scholarly journals Corneal Dendritic Cell Density Is Associated with Subbasal Nerve Plexus Features, Ocular Surface Disease Index, and Serum Vitamin D in Evaporative Dry Eye Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Rohit Shetty ◽  
Swaminathan Sethu ◽  
Rashmi Deshmukh ◽  
Kalyani Deshpande ◽  
Arkasubhra Ghosh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dendritic Cell ◽  
Cell Density ◽  
Dry Eye ◽  
Serum Vitamin ◽  
Eye Disease ◽  
Serum Vitamin D ◽  
Evaporative Dry Eye ◽  
Branch Density ◽  
Subbasal Nerve Plexus

Dry eye disease (DED) has evolved into a major public health concern with ocular discomfort and pain being responsible for significant morbidity associated with DED. However, the etiopathological factors contributing to ocular pain associated with DED are not well understood. The current IVCM based study investigated the association between corneal dendritic cell density (DCD), corneal subbasal nerve plexus (SBNP) features, and serum vitamin D and symptoms of evaporative dry eye (EDE). The study included age and sex matched 52 EDE patients and 43 heathy controls. A significant increase in the OSDI scores (discomfort subscale) was observed between EDE (median, 20.8) and control (median, 4.2) cohorts(P<0.001). Similarly, an increase in DCD was observed between EDE (median, 48.1 cells/mm2) patients and controls (median, 5.6 cells/mm2)(P<0.001). A significant decrease in SBNP features (corneal nerve fiber length, fiber density, fiber width, total branch density, nerve branch density, and fiber area) was observed in EDE patients with OSDI score >23(P<0.05). A positive correlation was observed between DCD and OSDI discomfort subscale (r=0.348;P<0.0003) and SBNP features. An inverse correlation was observed between vitamin D and OSDI scores (r=-0.332;P=0.0095) and DCD with dendritic processes (r=-0.322;P=0.0122). The findings implicate DCD, SBNP features, and vitamin D with EDE symptoms.

scholarly journals Are Serum Vitamin D Levels Associated With Dry Eye Disease? Results From the Study Group for Environmental Eye Disease

2017 ◽  
Vol 50 (6) ◽  
pp. 369-376 ◽  
Author(s):  
Da-Hye Jeon ◽  
Hyungseon Yeom ◽  
Jaewon Yang ◽  
Jong Suk Song ◽  
Hyung Keun Lee ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dry Eye ◽  
Serum Vitamin ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Study Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Dysregulated Tear Fluid Nociception-Associated Factors, Corneal Dendritic Cell Density, and Vitamin D Levels in Evaporative Dry Eye

2019 ◽  
Vol 60 (7) ◽  
pp. 2532 ◽  
Author(s):  
Pooja Khamar ◽  
Archana Padmanabhan Nair ◽  
Rohit Shetty ◽  
Tanuja Vaidya ◽  
Murali Subramani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dendritic Cell ◽  
Cell Density ◽  
Dry Eye ◽  
Associated Factors ◽  
Tear Fluid ◽  
Vitamin D Levels ◽  
Evaporative Dry Eye

scholarly journals Oral Vitamin D3 Supplementation for Femtosecond LASIK–Associated Dry Eye

2021 ◽  
Author(s):  
Ying Lin ◽  
Huanjun Su ◽  
Jianbin Wu ◽  
Muzhi Yuan ◽  
Yong Zhang
Keyword(s):  
Vitamin D ◽  
Dry Eye ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Control Group ◽  
Oral Vitamin ◽  
Serum Vitamin D ◽  
The Mean ◽  
Experimental Group ◽  
Schirmer I Test

Abstract Purpose: To assess the effect of oral vitamin D3 supplementation in dry eye after femtosecond laser-assisted in situ keratomileusis (FS-LASIK).Setting: Liuzhou Worker’s Hospital.Design: This prospective study included 90 patients selected between January and December in 2019, who underwent fs-lasik operation in our hospital and had obvious symptoms indicating dry eyes one month after operation. The subjects were randomly divided into two groups: the experimental group (n = 45) received vitamin D3 2000 IU / D continuously for 12 weeks; the control group (n = 45) did not take vitamin D3 orally. Ocular surface disease index（OSDI）, tear breakup time（TBUT）and Schirmer’s Test I were evaluated pre-medication and 1,3,6 months after treatment. Serum vitamin D level, and the mean concentration of cytokine IL-6, IL-17, IL-23 in tears were also measured. Results: One month after treatment, the mean OSDI score of the experimental group (11.67 ± 8.53) was significantly lower than that of the control group (23.82 ± 13.22) (P = 0.007). TBUT (10.71±1.02s) and Schirmer I (9.36±0.40mm) of the experimental group were higher than those of the control group (7.49±1.29 s and 7.51±0.44 mm). The OSDI (10.25 ± 5.49), TBUT (10.75±1.09 seconds) and Schirmer I test value (11.34±0.39 mm) of the experimental group were significantly lower than those of the control group (20.22±6.23, 8.36±1.23， 8.12±0.50) at 3 months after treatment. There were significant differences in OSDI, TBUT (P ＜ 0.05) and Schirmer I test value between the two groups at 6 months after treatment. Serum vitamin D3 level was negatively correlated with OSDI score (r=-0.90；P=0.00), and positively correlated with Schirmer I test (r=0.88；P=0.00), TBUT score (r=0.89；P=0.00) and TMH (r=0.80；P=0.00). IL-17 level was shown to be significantly correlated with TBUT (r=-0.25, P=0.014) and Schirmer I test (r=-0.21, P=0.018). IL-6 level was significantly correlated with OSDI (R=0.18, P = 0.020) and TBUT (R=0.20, P = 0.019).

Serum Vitamin D Deficiency Is an Independent Risk Factor for Thyroid Eye Disease

2020 ◽  
Vol 36 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Curtis J. Heisel ◽  
Alixandra L. Riddering ◽  
Christopher A. Andrews ◽  
Alon Kahana
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Vitamin D Deficiency ◽  
Independent Risk Factor ◽  
Serum Vitamin ◽  
Thyroid Eye Disease ◽  
Eye Disease ◽  
Serum Vitamin D

Impact of oral vitamin D supplementation on the ocular surface in people with dry eye and/or low serum vitamin D

2018 ◽  
Vol 41 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Chih-Huang Yang ◽  
Julie Albietz ◽  
Damien G. Harkin ◽  
Michael G. Kimlin ◽  
Katrina L. Schmid
Keyword(s):  
Vitamin D ◽  
Dry Eye ◽  
Ocular Surface ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Oral Vitamin ◽  
Serum Vitamin D ◽  
Low Serum

The Association of Serum Vitamin D Level With the Severity of Dry Eye Parameters in Primary Sjögren Syndrome

Cornea ◽  
2020 ◽  
Vol 39 (6) ◽  
pp. 702-705
Author(s):  
Jee Hye Lee ◽  
Sun Joo Kim ◽  
Yong-Soo Byun ◽  
Jennifer Lee ◽  
Sung-Hwan Park ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dry Eye ◽  
Serum Vitamin ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Serum Vitamin D ◽  
Primary Sjögren Syndrome

scholarly journals Serum Vitamin D & Dry Eye Syndrome

2019 ◽  
pp. 1-4
Author(s):  
Shaveta . ◽  
Shah Nawaz
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Dry Eye ◽  
Ocular Surface ◽  
Serum Vitamin ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Ocular Surface Disease Index ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Introduction: Dry eye syndrome [DES] is one of the commonest ocular disorders characterized by tear film instability, visual discomfort & disturbance with ocular surface inflammation potentially leading to damage to the ocular surface. Serum Vitamin-D deficiency has been reported to be associated with DES. Aim: To determine the Serum 25-hydroxy-vitamin-D levels in patients diagnosed as having DES. Methods: We conducted a prospective observational study and included in our study, serum vitamin D levels of the first 40 patients over the age of 18 years presenting with signs and symptoms and later diagnosed to have DES [confirmed with ocular surface disease index-OSDI questionnaire, Schirmer I test, kerato-epitheliopathy examination and tear-film breakup time-[TBUT] were analysed. Results: Schirmer's I test, interpreted as mild [11-15mm/5min], moderate [6-10 mm/5 min] and severe [<5mm/5min] had 8, 17 and 15 patients, respectively, with a mean value of 8 mm/5 min Schirmers I test. The minimum and maximum of Fluorescein TBUT measured in seconds was 4 and 10 seconds, respectively, with a mean of 6.2 seconds. Twenty four of our test subjects were found to have deficient Serum Vit 25[OH] D levels, nine had insufficient levels and seven had normal levels. Conclusion: Vitamin D deficiency is prevalent in patient having DES.

scholarly journals Impact of Vitamin D Supplementation on Dry Eye in People with Low Serum Vitamin D

2021 ◽  
Vol 84 (1) ◽  
pp. 2008-2013
Author(s):  
Saber Hamed El Said ◽  
Ahmed Ibrahim Basiony ◽  
Manar Mohammed Amin ◽  
Shaimaa Kamal El-deen
Keyword(s):  
Vitamin D ◽  
Dry Eye ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Serum Vitamin D ◽  
Low Serum

scholarly journals Lower Serum Vitamin D Level Was Associated with Risk of Dry Eye Syndrome

2017 ◽  
Vol 23 ◽  
pp. 2211-2216 ◽  
Author(s):  
Yi-Fang Meng ◽  
Jiong Lu ◽  
Qian Xing ◽  
Jian-Jun Tao ◽  
Pan Xiao
Keyword(s):  
Vitamin D ◽  
Dry Eye ◽  
Serum Vitamin ◽  
Dry Eye Syndrome ◽  
Lower Serum ◽  
Serum Vitamin D

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

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