disease ◽  
Necrotizing Lymphadenitis ◽  
Kikuchi's Disease

Kikuchi's disease is also known as histiocytic necrotizing lymphadenitis. Kikuchi-Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis, is a rare benign, self-limiting cervical lymphadenitis of unknown etiology. It predominantly affects young women and can closely mimic infective and immunological disorders. Recognition of this condition is crucial, specially because it can easily be mistaken for tuberculosis, lymphoma, or even adenocarcinoma. We report an 18 years old girl who presented with fever and cervical lymphadenopathy. She had multiple enlarged cervical lymphadenopathy. Examination of other systems was normal. Laboratory investigations were also normal. Fine needle aspiration cytology of the cervical node was not done. The patient took a course of oral antibiotics. Since the patient did not respond, lymph node biopsy was done and the histological features suggested the diagnosis of Kikuchi's disease. The Patient was treated symptomatically and complete remission occurred in few weeks. Although the incidence of Kikuchi-Fujimoto disease is rare, clinicians should be aware of this condition as early recognition of the disease will minimize potentially harmful and unnecessary evaluations and treatments. DOI: http://dx.doi.org/10.3329/fmcj.v8i2.20395 Faridpur Med. Coll. J. 2013;8(2): 96-98

scholarly journals Kikuchi-Fujimoto Disease: A Diagnostic Dilema

2014 ◽  
Vol 5 (2) ◽  
pp. 51-53
Author(s):  
SMK Nahar Begum ◽  
MMR Siddiqui ◽  
AS Arif ◽  
MA Kahhar
Keyword(s):  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Lymph Node Biopsy ◽  
Unknown Etiology ◽  
Cervical Lymphadenitis ◽  
Tropical Country ◽  
Medical College ◽  
Recommended Treatment ◽  
Granulomatous Lymphadenitis ◽  
Anti Tubercular Therapy

Fujimoto (KD) disease or histiocytic necrotizing lymphadenitis is a rare, benign, self limiting cervical lymphadenitis of unknown etiology. Since Tubercular lymphadenopathy is the commonest cause for chronic cervical lymphadenopathy in developing and tropical country like Bangladesh. Occasionally it is misdiagnosed as TB and subsequently shows unresponsiveness to ATT. As a result the morbidity increases and cost of antitubercular treatment (ATT) in wrong diagnosed case is enormous. We report a similar case of misdiagnosis. We report a 26 year old lady who reported with history of right sided neck pain and fever since last 2 months. Clinical examination revealed enlared right sided lymph nodes in the neck. Fine needle aspiration cytology revealed features suggestive of granulomatous lymphadenitis. The case was suspected to be tuberculosis and anti-tubercular therapy (ATT) was started immediately. Since the patient did not respond, lymph node biopsy was done and the histological features suggested the diagnosis of Kikuchi's disease. She did well after recommended treatment. DOI: http://dx.doi.org/10.3329/akmmcj.v5i2.21134 Anwer Khan Modern Medical College Journal Vol. 5, No. 2: July 2014, Pages 51-53

scholarly journals Kikuchi necrotizing lymphadenopathy: a tip of the iceberg disease?

2021 ◽  
Vol 8 (9) ◽  
pp. 1602
Author(s):  
Sushil Singla ◽  
Mohitesh Kumar ◽  
Vinod Kumar Jat ◽  
Deepika Parwan
Keyword(s):  
Lymph Node ◽  
Laboratory Test ◽  
Young Patient ◽  
Healthy Individual ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Benign Condition ◽  
Node Biopsy ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto disease (KFD) is a rare benign condition also called histiocytic necrotizing lymphadenitis, which typically presented as fever with cervical lymphadenopathy in previously healthy individual. We presented a case of 11 year old boy with fever and cervical lymphadenopathy since 2 months. Lymph node biopsy was performed which suggested of KFD and was treated symptomatically. KFD incidence is rare but clinicians should be alert if young patient comes with fever and cervical lymphadenopathy to lower the chance of unwanted laboratory test and harmful treatment. 

scholarly journals Persistent cervical lymphadenitis in a patient with prior thyroid cancer attributed to Kikuchi-Fujimoto disease

2018 ◽  
pp. bcr-2018-226457
Author(s):  
Roman Zuckerman ◽  
Louise Damiani ◽  
Hashem A Ayyad ◽  
Deborah R Alpert
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Lymph Node Biopsy ◽  
Lymphoproliferative Disease ◽  
Low Grade ◽  
Cervical Lymphadenitis ◽  
Granulomatous Lymphadenitis

We describe a 50-year-old woman with a history of thyroid cancer who presented with bilateral cervical and submandibular lymphadenopathy, low-grade fevers, and increasing fatigue. The patient underwent lymph node fine-needle aspiration, which showed no evidence of metastatic or lymphoproliferative disease. This procedure was complicated by a parapharyngeal abscess and cellulitis. She was treated unsuccessfully with various courses of antibiotics, but briefly responded to short courses of steroids. As her cervical lymphadenopathy returned, she underwent an excisional lymph node biopsy, which demonstrated caseating granulomatous lymphadenitis. Extensive review of systems, physical examination, laboratory and imaging studies demonstrated no evidence of malignancy, infection or systemic lupus erythematosus . Our patient was clinically diagnosed with Kikuchi-Fujimoto disease and successfully treated with prednisone tapered over 3 months. She remains in clinical remission.

scholarly journals Kikuchi-Fujimoto Disease Associated with Symptomatic CD4 Lymphocytopenia

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Meera Yogarajah ◽  
Bhradeev Sivasambu
Keyword(s):  
Oral Candidiasis ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Cd4 Count ◽  
African American Female ◽  
Retroviral Infection ◽  
Benign Condition ◽  
Hiv Rna ◽  
Node Biopsy ◽  
First Case

Kikuchi-Fujimoto disease is a rare benign condition of necrotising histiocytic lymphadenitis with unknown aetiology. We describe here a 30-year-old African American female who presented with fever, generalized rash, cervical lymphadenopathy, and oral candidiasis and was found to have Kikuchi-Fujimoto disease on lymph node biopsy with low CD4 count. The initial presentation was concerning for acute retroviral infection. Her HIV serology and HIV RNA PCR were negative however she had low CD4 count with reversal of CD4/CD8 ratio. Although low CD4 count has been associated with autoimmune disease, it has not been described with Kikuchi-Fujimoto disease. We report the first case of Kikuchi-Fujimoto disease associated with symptomatic CD4 lymphocytopenia.

scholarly journals A young woman presenting a kikuchi-fujimoto’s disease associated with induced lupus

2018 ◽  
Author(s):  
Galith Kalmi
Keyword(s):  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Screening Tests ◽  
Unknown Etiology ◽  
Caucasian Woman ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Drug Induced ◽  
First Case ◽  
Necrotizing Lymphadenitis

Introduction: Kikuchi-Fujimoto’s disease (KFD) or histiocytic necrotizing lymphadenitis is a benign and self-limited disease of unknown etiology mainly affecting young women. Although the association with systemic lupus erythematosus (SLE) is well described, no case of drug-induced lupus erythematosus (DILE) associated KFD has not been reported so far. Case report: We herein report a 25-year old Caucasian woman, with no medical history and no medication except for oral estrogen-progestin contraception (levonorgestrel-ethinylestradiol), who presented with cervical lymphadenopathy, fever and arthralgia without weight loss, night sweats or skin involvement. An exhaustive infectious disease screening was negative and lymph node biopsy revealed histiocytic necrotizing lymphadenitis suggesting KFD. Autoimmune screening tests evidenced high titers of anti-histone antibodies suggesting DILE induced by estrogen-progestin medication. The patient received a short course of non-steroidal anti-inflammatory treatment for painful lymphadenitis and arthralgia. Oral levonorgestrel-ethinylestradiol contraceptive medication was stopped and KFD and DILE completely recovered with a long-term disappearance of anti-histone antibodies. Conclusion: We report the first case of KFD associated-DILE following oral levonorgestrel-ethinylestradiol medication. Even though levonorgestrel-ethinylestradiol induced lupus is well known, the association with KFD has never been reported and the physiopathology remained unknown. Keywords: Kikuchi-Fujimoto disease, Lupus, Levonorgestrel-ethinylestradiol

scholarly journals Suppurative Lymphadenitis after Radioactive Iodine Therapy for Graves’ Disease: A Rare Complication?

2019 ◽  
Vol 8 (6) ◽  
pp. 324-327 ◽  
Author(s):  
Shi Hui Junice Wong
Keyword(s):  
Radioactive Iodine ◽  
Rare Complication ◽  
Cervical Lymphadenopathy ◽  
Symptomatic Treatment ◽  
Graves Disease ◽  
Radioactive Iodine Therapy ◽  
Short Term ◽  
Cervical Lymphadenitis ◽  
Incision And Drainage ◽  
Radiation Induced

Background: Radioiodine (RAI) therapy for Graves’ disease is a well-accepted and effective treatment with a good side effect profile. Short-term adverse effects can occasionally include radiation-induced thyroiditis. To my knowledge, cervical lymphadenitis associated with RAI therapy for Graves’ disease has not been reported before. Case Report: A 38-year-old woman initially presented with uncontrolled thyrotoxicosis secondary to Graves’ disease. She subsequently received RAI therapy for her condition. Within a week, she developed painful bilateral cervical lymphadenopathy that progressed to abscess formation requiring incision and drainage. No other causes (neoplastic or infective) were found. Symptomatic treatment was instituted, and within 2 months the lymphadenitis resolved completely. Discussion: RAI therapy for Graves’ disease can sometimes cause radiation-induced thyroiditis but associated cervical lymphadenopathy or lymphadenitis has not been described. This may represent a continuum of the proinflammatory state induced by RAI manifesting as a rare but potentially morbid complication.

Kawasaki Disease Presenting as Cervical Lymphadenitis or Deep Neck Infection

2001 ◽  
Vol 124 (4) ◽  
pp. 468-470 ◽  
Author(s):  
Hsiu-Tsun Kao ◽  
Yhu-Chering Huang ◽  
Tzou-Yien Lin
Keyword(s):  
Kawasaki Disease ◽  
Medical Records ◽  
Gamma Globulin ◽  
Cervical Lymphadenopathy ◽  
Deep Neck Infection ◽  
Cervical Lymphadenitis ◽  
Neck Infection ◽  
Empiric Antibiotics ◽  
The Mean ◽  
Immune Gamma Globulin

OBJECTIVE: To describe a group of patients with Kawasaki disease who had cervical lymphadenopathy as their dominant initial presentations. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 14 children who were admitted to Chang-Gung Children's Hospital between May 1996 and July 1998 with the initial impression of cervical lymphadenitis, cellulitis, and/or deep neck infection but for which a diagnosis of Kawasaki disease was established later. RESULTS: Five (35.7%) patients were less than 5 months of age, and 8 (57.1%) patients were more than 53 months of age. The mean duration for establishing a diagnosis of Kawasaki disease from the onset of illness was 8.2 (6 to 20) days. Initially, empiric antibiotics were prescribed in each case with unsatisfactory response. Intravenous immune gamma globulin (2 g/kg) was administered in 13 patients. Three (21.4%) patients developed coronary artery lesions. CONCLUSION: If a child less than 6 months or more than 4 years of age has a fever and an enlarged cervical lymph node and is unresponsive to empiric antibiotics, Kawasaki disease should be considered.

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