scholarly journals Oral Vitamin D3 Supplementation for Femtosecond LASIK–Associated Dry Eye

2021 ◽  
Author(s):  
Ying Lin ◽  
Huanjun Su ◽  
Jianbin Wu ◽  
Muzhi Yuan ◽  
Yong Zhang
Keyword(s):  
Vitamin D ◽  
Dry Eye ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Control Group ◽  
Oral Vitamin ◽  
Serum Vitamin D ◽  
The Mean ◽  
Experimental Group ◽  
Schirmer I Test

Abstract Purpose: To assess the effect of oral vitamin D3 supplementation in dry eye after femtosecond laser-assisted in situ keratomileusis (FS-LASIK).Setting: Liuzhou Worker’s Hospital.Design: This prospective study included 90 patients selected between January and December in 2019, who underwent fs-lasik operation in our hospital and had obvious symptoms indicating dry eyes one month after operation. The subjects were randomly divided into two groups: the experimental group (n = 45) received vitamin D3 2000 IU / D continuously for 12 weeks; the control group (n = 45) did not take vitamin D3 orally. Ocular surface disease index（OSDI）, tear breakup time（TBUT）and Schirmer’s Test I were evaluated pre-medication and 1,3,6 months after treatment. Serum vitamin D level, and the mean concentration of cytokine IL-6, IL-17, IL-23 in tears were also measured. Results: One month after treatment, the mean OSDI score of the experimental group (11.67 ± 8.53) was significantly lower than that of the control group (23.82 ± 13.22) (P = 0.007). TBUT (10.71±1.02s) and Schirmer I (9.36±0.40mm) of the experimental group were higher than those of the control group (7.49±1.29 s and 7.51±0.44 mm). The OSDI (10.25 ± 5.49), TBUT (10.75±1.09 seconds) and Schirmer I test value (11.34±0.39 mm) of the experimental group were significantly lower than those of the control group (20.22±6.23, 8.36±1.23， 8.12±0.50) at 3 months after treatment. There were significant differences in OSDI, TBUT (P ＜ 0.05) and Schirmer I test value between the two groups at 6 months after treatment. Serum vitamin D3 level was negatively correlated with OSDI score (r=-0.90；P=0.00), and positively correlated with Schirmer I test (r=0.88；P=0.00), TBUT score (r=0.89；P=0.00) and TMH (r=0.80；P=0.00). IL-17 level was shown to be significantly correlated with TBUT (r=-0.25, P=0.014) and Schirmer I test (r=-0.21, P=0.018). IL-6 level was significantly correlated with OSDI (R=0.18, P = 0.020) and TBUT (R=0.20, P = 0.019).

scholarly journals Research on the Levels of Serum Vitamin D and IgE and Their Correlations in Infants with Different Allergic Risks

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Lin-lin Feng ◽  
Ting-ting Meng ◽  
Fengyan Sun ◽  
Xiaoyun Chen
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Respiratory Infections ◽  
Serum Vitamin ◽  
Allergic Diseases ◽  
Control Group ◽  
Serum Vitamin D ◽  
Data Comparison ◽  
And Control ◽  
Experimental Group

Objective: To investigate the levels of serum vitamin D and IgE in infants with different allergic risks and to analyze their correlations. Methods: In the present study, the participants were selected and recruited from the infant ward of our hospital from February 2012 to December 2012. A total of 120 patients were selected and recruited. Among these patients, 64 patients with symptoms of allergic diseases were assigned to the experimental group. The remaining 56 patients who had respiratory infections, but without other symptoms of allergic diseases, were assigned to the control group. The serum 25-hydroxyvitamin D3 levels were measured using liquid chromatography tandem mass spectrometry and the IgE levels were measured using radioimmunoassay in both experimental and control groups. Subsequently, the serum 25-hydroxyvitamin D3 levels and IgE levels were compared between the experimental group and control group. Results: The following findings were obtained through data comparison. The serum 25-hydroxyvitamin D3 level in the experimental group was 18.19 ± 7.84 ng/mL, and the IgE level was 551.51 ± 705.88 IU/mL. The serum 25-hydroxyvitamin D3 level in the control group was 21.95 ± 7.834 ng/mL, IgE level was 49.39 ± 32.46 IU/mL. The data comparison indicates that the serum 25-hydroxyvitamin D3 level in the control group was higher than the experimental group, and the IgE level in the control group was lower than the experimental group (P<0.05). Conclusion: The level of vitamin D3 in patients with allergic symptoms is relatively low. This may be one of the causes leading to allergies. At the same time, IgE is also one of the causes contributing to allergies. An elevation of the IgE level is very likely to cause the allergic, and there is a correlation between serum vitamin D and IgE levels. At the same time, research has found that proper supplementation of vitamin D3 can help prevent allergic diseases, and can be considered in a new and high-quality program for the prevention of allergic diseases.

scholarly journals Vitamin D levels in children with COVID-19: a report from Turkey

2021 ◽  
Vol 149 ◽  
Author(s):  
Aysegul Alpcan ◽  
Serkan Tursun ◽  
Yaşar Kandur
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Statistical Significance ◽  
Serum Vitamin ◽  
University Hospital ◽  
Control Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Normal Vitamin ◽  
The Mean

Abstract Several studies have demonstrated that higher levels of vitamin D are associated with better prognosis and outcomes in infectious diseases. We aimed to compare the vitamin D levels of paediatric patients with mild/moderate coronavirus disease 2019 (COVID-19) disease and a healthy control group. We retrospectively reviewed the medical records of patients who were hospitalised at our university hospital with the diagnosis of COVID-19 during the period between 25 May 2020 and 24 December 2020. The mean age of the COVID-19 patients was 10.7 ± 5.5 years (range 1–18 years); 43 (57.3%) COVID-19 patients were male. The mean serum vitamin D level was significantly lower in the COVID-19 group than the control group (21.5 ± 10.0 vs. 28.0 ± 11.0 IU, P < 0.001). The proportion of patients with vitamin D deficiency was significantly higher in the COVID-19 group than the control group (44% vs. 17.5%, P < 0.001). Patients with low vitamin D levels were older than the patients with normal vitamin D levels (11.6 ± 4.9 vs. 6.2 ± 1.8 years, P = 0.016). There was a significant male preponderance in the normal vitamin D group compared with the low vitamin D group (91.7% vs. 50.8%, P = 0.03). C-reactive protein level was higher in the low vitamin D group, although the difference did not reach statistical significance (9.6 ± 2.2 vs. 4.5 ± 1.6 mg/l, P = 0.074). Our study provides an insight into the relationship between vitamin D deficiency and COVID-19 for future studies. Empiric intervention with vitamin D can be justified by low serum vitamin D levels.

Vitamin D levels in children with otitis media with effusion

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ahmed Adly Mohamed ◽  
Marwa Mohamed EL-Begermy ◽  
Ahmed Abdelmoneim Teaima ◽  
Mohamed Ali Abdelghafar
Keyword(s):  
Vitamin D ◽  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Serum Vitamin ◽  
Control Group ◽  
University Hospitals ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
The Mean

Abstract Objective To investigate the relationship between otitis media with effusion (OME) and serum vitamin D level in children. Methods This prospective case control study was conducted at Ain Shams University Hospitals between February 2018 and May 2019. The study population included 50 children with OME confirmed by tympanometry type (B) who will undergo adenotonsillectomy and grommet tube insertion compared to 50 children without OME confirmed by tympanometry type (A) who will undergo adenotonsillectomy. Measurement of serum 25-hydroxy vitamin D using electrochemiluminescence technique from a blood sample (3cm) taken from them on the day of surgery. Results In this study, the mean age of the cases was 4.24 ± 0.80 and 5.34 ± 1.19 years for the controls besides 23 (46%) of the OME group were boys and 27 (54%) were girls, compared with 29 (58%) boys and 21 (42%) were girls in the control group. The mean levels of vitamin D in children with OME was 16.24 ± 7.14 ng/mL and in children in the control group was 15.89 ± 5.84 ng/mL (P = 0.815) and it was statistically non significant. Conclusion There was no significant relation between vitamin D serum level and the incidence of OME in children.

scholarly journals Vitamin D and Parathyroid Hormone Status in Female Garment Workers: A Case-Control Study in Bangladesh

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Shakil Mahmood ◽  
Matiur Rahman ◽  
Subrata Kumar Biswas ◽  
Shaikh Nazmus Saqueeb ◽  
Shiblee Zaman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Control Group ◽  
Case Group ◽  
Serum Vitamin D ◽  
Garment Workers ◽  
Significant Difference ◽  
The Status ◽  
The Mean

Despite the abundant sunlight, vitamin D deficiency is prevalent in South Asian countries including Bangladesh. Information on vitamin D level is insufficient in adults particularly in female garment workers in Bangladesh. This study was designed to evaluate the status of vitamin D, parathormone (PTH), calcium, and alkaline phosphatase (ALP) among the female garment workers in Bangladesh. Blood samples were collected from female garment workers (n=40, case group) and general female workers (n=40, control group) in Dhaka. Serum vitamin D, PTH, calcium, and ALP were measured by chemiluminescence microparticle immunoassay. The mean level of vitamin D was significantly (p<0.001) lower in case (14.2±2.6 ng/mL) than in the control (22.4±2.4 ng/mL) group. No significant difference was found at mean of PTH and calcium between case (33.9±17.2 pg/mL;9.1±0.6 mg/dL, resp.) and control (35.9±16.3 pg/mL;9.3±0.6 mg/dL, resp.) group. The mean ALP in case (117.2±14.4 U/L) group was significantly (p<0.001) higher than the control group (80.5±30.6 U/L). Overall, PTH level did not show significant correlation with vitamin D. However, calcium and ALP levels showed a significant positive (p<0.05) and negative (p<0.001) correlation with vitamin D, respectively. This study indicates a high prevalence of vitamin D deficiency in the female garment workers in Bangladesh.

scholarly journals Assessment of Serum Vitamin D3 Level in One Year Old Children Using D3 Supplement

2020 ◽  
Author(s):  
Danial Alebouyeh ◽  
Nasrin Khalessi ◽  
Maryam Saboute ◽  
Maryam Alizadeh Chamkhaleh ◽  
Mandana Kashaki
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
P Value ◽  
Childhood And Adolescence ◽  
Serum Vitamin D ◽  
Vitamin D3 Supplementation ◽  
25 Hydroxy Vitamin D ◽  
The Mean ◽  
Sufficient Vitamin

Abstract Introduction. Vitamin D status is a key determinant of bone health and growth during childhood and adolescence. Therefore, we design a study to find out the association between the levels of serum vitamin D and need to consumption of vitamin D supplement.Method and materials. In this cross sectional study infants under 20 months referred to Ali Asghar Children's Hospital were included. Infants with maternal diseases and congenital malformations were excluded. All infants used vitamin D3 supplementation 400 IU per day from day fifth of birth. The level of 25-hydroxy vitamin D at the age of 1 years (month 12) were measured. Level of 25-hydroxy vitamin D in mothers were checked, too. Furthermore, we defined sufficient level of 25-hydroxy vitamin D ≥30ng/ml.Results. In this study, 68 infants under 20 months were examined. Half of them were boy. Mean age of infants was 16±3 months and mothers was 33±3 years old. In addition, the mean level of serum 25-hydroxy vitamin D in the infants were 40.99±13.86 ng/ml and in mothers were 31.39±13.14 ng/ml. 62.1% of mothers were in sufficient group and also 83% of infants had sufficient vitamin D level (25-hydroxy vitamin D ≥ 30ng/ml). There was not any significant correlation between vitamin D level in infants and mothers (P value=0.965). The mean level of serum vitamin D3 in boys was 39.55±3.79 ng/ml (12-51) and girls was 35.32±3.67 ng/ml (13.4-50). Similarly, significant relationship was not shown between gender and vitamin D of infants (P value = 0.437). Level of vitamin D in second children was significantly higher than first children (P value=0.011). The correlation between gestational age and vitamin D3 deficiency was also insignificant (P value=0.087). Head circumference (r= -0.404, P value=0.014) and age of mothers (r= 0.344, P value=0.04) correlated with vitamin D.Conclusion. In summary, we demonstrated most of the infants had sufficient vitamin D level at the age of 1 year. So it is recommended to continue vitamin D3 supplementation consumption.

Impact of oral vitamin D supplementation on the ocular surface in people with dry eye and/or low serum vitamin D

2018 ◽  
Vol 41 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Chih-Huang Yang ◽  
Julie Albietz ◽  
Damien G. Harkin ◽  
Michael G. Kimlin ◽  
Katrina L. Schmid
Keyword(s):  
Vitamin D ◽  
Dry Eye ◽  
Ocular Surface ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Oral Vitamin ◽  
Serum Vitamin D ◽  
Low Serum

scholarly journals Comparison of Umbilical Cord Serum Vitamin D Levels between Infants with Transient Tachypnea of the Newborn and those without Respiratory Distress

2020 ◽  
Vol 23 (8) ◽  
pp. 530-535
Author(s):  
Hassan Boskabadi ◽  
Gholamali Maamouri ◽  
Farnaz Kalani-moghaddam ◽  
Mohammad Hosein Ataee Nakhaei ◽  
Maryam Zakerihamidi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Respiratory Distress ◽  
Vitamin D Deficiency ◽  
Umbilical Cord ◽  
Serum Vitamin ◽  
Control Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Mild Deficiency ◽  
The Mean

Background: Transient tachypnea of the newborn (TTN) is one of the most frequent causes of respiratory distress in neonates. A relationship has been shown between vitamin D deficiency and respiratory disorders in neonates. This research was carried out to evaluate the serum level of vitamin D in TTN newborns and their mothers compared to the control group. Methods: This case-control research was conducted during 2016-2019 in a general hospital affiliated with Mashhad University of Medical Sciences, Iran. Thirty-four infants with TTN and 82 neonates in the control group as well as their mothers were investigated. The levels of umbilical cord serum vitamin D in infants with TTN and also their mothers were compared to the control group. Results: The mean levels of serum vitamin D in infants with TTN and their mothers were 8.11 ± 4.32 and 12.6 ± 10.12 ng/mL, respectively (P<0.001), whereas they were 19.21 ± 12.71 and 25.96 ± 16.6 ng/mL in the newborns of the control group and their mothers, respectively (P<0.001). The mean differences (95% CI) of neonatal and maternal vitamin D level between the two groups were 11.10 (7.92–14.28) and 13.36 (7.90–18.08), respectively. In the TTN group, 100% of the infants had vitamin D levels less than 30 ng/mL (79.4% had severe, 17.6% had moderate and 2.9% showed mild deficiency). However, vitamin D levels lower than 30 ng/mL were observed in 76.4% of the neonates in the control group (28.8% had severe, 31.1% showed moderate and 16.3% had a mild deficiency) (P<0.001). Conclusion: The serum vitamin D levels of infants with TTN and their mothers were significantly lower than the control group. Therefore, TTN in infants may be reduced through the treatment of vitamin D deficiency in mothers.

The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/Syndrome

2019 ◽  
Vol 19 (2) ◽  
pp. 166-170 ◽  
Author(s):  
Seyhan Dikci ◽  
Emrah Öztürk ◽  
Penpe G. Fırat ◽  
Turgut Yılmaz ◽  
Mehmet Ç. Taşkapan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Glaucoma Surgery ◽  
Control Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Glaucoma Group

Objective: To investigate whether serum vitamin D levels have an effect on pseudoexfoliation (PEX) glaucoma/syndrome development and on the control of glaucoma in these cases. </P><P> Method: A total of 31 cases with PEX glaucoma, 34 cases with the PEX syndrome and 43 control subjects of similar age and sex were included in the study. Vitamin D levels were compared between the groups and also between the cases where glaucoma surgery was performed or not. Results: PEX glaucoma group consisted of 17 males and 14 females, PEX syndrome group of 27 males and 7 females, and the control group of 27 males and 16 females. The mean age was 70.9±8.9 years, 72.1±7.3 years, and 67.9±9.1 years in PEX glaucoma, syndrome and control group, respectively. Mean vitamin D levels were 9.4±7.7 ng/mL, 7.9±6,1 ng/mL, 11.5±14.2 ng/mL in PEX glaucoma, syndrome and control group, respectively (p>0.05). The mean serum vitamin D level was 8.04±4.7 ng/mL in those who underwent glaucoma surgery and 10.1±8.7 ng/mL in those who didn't undergo glaucoma surgery in PEX glaucoma group (p>0.05). No difference was found between the PEX glaucoma subgroups in terms of the mean deviation when classified according to vitamin D levels (<10 ng/mL, ≥10 ng/mL) (p>0.05). Conclusion: Although we found no statistically significant difference between the PEX syndrome/ glaucoma, and control group in terms of serum vitamin D levels, serum vitamin D levels were lower in PEX syndrome and glaucoma group than control group. Our results indicate that serum vitamin D levels have no effect on the development of PEX glaucoma/syndrome or the control of the disorder in cases with PEX glaucoma. However, these results need to be supported with further studies on a larger number of patients and with longer follow-up.

scholarly journals MRONJ and VIT D insufficiency

2021 ◽  
Author(s):  
Gholamreza Shirani ◽  
Arghavan Tonkaboni ◽  
Mina Mazani ◽  
Babak Mirzashahi ◽  
Abel Garcia Garcia ◽  
...  
Keyword(s):  
Vitamin D ◽  
Demographic Data ◽  
Serum Vitamin ◽  
Osteonecrosis Of The Jaw ◽  
Control Group ◽  
Case Group ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Sex Type ◽  
The Mean

Background: medication related osteonecrosis of the jaw (MRONJ) is a chronic condition of the oral cavity resulting in mucosal ulceration and exposure of underlying necrotic bone, and the ensuing secondary complications. The aim of this study was to evaluate the relationship between vitamin D deficiency and osteonecrosis of the jaw related to bisphosphonates. Materials and methods: This was a case-control study. The samples were 20 patients taking bisphosphonates, that 10 of them were with MRONJ and 10 were non-MRONJ. Clinical examination of patients was performed to diagnose jaw osteonecrosis. Demographic data of the patients were recorded including age, sex, type of drug, duration and cause of drug intake, and measurement of serum vitamin D levels. Data were analyzed using SPSS software. Results: In the patients without MRONJ, the mean age was 60.60 (±14.975) years, and in the patients with MRONJ, the mean age was 68.30 (69.92) years. As a whole, of the 16 female patients in this study, 10 cases (62.5%) were non- MRONJ and 6 cases (37.5%) were suffered by MRONJ. All of the male patients presented with MRONJ. In control group mean of vitamin D was 63.990 ng/ml (±29.796) and in case group mean of vitamin D was 29.510 ng/ml (±23.723). The serum level of vitamin D (25-OHD) was significantly higher in control group than in the case group (p=0.010). Conclusion: According to our result, there were statistically significant relationship between age, sex, type of drug, vitamin D level, and MRONJ (p>0.05).

scholarly journals Evaluation of role of vitamin-D levels in osteoporosis

2017 ◽  
Vol 4 (3) ◽  
pp. 701
Author(s):  
Shambhu Prasad ◽  
Sharma B. P. ◽  
. Saurabh
Keyword(s):  
Vitamin D ◽  
Standard Deviation ◽  
Bone Strength ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
T Score ◽  
Vitamin D Levels ◽  
The Mean

Background: Osteoporosis is a serious, worldwide, and growing health problem; WHO has estimated the 30% of all women, older than 50 years (post-menopausal) has osteoporosis. Osteoporosis is a skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture. Bone strength reflects the integration of two main features: bone density and bone quality.Methods: After clinical examination, patients were subjected to lab and radiological investigation as under: complete hemogram with ESR, serum calcium, phosphate, alkaline phosphatase, parathyroid hormone, 25 (OH) vitamin-D, KFT, LFT, DEXA scan. From above data, vitamin-D levels DEXA scan (t-score) was collected and statistically analysed.Results: 53 radiologically established cases by DEXA score (spine) of osteoporosis/osteopenia and 50 persons in control group of the age and sex match with normal DEXA score, presenting to OPD of central institute of orthopaedics, VMMC and Safdarjung Hospital were selected. The mean vitamin D3 level in cases was 19.37ng/ml with standard deviation of 10.2. Range of serum vitamin D3 levels in cases was from 7 to 51.2. Whereas mean vitamin D3 level in control group was 25.92 ng/ml with standard deviation of 7.24. Range of serum vitamin D3 levels in controls was from 10 to 35.5. The mean vitamin D levels of cases and control was 19.735±10.2 and 25.92±7.2 ng/ml respectively, these values were compared by using student t test and results were found to be statistically significant (P= 0.0001). The mean T score in spine cases was -2.59 with standard deviation of 0.92. Range of T score in cases was from -5.1 to -1. Whereas, mean T score in control group was -0.26 with standard deviation of 0.68. Range of T score in controls was from -0.9 to 1.4. The mean T score spine of cases and controls was -2.59±0.92 and -0.264±0.68 respectively, these values were compared by using student t test and results were found to be statistically significant (P = 0.0001).Conclusions: Study recommend that, vitamin D supplementation should be given to patients with osteopenia/osteoporosis. Further prospective studies to firmly establish the relationship between vitamin D and osteoporosis as well as evaluation of vitamin D supplementation in osteoporosis are needed.  

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