scholarly journals Clinical Utility of Urinaryβ2-Microglobulin in Detection of Early Nephropathy in African Diabetes Mellitus Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-8
Author(s):  
U. E. Ekrikpo ◽  
E. E. Effa ◽  
E. E. Akpan ◽  
A. S. Obot ◽  
S. Kadiri
Keyword(s):  
Diabetic Nephropathy ◽  
Albumin Concentration ◽  
Inclusion Criteria ◽  
Type 2 Diabetics ◽  
Potential Biomarker ◽  
Beta 2 ◽  
Beta 2 Microglobulin ◽  
Diabetic Tubulopathy ◽  
Urinary Albumin Concentration

Background. Studies have indicated that diabetic tubulopathy may occur earlier than glomerulopathy, therefore providing a potential avenue for earlier diagnosis of diabetic nephropathy. Urinary beta-2-microglobulin (β2m) was investigated in this study as a potential biomarker in the detection of early nephropathy in type 2 diabetics.Methods. One hundred and two diabetic subjects and 103 controls that met the inclusion criteria had data (sociodemographic, medical history, physical examination, and laboratory) collected. Urinaryβ2m levels and urinary albumin concentration (UAC) were determined.Results. Elevated urinaryβ2m was more frequent among the diabetics (52%, 95% CI: 42.1–61.8%) than among the controls (32%, 95% CI: 22.9–41.2%). The frequency of microalbuminuria was higher in the diabetics (35.3%, 95% CI: 25.9–44.7%) than in the controls (15.5%, 95% CI: 8.4–22.6%). There was a positive correlation between urinaryβ2m and UAC (rho = 0.38,p<0.001). Multivariate analysis showed BMI (OR: 1.23, 95% CI: 1.05–1.45), eGFR (OR: 0.97, 95% CI: 0.94–0.99), and presence of microalbuminuria (OR: 3.94, 95% CI: 1.32–11.77) as independent predictors of elevated urinary beta-2-microglobulin among the diabetics.Conclusion. Urinaryβ2m may be useful, either as a single test or as a component of a panel of tests, in the early detection of diabetic nephropathy.

scholarly journals Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study

Children ◽  
2021 ◽  
Vol 8 (8) ◽  
pp. 627
Author(s):  
Pierluigi Marzuillo ◽  
Anna Di Sessa ◽  
Pier Luigi Palma ◽  
Giuseppina Rosaria Umano ◽  
Cesare Polito ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Renal Involvement ◽  
Kidney Injury ◽  
Fractional Excretion ◽  
Tubular Damage ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Type 2 Diabetes Mellitus (T2DM) is a main cause of chronic kidney disease (CKD) in adulthood. No studies have examined the occurrence of acute kidney injury (AKI)—that enhances the risk of later CKD—and renal tubular damage (RTD)—that can evolve to AKI—in children with onset of T2DM. We aimed to evaluate the prevalence and possible features of AKI and RTD in a prospectively enrolled population of children with onset of T2DM. We consecutively enrolled 10 children aged 12.9 ± 2.3 years with newly diagnosed T2DM. AKI was defined according to the KDIGO criteria. RTD was defined by abnormal urinary beta-2-microglobulin and/or tubular reabsorption of phosphate (TRP) < 85% and/or fractional excretion of Na > 2%. None of the patients developed AKI, whereas 3/10 developed RTD with high beta-2-microglobulin levels (range: 0.6–1.06 mg/L). One of these three patients also presented with reduced TRP levels (TRP = 70%). Proteinuria was observed in two out of three patients with RTD, while none of patients without RTD had proteinuria. Patients with RTD presented higher beta-2-microglobulin, acute creatinine/estimated basal creatinine ratio, and serum ketones levels compared with patients without RTD. In conclusion, in our pilot observation, we found that none of the 10 children with T2DM onset developed AKI, whereas three of them developed RTD.

Serum Beta- 2 Microglobulin is a Reliable Biomarker to Predict Diabetic Nephropathy

2021 ◽  
Vol 05 (05) ◽  
Author(s):  
Kamal M ◽  
Apu SA ◽  
kamal A ◽  
Alam I ◽  
kamal AM ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Beta 2 ◽  
Beta 2 Microglobulin

scholarly journals Endothelial dysfunction in type-2 diabetics with early diabetic nephropathy is associated with low circulating adiponectin

2008 ◽  
Vol 23 (5) ◽  
pp. 1621-1627 ◽  
Author(s):  
M. I. Yilmaz ◽  
M. Saglam ◽  
A. R. Qureshi ◽  
J. J. Carrero ◽  
K. Caglar ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Endothelial Dysfunction ◽  
Type 2 Diabetics ◽  
Early Diabetic Nephropathy

scholarly journals Prevalence and Risk Factors of Diabetic Nephropathy in Omani Type 2 Diabetics in Al-Dakhiliyah Region

2012 ◽  
Vol 27 (3) ◽  
pp. 212-216 ◽  
Author(s):  
Abdulhakeem Hamood Alrawahi ◽  
Syed Gauhar A. Rizvi ◽  
Dawood Al-Riyami ◽  
Zaher Al-Anqoodi
Keyword(s):  
Risk Factors ◽  
Diabetic Nephropathy ◽  
Type 2 Diabetics

Determination of urinary lysozyme for potential detection of tubular dysfunction in diabetic nephropathy.

1986 ◽  
Vol 32 (10) ◽  
pp. 1818-1822 ◽  
Author(s):  
K Shima ◽  
M Hirota ◽  
M Fukuda ◽  
A Tanaka
Keyword(s):  
Diabetic Nephropathy ◽  
Excretion Rate ◽  
Temporal Relation ◽  
Insulin Dependent Diabetes ◽  
Tubular Dysfunction ◽  
Insulin Dependent ◽  
Beta 2 ◽  
Beta 2 Microglobulin ◽  
Suitable Index

Abstract Seeking to study whether measurement of lysozyme (EC 3.2.1.17) in urine by a reliable radioimmunoassay can provide a suitable index of renal tubular function and how lysozymuria develops in temporal relation to proteinuria in diabetic nephropathy, we have compared the urinary excretion of lysozyme and beta 2-microglobulin with the 15-min excretion rate of phenolsulfonphthalein in 39 patients with Type 2 (non-insulin-dependent) diabetes and investigated the temporal relation between the onset of lysozymuria and proteinuria in 15 patients with Type 1 (insulin-dependent) diabetes. The concentrations of lysozyme and beta 2-microglobulin in urine increased in proportion to the decrease in the rate of excretion of phenolsulfonphthalein in these patients. The coefficient of correlation between lysozyme concentration and the 15-min excretion rate of phenolsulfonphthalein (r = -0.70) was higher than that between beta 2-microglobulin concentration and the 15-min excretion rate of phenolsulfonphthalein (r = -0.46). Abnormally high lysozymuria, suggesting the existence of tubular dysfunction, was demonstrated in six of the patients with Type 1 diabetes who showed no proteinuria or only a slight increase in urinary protein excretion. Lysozymuria may thus be added to a list of the indicators for diabetic nephropathy.

scholarly journals MON-621 Prescription Analysis Shows High Metformin Use and Acceptance in a Diabetes Specialty Centre in Eastern India

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Sanat Kumar Mishra ◽  
Susant Mishra ◽  
Abhay Kumar Sahoo ◽  
Rajesh Kumar Padhi ◽  
Biswaranjan Jena ◽  
...  
Keyword(s):  
Inclusion Criteria ◽  
Type 2 Diabetics ◽  
Daily Dose ◽  
History Of ◽  
Study Population ◽  
Artery Disease ◽  
The Individual ◽  
The Right ◽  
Type 2 Diabetic

Abstract Background and aims: Achieving glycemic goals is crucial in the overall management of diabetes. Selecting the right medication for the individual patient is of paramount importance in the present day’s patient centric glucose control. Metformin is the first line and gold standard antihyperglycemic agent that can be offered to type 2 diabetics. Addition of a second or third agent or insulin should be considered in those whose HbA1c remains high despite the up-regulated metformin dose or those who do not tolerate metformin. We aimed to find the pattern of metformin use in type 2 diabetic subjects in a diabetes specialty centre in coastal Odisha. Materials and methods: This observational study was conducted in a diabetes setup in coastal Odisha in June 2018. After obtaining consent from patients, authors looked into the prescriptions of all type 2 diabetic adults. Subjects who were prescribed metformin (in any dose) were enrolled in the study. Those with established nephropathy, coronary artery disease, stroke or cancers were excluded. Results:There were 802 footfalls noted during the study period, of which 723 metformin taking participants (298 females, 41.2%) were considered for analysis (79 persons were excluded: not meeting inclusion criteria/ not willing to participate/ history of nephropathy/ CAD/ stroke). Mean age, diabetes duration, FPG, HbA1c, serum creatinine, eGFR of the study population were 51.6±10.6 years, 11.9±11.2 years, 138.7±51.7 mg/dl, 7.8±2.1%, 0.93±0.29 mg/dl and 96.5±11.1ml/min respectively. Patients were prescribed metformin in various doses, i.e., 500mg (42 patients, 5.8%), 850mg (47 patients, 6.5%), 1000mg (396 patients, 54.8%), 1500mg (13 patients, 1.8%), 1700mg (86 patients, 11.9%) and 2000mg (130 patients, 18.0%), and 2500mg (9 patients, 1.2%). Metformin was prescribed as monotherapy (n=34, 4.7%) or along with other OADs (n=589, 81.5%) or in combination with insulin (n=178, 24.6%). Retrospective analysis of the medical records and further questioning revealed that gastric intolerance was the commonest reason for withdrawal of metformin in otherwise eligible subjects. Conclusion: Metformin was the most commonly prescribed antidiabetic drug and the daily dose of more than 85% of the metformin administered individuals was 1000mg or above.

scholarly journals Reno-protective effect of angiotensin converting enzyme inhibitor and angiotensin II receptor blockers in type 2 diabetic nephropathy with elevated urine albumin to creatinine ratio

2019 ◽  
Vol 6 (3) ◽  
pp. 657
Author(s):  
Ashok Vankayala ◽  
Karuna Sagar Mantha ◽  
Praveen Varma B. H. V. K. ◽  
Suresh Babu Sayana ◽  
Raju D. S. S. K.
Keyword(s):  
Diabetic Nephropathy ◽  
Angiotensin Ii ◽  
Enzyme Inhibitor ◽  
Creatinine Ratio ◽  
Converting Enzyme ◽  
Angiotensin Ii Receptor ◽  
Urine Albumin ◽  
Type 2 Diabetics ◽  
Receptor Blockers

Background: Nephropathy is responsible for an End Stage Renal Disease (ESRD) in type 2 diabetics if uncontrolled. The monotherapy/combination of Angiotensin Converting Enzyme inhibitor (ACEi) and Angiotensin II Receptor Blockers (ARBs) can retard the progression of urine albumin to creatinine ratio in diabetic nephropathy but, the data shows an inconsistency in the efficacy of these drugs. So, the present study was aimed at comparing the reno-protective effect of ACEi/ARBs in type 2 diabetics.Methods: A prospective, randomized study is conducted at Maharaja’s Institute of Medical Sciences, Nellimarla, Vizianagaram, Andhra Pradesh, India with 100 patients, who are randomly categorised and equally distributed among the two groups and treated with Enalapril (ACEi) and Losartan (ARBs) for 6 months. 24-hour urine albumin to creatinine ratio and HbA1c are recorded before and after the treatment.Results: Enalapril and losartan showed a non-significant reduction in urine albumin to creatinine ratio from 196.2±17.5 to 185.9±15.2 (p=0.66) and 236.8±16.3 to 193.7±20.6 (p=0.11) respectively. A strict glycemic control has shown a reduction in HbA1c in both the groups.Conclusions: Present findings suggested that losartan is relatively more effective than enalapril in reducing the 24-hour urine albumin to creatinine ratio of diabetic nephropathy patients. Along with these drugs, regulation of blood glucose will assist in retarding the progression of nephropathy in type 2 diabetics.

scholarly journals A Meta-Analysis of Randomized Controlled Trials of Yiqi Yangyin Huoxue Method in Treating Diabetic Nephropathy

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Jiao Ying Ou ◽  
Di Huang ◽  
Yan Sheng Wu ◽  
Lin Xu ◽  
Fei He ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Blood Glucose ◽  
Serum Creatinine ◽  
Randomized Controlled Trials ◽  
Postprandial Blood Glucose ◽  
Controlled Trials ◽  
Complementary And Alternative Therapy ◽  
Randomized Controlled ◽  
Beta 2 ◽  
Beta 2 Microglobulin

Objective. The purpose of this systematic review is to evaluate the evidence of Yiqi Yangyin Huoxue Method for diabetic nephropathy.Methods. 11 electronic databases, through September 2015, were searched to identify randomized controlled trials of Yiqi Yangyin Huoxue Method for diabetic nephropathy. The quality of the included trials was assessed using the Jadad scale.Results. 26 randomized controlled trials were included in our review. Of all the included trials, most of them were considered as high quality. The aggregated results suggested that Yiqi Yangyin Huoxue Method is beneficial to diabetic nephropathy in bringing down the microalbuminuria (SMD = −0.98, 95% CI −1.22 to −0.74), serum creatinine (SMD = −0.56, 95% CI −0.93 to −0.20), beta-2 microglobulin (MD = 0.06, 95% CI 0.01 to 0.12), fasting plasma glucose (MD = −0.35, 95% CI −0.62 to −0.08), and 2-hour postprandial blood glucose (MD = 1.13, 95% CI 0.07 to 2.20), but not in decreasing blood urea nitrogen (SMD = −0.72, 95% CI −1.47 to 0.02) or 2-hour postprandial blood glucose (SMD = −0.48, 95% CI −1.01 to 0.04).Conclusions. Yiqi Yangyin Huoxue Method should be a valid complementary and alternative therapy in the management of diabetic nephropathy, especially in improving UAER, serum creatinine, fasting blood glucose, and beta-2 microglobulin. However, more studies with long follow-up are warrant to confirm the current findings.

EXPRESS: Plasma miR-193a-3p can be a potential biomarker for the diagnosis of diabetic nephropathy

2020 ◽  
pp. 000456322098385
Author(s):  
Yan Hong ◽  
Jidong Wang ◽  
Lai Zhang ◽  
Wenjuan Sun ◽  
Xuefang Xu ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Microvascular Complications ◽  
Roc Curves ◽  
Plasma Samples ◽  
Free Survival ◽  
Kaplan Meier ◽  
Specificity And Sensitivity ◽  
Potential Biomarker ◽  
Patients With Diabetes

Background: Diabetic nephropathy (DN) is one of the most common microvascular complications in patients with diabetes. MicroRNA (miRNA, miR) is closely related to the formation, development and pathophysiology of DN. We aimed to investigate whether miR-193a-3p could be used as a potential biomarker for the diagnosis of DN. Methods: Plasma samples were collected from all the participants. TaqMan Low Density Array analysis was employed to obtain the miRNA profiles of plasma samples, and qRT-PCR was used to confirm the result. Receiver operating characteristic (ROC) curves were employed to evaluate the specificity and sensitivity of miR-193a-3p for predicting DN. Results: The expression of miR-193a-3p and miR-320c were elevated and miR-27a-3p was decreased in DN patients compared to patients with type 2 diabetes and healthy controls. We found that, in DN patients, the elevated miR-193a-3p expression had a negative correlation with the level of evaluate glomerular filtration rate, while a positive correlation with the level of proteinuria. We further demonstrated that miR-193a-3p could be employed to distinguish patients with DN. The Kaplan-Meier analysis showed that the high expression of miR-193a-3p significantly shortened the dialysis-free survival of DN patients. Conclusion: In conclusion, miR-193a-3p is involved in DN pathogenesis and may serve as a potentially novel diagnostic biomarker for DN.

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