scholarly journals Application of Bladder Acellular Matrix in Urinary Bladder Regeneration: The State of the Art and Future Directions

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Marta Pokrywczynska ◽  
Iga Gubanska ◽  
Gerard Drewa ◽  
Tomasz Drewa

Construction of the urinary bladderde novousing tissue engineering technologies is the “holy grail” of reconstructive urology. The search for the ideal biomaterial for urinary bladder reconstruction has been ongoing for decades. One of the most promising biomaterials for this purpose seems to be bladder acellular matrix (BAM). In this review we determine the most important factors, which may affect biological and physical properties of BAM and its regeneration potential in tissue engineered urinary bladder. We also point out the directions in modification of BAM, which include incorporation of exogenous growth factors into the BAM structure. Finally, we discuss the results of the urinary bladder regeneration with cell seeded BAM.

2017 ◽  
Vol 5 (12) ◽  
pp. 2427-2436 ◽  
Author(s):  
Chunying Shi ◽  
Wei Chen ◽  
Bing Chen ◽  
Tao Shan ◽  
Weisheng Jia ◽  
...  

Bladder reconstruction remains challenging for urological surgery due to lack of suitable regenerative scaffolds.


2016 ◽  
Vol 224 (2) ◽  
pp. 62-70 ◽  
Author(s):  
Thomas Straube

Abstract. Psychotherapy is an effective treatment for most mental disorders, including anxiety disorders. Successful psychotherapy implies new learning experiences and therefore neural alterations. With the increasing availability of functional neuroimaging methods, it has become possible to investigate psychotherapeutically induced neuronal plasticity across the whole brain in controlled studies. However, the detectable effects strongly depend on neuroscientific methods, experimental paradigms, analytical strategies, and sample characteristics. This article summarizes the state of the art, discusses current theoretical and methodological issues, and suggests future directions of the research on the neurobiology of psychotherapy in anxiety disorders.


2016 ◽  
Vol 17 (13) ◽  
pp. 1455-1470 ◽  
Author(s):  
Tomas Majtan ◽  
Angel L. Pey ◽  
June Ereño-Orbea ◽  
Luis Alfonso Martínez-Cruz ◽  
Jan P. Kraus

Author(s):  
Alvaro Gomez-Lopez ◽  
Satyannarayana Panchireddy ◽  
Bruno Grignard ◽  
Inigo Calvo ◽  
Christine Jerome ◽  
...  

Author(s):  
Masoumeh Zareapoor ◽  
Jie Yang

Image-to-Image translation aims to learn an image from a source domain to a target domain. However, there are three main challenges, such as lack of paired datasets, multimodality, and diversity, that are associated with these problems and need to be dealt with. Convolutional neural networks (CNNs), despite of having great performance in many computer vision tasks, they fail to detect the hierarchy of spatial relationships between different parts of an object and thus do not form the ideal representative model we look for. This article presents a new variation of generative models that aims to remedy this problem. We use a trainable transformer, which explicitly allows the spatial manipulation of data within training. This differentiable module can be augmented into the convolutional layers in the generative model, and it allows to freely alter the generated distributions for image-to-image translation. To reap the benefits of proposed module into generative model, our architecture incorporates a new loss function to facilitate an effective end-to-end generative learning for image-to-image translation. The proposed model is evaluated through comprehensive experiments on image synthesizing and image-to-image translation, along with comparisons with several state-of-the-art algorithms.


2021 ◽  
pp. 026553222110361
Author(s):  
Chao Han

Over the past decade, testing and assessing spoken-language interpreting has garnered an increasing amount of attention from stakeholders in interpreter education, professional certification, and interpreting research. This is because in these fields assessment results provide a critical evidential basis for high-stakes decisions, such as the selection of prospective students, the certification of interpreters, and the confirmation/refutation of research hypotheses. However, few reviews exist providing a comprehensive mapping of relevant practice and research. The present article therefore aims to offer a state-of-the-art review, summarizing the existing literature and discovering potential lacunae. In particular, the article first provides an overview of interpreting ability/competence and relevant research, followed by main testing and assessment practice (e.g., assessment tasks, assessment criteria, scoring methods, specificities of scoring operationalization), with a focus on operational diversity and psychometric properties. Second, the review describes a limited yet steadily growing body of empirical research that examines rater-mediated interpreting assessment, and casts light on automatic assessment as an emerging research topic. Third, the review discusses epistemological, psychometric, and practical challenges facing interpreting testers. Finally, it identifies future directions that could address the challenges arising from fast-changing pedagogical, educational, and professional landscapes.


2021 ◽  
Vol 54 (6) ◽  
pp. 1-35
Author(s):  
Ninareh Mehrabi ◽  
Fred Morstatter ◽  
Nripsuta Saxena ◽  
Kristina Lerman ◽  
Aram Galstyan

With the widespread use of artificial intelligence (AI) systems and applications in our everyday lives, accounting for fairness has gained significant importance in designing and engineering of such systems. AI systems can be used in many sensitive environments to make important and life-changing decisions; thus, it is crucial to ensure that these decisions do not reflect discriminatory behavior toward certain groups or populations. More recently some work has been developed in traditional machine learning and deep learning that address such challenges in different subdomains. With the commercialization of these systems, researchers are becoming more aware of the biases that these applications can contain and are attempting to address them. In this survey, we investigated different real-world applications that have shown biases in various ways, and we listed different sources of biases that can affect AI applications. We then created a taxonomy for fairness definitions that machine learning researchers have defined to avoid the existing bias in AI systems. In addition to that, we examined different domains and subdomains in AI showing what researchers have observed with regard to unfair outcomes in the state-of-the-art methods and ways they have tried to address them. There are still many future directions and solutions that can be taken to mitigate the problem of bias in AI systems. We are hoping that this survey will motivate researchers to tackle these issues in the near future by observing existing work in their respective fields.


2019 ◽  
Vol 36 (2) ◽  
pp. 60-69
Author(s):  
Paul H Cleverley ◽  
Simon Burnett

Enterprise search is changing. The explosion of information within organizations, technological advances and availability of free OpenSource machine learning libraries offer many possibilities. Eighteen informants from practice, academia, search technology vendors and large organizations (Oil and Gas, Governments, Pharmaceuticals, Aerospace and Retail) were interviewed to assess challenges and future directions. The findings confirmed the existence of the ‘Google Habitus’, technology propaganda and a need to transcend disciplines for a Systems thinking approach toward enterprise search. This encompasses information management, user search literacy, governance, learning feedback loops as well as technology. A novel four-level model for enterprise search use cases is presented, covering search as a utility, search as an answer machine, search task apps and a discovery engine. This could be used to reframe enterprise search perceptions, expanding possibilities and improving business outcomes.


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