As part of the population-based prenatal screening of 900 pregnant women, who underwent 1st trimester
screening at the RPMC “Mother and Child” in 2018–2019, an ultrasound scan of the fetal palate was performed
to evaluate the effectiveness of new ultrasound markers in detecting orofacial clefts (OFC). Fetal palatal defects
were screened at a 2D assessment of bone markers of the palate – the image of the palatal line in the sagittal
section, the retronasal triangle in the coronary section, the alveolar arch of the upper jaw in the axial section.
If a palate abnormality was detected or suspected in the 2D study, the fetal palate was evaluated using the 3D
mode. In 50 pregnant women of the control group, 3D sonography of the fetal palate was performed in the
norm. In total, during the gestation period of 10+5–12+5 weeks, 10 cases of OFC were detected, of which 1 case
was a median lip/palate cleft (LPC), 6 — bilateral LPC, 1 — left-sided LPC, 1 — unspecified LPC, 1 — PC.
Visualization of 2D ultrasound markers was possible in 9 cases of palate anomalies, 3D assessment worked out
in all 10 cases. In all identified OFC cases, cytogenetic and/or pathomorphological studies were performed.