scholarly journals Posterior Cingulate Lactate as a Metabolic Biomarker in Amnestic Mild Cognitive Impairment

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Kurt E. Weaver ◽  
Todd L. Richards ◽  
Rebecca G. Logsdon ◽  
Ellen L. McGough ◽  
Satoshi Minoshima ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Disease Progression ◽  
Hippocampal Volume ◽  
Amnestic Mild Cognitive Impairment ◽  
Resonance Spectroscopy ◽  
Compensatory Response ◽  
Posterior Cingulate ◽  
Therapeutic Trials

Mitochondrial dysfunction represents a central factor within the pathogenesis of the Alzheimer’s disease (AD) spectrum. We hypothesized that in vivo measurements of lactate (lac), a by-product of glycolysis, would correlate with functional impairment and measures of brain health in a cohort of 15 amnestic mild cognitive impairment (aMCI) individuals. Lac was quantified from the precuneus/posterior cingulate (PPC) using 2-dimensional J-resolved magnetic resonance spectroscopy (MRS). Additionally, standard behavioral and imaging markers of aMCI disease progression were acquired. PPC lac was negatively correlated with performance on the Wechsler logical memory tests and on the minimental state examination even after accounting for gray matter, cerebral spinal fluid volume, and age. No such relationships were observed between lac and performance on nonmemory tests. Significant negative relationships were also noted between PPC lac and hippocampal volume and PPC functional connectivity. Together, these results reveal that aMCI individuals with a greater disease progression have increased concentrations of PPC lac. Because lac is upregulated as a compensatory response to mitochondrial impairment, we propose that J-resolved MRS of lac is a noninvasive, surrogate biomarker of impaired metabolic function and would provide a useful means of tracking mitochondrial function during therapeutic trials targeting brain metabolism.

Tracking Cognitive Decline in Amnestic Mild Cognitive Impairment and Early-Stage Alzheimer Dementia: Mini-Mental State Examination versus Neuropsychological Battery

2017 ◽  
Vol 44 (1-2) ◽  
pp. 105-117 ◽  
Author(s):  
Joonho Kim ◽  
Han Kyu Na ◽  
Justin Byun ◽  
Jiwon Shin ◽  
Sungsoo Kim ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Disease Progression ◽  
Mental State ◽  
Test Scores ◽  
Mini Mental State Examination ◽  
Magnetic Resonance Images ◽  
Amnestic Mild Cognitive Impairment ◽  
Neuropsychological Battery ◽  
State Examination

Background/Aims: Although the Mini-Mental State Examination (MMSE), Clinical Dementia Rating-Sum of Boxes (CDR-SOB), and neuropsychological batteries are widely used for evaluating cognitive function, it remains elusive which instrument best reflects the longitudinal disease progression in amnestic mild cognitive impairment (aMCI) and probable Alzheimer disease (AD). We investigated whether changes in these three instruments over time correlate with loss of cortical gray matter volume (cGMV). Methods: We retrospectively investigated 204 patients (aMCI, n = 114; AD, n = 90) who had undergone MMSE, CDR-SOB, the dementia version of the Seoul Neuropsychological Screening Battery (SNSB-D), and 3-dimensional T1-weighted magnetic resonance images at least twice. We investigated the partial correlation between annual decline in test scores and percent change of cGMV. Results: In aMCI patients, changes in the SNSB-D total score (r = 0.340, p < 0.001) and CDR-SOB (r = 0.222, p = 0.020), but not MMSE, showed a correlation with cGMV loss, with the SNSB-D total score showing the strongest correlation. In AD patients, decline in all three test scores correlated significantly with cGMV loss, with MMSE exhibiting the strongest correlation (r = 0.464, p < 0.001). Conclusion: In aMCI patients, neuropsychological battery, though time-consuming, was the most adequate tool in tracking disease progression. In AD patients, however, MMSE may be the most effective longitudinal monitoring tool when considering cost-effectiveness.

The reduced left hippocampal volume related to the delayed P300 latency in amnestic mild cognitive impairment

2020 ◽  
pp. 1-9 ◽  
Author(s):  
Lijuan Gao ◽  
Lihua Gu ◽  
Hao Shu ◽  
Jiu Chen ◽  
Jianli Zhu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Hippocampal Volume ◽  
Amnestic Mild Cognitive Impairment ◽  
Parahippocampal Gyrus ◽  
Structural Basis ◽  
P300 Latency ◽  
Information Processing Speed ◽  
Amci Group ◽  
The Relationship

Abstract Background Amnestic mild cognitive impairment (aMCI) is characterized by delayed P300 latency and reduced grey matter (GM) volume, respectively. The relationship between the features in aMCI is unclear. This study was to investigate the relationship between the altered P300 latency and the GM volume in aMCI. Methods Thirty-four aMCI and 34 well-matched normal controls (NC) were studied using electroencephalogram during a visual oddball task and scanned with MRI. Both tests were finished in the same day. Results As compared with the NC group, the aMCI group exhibited delayed P300 latency in parietal cortex and reduced GM volumes in bilateral temporal pole and left hippocampus/parahippocampal gyrus. A remarkable negative correlation was found between delayed P300 latency and reduced left hippocampal volume only in the aMCI group. Interestingly, the mediating analysis found P300 latency significantly mediated the association between right supramarginal gyrus volume and information processing speed indicated by Stroop Color and Word Test A scores. Conclusions The association between delayed P300 latency and reduced left hippocampal volume in aMCI subjects suggests that reduced left hippocampal volume may be the potential structural basis of delayed P300 latency.

The Effects of Three Months of Aerobic Dance on Hippocampal Volume and Cognition in Elderly People with Amnestic Mild Cognitive Impairment: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Yi Zhu ◽  
Yaxin Gao ◽  
Ming Qi ◽  
Ming Xiao ◽  
Han Wu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Elderly People ◽  
Controlled Trial ◽  
Hippocampal Volume ◽  
Amnestic Mild Cognitive Impairment ◽  
Control Group ◽  
Aerobic Dance ◽  
Randomized Controlled

Abstract Whether dancing could increases the hippocampal volume of seniors with amnestic mild cognitive impairment(aMCI) remains debatable. The aim of the present study was to investigate the influence of aerobic dance on hippocampal volume and cognition after three months' aerobic dance in older adults with aMCI. In this randomized controlled trial, 68 elderly people with aMCI were randomized to either aerobic dance group or the control group using 1:1 allocation ratio. Specially designed aerobic dance routine was performed by the dance group three times a week for three months, while all participants received monthly health care education after inclusion. MRI with a 3.0 T MRI scanner and cognitive assessments were performed before and after intervention. The high-resolution 3D T1-weighted anatomical images were acquired for the analysis of hippocampal volume. A total of 35 participants (mean age: 71.51 ± 6.62 years) were randomized into aerobic dance group and 33(mean age:69.82 ± 7.74 years ) into control group, and all the data was analyzed based on the intention to treat (ITT) method. Patients in the treatment group showed increased volume in the right hippocampus (mean difference [MD] in right hippocampus volume over 3 months 0.13; 95% confidence interval [CI] 0.05, 0.21; p<0.001) and memory enhancement (MD in Memory Scale-Revised Logical Memory change over 3 months 2.12; 95% CI -0.06, 4.13; p = 0.02) compared to the control group. In conclusion, three months of aerobic dance could increase the volume of right hippocampus and improve episodic memory in elderly persons with aMCI. This study was registered on the Chinese Clinical Trial Registry (www.chictr.org.cn). Registration number：ChiCTR-INR-15007420.

P3-225: POSTERIOR CINGULATE GABA AND GLX ARE REDUCED IN AMNESTIC MILD COGNITIVE IMPAIRMENT

2014 ◽  
Vol 10 ◽  
pp. P713-P713
Author(s):  
Florian Riese ◽  
Anton Gietl ◽  
Nikolaus Zölch ◽  
Anke Henning ◽  
Ruth O'Gorman ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Posterior Cingulate
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