scholarly journals Fetal Valproate Syndrome with Limb Defects: An Indian Case Report

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Manisha Goyal ◽  
Ashok Gupta ◽  
Manish Sharma ◽  
Priyanshu Mathur ◽  
Naresh Bansal
Keyword(s):  
Valproic Acid ◽  
Case Report ◽  
Developmental Delay ◽  
Antiepileptic Drugs ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
First Trimester ◽  
Facial Features ◽  
Limb Defects ◽  
Fetal Valproate Syndrome

Epilepsy is a common disorder and exposure to antiepileptic drugs during pregnancy increases the risk of teratogenicity. Older AEDs such as valproate and phenobarbital are associated with a higher risk of major malformations in the fetus than newer AEDs like lamotrigine and levetiracetam. Exposure to valproic acid during first trimester can result in fetal valproate syndrome (FVS), comprising typical facial features, developmental delay, and a variety of malformations such as neural tube defects, cardiac and genitourinary malformations, and limb defects. We are presenting an Indian case of FVS with major limb defects.

Valproate Teratogenicity

PEDIATRICS ◽  
1983 ◽  
Vol 71 (6) ◽  
pp. 980-980
Author(s):  
Keyword(s):  
Valproic Acid ◽  
Disease Control ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Prenatal Testing ◽  
First Trimester ◽  
Teratogenic Effects ◽  
Recent Statement ◽  
Estimated Risk ◽  
First Trimester Of Pregnancy

In a recent statement entitled, "Valproic Acid: Benefits and Risks" we reported that despite the presence of teratogenic effects in animals there existed only one possible case in man.1 Recently the Centers for Disease Control has reported that the use of valproic acid (Depakene), during the first trimester of pregnancy, may increase the risk of having a child with spina bifids.2 The report, based upon a study undertaken in Rhône-Alpes, France,3,4 quotes an estimated risk of 1.2%. Based upon this information, we believe that a woman who becomes pregnant while on valproic acid should consult with her physician about prenatal testing for neural tube defects. Additional recommendations for the counseling of women who require anticounvulsant treatment during pregnancy have been published previously.5

Fetal valproate syndrome with coronary arteriovenous fistula: a case report

2021 ◽  
pp. 1-3
Author(s):  
Alper Doğan ◽  
Ali Baykan ◽  
Cagdas Vural
Keyword(s):  
Valproic Acid ◽  
Differential Diagnosis ◽  
Case Report ◽  
Laboratory Tests ◽  
First Trimester ◽  
Av Fistula ◽  
Detailed History ◽  
Coronary Arteriovenous Fistula ◽  
Fetal Valproate Syndrome ◽  
First Trimester Of Pregnancy

Abstract Interestingly, our case presenting with coronary AV fistula firstly reported in the literature with fetal valproate syndrome. Although differential diagnosis is sometimes difficult, it can be diagnosed with detailed history, physical examination and appropriate laboratory tests. Fetal valproate syndrome can be prevented by discontinue of the valproic acid especially during first trimester of pregnancy.

Detection of spina bifida in the first trimester of gestation in association with triploidy

2017 ◽  
Author(s):  
K.K. Otaryan , C.G. Gagaev
Keyword(s):  
Spina Bifida ◽  
Early Detection ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
First Trimester ◽  
Termination Of Pregnancy ◽  
Diagnostic Tools ◽  
Prenatal Detection ◽  
Post Abortion

The case of prenatal detection of spina bifida at 12+3 weeks of gestation is described. Termination of pregnancy was performed at 13+3 weeks. Post-abortion karyotyping revealed triploidy (69XXX). Diagnostic tools for early detection of neural tube defects in the 1st trimester of gestation and subsequent appropriate management of pregnancy are discussed.

Fetal Occipital Encephalocele: A Case Report

2021 ◽  
pp. 875647932110668
Author(s):  
Amanda Hogan ◽  
Natalie Ullmer
Keyword(s):  
Case Report ◽  
Patient Care ◽  
Treatment Planning ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Three Dimensional ◽  
Improve Patient Care ◽  
Two Dimensional ◽  
Occipital Encephalocele ◽  
Improve Patient

Encephaloceles are considered neural tube defects, but their exact cause is unknown. The outcome is dismal, and essential management and counseling are needed for patients. Two-dimensional and three-dimensional sonography can be used to detect encephaloceles as early as 11 weeks, assist in treatment planning, and improve patient care. This case report presents an occipital encephalocele diagnosed by sonography and followed until delivery.

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