Type 1 Diabetes Modifies Brain Activation in Young Patients While Performing Visuospatial Working Memory Tasks

In recent years, increasing attention has been paid to the effects of Type 1 Diabetes (T1D) on cognitive functions. T1D onset usually occurs during childhood, so it is possible that the brain could be affected during neurodevelopment. We selected young patients of normal intelligence with T1D onset during neurodevelopment, no complications from diabetes, and adequate glycemic control. The purpose of this study was to compare the neural BOLD activation pattern in a group of patients with T1Dversushealthy control subjects while performing a visuospatial working memory task. Sixteen patients and 16 matched healthy control subjects participated. There was no significant statistical difference in behavioral performance between the groups, but, in accordance with our hypothesis, results showed distinct brain activation patterns. Control subjects presented the expected activations related to the task, whereas the patients had greater activation in the prefrontal inferior cortex, basal ganglia, posterior cerebellum, and substantia nigra. These different patterns could be due to compensation mechanisms that allow them to maintain a behavioral performance similar to that of control subjects.

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Parent Report of Mealtime Behavior and Parenting Stress in Young Children With Type 1 Diabetes and in Healthy Control Subjects

Diabetes Care ◽

10.2337/diacare.25.2.313 ◽

2002 ◽

Vol 25 (2) ◽

pp. 313-318 ◽

Cited By ~ 110

Author(s):

S. W. Powers ◽

K. C. Byars ◽

M. J. Mitchell ◽

S. R. Patton ◽

D. A. Standiford ◽

...

Keyword(s):

Type 1 Diabetes ◽

Young Children ◽

Parenting Stress ◽

Parent Report ◽

Control Subjects ◽

Mealtime Behavior ◽

Healthy Control

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W09.239 Systolic blood pressure response after exercise in type 1 diabetes families compared with healthy control subjects

Atherosclerosis Supplements ◽

10.1016/s1567-5688(04)90238-9 ◽

2004 ◽

Vol 5 (1) ◽

pp. 56

Author(s):

E. Matteucci ◽

J. Rosada ◽

M. Pallini ◽

F. Fagnani ◽

C. Giusti ◽

...

Keyword(s):

Blood Pressure ◽

Type 1 Diabetes ◽

Systolic Blood Pressure ◽

Blood Pressure Response ◽

Pressure Response ◽

Control Subjects ◽

Healthy Control

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Children and adolescents with type 1 diabetes eat a more atherosclerosis-prone diet than healthy control subjects

Diabetologia ◽

10.1007/s00125-006-0540-9 ◽

2006 ◽

Vol 50 (2) ◽

pp. 307-316 ◽

Cited By ~ 53

Author(s):

N. C. Øverby ◽

V. Flaaten ◽

M. B. Veierød ◽

I. Bergstad ◽

H. D. Margeirsdottir ◽

...

Keyword(s):

Type 1 Diabetes ◽

Children And Adolescents ◽

Control Subjects ◽

Healthy Control

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Evidence That Hyperglycemia After Recovery From Hypoglycemia Worsens Endothelial Function and Increases Oxidative Stress and Inflammation in Healthy Control Subjects and Subjects With Type 1 Diabetes

Diabetes ◽

10.2337/db12-0224 ◽

2012 ◽

Vol 61 (11) ◽

pp. 2993-2997 ◽

Cited By ~ 83

Author(s):

A. Ceriello ◽

A. Novials ◽

E. Ortega ◽

L. La Sala ◽

G. Pujadas ◽

...

Keyword(s):

Oxidative Stress ◽

Type 1 Diabetes ◽

Endothelial Function ◽

Control Subjects ◽

Healthy Control

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Detection of Mycobacterium avium subsp. paratuberculosis in Iranian patients with type 1 diabetes mellitus by PCR and ELISA

The Journal of Infection in Developing Countries ◽

10.3855/jidc.7473 ◽

2016 ◽

Vol 10 (08) ◽

pp. 857-862 ◽

Cited By ~ 4

Author(s):

Sonia Hesam Shariati ◽

Anoosha Alaei ◽

Rouhollah Keshavarz ◽

Nader Mosavari ◽

Ali Rabbani ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Mycobacterium Avium ◽

Mycobacterium Avium Subsp ◽

Blood Samples ◽

Control Subjects ◽

Healthy Control ◽

Mycobacterium Avium Subsp Paratuberculosis

Introduction: Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis or Johne’s disease in ruminants. Its role in triggering autoimmunity, including type 1 diabetes mellitus (T1DM), has been reported in recent years. Due to the high contamination rate of MAP in Iran’s livestock and the increasing outbreak of T1DM, we investigated this association in a small group of patients with T1DM in Iran. Methodology: Blood samples of 29 T1DM patients and 29 healthy control subjects were tested through enzyme-linked immunosorbent assay (ELISA) to detect antibodies against MAP3865c and ZnT8 homologous epitopes and the presence of MAP DNA. Blood samples were also cultured in mycobacterial growth indicator tubes and Herrold's egg yolk medium containing mycobactin J. Results: The results of ELISA showed a significant difference between T1DM patients and healthy group. IS900 was also detected in 51.72% of T1DM patients but in none of the control group. None of the samples grew in culture media. Conclusions: Due to the presence of MAP DNA and antibodies against MAP peptides in a significant number of T1DM patients compared with healthy control subjects, we may consider MAP as a possible trigger of T1DM in Iran. This indicates that exposure to MAP occurred in the positive subjects. Identifying the sources of contamination and routes of MAP transmission to humans seems necessary to prevent and reduce the burden of MAP infection in Iran.

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