Nonalcoholic fatty liver disease is associated with low-grade albuminuria in Chinese adults (change not displayed)

QJM ◽  
2016 ◽  
Vol 109 (11) ◽  
pp. 737-743 ◽  
Author(s):  
L. Lin ◽  
J. Lu ◽  
X. Huang ◽  
L. Ding ◽  
Y. Huang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Low Grade ◽  
Chinese Adults ◽  
Nonalcoholic Fatty Liver

scholarly journals The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study

2019 ◽  
Vol 12 ◽  
pp. 175628481985803 ◽  
Author(s):  
Stefanos Tyrovolas ◽  
Demosthenes B. Panagiotakos ◽  
Ekavi N. Georgousopoulou ◽  
Christina Chrysohoou ◽  
John Skoumas ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Dietary Habits ◽  
Low Grade ◽  
Inverse Association ◽  
Nonalcoholic Fatty Liver ◽  
Lower Odds ◽  
Anti Inflammatory

Background: Nonalcoholic fatty liver disease (NAFLD) is correlated with low-grade inflammation and dietary habits. Until today, there have been limited epidemiologic data assessing the role of diet’s inflammatory potential on NAFLD. The aim was to evaluate the relationship between an anti-inflammatory diet, as reflected by the Dietary Anti-Inflammation Index (D-AII), and NAFLD among cardiovascular disease (CVD)-free adults. Methods: ATTICA is a prospective, population-based study that recruited 3042 adults without pre-existing CVD from the Greek population (Whites; age ⩾18 years; 1514 men and 1528 women). D-AII was calculated using a standard procedure. The baseline study captured various sociodemographic, lifestyle and clinical characteristics as well as hepatic markers. These were used to calculate four NAFLD assessment indices: triglyceride-glucose (TyG) index, fatty liver index (FLI), hepatic steatosis index (HSI), and NAFLD Fatty Liver Score (NAFLD-FLS). Specific cutoffs were applied to capture NAFLD. Results: D-AII showed a significant inverse association with NAFLD, applying the four indices with NAFLD cutoffs [odds ratio (OR) with 95% confidence interval (CI); TyG (0.95, 0.93–0.98); HSI (0.89, 0.86–0.92); FLI (0.88, 0.85–0.91); NAFLD-FLS (0.89, 0.86–0.92)], after adjusting for various confounders. Participants in the highest D-AII tertile had lower odds of having NAFLD, compared with those in the lowest D-AII tertile [(OR, 95% CI); TyG (0.33, 0.24–0.47); HSI (0.13, 0.08–0.23); FLI (0.05, 0.02–0.11); NAFLD-FLS (0.13, 0.07–0.23)]. Anti-inflammatory nutrition was related to lower odds of NAFLD among daily alcohol drinkers and individuals with metabolic syndrome. Conclusions: Anti-inflammatory diet is an important predictor of NAFLD among adults without pre-existing CVD. Adherence to a high anti-inflammatory diet seems to contribute to NAFLD prevention.

scholarly journals Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Ya-Nan Zhang ◽  
Qin-Qiu Wang ◽  
Yi-Shu Chen ◽  
Chao Shen ◽  
Cheng-Fu Xu
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Hdl Cholesterol ◽  
Chinese Adults ◽  
Nonalcoholic Fatty Liver ◽  
Cholesterol Ratio

Background/Aim. The risk factors for nonalcoholic fatty liver disease (NAFLD) in lean population have not been fully clarified. This study aimed to explore the association between uric acid to HDL-cholesterol ratio (UHR) and NAFLD in lean Chinese adults. Methods. A cross-sectional study was performed among 6285 lean Chinese adults (body mass index < 24 kg/m2) who took their annual health checkups. NAFLD was diagnosed based on hepatic ultrasound examination, with exclusion of other etiologies. Results. Of 6285 lean participants enrolled, 654 NAFLD cases were diagnosed. The overall NAFLD prevalence was 10.41%, and the prevalence was 15.45% and 7.16% in men and women, respectively. UHR was significantly higher in NAFLD patients than in controls (14.25 ± 5.33% versus 10.09 ± 4.23%, P<0.001). UHR quintiles were positively associated with NAFLD prevalence, which was 1.91% in the first UHR quintile and increased to 3.58%, 7.81%, 14.17%, and 24.54% in the second, third, fourth, and fifth quintile groups, respectively (P<0.001 for trend). Multivariate logistic regression analysis showed that UHR was independently associated with an increased risk of NAFLD (odds ratio: 1.105; 95% CI: 1.076–1.134; P<0.001). Sensitivity analysis showed that UHR remained significantly associated with NAFLD in lean participants with normal range of serum uric acid and HDL-cholesterol levels. Conclusions. UHR was significantly associated with NAFLD and may serve as a novel and reliable marker for NAFLD in lean adults.

scholarly journals Nonalcoholic fatty liver disease, spleen and psoriasis: New aspects of low-grade chronic inflammation

2015 ◽  
Vol 21 (22) ◽  
pp. 6892-6897 ◽  
Author(s):  
Nicola Balato ◽  
Maddalena Napolitano ◽  
Fabio Ayala ◽  
Cataldo Patruno ◽  
Matteo Megna ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Chronic Inflammation ◽  
Fatty Liver Disease ◽  
Low Grade ◽  
Nonalcoholic Fatty Liver

scholarly journals Comparison of Body Mass Index and Fat Indices in Predicting the Severity of Nonalcoholic Fatty Liver Disease Among Children Who Are Overweight and Obese

2021 ◽  
Vol 9 ◽  
Author(s):  
Hsun-Chin Chao ◽  
Hsin-Yeh Lin
Keyword(s):  
Body Mass Index ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Body Mass ◽  
Fatty Liver Disease ◽  
Predictive Accuracy ◽  
Subcutaneous Fat ◽  
Low Grade ◽  
Nonalcoholic Fatty Liver

Background: Information of the relationships between body mass parameters and the severity of fatty liver is deficient in pediatric nonalcoholic fatty liver disease (NAFLD).Methods: The relationships between body mass parameters (waist circumference [WC], body mass index [BMI], and abdominal subcutaneous fat thickness [ASFT]) and the severity of fatty liver were prospectively evaluated in pediatric patients who are overweight or obese, suffering from NAFLD. Ultrasonography was performed to assess fatty liver and its severity on a three-grade scale (low-grade fatty liver [LGFL], grade 1 or 2; high-grade fatty liver [HGFL], grade 3).Results: A total of 110 subjects (55 LGFL and 55 HGFL) aged 6.2–17.9 years were included. The WC, BMI, and ASFT values were significantly higher in the HGFL group compared to those in the LGFL group (p = 0.00004, 0.01, and 0.04, respectively). WC had the greatest power to predict HGFL under receiver-operating characteristic curve analyses and was positively correlated with the severity of fatty liver in subjects aged 6–12-year old and 13–17-year old (p = 0.007, and 0.0039, respectively). ASFT showed a positive correlation with the severity of fatty liver in subjects aged 13–17-year old (p = 0.04).Conclusions: WC, BMI, and ASFT are predictive of severe NAFLD among children who are overweight and obese; particularly, WC has the most predictive accuracy. Among the parameters, WC and ASFT are predictive in specific age groups.

scholarly journals Association between Serum Uric Acid to HDL-cholesterol Ratio and Nonalcoholic Fatty Liver Disease among Chinese Adults

2021 ◽  
Author(s):  
Hui Zhao ◽  
Xia Qiu ◽  
Jiajia Cui ◽  
Yongye Sun
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Serum Uric Acid ◽  
Fatty Liver Disease ◽  
Hdl Cholesterol ◽  
Response Analysis ◽  
Chinese Adults ◽  
Nonalcoholic Fatty Liver

Abstract We conducted this case-control study to explore the association of serum uric acid (SUA) to HDL-cholesterol (HDL-C) ratio (UHR) with the risk of nonalcoholic fatty liver disease (NAFLD) in general Chinese adults. A total of 636 patients with NAFLD and 754 controls from affiliated hospital of Qingdao University in China between January to December 2016 were involved. NAFLD was diagnosed by ultrasonography after excluding other etiologies. The multivariable adjusted odds ratio and 95% confidence interval (CI) of NAFLD for the highest versus lowest quartile of UHR was 3.888 (2.324-6.504). In stratified analyses by sex and age, the positive associations between UHR and the risk of NAFLD were statistically significant in each subgroup. In stratified by BMI, the significant positive association was only found in the individuals with BMI≥23.9 kg/m2. Dose-response analysis indicated a linear positive correlation between UHR and NAFLD risk.

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