scholarly journals In VitroAntimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Dayanne Rakelly de Oliveira ◽  
Saulo Relison Tintino ◽  
Maria Flaviana Bezerra Morais Braga ◽  
Aline Augusti Boligon ◽  
Margareth Linde Athayde ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Inhibitory Concentration ◽  
Major Constituent ◽  
Significant Activity ◽  
Antibacterial And Antifungal Activity ◽  
Bacterial Strains ◽  
Silybum Marianum ◽  
Microbial Strains ◽  
Antibacterial And Antifungal ◽  
Mic Minimum Inhibitory Concentration

Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianumL. Gaertn.) clinically used as an antihepatotoxic agent. The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice. Silymarin demonstrated antimicrobial activity of little significance against the bacterial strains tested, with MIC (minimum inhibitory concentration) values of 512 µg/mL. Meanwhile, silibinin showed significant activity againstEscherichia coliwith a MIC of 64 µg/mL. The results for the antifungal activity of silymarin and silibinin demonstrated a MIC of 1024 µg/mL for all strains. Silymarin and silibinin appear to have promising potential, showing synergistic properties when combined with antibacterial drugs, which should prompt further studies along this line.

scholarly journals Antibacterial and Antifungal Activity of Zinc(II) Carboxylates With/Without N-Donor Organic Ligands

2002 ◽  
Vol 8 (5) ◽  
pp. 269-274 ◽  
Author(s):  
V. Zelenák ◽  
K. Györyová ◽  
D. Mlynarcík
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Biological Activity ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Organic Ligands ◽  
Antibacterial And Antifungal Activity ◽  
Bacterial Strains ◽  
Structural Types ◽  
Antibacterial And Antifungal

The antibacterial and antifungal activity of zinc(II) carboxylates with composition Zn(RCOO)2•nH2O(R =H-, CH3− , CH3CH2CH2- , (CH3)2CH- , XCH2- , X=Cl, Br, I, n=0 or 2), [ZnX2(Nia+CH2COO-)2] (Nia=nicotinamide, X=Cl, Br, I) and [Zn(XCH2COO)2(Caf)2]•2H2O (Car=caffeine, X=Cl, Br) is studied against bacterial strains Staphylococcus aureus, Escherichia coli and yeast Candida albicans. The structural types are assigned to the prepared compounds and the influence of (i) carboxylate chain length, (ii) substitution of hydrogen atom of carboxylate by halogen and (iii) presence of N-donor organic ligands on the biological activity is discussed.

Evaluation of Antibacterial and Antifungal Activity of Moringa Concanensis

2021 ◽  
Vol 14 (4) ◽  
pp. 5566-5570
Author(s):  
Bindu Singh Yadav ◽  
Yeddu Trilochana ◽  
Kiran Kumari ◽  
Saurabh Singh ◽  
Anupam K Sachan
Keyword(s):  
Antifungal Activity ◽  
Bacterial Infections ◽  
Methyl Cellulose ◽  
Enterobacter Aerogenes ◽  
Chloroform Extract ◽  
High Rate ◽  
Diffusion Method ◽  
Significant Activity ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal

In today’s scenario, fungal and bacterial infections are one of the most challenging pestilential diseases for the health-care professional which is increasing with a very high rate in the growing population, especially among the immune compromised people.The present work involved the study to extract active principles of Moringa concanensis and perform antibacterial and antifungal activity for various extracts. The leaves were dried powdered unexpected using solvents petroleum ether, chloroform, ethanol and water. Chemical tests were performed to ascertain presence of various classes of phyto-constituents like alkaloids, glycosides, saponins, carbohydrates, proteins, amino acids tannins, flavonoids and phenolic substances. All four extracts showed the presence of various phytochemicals responsible for multiple pharmacological activities. The extracts were reconstituted using 1% aqueous solution of carboxy methyl cellulose and were tested for antibacterial and antifungal activity against six microorganisms, namely Bacillus subtilis, Enterobacter aerogenes, Bacillus cereus, Aspergillus Flavus, Aspergillus Niger and Helminthosporium, using well diffusion method. The results of the activity are promising with chloroform extract showing highest inhibitory activity against most of the organisms. All the extracts were able to demonstrate significant activity compared to control inhibition of microorganisms tested and hold key to discover lead molecules after further scientific investigation.

Synthesis and Biological Evaluation of Chalconyl Incorporated Schiff’s Bases of Sulphonamides

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Neeraj Kumar ◽  
Dhruti Bhatt ◽  
Chandra Shekhar Sharma ◽  
Hamendra Pratap Singh ◽  
Harshda Pandiya ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Biological Evaluation ◽  
Antibacterial And Antifungal Activity ◽  
Schiff’S Bases ◽  
E Coli ◽  
Schiff's Bases ◽  
Microbial Strains ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation

A series of of Chalconyl Incorporated Schiff’s Bases of Sulphonamides was synthesized by reacting substituted chalcone derivatives with Sulphacetamide sodium in methanol. All the title compounds synthesized (2a-2d) were tested for antibacterial and antifungal activity using E. coli, P. aeruginosa, S. aureus, S. pyogenus and C. albicans, A. niger and A. clavatus respectively as microbial strains and Sulphacetamide sodium as standard. The compound 2d showed significant antibacterial activity and 2a showed moderate antifungal activity as compared with Sulphacetamide Sodium.

Antimicrobial Activity of Some Novel 1-(3-(4-Chlorophenylimino)-3,4- dihydroquinoxalin-2-yl)-3-substituted phenyl-1H-pyrazole-4-carbaldehyde

2020 ◽  
Vol 18 (2) ◽  
pp. 128-134
Author(s):  
Dhanapal Visagaperumal ◽  
Vineeth Chandy
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Dilution Method ◽  
Significant Activity ◽  
Antibacterial And Antifungal Activity ◽  
Reference Drug ◽  
Mass Spectral ◽  
Diffusion Technique ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal

Background: In this study, synthesis of some novel 1-(3-(4-chlorophenylimino)-3,4- dihydroquinoxalin-2-yl)-3-substituted phenyl-1H-pyrazole-4-carbaldehyde were done by cyclization of dehydrated hemiketal using VilsmeierHaack reaction. The structures of synthesized compounds were in accordance of the basis of IR, 1HNMR, Mass spectral data and elemental analyses. The synthesized compounds had given good yields and high purity. Methods: The antimicrobial activity of the synthesized compounds was preliminarily screened by paper disc diffusion technique. The determination of minimum inhibitory concentrations (MIC) of the synthesized compounds were done by using tube dilution method. Results and Conclusion: All the screened compounds showed antibacterial and antifungal activity against selected strains of Gram positive and Gram negative bacteria and two strains of fungus, respectively but exhibited considerably less activity when compared to the reference drug ciprofloxacin and Fluconazole for antibacterial and antifungal activity, respectively. Among the synthesized compounds VV5 exhibited significant activity.

scholarly journals SYNTHESIS AND INVESTIGATION OF ANTHELMINTIC, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF 3,3-DIPHENYL PROPANAMIDE DERIVATIVES

2019 ◽  
Vol 12 (1) ◽  
pp. 310 ◽  
Author(s):  
Sachin Chaudhary ◽  
Harish Chandra Verma ◽  
Mandeep Kumar Gupta ◽  
Ramesh Kumar Gupta ◽  
Amit Kumar ◽  
...  
Keyword(s):  
Amino Acid ◽  
Antifungal Activity ◽  
Anthelmintic Activity ◽  
Maximum Activity ◽  
Antibacterial And Antifungal Activity ◽  
Bacterial Strains ◽  
Standard Drug ◽  
Amino Acid Peptide ◽  
Death Time ◽  
Antibacterial And Antifungal

Objective: A novel series of substituted 3,3-diphenyl propanamide derivatives (I-VIII) were synthesized by reacting 3,3-diphenyl propanoyl chloride with different amines/amino acids, and all the derivatives were investigated for anthelmintic, antibacterial, and antifungal activity.Methods: All the compounds were characterized by infrared (IR) and1H- nuclear magnetic resonance spectrometry data. The synthesized derivatives were investigated for their anthelmintic activity employing housefly worms method and earthworm species model. The antibacterial and antifungal activity was performed employing cup plate method.Results: The synthesized compounds (VII and VIII) exhibited maximum anthelmintic activity as compared with standard drug albendazole at doses of 50 and 100 mg/mL, due to minimal paralyzing and death time in both housefly and earthworm models. The compounds (IV, VII, and VIII) at 50 μg/mL exhibited maximum activity against Gram-negative bacterial strains, namely, Escherichia coli, Pseudomonas aeruginosa as compared with ciprofloxacin and same compounds exhibited maximum antifungal activity against Candida albicans and Aspergillus niger in comparison with standard drug griseofulvin at 50 μg/mL.Conclusion: The synthesized compounds bearing amino acid moiety in their structure (VII-VIII) exhibited impressive anthelmintic activity in comparison with albendazole. This suggests that amino acid/peptide derivative of diphenyl propanamides can act as great anthelmintic agents. Further, the research can be performed to design potent antimicrobial diphenyl propanamide derivatives. 

scholarly journals Comparative Study of Antimicrobial and Staining Activity of Selected Anthraquinone Dyes

2019 ◽  
Vol 62 (2) ◽  
pp. 92-97
Author(s):  
Olufunmilayo Adeola Ajayi ◽  
Gabriel Ademola Olatunji
Keyword(s):  
Biological Activity ◽  
Antifungal Activity ◽  
Cell Walls ◽  
Significant Activity ◽  
Antibacterial And Antifungal Activity ◽  
Anthraquinone Dye ◽  
Anthraquinone Dyes ◽  
Fungal Identification ◽  
Mechanism Of Reaction ◽  
Antibacterial And Antifungal

The staining activity of twelve (12) anthraquinone dye derivatives was carried out to investigate the potential of the compounds as staining agents. The reactions of the compounds on organism cell walls were determined, and a comparison was drawn between the mechanism of action of the compounds against established mechanism of reaction of standard dyes used in biological staining. These compounds are BRAM/acetylated PPD, BRAM/PAP/p-TsCl, BRAM/Biaryl/PAP and BRAM/BzCl/PAP, BRAM/aniline, BRAM/o-toluidine, BRAM/p-toluidine, BRAM/m-toluidine, BRAM/p-anisidine, BRAM/m-anisidine, BRAM/PAP, and BRAM/p-iodoaniline. The antibacterial and antifungal activity of these compounds was determined. BRAM/BzCl/PAP exhibited higher biological activity on the bacterial types than most of the controls. From the results of the antifungal test, BRAM/m-toluidine and BRAM/acetylated PPD indicated very significant activity as much as the controls. The staining tests carried out on the compounds show that they are viable alternatives to existing dyes currently used in bacterial and fungal identification.

scholarly journals SYNTHESIS AND INVESTIGATION OF ANTHELMINTIC, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF 3,3-DIPHENYL PROPANAMIDE DERIVATIVES

2019 ◽  
Vol 12 (1) ◽  
pp. 310
Author(s):  
Sachin Chaudhary ◽  
Harish Chandra Verma ◽  
Mandeep Kumar Gupta ◽  
Ramesh Kumar Gupta ◽  
Amit Kumar ◽  
...  
Keyword(s):  
Amino Acid ◽  
Antifungal Activity ◽  
Anthelmintic Activity ◽  
Maximum Activity ◽  
Antibacterial And Antifungal Activity ◽  
Bacterial Strains ◽  
Standard Drug ◽  
Amino Acid Peptide ◽  
Death Time ◽  
Antibacterial And Antifungal

Objective: A novel series of substituted 3,3-diphenyl propanamide derivatives (I-VIII) were synthesized by reacting 3,3-diphenyl propanoyl chloride with different amines/amino acids, and all the derivatives were investigated for anthelmintic, antibacterial, and antifungal activity.Methods: All the compounds were characterized by infrared (IR) and1H- nuclear magnetic resonance spectrometry data. The synthesized derivatives were investigated for their anthelmintic activity employing housefly worms method and earthworm species model. The antibacterial and antifungal activity was performed employing cup plate method.Results: The synthesized compounds (VII and VIII) exhibited maximum anthelmintic activity as compared with standard drug albendazole at doses of 50 and 100 mg/mL, due to minimal paralyzing and death time in both housefly and earthworm models. The compounds (IV, VII, and VIII) at 50 μg/mL exhibited maximum activity against Gram-negative bacterial strains, namely, Escherichia coli, Pseudomonas aeruginosa as compared with ciprofloxacin and same compounds exhibited maximum antifungal activity against Candida albicans and Aspergillus niger in comparison with standard drug griseofulvin at 50 μg/mL.Conclusion: The synthesized compounds bearing amino acid moiety in their structure (VII-VIII) exhibited impressive anthelmintic activity in comparison with albendazole. This suggests that amino acid/peptide derivative of diphenyl propanamides can act as great anthelmintic agents. Further, the research can be performed to design potent antimicrobial diphenyl propanamide derivatives. 

scholarly journals Synthesis and Antimicrobial Properties of Naphthylamine Derivatives Having a Thiazolidinone Moiety

Medicina ◽  
2011 ◽  
Vol 47 (6) ◽  
pp. 47
Author(s):  
Vilma Petrikaitė ◽  
Eduardas Tarasevičius ◽  
Alvydas Pavilonis
Keyword(s):  
Antibacterial Activity ◽  
Minimum Inhibitory Concentration ◽  
Antifungal Activity ◽  
Inhibitory Concentration ◽  
Antimicrobial Properties ◽  
Microbiological Analysis ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal ◽  
New Compounds

Objective. The aim of this study was to evaluate the influence of pharmacophores having naphthylamine and nitro groups on the antimicrobial (antibacterial and antifungal) activity of thiazolidinone derivatives. Materials and Methods. The initial 5-substituted-2-methylmercaptothiazolidin-4-ones were subjected to S-demethylation to yield 2-amino-substituted thiazolidinones. 4-Nitro-1-naphthylamine, nitrofuran aldehydes, and nitrobenzene aldehydes were used as pharmacophoric compounds having amino or aldehyde groups. Antimicrobial (antibacterial and antifungal) activity of the new compounds was tested in vitro against bacterial cultures – Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsiella pneumoniae – and fungal cultures – Candida albicans, Candida glabrata, Candida krusei, Candida kefyr, Candida tropicalis, and Candida parapsilosis. Results. Microbiological analysis showed that all new thiazolidinone derivatives with nitronaphthylamine substituent possessed antibacterial and antifungal properties. New compounds 2a-b showed similar antibacterial activity in vitro against S. aureus and B. subtilis as aminopenicillins. The lowest antibacterial activity of all newly synthesized compounds was against capsule-forming bacteria K. pneumoniae and against gram-negative bacteria E. coli (minimum inhibitory concentration range, 500–1000 μg/mL). Conclusions. The minimum inhibitory concentration of naphthylamine derivatives varied in the range of 0.4–1000 μg/mL, and activity of some newly synthesized compounds was similar to the activity of aminopenicillins and fluconazole, an antifungal preparation. Based on the results, it is possible to separate the perspective group of potential antimicrobial compounds.

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