scholarly journals Identification of Neuroprotective Factors Associated with Successful Ageing and Risk of Cognitive Impairment among Malaysia Older Adults

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Huijin Lau ◽  
Arimi Fitri Mat Ludin ◽  
Nor Fadilah Rajab ◽  
Suzana Shahar
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Cognitive Impairment ◽  
Telomere Length ◽  
Serum Vitamin ◽  
Dietary Vitamin ◽  
Ageing Population ◽  
Successful Ageing ◽  
Bdnf Level ◽  
Serum Vitamin D

The increase of ageing population has raised public attention on the concept of successful ageing. Studies have shown that vitamin D, telomere length, and brain-derived neurotrophic factor (BDNF) have been associated with cognitive function. Therefore, this study aimed to identify neuroprotective factors for cognitive decline in different ageing groups. A total of 300 older adults aged 60 years and above were recruited in this population based cross-sectional study. Participants were categorized into three groups: mild cognitive impairment (MCI) (n=100), usual ageing (UA) (n=100), and successful ageing (SA) (n=100). Dietary vitamin D intake was assessed through Diet History Questionnaire (DHQ). Out of the 300 participants, only 150 were subjected to fasting blood sample collection. These samples were used for serum vitamin D and plasma BDNF measurements. Whole blood telomere length was measured using RT-PCR method. The results show that the reduction of the risk of MCI was achieved by higher serum vitamin D level (OR: 0.96, 95% CI: 0.92–0.99, p<0.05), higher plasma BDNF level (OR: 0.51, 95% CI: 0.30–0.88,  p<0.05), and longer telomere (OR: 0.97, 95% CI: 0.95–0.99,  p<0.001). In conclusion, participants with higher vitamin D level, higher BDNF level, and longer telomere length were more likely to age successfully.

scholarly journals Serum vitamin D in patients with mild cognitive impairment and Alzheimer's disease

2018 ◽  
Vol 8 (3) ◽  
pp. e00936 ◽  
Author(s):  
Shinji Ouma ◽  
Midori Suenaga ◽  
Funda F. Bölükbaşı Hatip ◽  
Izzettin Hatip-Al-Khatib ◽  
Yoshio Tsuboi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vitamin D ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Serum Vitamin ◽  
Serum Vitamin D

scholarly journals Association of vitamin D with adiposity measures and other determinants in a cross-sectional study of Cypriot adolescents

2014 ◽  
Vol 18 (1) ◽  
pp. 112-121 ◽  
Author(s):  
Ourania Kolokotroni ◽  
Anna Papadopoulou ◽  
Panayiotis K Yiallouros ◽  
Vasilios Raftopoulos ◽  
Christiana Kouta ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Reference Group ◽  
Serum Vitamin ◽  
Sun Exposure ◽  
Dietary Vitamin ◽  
Vitamin D Status ◽  
Fat Percentage ◽  
Cross Sectional ◽  
Serum Vitamin D

AbstractObjectiveTo assess vitamin D status among Cypriot adolescents and investigate potential determinants including BMI and body fat percentage (BF%).DesignParticipants had cross-sectional assessments of serum vitamin D, physical activity, dietary vitamin D intake and sun exposure. Linear and logistic regression models were used to explore the associations of vitamin D with potential predictors.SettingHospitals, Cyprus, November 2007–May 2008.SubjectsAdolescents (n 671) aged 16–18 years.ResultsMean serum vitamin D was 22·90 (sd 6·41) ng/ml. Only one in ten children had sufficient levels of vitamin D (≥30 ng/ml), while the prevalence of vitamin D deficiency (12–20 ng/ml) and severe deficiency (<12 ng/ml) was 31·7 % and 4·0 %, respectively. Lower vitamin D was associated with winter and spring season, female gender, reduced sun exposure in winter and darker skin. Participants with highest BMI and BF% when compared with a middle reference group had increased adjusted odds of vitamin D insufficiency (OR = 3·00; 95 % CI 1·21, 7·45 and OR = 5·02; 95 % CI 1·80, 13·97, respectively). A similar pattern, although not as strong, was shown for vitamin D deficiency with BF% (OR = 1·81; 95 % CI 1·04, 3·16) and BMI (OR = 1·51; 95 % CI 0·85, 2·67). Participants in the lowest BMI and BF% groups also displayed compromised vitamin D status, suggesting a U-shaped association.ConclusionsVitamin D deficiency in adolescence is very prevalent in sunny Cyprus, particularly among females, those with darker skin and those with reduced sun exposure in winter. Furthermore, vitamin D status appears to have a U-shaped association with adiposity measures.

Higher Serum Vitamin D Concentration Is Associated with Better Balance in Older Adults with Supra-Optimal Vitamin D Status

2013 ◽  
Vol 61 (1) ◽  
pp. 163-165 ◽  
Author(s):  
Cedric Annweiler ◽  
Susan W. Muir ◽  
Shamis Nabeel ◽  
Karen Gopaul ◽  
Olivier Beauchet ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Vitamin D Status ◽  
Serum Vitamin D

scholarly journals Serum vitamin d concentrations are associated with falling and cognitive function in older adults

2012 ◽  
Vol 16 (10) ◽  
pp. 898-901 ◽  
Author(s):  
Amie Peterson ◽  
N. Mattek ◽  
A. Clemons ◽  
G. L. Bowman ◽  
T. Buracchio ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Cognitive Function ◽  
Serum Vitamin ◽  
Serum Vitamin D

Serum Vitamin D Concentrations and Cognitive Function in a Population-Based Study among Older Adults in South Germany

2015 ◽  
Vol 45 (4) ◽  
pp. 1119-1126 ◽  
Author(s):  
Gabriele Nagel ◽  
Florian Herbolsheimer ◽  
Matthias Riepe ◽  
Thorsten Nikolaus ◽  
Michael D. Denkinger ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Cognitive Function ◽  
Serum Vitamin ◽  
Population Based ◽  
Population Based Study ◽  
Serum Vitamin D

IMPACT OF DIETARY FACTORS AND INFLAMMATION ON COGNITION AMONG OLDER ADULTS

2015 ◽  
pp. 1-7
Author(s):  
E.P. Handing ◽  
B.J. Small ◽  
S.L. Reynolds ◽  
N.B. Kumar
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Cognitive Function ◽  
Cognitive Performance ◽  
Serum Vitamin ◽  
Plasma Homocysteine ◽  
Dietary Factors ◽  
Serum Folate ◽  
Serum Vitamin D ◽  
Age Related

OBJECTIVE: This study examined the influence of age, nutrition (as measured through food diaries and serum/plasma biomarkers) and inflammatory markers on cognitive performance in adults 60 years of age and older. DESIGN: A cross-sectional population based study, data from the National Health and Nutrition Examination Survey (NHANES; 2001-2002 wave). PARTICIPANTS: This study included 1,048 adults who had valid dietary data, blood biomarkers, were 60 years or older, completed the cognitive test, and had complete demographic information. METHOD: A series of regression models were used to examine the relationship between cognitive function as measured by the Digit Symbol Substitution Task (DSST), dietary factors/biomarkers and inflammation. Mediation analyses were then utilized to examine whether individual nutrients accounted for the relationships between age and DSST performance. RESULTS: Dietary fat intake, serum vitamin E, serum folate, serum iron, plasma homocysteine, and serum vitamin D were significantly associated with better DSST performance. Elevated fibrinogen and C-reactive protein, were significantly associated with poorer cognitive function, but did not remain statistically significant after controlling for age, gender, education, ethnicity, income, and total calorie intake. Serum vitamin D and plasma homocysteine accounted for a portion of age-related variance in DSST. Specifically, higher levels of vitamin D were related to better DSST performance, while higher homocysteine resulted in poorer cognitive performance. CONCLUSION: Diet and nutrition are important modifiable factors that can influence health outcomes and may be beneficial to remediate age-related declines in cognition. Adequate nutrition may provide a primary preventive approach to healthy aging and maintenance of cognitive functioning in older adults.

scholarly journals Vitamin D intake and serum vitamin D in ethnically diverse urban schoolchildren

2012 ◽  
Vol 15 (11) ◽  
pp. 2047-2053 ◽  
Author(s):  
Lauren E Au ◽  
Christina D Economos ◽  
Elizabeth Goodman ◽  
Aviva Must ◽  
Virginia R Chomitz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Ethnic Differences ◽  
Serum Vitamin ◽  
Dietary Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Intake ◽  
North East ◽  
Race Ethnicity ◽  
Racial Ethnic ◽  
Dietary Vitamin D

AbstractObjectiveLow serum vitamin D, which largely affects ethnic minorities, is associated with obesity and other chronic diseases. Little is known about racial/ethnic differences in intake, particularly in children, or if any differences are associated with differences in serum 25-hydroxyvitamin D (25(OH)D). The objective of the present study was to determine whether racial/ethnic differences in dietary vitamin D intake exist and whether they explain differences in 25(OH)D.DesignVitamin D intakes (Block Kids 2004 FFQ) and 25(OH)D were measured. Race/ethnicity was parent-reported (white (37·9 %), Hispanic (32·4 %), black (8·3 %), Asian (10·3 %), multi-racial/other (11·0 %)). Multivariable analyses were conducted to examine the associations among dietary vitamin D and race/ethnicity, as well as 25(OH)D, independent of BMI Z-score and other covariates.SettingElementary/middle schools in Somerville, MA, USA, during January–April 2010.SubjectsSchoolchildren (n 145) in 4th–8th grade.ResultsOnly 2·1 % met the 2011 RDA (15 μg/d (600 IU/d)). Average dietary intake was 3.5 (sd 2.2) μg/d (140 (sd 89·0) IU/d). No racial/ethnic differences in intake were evident. Most (83·4 %) were 25(OH)D deficient (<20 ng/ml; 16·0 (sd 6·5) ng/ml). In ANOVA post hoc analyses, 25(OH)D levels were lower in Hispanics than whites (14·6 (sd 6·1) ng/ml v. 17·9 (sd 4·6) ng/ml; P < 0·01). Dietary vitamin D was associated with 25(OH)D overall (P < 0·05), but did not explain the racial/ethnic differences in 25(OH)D.ConclusionsMost children in this north-east US sample did not meet dietary recommendations for vitamin D and were vitamin D deficient. Dietary vitamin D did not explain the difference in 25(OH)D between Hispanic and white children. Further research is needed to determine if changes in dietary vitamin D by race/ethnicity can impact 25(OH)D levels.

scholarly journals Vitamin D, Falls and Balance Capacity Impacts in Older Adults: Update

2021 ◽  
Vol 3 (4) ◽  
pp. 22-39
Author(s):  
Ray Marks
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Successful Aging ◽  
English Language ◽  
Balance Control ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Falls Prevention ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background Falls injuries continue to contribute to numerous premature deaths as well as high disability levels, and excess morbidity rates among older adults, worldwide. But can vitamin D account for excess falls injuries among older adults? This review specifically focuses on what is known about vitamin D in the context of postural stability or balance control, both fairly consistent independent predictors of falls among older adults. Methods and Procedures Drawn largely from a review of current relevant English language peer reviewed research publications published over the last 10 years detailing the relationship between vitamin D levels and balance control among the elderly, as this relates to falls injuries, evidence for any emerging consensus on this controversial topic was sought. Used to conduct the search were various key word combinations including: falls injuries and older adults, vitamin D or vitamin D deficiency and balance or postural control. The database used predominantly to provide input into this largely descriptive assessment and narrative overview was PUBMED. Results The prevailing data show falls injuries currently constitute a widespread costly major impediment to successful aging and longevity for many older adults, despite numerous efforts to prevent this disabling set of events over the past two to three decades. However, no consistent association appears to exist between the variables of vitamin D, falls, and balance attributes in the older population-despite years of research, regardless of study approach, and a strong rationale for hypothesizing a clinically meaningful relationship. Conclusion It is not possible to arrive at any universal recommendation concerning the value of vitamin D supplementation as regards its possible influence on balance capacity among older adults in the realm of falls prevention efforts, as has been frequently proposed. However, until more definitive research is conducted, there still appears sufficient justification for considering the screening of vulnerable aging adults for serum vitamin D levels, along with balance impairments, and intervening as required in the case of deficits in either or both of these possible falls determinants.

CORRELATION STUDY OF ACNE VULGARIS AND SERUM VITAMIN D LEVELS IN ADOLESCENTS

2020 ◽  
pp. 19-21
Author(s):  
DYAH SAPTARINI ◽  
FIASTUTI WITJAKSONO ◽  
IRMA BERNADETTE S. SITOHANG
Keyword(s):  
Vitamin D ◽  
Acne Vulgaris ◽  
Serum Vitamin ◽  
Dietary Vitamin ◽  
World Population ◽  
Cross Sectional ◽  
Inflammatory Lesions ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Mean

Objective: Approximately 9.4% of the world population is affected by acne during adolescence. Several previous studies have shown a significant relationship between acne vulgaris (AV) and serum vitamin D levels. The purpose of this study was to determine the correlation between AV and serum vitamin D levels in adolescents. Methods: This cross-sectional study included 60 healthy students with AV aged 15-18 y from three high schools in Depok, which were selected via simple random selection, and the selection of participants was based on consecutive sampling selection after screening with the inclusion criteria. Serum vitamin D levels were evaluated using a direct Chemiluminescence immunoassay (CLIA) method. The lesions of AV were counted by a dermatologist. Dietary vitamin D and fat intake were assessed using a semiquantitative Food Frequency Questionnaire and 24-hour dietary recall. The data were processed using SPSS Statistics 20.0 and analyzed using Pearson or Spearman correlation tests. Results: The mean serum vitamin D level was 17.29±6.77 ng/ml. The mean number of non-inflammatory lesions was 20.5±12.08, and the median number of inflammatory lesions was 6 (range 0-28). The correlation between the number of non-inflammatory lesion and serum vitamin D levels was r = 0.25 (p = 0.052) and the correlation between the number of inflammatory lesions and serum vitamin D levels was r = 0.047 (p = 0.72). Conclusion: Serum vitamin D levels are not significantly correlated with AV despite whether the lesions are inflammatory or non-inflammatory.

Sign in / Sign up

Export Citation Format

Share Document