Shrinkage of Prostate and Improved Quality of Life: Management of BPH Patients with Croton membranaceus Ethanolic Root Extract

Benign prostatic hyperplasia (BPH) is an enlargement of the prostate. The study aimed at validating the use of freeze-dried Croton membranaceus ethanolic root extract for BPH management. Thirty-three patients were observed before and after 3-month administration of 20 mg t.i.d orally. The International Prostate Symptom Score (IPSS), and the International Index of Erectile Function (IIEF) questionnaires were used. Total/free PSA (tPSA, fPSA), renal, liver function, lipid tests, and ultrasonographic imaging were performed. Thirty (30) patients (66 ± 11 years) completed the study. IPSS results showed 37% had severe, 40% moderate, and 23% mild symptoms before; 57% and 43% had moderate and mild symptoms, respectively, after treatment. IIED of patients’ results showed 30% with severe, 40% moderate, 24% mild-moderate, 3% mild, and 3% no erectile dysfunction before treatment and 20% severe, 43% moderate, and 37% mild-moderate dysfunction, after treatment. Quality of life (QoL) improved (P=0.001). Significant but non-pathological increases in total and indirect bilirubin as well as apolipoprotein A occurred. Mean tPSA reduced from 27.9 ± 19.0 to 16.2 ± 11.8 ng/mL (P=0.002); fPSA from 6.1 ± 4.8 to 3.9 ± 2.9 ng/mL (P=0.045); and prostate volume from 101.8 ± 41.3 to 54.5 ± 24.8 cm3 (P=0.023). C. membranaceus shrinks the prostate and improves QoL.

Download Full-text

Improvement but no normalization of quality of life and cognitive functioning after treatment for Cushing’s syndrome

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2019-01054 ◽

2019 ◽

Cited By ~ 2

Author(s):

Leonie H A Broersen ◽

Cornelie D Andela ◽

Olaf M Dekkers ◽

Alberto M Pereira ◽

Nienke R Biermasz

Keyword(s):

Quality Of Life ◽

Cognitive Functioning ◽

Cushing’S Syndrome ◽

Meta Analysis ◽

Cushing's Syndrome ◽

Treatment Quality ◽

Cross Sectional ◽

Effective Interventions ◽

Before And After

Abstract Background Cushing’s syndrome is characterized by glucocorticoid excess, which induces physical and mental symptoms, impairments in functional status and perceived health, resulting in impaired quality of life. Biochemical remission is urgently required; however, quality of life and cognitive function may remain impaired. Objective To perform a systematic review and meta-analysis evaluating changes in health-related quality of life and cognitive functioning in patients with Cushing’s syndrome after treatment. Methods Eight electronic databases were searched in March 2017, and PubMed again in May 2018, to identify potentially relevant articles. Eligible studies were (randomized controlled) trials, cohort studies, and cross-sectional studies assessing quality of life or cognitive functioning in patients treated for Cushing’s syndrome. Differences were expressed as standardized mean difference, and reported with 95% confidence intervals. We compared patients before and after treatment (improvement), and patients after treatment and healthy controls (normalization). Results We included 47 articles with 2,643 patients. Most patients had Cushing’s disease and were in remission after treatment. Quality of life and cognitive functioning improved after treatment in all studied domains. Compared to a healthy control population, quality of life did not normalize. Cognitive functioning normalized in part, but not all, of the studied domains. Conclusions Treatment of Cushing’s syndrome improves quality of life and cognitive functioning. As normalization was not achieved in quality of life and in some aspects of cognitive functioning, special and continuous attention should be given to these aspects for patients after treatment. Effective interventions for further improvement and possibly normalization are urgently needed.

Download Full-text

P-OGC03 Pancreatic enzyme supplementation improves quality of life in patients following surgery for upper GI cancer

British Journal of Surgery ◽

10.1093/bjs/znab430.131 ◽

2021 ◽

Vol 108 (Supplement_9) ◽

Author(s):

Robert Kay ◽

Callum Alexander ◽

Sajid Waheed Rahman ◽

Chris Deans

Keyword(s):

Quality Of Life ◽

Pancreatic Enzyme ◽

Treatment Quality ◽

Exocrine Insufficiency ◽

Abdominal Symptoms ◽

Patient Reported ◽

Before And After ◽

Health Domains ◽

Enzyme Supplementation

Abstract Background Unpleasant abdominal symptoms are common following surgery for upper gastrointestinal (UGI) cancer and may occur secondary to pancreatic exocrine insufficiency (EPI). This study investigated symptoms of EPI in patients following surgery and assessed the effect of pancreatic enzyme supplementation (PERT) on these symptoms and the effect of supplementation on quality of life. Methods Patients were assessed for symptoms of EPI using a novel questionnaire. Patients who reported two or more symptoms suggestive of EPI were prescribed PERT. Abdominal symptoms were reassessed following treatment. Quality of life (QoL) was studied using the SF-36 questionnaire before and after treatment. Faecal elastase was also measured in a patient subgroup. Results Fifty-six out of 57 patients (98%) reported at least two symptoms of EPI. Following PERT every patient reported fewer abdominal symptoms; median 5 symptoms before treatment reduced to two symptoms following treatment (p < 0.0001; Wilcoxon rank). Reduced faecal elastase concentration was associated with more frequent abdominal symptoms; median 5 symptoms versus 3 symptoms (p = 0.043; Mann Whitney U test). PERT increased quality of life scores for every patient in each of the 5 principle health domains. Conclusions Symptoms of EPI are common among patients following UGI cancer surgery. PERT reduces unpleasant abdominal symptoms and this leads to significant improvements in quality of life across global health domains. PERT should be offered to all post-operative UGI cancer patients with symptoms suggestive of EPI.

Download Full-text

1671: Association of Race, Cancer Severity, Pre-Treatment Quality of Life, and Patient Optimism/Pessimism with Patient Selection of Primary Prostate Cancer Treatment

The Journal of Urology ◽

10.1016/s0022-5347(18)35793-8 ◽

2005 ◽

Vol 173 (4S) ◽

pp. 453-453

Author(s):

Martin G. Sanda ◽

Rodney L. Dunn ◽

Christopher S. Saigal ◽

Eric A. Klein ◽

Louis L. Pisters ◽

...

Keyword(s):

Quality Of Life ◽

Prostate Cancer ◽

Cancer Treatment ◽

Patient Selection ◽

Treatment Quality ◽

Prostate Cancer Treatment ◽

Primary Prostate Cancer ◽

Pre Treatment ◽

Selection Of

Download Full-text

153 Quality of life in typical atrial flutter patients before and after radiofrequency catheter ablation using irrigational and conventional techniques

EP Europace ◽

10.1016/s1099-5129(05)80070-4 ◽

2005 ◽

Vol 7 ◽

pp. 25-25

Keyword(s):

Quality Of Life ◽

Catheter Ablation ◽

Atrial Flutter ◽

Radiofrequency Catheter Ablation ◽

Typical Atrial Flutter ◽

Before And After

Download Full-text

Strategic Role of Zakat in Multidimensional Quality of Life in Sijunjung, Indonesia

The Journal of Muamalat and Islamic Finance Research ◽

10.33102/jmifr.v15i1.101 ◽

2018 ◽

Vol 15 (1) ◽

pp. 55-72

Author(s):

Herlin Hamimi ◽

Abdul Ghafar Ismail ◽

Muhammad Hasbi Zaenal

Keyword(s):

Quality Of Life ◽

Positive Impact ◽

Wealth Distribution ◽

Absolute Poverty ◽

Before And After ◽

The Status ◽

Being There ◽

The Impact

Zakat is one of the five pillars of Islam which has a function of faith, social and economic functions. Muslims who can pay zakat are required to give at least 2.5 per cent of their wealth. The problem of poverty prevalent in disadvantaged regions because of the difficulty of access to information and communication led to a gap that is so high in wealth and resources. The instrument of zakat provides a paradigm in the achievement of equitable wealth distribution and healthy circulation. Zakat potentially offers a better life and improves the quality of human being. There is a human quality improvement not only in economic terms but also in spiritual terms such as improving religiousity. This study aims to examine the role of zakat to alleviate humanitarian issues in disadvantaged regions such as Sijunjung, one of zakat beneficiaries and impoverished areas in Indonesia. The researcher attempted a Cibest method to capture the impact of zakat beneficiaries before and after becoming a member of Zakat Community Development (ZCD) Program in material and spiritual value. The overall analysis shows that zakat has a positive impact on disadvantaged regions development and enhance the quality of life of the community. There is an improvement in the average of mustahik household incomes after becoming a member of ZCD Program. Cibest model demonstrates that material, spiritual, and absolute poverty index decreased by 10, 5, and 6 per cent. Meanwhile, the welfare index is increased by 21 per cent. These findings have significant implications for developing the quality of life in disadvantaged regions in Sijunjung. Therefore, zakat is one of the instruments to change the status of disadvantaged areas to be equivalent to other areas.

Download Full-text