scholarly journals Brain Abscess and Keratoacanthoma Suggestive of Hyper IgE Syndrome

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Soheyla Alyasin ◽  
Reza Amin ◽  
Alireza Teymoori ◽  
Hamidreza Houshmand ◽  
Gholamreza Houshmand ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
Frontal Lobe ◽  
Eosinophil Count ◽  
Immunoglobulin E ◽  
Hyper Ige Syndrome ◽  
Magnetic Resonance Imaging Mri ◽  
The Right ◽  
High Level ◽  
The Brain ◽  
Left Inguinal Region

Hyper immunoglobulin-E (IgE) syndrome is an autosomal immune deficiency disease. It is characterized by an increase in IgE and eosinophil count with both T-cell and B-cell malfunction. Here, we report an 8-year-old boy whose disease started with an unusual skin manifestation. When 6 months old he developed generalized red, nontender nodules and pathologic report of the skin lesion was unremarkable (inflammatory). Then he developed a painless, cold abscess. At the age of 4 years, he developed a seronegative polyarticular arthritis. Another skin biopsy was taken which was in favor of Keratoacanthoma. Laboratory workup for immune deficiency showed high eosinophil count and high level of immunoglobulin-E, due to some diagnostic criteria (NIH sores: 41 in 9-year-olds), he was suggestive of hyper IgE syndrome. At the age of 8, the patient developed an abscess in the left inguinal region. While in hospital, the patient developed generalized tonic colonic convulsion and fever. Brain computed tomography scan revealed an abscess in the right frontal lobe. Subsequently magnetic resonance imaging (MRI) of the brain indicated expansion of the existing abscess to contralateral frontal lobe (left side). After evacuating the abscesses and administrating intravenous antibiotic, the patient’s condition improved dramatically and fever stopped.

Lateral Medullary Infarction with Contralateral Segmental Dysesthesia and Ipsilateral Headache: A Case Report

2021 ◽  
Vol 17 ◽  
Author(s):  
Renjie Wang ◽  
Yankun Shao ◽  
Lei Xu
Keyword(s):  
Medulla Oblongata ◽  
Clinical Manifestations ◽  
Lateral Medullary Infarction ◽  
Case Presentation ◽  
Specific Sign ◽  
Temperature Sense ◽  
Magnetic Resonance Imaging Mri ◽  
The Right ◽  
The Brain ◽  
Medullary Infarction

Introduction: The medulla oblongata is the lowest segment of the brain stem, located adjacent to the spinal cord, with a complex anatomical structure. Thus, a small injury to the medulla oblongata can show complex clinical manifestations. Case Presentation: A patient experienced dysesthesia, which manifested as numbness in her right lower limb and decreased temperature sense, and dizziness 20 days before admission. The numbness worsened 1 week before admission, reaching the right thoracic (T) 12 dermatomes. Her thermoception below the T12 dermatomes decreased, and the degree of dizziness increased, accompanied by nausea and vomiting. Magnetic resonance imaging (MRI) of the neck, chest, and abdomen performed at a local hospital showed no abnormalities. MRI of the brain was performed after admission. One week after admission, she experienced a severe headache in the upper left periorbital area. The numbness extended to T4, and thermoception decreased below T4. Diagnosis: Lateral medullary infarction. Interventions: Anti-platelet aggregation and mitochondrial nutritional therapies were performed along with treatments for improving circulation and establishing collateral circulation. Outcomes: The intensity of limb numbness decreased, and the symptoms of headache and dizziness resolved. Conclusion: Lesions leading to segmental sensory disorders can occur in the medulla oblongata. Ipsilateral headaches with contralateral segmental paresthesia can be a specific sign of lateral medullary infarction.

Aspergillus meningitis and discitis from low-back procedures in an immunocompetent patient

2007 ◽  
Vol 48 (6) ◽  
pp. 687-689 ◽  
Author(s):  
A. B. Larson Kolbe ◽  
A. M. McKinney ◽  
A. Tuba Karagulle Kendi ◽  
D. Misselt
Keyword(s):  
Steroid Injection ◽  
Rare Complication ◽  
Immunocompetent Patient ◽  
Epidural Steroid Injection ◽  
Low Back ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
The Right ◽  
Epidural Steroid ◽  
The Brain

We present a case of an immunocompetent patient who developed Aspergillus meningitis, subsequent to discitis, presumed to be from an epidural steroid injection. Magnetic resonance imaging (MRI) of the lumbar spine confirmed the diagnosis of discitis. Fluoroscopic-guided aspiration of the disc showed growth of Aspergillus fumigatus. MRI of the brain revealed involvement of the right third cranial nerve. Repeat MRIs demonstrated multiple leptomeningeal masses consistent with granulomatous meningitis. Meningitis is a rare complication of discitis, discogram, or epidural steroid injection. Aspergillus usually only infects immunocompromised patients, but rarely can affect immunocompetent patients.

A Conjunctival Vascular Malformation as a Rare Presenting Sign of Wyburn–Mason Syndrome

2017 ◽  
Vol 16 (04) ◽  
pp. 239-242
Author(s):  
Gunnar Buyse ◽  
Lieven Lagae ◽  
Philippe Demaerel ◽  
Frank Kesteloot ◽  
Ingele Casteels ◽  
...  
Keyword(s):  
Vascular Malformation ◽  
Arteriovenous Malformations ◽  
Brain Magnetic Resonance Imaging ◽  
Rare Condition ◽  
Vascular Lesion ◽  
Facial Skin ◽  
Sudden Appearance ◽  
Magnetic Resonance Imaging Mri ◽  
The Right ◽  
The Brain

AbstractWyburn–Mason syndrome is a rare condition that is characterized by ipsilateral arteriovenous malformations affecting the eye, brain, and facial skin. A conjunctival vascular dilation can be a rare ocular presenting sign. We report a 6-year-old boy who attended the hospital because of the sudden appearance of a conjunctival vascular lesion in his right eye. Inspection of his facial skin showed a subtle discoloration along the right trigeminal nerve and a vascular structure of the conjunctiva. Fundoscopy showed dilated and tortuous retinal vessels. Brain magnetic resonance imaging (MRI) revealed a large arteriovenous malformation involving the thalamus and perimesencephalic area. Ophthalmologic and neuroradiologic findings were consistent with the diagnosis of Wyburn–Mason syndrome. The sudden emergence of a vascular malformation in the conjunctiva should alert the clinician to perform an ophthalmoscopy, and in our patient, this finding was the clue to diagnosis of Wyburn–Mason syndrome. Because of the association between retinal and intracranial arteriovenous malformations, an MRI of the brain is strongly recommended in all patients with ocular arteriovenous malformations.

scholarly journals Asymmetry in the content of brain monoamines of BALB/c mice reared in social isolation conditions

2012 ◽  
Vol 10 (4) ◽  
pp. 42-48 ◽  
Author(s):  
Inessa Vladimirovna Karpova ◽  
Vladimir Vladimirovich Mikheyev ◽  
Yevgeniy Rudolfovich Bychkov ◽  
Andrey Andreyevich Lebedev ◽  
Petr Dmitriyevich Shabanov
Keyword(s):  
Social Isolation ◽  
Elevated Level ◽  
Right Hemisphere ◽  
Brain Structures ◽  
Brain Monoamines ◽  
Left Hippocampus ◽  
The Right ◽  
High Level ◽  
The Brain

The effects of long-term social isolation on the content and metabolism of dopamine and serotonin systems were studied in symmetrical brain structures of BALB/c male mice. With HPLC the contents of dopamine (DA), serotonin (5-HT) and their metabolites dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindolacetic acid (5-HIAA) were measured in the cortex, hippocampus and striatum of both the right and the left hemispheres of the brain in mice reared in groups and social isolation. The isolated mice were characterized by reduced level of DA in the left striatum and elevated level of 5-HIAA and ratio 5-HIAA/5-HT in the right striatum. In the hippocampus of isolated mice, the activation of both DA-ergic and 5-HT-ergic systems was observed, that is the high level of DA and DOPAC in the left hippocampus and the elevated level of 5-HT in both hemispheres and of 5-HIAA in the right hippocampus were registered. On the other hand, the reduction of both DA-ergic and 5-HT-ergic systems activity was shown to be in the right hemisphere. The decreased concentration of DOPAC and ratio DOPAC/DA in the right cortex were observed as well. As to 5-HT-ergic system, the reduced level of 5-HT in the both cortex of the hemispheres as well as 5-HIAA in the right hemisphere of isolated mice was determined. The phenomenon of interhemispheric asymmetry was revealed in the hippocampus only, which was characterized by the increased DA-ergic activity in the left hippocampus but not in the striatum and the cortex.

scholarly journals The Human Dynamic Clamp reveals the fronto-parietal network linking real-time social coordination and cognition

2019 ◽  
Author(s):  
G. Dumas ◽  
Q. Moreau ◽  
E. Tognoli ◽  
J.A.S. Kelso
Keyword(s):  
Social Cognition ◽  
Social Behavior ◽  
Real Time ◽  
Dynamic Clamp ◽  
Sensorimotor Coordination ◽  
Self And Other ◽  
The Right ◽  
High Level ◽  
Sensorimotor Mechanisms ◽  
The Brain

AbstractHow does the brain allow us to interact with others, and above all how does it handle situations when the goals of the interactors overlap (i.e. cooperation) or differ (i.e. competition)? Social neuroscience has already provided some answers to these questions but has tended to treat high-level, cognitive interpretations of social behavior separately from the sensorimotor mechanisms upon which they rely. The goal here is to identify the underlying neural processes and mechanisms linking sensorimotor coordination and intention attribution. We combine the Human Dynamic Clamp (HDC), a novel paradigm for studying realistic social behavior between self and other in well-controlled laboratory conditions, with high resolution electroencephalography (EEG). The collection of humanness and intention attribution reports, kinematics and neural data affords an opportunity to relate brain activity to the behavior of the HDC as well as to what the human is doing. Behavioral results demonstrate that sensorimotor coordination influences judgements of cooperativeness and humanness. Analysis of brain dynamics reveals two distinct networks related to integration of visuo-motor information from self and other. The two networks overlap over the right parietal region, an area known to be important for interpersonal motor interactions. Furthermore, connectivity analysis highlights how the judgement of humanness and cooperation of others modulate the connection between the right parietal hub and prefrontal cortex. These results reveal how distributed neural dynamics integrates information from ‘low-level’ sensorimotor mechanisms and ‘high-level’ social cognition to support the realistic social behaviors that play out in real time during interactive scenarios.Significance StatementDaily social interactions require us to coordinate with others and to reflect on their potential motives. This study investigates the brain and behavioral dynamics of these two key aspects of social cognition. Combining high-density electroencephalography and the Human Dynamic Clamp (a Virtual Partner endowed with human-based coordination dynamics), we show first, that several features of sensorimotor coordination influence attribution of intention and judgement of humanness; second, that the right parietal lobe is a key integration hub between information related to self- and other-behavior; and third, that the posterior online social hub is functionally coupled to anterior offline brain structures to support mentalizing about others. Our results stress the complementary nature of low-level and high-level mechanisms that underlie social cognition.

scholarly journals Spontaneous Convexity Subarachnoid Hemorrhage Caused by Internal Carotid Occlusion: Radiological Features

2019 ◽  
Vol 39 (01) ◽  
pp. 016-017
Author(s):  
Benedito Jamilson Araújo Pereira ◽  
Radmila Agra Cariry Targino de Holanda ◽  
José Targino Neto ◽  
Luciano Ferreira de Holanda
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Internal Carotid ◽  
Digital Subtraction ◽  
Resonance Imaging ◽  
Left Hand ◽  
Internal Carotid Occlusion ◽  
Similar Report ◽  
Magnetic Resonance Imaging Mri ◽  
The Right ◽  
The Brain

AbstractA 79-year-old patient was admitted to the emergency room with transitory monoparesis in the left hand and dysphasia. The brain computed tomography (CT) and magnetic resonance imaging (MRI) showed a spontaneous right convexity subarachnoid hemorrhage (cSAH). Digital subtraction angiography (DSA) confirmed an asymptomatic occlusion of the right internal carotid artery (ICA) . Cases related to stenosis have already been described, but there is no similar report of a case related to occlusion, even though the pathophysiology of both entities is similar. Atraumatic SAH has been associated with intracranial and extracranial artery stenosis.

scholarly journals Vitamin D Levels in Asymptomatic Children and Adolescents with Atopy during the COVID-19 Era

2021 ◽  
Vol 11 (8) ◽  
pp. 712
Author(s):  
Gavriela Feketea ◽  
Vasiliki Vlacha ◽  
Georgios Tsiros ◽  
Panagiota Voila ◽  
Raluca Maria Pop ◽  
...  
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Eosinophil Count ◽  
Immunoglobulin E ◽  
Serum Levels ◽  
Asymptomatic Children ◽  
Vitamin D Levels ◽  
Median Level ◽  
25 Hydroxy Vitamin D ◽  
High Level

This study assessed vitamin D status in asymptomatic children and adolescents in Greece, with and without atopy, and possible changes during the coronavirus disease 2019 (COVID-19) pandemic. Serum levels of 25-hydroxy-vitamin D (25(OH)D) and total immunoglobulin E (IgE), and eosinophil count were measured in 340 asymptomatic children and adolescents (155 males, 185 females), mean age 8.6 ± 4.6 years, recruited over a period of 24 months (February 2019–January 2021). Atopy, defined by high level of IgE for age, was associated with vitamin D deficient status (p = 0.041). Subjects with and without atopy showed similar rates of insufficient and normal levels of 25(OH)D. The median level of 25(OH)D was significantly higher in subjects recruited during the pandemic, when home confinement rules were observed, than before the pandemic, and significantly more children had normal levels of 25(OH)D (p < 0.001), but no differences were noticed for IgE levels or eosinophil count. These results support a link between vitamin D and allergic and infectious inflammations, and specifically the association of vitamin D deficiency with asymptomatic atopy, defined as increased IgE level for age.

scholarly journals Predictors of embolic complications during carotid stenting (TACTILE trial)

2020 ◽  
Vol 24 (1) ◽  
pp. 28
Author(s):  
D. U. Malaev ◽  
A. A. Boykov ◽  
A. A. Prohorihin ◽  
A. R. Tarkova ◽  
V. I. Baystrukov ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Aortic Arch ◽  
Conflict Of Interest ◽  
Carotid Stenting ◽  
Percutaneous Transluminal Coronary Angioplasty ◽  
Type Ii ◽  
Magnetic Resonance Imaging Mri ◽  
Transluminal Coronary Angioplasty ◽  
The Right ◽  
The Brain

<p><strong>Background.</strong> In 30% to 87% patients undergoing carotid artery stenting (CAS), new ischaemic lesions (NILs) of the brain are detected on magnetic resonance imaging (MRI). According to some authors, in 60% cases who undergo CAS via transfemoral (TF) access, NILs are also found in the contralateral and other vascular pools of the brain that are not directly related to the target carotid artery, most likely a result of the endovascular manipulation of the catheter on the aortic arch. An alternative access site for CAS is transradial (TR) access. Theoretically, with TR access, the catheter’s contact with the aortic arch is reduced, particularly with an intervention on the right internal carotid artery, and the risk of embolic events is possibly reduced. However, this aspect has not yet been explored.</p><p><strong>Aim.</strong> The aim of this study was to identify the predictors of NILs of the brain in patients undergoing CAS via the TR and TF approaches.</p><p><strong>Methods.</strong> The study included 96 patients with indications for CAS. Patients were randomised in a 1:1 ratio to either the TR (n = 48) or TF (n = 48) groups. All patients underwent diffusion-weighted imaging MRI before and 12 to 24 hours after the procedure. Multiple logistic regression with step-by-step turning off of variables was used to determine the predictors of NIL.</p><p><strong>Results.</strong> A total of 40 clinical, demographic, instrumental and intraoperative variables were analysed. Based on the results of single regression analysis, 6 predictors (age, male sex, hypertension, history of percutaneous transluminal coronary angioplasty, intersection of the aortic arch and type II/III aortic arch) were included in the multivariate model. From the final multivariate analysis, it was found that age, intersection of the aortic arch and type II/III aortic arch are independent predictors of NILs after CAS.</p><p><strong>Conclusion</strong>. Patient age, type II/III aortic arch and need for a catheter to cross the aortic arch are independent predictors of NILs during carotid stenting.</p><p>Received 9 January 2020. Revised 21 February 2020. Accepted 25 February 2020.</p><p><strong>Funding:</strong> The study did not have sponsorship.</p><p><strong>Conflict of interest</strong>: Authors declare no conflict of interest.</p>

Abscess in Frontal Lobe: Post-Mortem Findings in Case Shown at a Previous Meeting of the Section with Elizabeth O’Flynn

2016 ◽  
pp. 119-122
Author(s):  
Donald W. Winnicott ◽  
Elizabeth O’Flynn
Keyword(s):  
Frontal Lobe ◽  
Tuberculous Meningitis ◽  
Right Hemisphere ◽  
Post Mortem ◽  
Anterior Half ◽  
Intracranial Disease ◽  
Post Mortem Findings ◽  
The Right ◽  
The Brain ◽  
Important Disease

Winnicott and O’Flynn present the case of a six-year-old at death, who had been under observation at the Queen’s Hospital for Children for several years. Besides the odd complaints from which she suffered, it was always felt that some more important disease might be present. The child always did well in hospital and at the convalescent home. Later, acute symptoms pointed directly to intracranial disease, and tuberculous meningitis was expected. A postmortem report revealed a large abscess in the right frontal lobe of the brain, involving the whole anterior half of the right hemisphere, and extremely congested kidneys.

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