scholarly journals Associations between White Blood Cell Count and the Development of Incidental Nonalcoholic Fatty Liver Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Goh Eun Chung ◽  
Jeong Yoon Yim ◽  
Donghee Kim ◽  
Min-Sun Kwak ◽  
Jong In Yang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Blood Cell ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
White Blood Cell ◽  
Fatty Liver Disease ◽  
Hdl Cholesterol ◽  
Low Grade ◽  
Abdominal Ultrasonography ◽  
Nonalcoholic Fatty Liver

Aims. Chronic low-grade inflammation is thought to be associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD). This study aimed to determine the association between serum white blood cell (WBC) counts and the development of incidental NAFLD.Methods. In this retrospective longitudinal cohort study, we recruited participants who underwent abdominal ultrasonography and blood samplings during medical checkups in both 2005 and 2010. A total of 2,216 subjects were included in our analyses.Results. The prevalence of NAFLD in 2010 increased steadily in conjunction with increasing WBC counts in 2005 after adjustment for body mass index (BMI) [odds ratio (OR) 2.44, 95% confidence interval (CI) = 1.49–4.00 for women and OR 2.42, 95% CI = 1.61–3.63 for men, lowest quartile versus highest quartile]. Multivariate regression analysis after adjusting for age, BMI, hypertension, smoking, triglycerides, HDL cholesterol, and glucose levels revealed that NAFLD was significantly associated with the highest WBC quartile compared to the lowest quartile [OR 1.85, 95% CI, 1.10−3.10 for women and OR 1.68, 95% CI, 1.08−2.61 for men].Conclusions. We demonstrated that the risk of developing NAFLD was significantly associated with WBC counts independently of metabolic factors. This finding provides novel evidence indicating that serum WBC counts may be potential surrogate markers of NAFLD.

scholarly journals The association between white blood cell subtypes and prevalence and incidence of nonalcoholic fatty liver disease

2019 ◽  
Vol 17 ◽  
pp. 205873921983447
Author(s):  
Hongmei Zhang ◽  
Yixin Niu ◽  
Hongxia Gu ◽  
Shuai Lu ◽  
Weikang Su ◽  
...  
Keyword(s):  
Liver Disease ◽  
Blood Cell ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
White Blood Cell ◽  
Fatty Liver Disease ◽  
Complete Information ◽  
Nonalcoholic Fatty Liver ◽  
Independent Risk Factors

The association between white blood cell (WBC) and nonalcoholic fatty liver disease (NAFLD) has been studied before, but whether different WBC subtypes were related to NAFLD was not detailed. The aim of our study was to investigate the relationship between WBC subtypes and NAFLD cross-sectionally and prospectively. The detailed research design has been described previously. At baseline, there were 9930 participants who had complete information, in the end a total of 8079 participants (2588 men and 5491 women) were eventually included in this study. Hepatic ultrasound examination was performed on each participant at baseline and at the end of follow-up. Alcohol abuse and hepatitis were excluded. WBC subtypes and other serum indices were measured at baseline. We found that the total WBC, neutrophil, and lymphocyte counts were independently associated with the prevalence and incidence of NAFLD. After multiple adjustments for age, gender, body mass index (BMI), insulin, HOMA-IR, TG, TC, LDL, and HDL, increased odds ratios (ORs) for new onset NAFLD were observed from the 1st to the 4th quartiles of WBC, neutrophil, and lymphocyte (all P < 0.001 for trend). In conclusion, total WBC counts, neutrophils, and lymphocytes were all independent risk factors for NAFLD in the rural Chinese population. The association was independent of insulin resistance.

Relationship between white blood cell count and nonalcoholic fatty liver disease

2010 ◽  
Vol 42 (12) ◽  
pp. 888-894 ◽  
Author(s):  
Yong-Jae Lee ◽  
Hye-Ree Lee ◽  
Jae-Yong Shim ◽  
Byung-Soo Moon ◽  
Jung-Hyun Lee ◽  
...  
Keyword(s):  
Liver Disease ◽  
Blood Cell ◽  
Fatty Liver ◽  
Cell Count ◽  
Nonalcoholic Fatty Liver Disease ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Fatty Liver Disease ◽  
Blood Cell Count ◽  
Nonalcoholic Fatty Liver

Association between the frequency of daily tooth brushing and development of nonalcoholic fatty liver disease

2021 ◽  
Author(s):  
Kazuki Yamamoto ◽  
Takashi Ikeya ◽  
Shuhei Okuyama ◽  
Katsuyuki Fukuda ◽  
Daiki Kobayashi
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Primary Outcome ◽  
Tooth Brushing ◽  
Health Checkup ◽  
Abdominal Ultrasonography ◽  
Nonalcoholic Fatty Liver ◽  
The Mean

Background & Aims: This study aimed to evaluate the association between the frequency of daily tooth brushing and the development of nonalcoholic fatty liver disease (NAFLD). Methods: A retrospective longitudinal study was conducted from 2005 to 2012 at the Center for Preventive Medicine at St. Luke's International Hospital, Japan. Data on all participants who underwent a health checkup during the study period were collected. NAFLD was diagnosed by abdominal ultrasonography, and all participants who were diagnosed with NALFD at the time of their initial visit, consumed alcohol in any amount, or had received only one health checkup were excluded. The questionnaire for the frequency of daily tooth brushing was conducted as part of health checkups. The primary outcome was the risk of developing NAFLD according to the frequency of daily tooth brushing (1-2 times a day, or 3 times a day) compared to those who brush teeth once or less than once a day. Results: Data were collected from 25,804 people. A total of 3,289 (12.7%) participants developed NAFLD. The mean age was 45.2 years, and 6,901 (26.7%) of the participants were male. The risk of developing NAFLD significantly decreased with increased frequency of daily tooth brushing. Adjusted odds ratios (ORs) are as follows: Brushing teeth 1-2 times a day (OR: 0.85, 95% CI: 0.77-0.95), and 3 times a day (OR: 0.74, 95% CI: 0.67-0.82). Conclusions: Frequent tooth brushing was shown to significantly reduce the risk of developing NAFLD.　

Nonalcoholic fatty liver disease is associated with low-grade albuminuria in Chinese adults (change not displayed)

QJM ◽  
2016 ◽  
Vol 109 (11) ◽  
pp. 737-743 ◽  
Author(s):  
L. Lin ◽  
J. Lu ◽  
X. Huang ◽  
L. Ding ◽  
Y. Huang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Low Grade ◽  
Chinese Adults ◽  
Nonalcoholic Fatty Liver

scholarly journals Serum paraoxonase 1 activity is paradoxically maintained in nonalcoholic fatty liver disease despite low HDL cholesterol

2018 ◽  
Vol 60 (1) ◽  
pp. 168-175 ◽  
Author(s):  
Eline H. van den Berg ◽  
Eke G. Gruppen ◽  
Richard W. James ◽  
Stephan J. L. Bakker ◽  
Robin P. F. Dullaart
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Hdl Cholesterol ◽  
Paraoxonase 1 ◽  
Nonalcoholic Fatty Liver ◽  
Low Hdl ◽  
Serum Paraoxonase

Serum HGF ,PCIII and PLT are Noninvasive Markers for the diagnosis of nonalcoholic fatty liver disease

2019 ◽  
Author(s):  
Xiuqin An ◽  
Jinchun Liu ◽  
Xiaojuan Zheng ◽  
Zhangfeng Dou ◽  
Yue Li ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Abdominal Ultrasonography ◽  
Nonalcoholic Fatty Liver ◽  
Non Invasive ◽  
Invasive Method ◽  
Noninvasive Markers ◽  
Severe Fatty Liver

Abstract Background/Aims: It was suggested that serum HGF,PCIII and PLT play important roles in nonalcoholic fatty liver disease (NAFLD). Thus, we aimed to evaluate their clinical utility in the diagnosis of patients with suspected NAFLD.Methods:300 Patients with NAFLD were compared to 102 matched controls.All were subjected to history taking, anthropometric measurements, and abdominal ultrasonography, as well as laboratory assessments of liver functions, fasting lipid profile, GLU, serum PLT, HGF and PCIII.Results:The levels of HGF,PCIII and PLT were higher in NAFLD cases than controls ,and with progressive increases as the severity of fatty liver increased（P<0.05）.HGF,PCIII and PLT were correlated with various clinical parameters and severity of NAFLD（P<0.05）.The optimal cut-off values for HGF in diagnosis of mild, moderate and severe fatty liver were 14.1pg/ml(AUROC 0.753,P＝0.004), 15.4pg/ml(AUROC 0.836, P < 0.001), 17.7pg/ml(AUROC 0.903, P < 0.001). PCIII had no value in differentiate mild from moderate fatty liver ,but its ability to diagnose severe fatty liver was significant. A cut-off value for PCIII to diagnose severe fatty liver was 7.9ng/L(AUROC 0.773).The optimal cut-off values for PLT in the diagnosis of mild, moderate and severe fatty liver were 194×10^9/L(AUROC 0.732), 195×10^9/L(AUROC 0.765), 200×10^9/L(AUROC 0.925), respectively with P < 0.001. When three indicators were tested together,the AUROC(95%CI)curve for diagnose NAFLD was 0.881(sensitivity0.760,specificity 0.873)(P<0.001) .Conclusion:.Combined detection of serum HGF, PCIII and PLT may be an effective non-invasive method for diagnosing NAFLD.

scholarly journals The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study

2019 ◽  
Vol 12 ◽  
pp. 175628481985803 ◽  
Author(s):  
Stefanos Tyrovolas ◽  
Demosthenes B. Panagiotakos ◽  
Ekavi N. Georgousopoulou ◽  
Christina Chrysohoou ◽  
John Skoumas ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Dietary Habits ◽  
Low Grade ◽  
Inverse Association ◽  
Nonalcoholic Fatty Liver ◽  
Lower Odds ◽  
Anti Inflammatory

Background: Nonalcoholic fatty liver disease (NAFLD) is correlated with low-grade inflammation and dietary habits. Until today, there have been limited epidemiologic data assessing the role of diet’s inflammatory potential on NAFLD. The aim was to evaluate the relationship between an anti-inflammatory diet, as reflected by the Dietary Anti-Inflammation Index (D-AII), and NAFLD among cardiovascular disease (CVD)-free adults. Methods: ATTICA is a prospective, population-based study that recruited 3042 adults without pre-existing CVD from the Greek population (Whites; age ⩾18 years; 1514 men and 1528 women). D-AII was calculated using a standard procedure. The baseline study captured various sociodemographic, lifestyle and clinical characteristics as well as hepatic markers. These were used to calculate four NAFLD assessment indices: triglyceride-glucose (TyG) index, fatty liver index (FLI), hepatic steatosis index (HSI), and NAFLD Fatty Liver Score (NAFLD-FLS). Specific cutoffs were applied to capture NAFLD. Results: D-AII showed a significant inverse association with NAFLD, applying the four indices with NAFLD cutoffs [odds ratio (OR) with 95% confidence interval (CI); TyG (0.95, 0.93–0.98); HSI (0.89, 0.86–0.92); FLI (0.88, 0.85–0.91); NAFLD-FLS (0.89, 0.86–0.92)], after adjusting for various confounders. Participants in the highest D-AII tertile had lower odds of having NAFLD, compared with those in the lowest D-AII tertile [(OR, 95% CI); TyG (0.33, 0.24–0.47); HSI (0.13, 0.08–0.23); FLI (0.05, 0.02–0.11); NAFLD-FLS (0.13, 0.07–0.23)]. Anti-inflammatory nutrition was related to lower odds of NAFLD among daily alcohol drinkers and individuals with metabolic syndrome. Conclusions: Anti-inflammatory diet is an important predictor of NAFLD among adults without pre-existing CVD. Adherence to a high anti-inflammatory diet seems to contribute to NAFLD prevention.

Sign in / Sign up

Export Citation Format

Share Document