scholarly journals The Effect of Probiotics on Childhood Constipation: A Randomized Controlled Double Blind Clinical Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
M. Sadeghzadeh ◽  
A. Rabieefar ◽  
P. Khoshnevisasl ◽  
N. Mousavinasab ◽  
K. Eftekhari
Keyword(s):  
Abdominal Pain ◽  
Weight Gain ◽  
Fecal Incontinence ◽  
Controlled Trial ◽  
Intervention Group ◽  
Double Blind ◽  
Positive Role ◽  
Randomized Controlled ◽  
Double Blind Clinical Trial

Background. Inconsistent data exist about the role of probiotics in the treatment of constipated children. The aim of this study was to investigate the effectiveness of probiotics in childhood constipation.Materials and Methods. In this placebo controlled trial, fifty-six children aged 4–12 years with constipation received randomly lactulose plus Protexin or lactulose plus placebo daily for four weeks. Stool frequency and consistency, abdominal pain, fecal incontinence, and weight gain were studied at the beginning, after the first week, and at the end of the 4th week in both groups.Results. Forty-eight patients completed the study. At the end of the fourth week, the frequency and consistency of defecation improved significantly (P=0.042andP=0.049, resp.). At the end of the first week, fecal incontinence and abdominal pain improved significantly in intervention group (P=0.030andP=0.017, resp.) but, at the end of the fourth week, this difference was not significant (P=0.125andP=0.161, resp.). A significant weight gain was observed at the end of the 1st week in the treatment group.Conclusion. This study showed that probiotics had a positive role in increasing the frequency and improving the consistency at the end of 4th week.

Abstract MP07: Automated, Personalized Feedback and Behavioral Nudges to Improve Workplace Food Choices and Prevent Weight Gain: Choosewell 365 Randomized Controlled Trial

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Anne N Thorndike ◽  
Jessica L McCurley ◽  
Emily D Gelsomin ◽  
Eric B Rimm ◽  
Yuchiao Chang ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Weight Gain ◽  
Health Outcomes ◽  
Controlled Trial ◽  
Intervention Group ◽  
Food Choices ◽  
Healthy Food ◽  
Traffic Light ◽  
Randomized Controlled ◽  
Prevent Weight Gain

Importance: Workplace health promotion programs often have limited reach and effectiveness because they are time-intensive and not integrated with the work environment. Objective: Conduct a randomized controlled trial testing an automated intervention combined with workplace cafeteria traffic-light labels to prevent weight gain and increase healthy food choices. Methods: 602 hospital employees who regularly used 6 on-site cafeterias and paid with their ID were randomized in 2016-18. Cafeteria labels identified healthy (green), less healthy (yellow), and unhealthy (red) items. Participants completed visits, surveys, and dietary recalls at baseline and 12 months (end of intervention). The intervention group received personalized emails (2/week) and letters (1/month) that were automatically generated by a software platform that integrated cafeteria sales, health, and survey data. Emails included a log of weekly purchases (item, traffic light label, and calories) and health tips. Letters included social norm comparisons and small incentives for healthy purchases. The control group received standard lifestyle advice in monthly letters. A Healthy Purchasing Score was calculated by weighting purchased items by traffic light labels (red=0; yellow=0.5; green=1) using 12 mo of purchases during both baseline (pre-intervention) and intervention. Differences in differences in health outcomes, purchases, and dietary quality were compared, with missing values imputed. Results: Participants were 43.6 years (mean), 79% female, and 81% white. The intervention group increased healthy purchases compared to control, but changes in BMI and health outcomes were not different (see Table). Conclusion: An automated intervention linked to the workplace food environment increased healthy food choices but did not prevent weight gain. To improve health, this scalable healthy eating intervention could be augmented with additional technology to improve other health behaviors, such as physical activity, both at work and home.

scholarly journals Comparing the Role of Different Treatment Modalities for Plantar Fasciitis: A Double Blind Randomized Controlled Trial

2020 ◽  
Vol 54 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Ravi Gupta ◽  
Anubhav Malhotra ◽  
Gladson David Masih ◽  
Tanu Khanna ◽  
Harsimranjit Kaur ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Plantar Fasciitis ◽  
Controlled Trial ◽  
Treatment Modalities ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals A double-blind randomized controlled trial of low doses of propranolol, nortriptyline, and the combination of propranolol and nortriptyline for the preventive treatment of migraine

2009 ◽  
Vol 67 (4) ◽  
pp. 973-977 ◽  
Author(s):  
Renan B. Domingues ◽  
André L. Pirajá da Silva ◽  
Simone A. Domingues ◽  
Camila Catherine H. Aquino ◽  
Gustavo W. Kuster
Keyword(s):  
Treatment Period ◽  
Adverse Reactions ◽  
Controlled Trial ◽  
Combined Therapy ◽  
Preventive Treatment ◽  
Double Blind ◽  
Randomized Controlled ◽  
Pre Treatment ◽  
Higher Doses

Few trials have evaluated combination of two or more drugs in the preventive treatment of migraine. In this study three therapeutic regimens were compared: (a) propranolol, at a dose of 40 mg per day, (b) nortriptyline, at a dose of 20 mg per day, and (c) the combination of these two drugs in these dosages. The groups were matched according to age, gender, and frequency of migraine attacks prior to treatment. The period of treatment was two months and the frequency and intensity of headache attacks of the 30 days pre-treatment period were compared with the frequency of headaches in the treatment period. Fourteen patients in groups A and B and sixteen patients in group C have completed the study. Treatment with propranolol, alone or in combination, was shown to be effective. Treatment with nortriptyline alone was not effective. All three therapeutic regimens were safe and side effects were minimal. The frequency of discontinuation of the study was the same in the 3 groups but no patient left the study due to adverse reactions. The combined therapy proved to be as safe as the monotherapy. Further studies evaluating this and other possible combinations of drugs in higher doses and for longer periods, should more clearly elucidate the role of combined therapy in the treatment of migraine.

scholarly journals VITAMIN D AND PNEUMONIA

2018 ◽  
Vol 25 (04) ◽  
pp. 532-537
Author(s):  
Muhammad Shamaoon ◽  
Dr Maryam ◽  
Muhammad Ahsan ◽  
Rahman Ahmad
Keyword(s):  
Vitamin D ◽  
Controlled Trial ◽  
Intervention Group ◽  
Vitamin D Supplementation ◽  
Hospital Treatment ◽  
Randomized Controlled ◽  
Inflammatory Conditions ◽  
Group A ◽  
Group B

Background: Pneumonia is lower respiratory tract infection (LRTI) andrepresents inflammatory conditions of the lungs i.e of the lower respiratory tracts, air sacs andlung parenchyma.1 Objectives: To determine the role of vitamin D supplementation in reducingmorbidity in children with pneumonia. Study Design: Randomized Controlled trial. Place andDuration of Study: Pediatric Department, Mayo Hospital Lahore from December 2014 to May2015. Patient & Methods: Two hundred children of age 2 – 59 months with pneumonia (fever,cough, tachypnea, and subcostal recessions) and low vitamin D level (< 20 ng/ml) were includedin the study. One Hundred pneumonia patients received antibiotics (group A) and vitamins D(100,000 IU) while another group of hundred patients received only antibiotics without vitaminsupplementation (group B). When respiratory distress settled, length of stay in hospital wascalculated at the time of discharged. All patients were followed in pediatric OPDs for 3 monthsafter in-hospital treatment to pick recurrence of pneumonia symptoms (if any). Results: Themean recovery time for vitamin D group (5.7 +2.8 days) and non-vitamin D (6.1+2.8 days)was almost same with P=0.29. But the frequency of repeated episodes of pneumonia within30 days of treatment was lower in intervention group n=4 (2%) than the non-intervention groupn=18 (9%) (P = 0.002). Conclusion: 100,000 IU of vitamin D given once during treatment ofpneumonia decreases the chances of recurrence in the next 30 days.

scholarly journals Weight Loss After Stroke Through an Intensive Lifestyle Intervention (Group Lifestyle Balance-Cerebrovascular Accident): Protocol for a Randomized Controlled Trial (Preprint)

2019 ◽  
Author(s):  
Simon Driver ◽  
Chad Swank ◽  
Katherine Froehlich-Grobe ◽  
Evan McShan ◽  
Stephanie Calhoun ◽  
...  
Keyword(s):  
Weight Loss ◽  
Randomized Controlled Trial ◽  
Weight Gain ◽  
Emotional Disorders ◽  
Cerebrovascular Accident ◽  
Recurrent Stroke ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Randomized Controlled

BACKGROUND Weight gain can be a consequence of stroke, or cerebrovascular accident (CVA), because of impaired mobility, behavioral and emotional disorders, and sensory losses. Weight gain increases the patient’s risk of recurrent stroke and chronic diseases, such as diabetes, metabolic syndrome, and pulmonary and heart disease. Approaches to weight loss in this population are lacking, although necessary because of the unique physiological and cognitive needs of persons after a stroke. Evidence shows that intensive behavioral therapy interventions that address both physical activity and diet offer the greatest potential for weight loss. The Group Lifestyle Balance (GLB) intervention is a 12-month, evidence-based weight loss program that has been used extensively with the general population; this program was modified to meet the needs of people who have had a stroke (GLB-CVA). OBJECTIVE This randomized controlled trial (RCT) aims to examine the efficacy of the GLB-CVA on weight and secondary outcomes, compared with that of a waitlist control group. METHODS This RCT will enroll and randomize 64 patients over an 18-month period. RESULTS Currently, 51 people are waitlisted, with 23 out of 51 screened and 16 out of 23 eligible. CONCLUSIONS It is anticipated that the findings from this RCT will contribute to the evidence base regarding weight loss strategies for people living with stroke. CLINICALTRIAL ClinicalTrials.gov NCT03873467; https://clinicaltrials.gov/ct2/show/NCT03873467. INTERNATIONAL REGISTERED REPORT PRR1-10.2196/14338

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