IMPACT OF DIETARY FACTORS AND INFLAMMATION ON COGNITION AMONG OLDER ADULTS

2015 ◽  
pp. 1-7
Author(s):  
E.P. Handing ◽  
B.J. Small ◽  
S.L. Reynolds ◽  
N.B. Kumar
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Cognitive Function ◽  
Cognitive Performance ◽  
Serum Vitamin ◽  
Plasma Homocysteine ◽  
Dietary Factors ◽  
Serum Folate ◽  
Serum Vitamin D ◽  
Age Related

OBJECTIVE: This study examined the influence of age, nutrition (as measured through food diaries and serum/plasma biomarkers) and inflammatory markers on cognitive performance in adults 60 years of age and older. DESIGN: A cross-sectional population based study, data from the National Health and Nutrition Examination Survey (NHANES; 2001-2002 wave). PARTICIPANTS: This study included 1,048 adults who had valid dietary data, blood biomarkers, were 60 years or older, completed the cognitive test, and had complete demographic information. METHOD: A series of regression models were used to examine the relationship between cognitive function as measured by the Digit Symbol Substitution Task (DSST), dietary factors/biomarkers and inflammation. Mediation analyses were then utilized to examine whether individual nutrients accounted for the relationships between age and DSST performance. RESULTS: Dietary fat intake, serum vitamin E, serum folate, serum iron, plasma homocysteine, and serum vitamin D were significantly associated with better DSST performance. Elevated fibrinogen and C-reactive protein, were significantly associated with poorer cognitive function, but did not remain statistically significant after controlling for age, gender, education, ethnicity, income, and total calorie intake. Serum vitamin D and plasma homocysteine accounted for a portion of age-related variance in DSST. Specifically, higher levels of vitamin D were related to better DSST performance, while higher homocysteine resulted in poorer cognitive performance. CONCLUSION: Diet and nutrition are important modifiable factors that can influence health outcomes and may be beneficial to remediate age-related declines in cognition. Adequate nutrition may provide a primary preventive approach to healthy aging and maintenance of cognitive functioning in older adults.

scholarly journals Serum vitamin d concentrations are associated with falling and cognitive function in older adults

2012 ◽  
Vol 16 (10) ◽  
pp. 898-901 ◽  
Author(s):  
Amie Peterson ◽  
N. Mattek ◽  
A. Clemons ◽  
G. L. Bowman ◽  
T. Buracchio ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Cognitive Function ◽  
Serum Vitamin ◽  
Serum Vitamin D

Serum Vitamin D Concentrations and Cognitive Function in a Population-Based Study among Older Adults in South Germany

2015 ◽  
Vol 45 (4) ◽  
pp. 1119-1126 ◽  
Author(s):  
Gabriele Nagel ◽  
Florian Herbolsheimer ◽  
Matthias Riepe ◽  
Thorsten Nikolaus ◽  
Michael D. Denkinger ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Cognitive Function ◽  
Serum Vitamin ◽  
Population Based ◽  
Population Based Study ◽  
Serum Vitamin D

scholarly journals Cognitive Performance: A Cross-Sectional Study on Serum Vitamin D and Its Interplay With Glucose Homeostasis in Dutch Older Adults

2015 ◽  
Vol 16 (7) ◽  
pp. 621-627 ◽  
Author(s):  
Elske M. Brouwer-Brolsma ◽  
Rosalie A.M. Dhonukshe-Rutten ◽  
Janneke P. van Wijngaarden ◽  
Nikita L. van de Zwaluw ◽  
Paulette H. in 't Veld ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Cognitive Performance ◽  
Glucose Homeostasis ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D

Pysical Fitness And Serum Vitamin D And Cognitive Function In Older Adults

2016 ◽  
Vol 48 ◽  
pp. 317
Author(s):  
Sang-Koo Woo ◽  
Ji-Young Lee ◽  
Haeryun Hong ◽  
Hyun-Sik Kang
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Cognitive Function ◽  
Serum Vitamin ◽  
Serum Vitamin D

The association between serum vitamin d level and cognitive function in older adults: Cooper Center Longitudinal Study

2018 ◽  
Vol 113 ◽  
pp. 57-61 ◽  
Author(s):  
Andjelka Pavlovic ◽  
Katelyn Abel ◽  
Carolyn E. Barlow ◽  
Stephen W. Farrell ◽  
Myron Weiner ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Longitudinal Study ◽  
Cognitive Function ◽  
Serum Vitamin ◽  
Serum Vitamin D

scholarly journals Nutritional Status and Micro Nutrient Deficiencies Among adolescents: A Pilot Study from Northern India (P18-101-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Ankita Kankaria ◽  
Mona Duggal ◽  
Parul Chawla Gupta ◽  
Limalemla Jamir ◽  
Akash Kumar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pilot Study ◽  
Nutritional Status ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Folate Deficiency ◽  
Serum Folate ◽  
Care Hospital ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Abstract Objectives To study the nutritional status and prevalence of RBC folate, Serum folate and vitamin D deficiency among adolescents. Methods A cross sectional pilot study was carried out among 96 adolescents visiting outpatient department for refraction at tertiary care hospital in North India. Anthropometric data was obtained for height in centimetres and weight in kilograms. A pretested questionnaire was used to capture quantitative data. Venous blood samples were collected where red blood cell (RBC), serum folate and serum Vitamin D concentrations were measured. Anaemia was defined as normal, mild, moderate and severe as Hb > 12gm/dl, 11–11.9 gm/dl, 8–10.9 gm/dl and < 8 gm/dl respectively. Serum folate deficiency was defined as serum folate < 7 nmol/l, and RBC folate deficiency and insufficiency were defined as RBC folate < 305 nmol/l and & < 748 nmol/l, respectively. Vitamin D deficiency, insufficiency and sufficiency was defined as 25(OH)D < 20 ng/ml, 20–29 ng/ml and ≥ 30 ng/ml respectively. Descriptive statistics and inferential statistics were used. Results Almost 46% of adolescents were malnourished (10.4% were underweight, 35.4% were overweight or obese) and mean BMI was 19.7 kg/meter2 however it did not differ significantly across gender. As compared to boys more girls were vegetarian by diet. The mean concentrations for Hb, serum folate and RBC folate were 12.7 (95% CI: 12.4, 13.0) gm/dl, 15.1 (95% CI 12.5, 17.7) nmol/L and 492.9 (95% CI 431.9, 553.9) nmol/L, respectively. Mean concentration for Hb was significantly different across gender (p – 0.0). Around 17% of adolescents were anaemic, 60% were deficient for serum folate and 79% were deficient for RBC folate. Mean serum vitamin D levels were 18 ng/dl (95% CI: 17.0, 22.3) no significant difference found across gender. A total of 62.5% were deficient and 28% were insufficient for vitamin D (ng/ml). Around 50% of the adolescents lack adequate sleep (<8 hours) and increase vitamin D levels were associated with increase sleep duration (r-0.02, p-0.02). Conclusions The nutritional status of adolescents in this study is poor and reflects a need to conduct a community-based study which can help in planning strategies to improve nutritional status during critical period of adolescence Funding Sources nil. Supporting Tables, Images and/or Graphs

Higher Serum Vitamin D Concentration Is Associated with Better Balance in Older Adults with Supra-Optimal Vitamin D Status

2013 ◽  
Vol 61 (1) ◽  
pp. 163-165 ◽  
Author(s):  
Cedric Annweiler ◽  
Susan W. Muir ◽  
Shamis Nabeel ◽  
Karen Gopaul ◽  
Olivier Beauchet ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Vitamin D Status ◽  
Serum Vitamin D

scholarly journals Effects of Daily Vitamin D Supplementation on Objectively Measured Physical Activity: Results From the STURDY Trial

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 760-760
Author(s):  
Jennifer Schrack ◽  
Jacek Urbanek ◽  
Amal Wanigatunga ◽  
Stephen Juraschek ◽  
Christine Mitchell ◽  
...  
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Cross Sectional ◽  
Physically Active ◽  
Serum Vitamin D ◽  
Daily Vitamin ◽  
Age Related

Abstract Cross-sectional evidence suggests older adults with higher serum vitamin D are more physically active, but whether long-term vitamin D supplementation attenuates age-related declines in physical activity (PA) is undefined. We examined the association between vitamin D supplementation and daily PA in 639 STURDY participants (aged 77 (5.4) years; 44% women) over up to 24-months. Participants were randomized to receive 200 (n=275), 1000 (n=168), 2000 (n=59), or 4000 (n=63) IU/day of vitamin D3. PA was measured using the Actigraph Link wrist-worn accelerometer 24 hours/day for 7-days at baseline, 3, 12, and 24 months. In linear mixed models adjusted for baseline PA level, total daily PA appeared to decline (β=-43.3 counts, p=0.06) annually for all groups and there was no difference by vitamin D3 dose (p for group*time =0.14). These results suggest daily vitamin D supplementation has no effect on quantities of daily PA.

scholarly journals Effects of 12-Week Multivitamin and Omega-3 Supplementation on Micronutrient Levels and Red Blood Cell Fatty Acids in Pre-menopausal Women

2021 ◽  
Vol 8 ◽  
Author(s):  
Shelby C. Osburn ◽  
Paul A. Roberson ◽  
Jessica A. Medler ◽  
Jacob Shake ◽  
Robert D. Arnold ◽  
...  
Keyword(s):  
Vitamin D ◽  
Placebo Group ◽  
Fatty Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Serum Vitamin ◽  
Serum Folate ◽  
Omega 3 ◽  
Serum Vitamin D ◽  
Vitamin D Levels

The purpose of this study was to validate the efficacy of a customized vitamin-mineral supplement on blood biomarkers in pre-menopausal females. Women (21–40 years old) who were apparently healthy were recruited from the local community (ClinicalTrials.gov trial registration NCT03828097). Pretesting (PRE) occurred in the morning 5 ± 2 days following each participant's menses and involved a fasted blood draw, body mass assessment, and blood pressure assessment. Participants were then randomly assigned in a double-blinded fashion to either the multivitamins (MV) (n = 43) or placebo group (n = 51). Participants consumed two capsules per day with breakfast for 12 weeks. Following the trial, participants reported to the laboratory for POST assessments, which replicated PRE procedures. Red blood cell fatty acid and serum micronutrient analyses were performed in a blinded fashion at hematology laboratories. A group × time interaction was observed for serum vitamin D levels (p &lt; 0.001). MV increased levels from PRE to POST (+43.7%, p &lt; 0.001), whereas no change occurred in the placebo group. Additionally, 78% of MV participants at PRE exhibited inadequate vitamin D levels (&lt;40 ng/dl), whereas only 30% exhibited levels below this threshold at POST. An interaction was also observed for serum folate levels (p &lt; 0.001). MV increased serum folate from PRE to POST (p &lt; 0.001), whereas no change occurred in the placebo group. Red blood cell omega-3 fatty acid content increased from PRE to POST in the MV group (p &lt; 0.001) and placebo group (p &lt; 0.05), although POST values were greater in the MV group (p &lt; 0.001). An interaction was observed for serum HDL cholesterol levels (p = 0.047), and a non-significant increase in this variable from PRE to POST occurred in the MV group (p = 0.060). Four-day food recalls indicated MV increased intake of omega-3 fatty acids, vitamin D, folate, and other micronutrients. In summary, MV supplementation increased serum vitamin D, serum folate, and red blood cell omega-3 fatty acid levels. However, these data are limited to healthy females, and more research is needed to examine if MV can affect metabolic disturbances in individuals with micronutrient deficiencies.

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