scholarly journals Oral Manifestations of Crohn’s Disease: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Victoria L. Woo
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Failure To Thrive ◽  
Intestinal Bacteria ◽  
Inflammatory Disorder ◽  
Oral Manifestations ◽  
Initial Manifestation ◽  
Presenting Symptoms ◽  
Early Markers ◽  
Delayed Growth

Crohn’s disease (CD) is an inflammatory disorder of the gastrointestinal tract that is likely caused by an inappropriate mucosal inflammatory response to intestinal bacteria in a genetically predisposed host. The lesions of CD can involve any region of the GI tract as well as extraintestinal sites such as the skin, joints, and eyes. The most common presenting symptoms are abdominal pain and prolonged diarrhea associated with fevers, fatigue, and malaise. Delayed growth and failure to thrive may also be observed in pediatric patients. Oral manifestations of CD are known as oral CD and may precede GI involvement, thus serving as early markers of this condition. We describe a 6-year-old male who presented with oral lesions as his initial manifestation of disease and review the current literature pertaining to oral CD.

scholarly journals A specific gene-microbe interaction drives the development of Crohn’s disease–like colitis in mice

2019 ◽  
Vol 4 (34) ◽  
pp. eaaw4341 ◽  
Author(s):  
R. Caruso ◽  
T. Mathes ◽  
E. C. Martens ◽  
N. Kamada ◽  
A. Nusrat ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intestinal Inflammation ◽  
Intestinal Bacteria ◽  
Specific Gene ◽  
Inflammatory Disorder ◽  
Phagocyte Nadph Oxidase ◽  
Abnormal Immune Response ◽  
Marked Accumulation ◽  
Combined Deficiency

Bacterial dysbiosis is associated with Crohn’s disease (CD), a chronic intestinal inflammatory disorder thought to result from an abnormal immune response against intestinal bacteria in genetically susceptible individuals. However, it is unclear whether dysbiosis is a cause or consequence of intestinal inflammation and whether overall dysbiosis or specific bacteria trigger the disease. Here, we show that the combined deficiency of NOD2 and phagocyte NADPH oxidase, two CD susceptibility genes, triggers early-onset spontaneous TH1-type intestinal inflammation in mice with the pathological hallmarks of CD. Disease was induced byMucispirillum schaedleri, a Gram-negative mucus-dwelling anaerobe. NOD2 and CYBB deficiencies led to marked accumulation ofMucispirillum, which was associated with impaired neutrophil recruitment and killing of the bacterium by luminal neutrophils. Maternal immunoglobulins againstMucispirillumprotected mutant mice from disease during breastfeeding. Our results indicate that a specific intestinal microbe triggers CD-like disease in the presence of impaired clearance of the bacterium by innate immunity.

scholarly journals AggressiveHelicobacter pylori-negative peptic ulceration as the initial manifestation of Crohn's disease

2012 ◽  
Vol 3 (3) ◽  
pp. 201-205 ◽  
Author(s):  
James Callaghan ◽  
Sarah Brown ◽  
Tim Battcock ◽  
Sally Parry ◽  
Jonathon Snook
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Peptic Ulceration ◽  
Initial Manifestation

scholarly journals Pulmonary Crohn's Disease in Down Syndrome: A Link or Linkage Problem

2016 ◽  
Vol 10 (2) ◽  
pp. 206-211
Author(s):  
Danyal Thaver ◽  
Mirza Beg
Keyword(s):  
Down Syndrome ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Pediatric Population ◽  
Pulmonary Nodules ◽  
Pulmonary Involvement ◽  
Lung Nodules ◽  
Inflammatory Disorder ◽  
Ct Guided ◽  
History Of

Crohn’s disease (CD) is an autoimmune inflammatory disorder that primarily affects the gastrointestinal tract. It may have pulmonary involvement, which has been rarely reported in pediatric patients. Down syndrome (DS) has been associated with increased frequency of autoimmune diseases. However, associations between CD and DS have been rarely reported. We present the case of a 5-year-old girl with known DS and a history of chronic intermittent abdominal pain who presented with persistent pneumonia. Her workup included a chest computed tomography (CT) scan that showed multiple noncalcified pulmonary nodules. An extensive infectious workup was done that was negative. CT-guided needle biopsy of the lung nodules showed necrotizing granulomas. This raised concern for primary CD with extraintestinal pulmonary manifestation. An esophagogastroduodenoscopy and colonoscopy were performed, and colon biopsies showed scattered epithelioid granulomas. Based on this information, there was consensus that her lung nodules were secondary to CD. She was started on standard therapy for CD, and her abdominal and respiratory symptoms gradually improved. However, she continues to have mild residual lung calcification and fibrosis. To our knowledge, this is the first reported case of pulmonary CD in a child with DS. The natural history of pulmonary CD in the pediatric population is not very well studied. Furthermore, since DS has been well known to be associated with increased frequency of malignancies and autoimmune conditions due to immune dysregulation, it is difficult to predict the severity and possible complications in this patient.

scholarly journals Crohn’s Disease Presenting with Pyogenic Liver Abscess: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Sharon McGreal ◽  
Rupert Sayers ◽  
Peter Wurm ◽  
Kevin West
Keyword(s):  
Computed Tomography ◽  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Liver Abscess ◽  
Percutaneous Drainage ◽  
Severe Disease ◽  
Pyogenic Liver Abscess ◽  
Initial Manifestation ◽  
Laboratory Findings

Pyogenic liver abscess (PLA) is a rare extraintestinal complication of Crohn’s disease (CD), and the clinical and laboratory findings may emulate the reactivation of CD, therefore, delaying diagnosis. In this paper the patient presented with PLA as the initial manifestation of CD and experienced severe disease. The finding of PLA was established by computed tomography and initial treatment involved percutaneous drainage and antibiotics. The diagnosis of CD was made after colonoscopy and histological investigations.

scholarly journals Oral manifestations of Crohn's disease.

Gut ◽  
1975 ◽  
Vol 16 (4) ◽  
pp. 249-254 ◽  
Author(s):  
P Asquith ◽  
R A Thompson ◽  
W T Cooke
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Oral Manifestations

scholarly journals Possible Biomarkers in Blood for Crohn’s Disease: Oxidative Stress and MicroRNAs—Current Evidences and Further Aspects to Unravel

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Inés Moret-Tatay ◽  
Marisa Iborra ◽  
Elena Cerrillo ◽  
Luis Tortosa ◽  
Pilar Nos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Intestinal Wall ◽  
Inflammatory Disorder ◽  
Ros Production ◽  
Oxygen Species ◽  
Antioxidant Defences ◽  
Transmural Inflammation ◽  
Harmful Effects

Crohn’s disease (CD) is an inflammatory disorder characterised by a transmural inflammation of the intestinal wall. Although the physiopathology of the disease is not yet fully understood, it is clear that the immune response plays an important role in it. This hyperreactive immune system is accompanied by the presence of unregulated reactive oxygen species (ROS). These elements are modulated in normal conditions by different elements, including enzymes that function as antioxidant defences preventing the harmful effects of ROS. However, in CD there is an imbalance between ROS production and these antioxidant elements, resulting in oxidative stress (OxS) phenomena. In fact, now OxS is being considered more a potential etiological factor for Crohn’s disease rather than a concomitant effect in the disease. The persistence of the OxS can also be influencing the evolution of the disease. Furthermore, the epigenetic mechanisms, above all microRNAs, are being considered key elements in the pathogenesis of CD. These elements and the presence of OxS have also been linked to several diseases. We, therefore, describe in this review the most significant findings related to oxidative stress and microRNAs profiles in the peripheral blood of CD patients.

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