scholarly journals Low Magnesium Exacerbates Osteoporosis in Chronic Kidney Disease Patients with Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jui-Hua Huang ◽  
Fu-Chou Cheng ◽  
Hsu-Chen Wu
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Inverse Correlation ◽  
Mineral Density ◽  
Lower Serum ◽  
Patients With Diabetes ◽  
The Impact ◽  
Low Serum

The aim of this study is to investigate the impact of serum Mg on bone mineral metabolism in chronic kidney disease (CKD) patients with or without diabetes. A total of 56 CKD patients not receiving dialysis were recruited and divided into two groups, one group of 27 CKD patients with diabetes and another group of 29 CKD patients without diabetes. Biochemical determinations were made, and the estimated glomerular filtration rate (eGFR) was measured. Bone mineral density was measured by dual-energy X-ray absorptiometry. Serum Mg was inversely correlated with serum CaP=0.023and positively correlated with serum parathyroid hormone (PTH)P=0.020, alkaline phosphataseP=0.044, and phosphateP=0.040in the CKD patients with diabetes. The CKD patients with diabetes had lower serum albumin and a higher proportion of hypomagnesemia and osteoporosis than the nondiabetic patients didP<0.05. Serum Mg was inversely correlated with eGFR in the CKD patients with or without diabetesP<0.05. Serum Mg showed an inverse correlation with 25-hydroxyvitamin D in CKD patients without diabetesP=0.006. Furthermore, the diabetic CKD patients with low serum Mg had a lower iPTHP=0.007and a higher serum Ca/Mg ratioP<0.001than the other CKD patients. The lower serum Mg subgroup showed a higher incidence of osteoporosis than the moderate and higher serum Mg subgroups did (66.7%, 39.4%, and 29.4%, resp.). In conclusion, low serum Mg may impact iPTH and exacerbates osteoporosis in CKD patients, particularly with diabetes.

Mineral metabolism, cortical volumetric bone mineral density and fracture risk in childhood chronic kidney disease

2013 ◽  
Author(s):  
Denburg Michelle ◽  
Tsampalieros Anne ◽  
de Boer Ian ◽  
Shults Justine ◽  
Kalkwarf Heidi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density

scholarly journals Mineral Metabolism and Cortical Volumetric Bone Mineral Density in Childhood Chronic Kidney Disease

2013 ◽  
Vol 98 (5) ◽  
pp. 1930-1938 ◽  
Author(s):  
Michelle R. Denburg ◽  
Anne K. Tsampalieros ◽  
Ian H. de Boer ◽  
Justine Shults ◽  
Heidi J. Kalkwarf ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density

scholarly journals Bone Mineral Metabolism and Muscle Alterations in Non-dialysis Dependent Patients With Chronic Kidney Disease

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 38-38
Author(s):  
Julia Montenegro ◽  
Márcia Klein ◽  
Carla Prado ◽  
Maria Inês Barreto Silva
Keyword(s):  
Chronic Kidney Disease ◽  
Body Composition ◽  
Kidney Disease ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Interdisciplinary Treatment ◽  
Mineral Density ◽  
T Score ◽  
Funding Sources

Abstract Objectives Abnormal bone mineral density (BMD) is common in chronic kidney disease (CKD) and related with higher risk of disease progression, cardiovascular disease, and mortality. The aim of this study was to assess BMD, its change overtime and association with body composition and biochemical parameters of mineraly metabolism. Methods This was a longitudinal study of patients with NDD-CKD (stages 3–5) undergoing interdisciplinary treatment at an outpatient Nephrology Clinic and instructed to follow a low protein diet. Dual energy X-ray absorptiometry (DXA) was performed to estimate body composition and BMD (T-score). Mineral metabolism parameters included parathormone (PTH), calcium, phosphorus and vitamin D. Glomerular filtration rate was estimated (eGFR) by the CKD-EPI equation. Osteopenia was defined as T-score &lt; -1.0. Baseline and follow-up comparisons between groups with and without osteopenia were performed by two-way ANOVA. Correlations were adjusted by sex, age and eGFR. Results Forty-five patients (56% males) aged 64.4 ± 9.9 y and eGFR 31.4 ± 10.9 ml/min completed a follow-up of ∼3 years (2.7 ± 1.3). As expected, a reduction in renal function was observed (median = −1.10 ml/min; 95% CI: −8.8 to 0.64, P &lt; 0.05). BMD and appendicular skeletal muscle (ASM) decreased: 1.06 ± 0.15 vs. 1.05 ± 0.03g/cm2 (P = 0.03) and 20.3 ± 4.6 vs. 18.9 ± 0.8kg (P = 0.01), respectively. Prevalence of osteopenia was 42.2% with no significant change overtime. Patients with osteopenia presented with higher (P &lt; 0.0001) change in ASM (median: −1.58kg;  95% CI: −3.8 to 0.66 vs. −0.83; −4.0 to 2.4) and in LST (−1.08 kg; −5.0 to 2.8 vs. 0.88; −4.6 to 6.3), compared with patients without osteopenia. Changes in eGFR and mineral metabolism parameters were similar between groups. T-score change was negatively correlated with change in LST (r = 0.66; P = 0.04) and PTH (r = −0.70; P = 0,03), and with baseline LST (r = −0.35; P = 0.04) independent of age, sex and eGFR. Body fat increased (22.7 kg ± 8.1 vs. 23.8 kg ± 8.7; P = 0.04) during follow up, but it was not significantly correlated with T-score. Conclusions Prevalence of osteopenia was high in patients with NDD-CKD, and BMD decreased after 3 years, which was associated with a reduction in LST and increase in PTH, independent of eGFR, age, and sex. LST should be monitored in NDD-CKD to prevent risk for abnormal BMD. Funding Sources FAPERJ

RELATION BETWEEN BODY MASS INDEX AND BONE MINERAL DENSITY AMONG HAEMODIALYSIS PATIENTS WITH CHRONIC KIDNEY DISEASE

2009 ◽  
Vol 35 ◽  
pp. 57-64 ◽  
Author(s):  
Rafael Fernández Castillo ◽  
Rafael José Esteban de la Rosa
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Body Mass ◽  
Bone Mineral ◽  
Mineral Density

Vitamin D Status and Bone Mineral Density is Influenced by Vitamin D Supplementation and Vitamin K1 Intake in Adults with Diabetes and Chronic Kidney Disease

2017 ◽  
Vol 78 (1) ◽  
pp. 11-19
Author(s):  
Michelle R. Hoffmann ◽  
Peter A. Senior ◽  
Stephanie T. Jackson ◽  
Guylaine Ferland ◽  
Nancy Presse ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Bone Mineral ◽  
Vitamin D Supplementation ◽  
Vitamin K1 ◽  
Vitamin D Status ◽  
Mineral Density

SP449RELATIONSHIP BETWEEN BONE MINERAL DENSITY AND SUBCLINICAL ATHEROSCLEROSIS IN DIABETIC PATIENTS WITH CHRONIC KIDNEY DISEASE

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i499-i499
Author(s):  
Volha Vasilkova ◽  
Tatiana Mokhort ◽  
Elena Naumenko ◽  
Ivan Pchelin ◽  
Valentina Bayrasheva ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Bone Mineral ◽  
Subclinical Atherosclerosis ◽  
Diabetic Patients ◽  
Mineral Density

scholarly journals Bone Activity Biomarkers and Bone Mineral Density in Children with Chronic Kidney Disease

2011 ◽  
Vol 3 (3) ◽  
Author(s):  
YF Ali ◽  
AM Abdel-Latif ◽  
MA El-Koumi ◽  
AAM Ghorab ◽  
HA Labib
Keyword(s):  
Bone Mineral Density ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Bone Mineral ◽  
Mineral Density

The use of bone mineral density measured by dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed microtomography in chronic kidney disease

2017 ◽  
Vol 30 (5) ◽  
pp. 635-643 ◽  
Author(s):  
Martin Jannot ◽  
Fabrice Mac-Way ◽  
Vanessa Lapierre ◽  
Marie-Helene Lafage-Proust
Keyword(s):  
Bone Mineral Density ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Bone Mineral ◽  
Dual Energy ◽  
Mineral Density ◽  
X Ray ◽  
Computed Microtomography

Bone mineral density and biochemical markers of bone metabolism in predialysis patients with chronic kidney disease

2016 ◽  
Vol 64 (4) ◽  
pp. 861-866 ◽  
Author(s):  
Nuri Fidan ◽  
Ayca Inci ◽  
Melahat Coban ◽  
Cevval Ulman ◽  
Seyhun Kursat
Keyword(s):  
Bone Mineral Density ◽  
Chronic Kidney Disease ◽  
Alkaline Phosphatase ◽  
Kidney Disease ◽  
Bone Loss ◽  
Bone Mineral ◽  
Serum Alkaline Phosphatase ◽  
Mineral Density ◽  
T Score ◽  
Z Scores

The aim of the study was to evaluate the usefulness of serum bone turnover markers (BTM) and bone mineral density (BMD) determined by dual-energy X-ray absorptiometry (DEXA) in predialysis patients with chronic kidney disease (CKD). We enrolled 83 patients with CKD, 41 (49.4%) males, 42 (50.6%) females, with mean estimated glomerular filtration rate (eGFR) 23.90±12 (range=6.0–56.0). BMD of the lumbar spine (LS) (anteroposterior, L2 through L4), femoral neck (FN) and femoral trochanter (FT) were measured by DEXA. Biochemical BTM, including calcium (Ca), phosphorus (P), intact parathyroid hormone (PTH), serum specific alkaline phosphatase (serum AP), bone-specific AP (BSAP), plasma bicarbonate and 25-hydroxy-vitamin D (25hD) were used for the prediction of BMD loss. T score results of LS and FN were worse than FT. BMD levels were lower in females than in males (all p<0.05). According to different BMD T score levels, patients with age ≥65 years and patients in menopause were significantly more osteopenic (p=0.026) and there was no relation between different BMD T scores and presence of diabetes (p=0.654). A positive correlation was identified between the BMD of FN T-Z scores (r=0.270, p=0.029, r=0.306, p=0.012), FT T-Z scores (r=0.220, p=0.076, r:0.250, p=0.043) and serum HCO3, while the correlation with serum alkaline phosphatase (AP) and BSAP was considered to be negative. No statistically significant association was found between BMD of all the measured skeletal sites and eGFR. Loss of BMD was identified mostly in females over ≥65 years of age and after menopause. Higher serum levels of BSAP and AP can be determined in the advanced stages of renal failure and they reflect fracture risk of the femur, but not spine. Measurements of BMD by DEXA are useful to demonstrate bone loss, but not technical enough to distinguish the quantity of bone loss between different stages of CKD.

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