CORRELATION STUDY OF ACNE VULGARIS AND SERUM VITAMIN D LEVELS IN ADOLESCENTS

Author(s):  
DYAH SAPTARINI ◽  
FIASTUTI WITJAKSONO ◽  
IRMA BERNADETTE S. SITOHANG

Objective: Approximately 9.4% of the world population is affected by acne during adolescence. Several previous studies have shown a significant relationship between acne vulgaris (AV) and serum vitamin D levels. The purpose of this study was to determine the correlation between AV and serum vitamin D levels in adolescents. Methods: This cross-sectional study included 60 healthy students with AV aged 15-18 y from three high schools in Depok, which were selected via simple random selection, and the selection of participants was based on consecutive sampling selection after screening with the inclusion criteria. Serum vitamin D levels were evaluated using a direct Chemiluminescence immunoassay (CLIA) method. The lesions of AV were counted by a dermatologist. Dietary vitamin D and fat intake were assessed using a semiquantitative Food Frequency Questionnaire and 24-hour dietary recall. The data were processed using SPSS Statistics 20.0 and analyzed using Pearson or Spearman correlation tests. Results: The mean serum vitamin D level was 17.29±6.77 ng/ml. The mean number of non-inflammatory lesions was 20.5±12.08, and the median number of inflammatory lesions was 6 (range 0-28). The correlation between the number of non-inflammatory lesion and serum vitamin D levels was r = 0.25 (p = 0.052) and the correlation between the number of inflammatory lesions and serum vitamin D levels was r = 0.047 (p = 0.72). Conclusion: Serum vitamin D levels are not significantly correlated with AV despite whether the lesions are inflammatory or non-inflammatory.

2021 ◽  
Vol 15 (8) ◽  
pp. 1896-1898
Author(s):  
Aisha Bashir ◽  
Asima Karim ◽  
Asia Kanwal ◽  
Asma Salam

Background: Research reports that serum Vitamin D levels are deficient in AMI patients. Aim: To compare serum Vitamin D levels between AMI patients and healthy controls. Methods: Study design was Cross Sectional Comparative. The study was conducted at Department of Physiology & Cell Biology, University of Health Sciences, Lahore 2018 to 2019. Serum vitamin D levels were measured in 80 study subjects. Among 80 study subjects, 40 had AMI and 40 were healthy controls. Results: The serum Vitamin D levels less than 20ng/ml were considered deficient. Mann Whitney U test was used to compare the groups. The mean serum Vitamin D levels of the AMI patients were significantly lower (7±2.47ng/ml) as compared to healthy controls (17.17±4.8ng/ml) at (p=0.000). Conclusion: AMI patients have significantly lower serum Vit. D levels as compared to healthy individuals. Keywords: Acute myocardial infarction, Serum Vitamin D


Author(s):  
Adil Dinata Simangunsong ◽  
Aryati Aryati ◽  
Azimatul Karimah ◽  
Ferdy Royland Marpaung

Introduction. Vitamin D deficiency is a common health problem that occurs in various countries. Vitamin D deficiency is linked to various diseases such as kidney failure, liver damage, atherosclerosis, obesity and psychiatric disorders such as depression and schizophrenia. This study aimed to analyze the correlation between serum vitamin D levels and schizophrenia severity. Methods. Schizophrenia patients who visited the Inpatient and Outpatient Clinic Department of Psychiatry of the Dr. Soetomo Hospital Surabaya. This was a cross-sectional observational study, conducted in December 2017 - April 2018 . The subjects consisted of 53 schizophrenia patients, vitamin D levels < 30 ng /mL (35 (66.04%); > 30 ng/mL (18 (33.96%). Serum vitamin D levels test by enzyme linked fluorescent assay (ELFA) method using Vidas. The severity of schizophrenia was measured using a positive and negative syndrome scale (PANSS) score. Results. Mean serum vitamin D levels in schizophrenia were 23.45 ± 9.16 ng / mL, serum vitamin D levels in males were 24.36 ± 9.80 ng / ml and females 21.96 ± 7.98 ng / ml. The mean serum vitamin D level and PANSS scores of positive symptoms was 16.42 ± 8.50. The mean serum vitamin D level and PANSS scores of negative symptoms was 15.60 ± 6.12. The mean serum vitamin D level and PANSS scores of general psychopathology symptoms was 29.51 ± 10.29. The statistical results showed no association between vitamin D levels and PANSS scores. Conclusion. The results of this study indicated low serum vitamin D levels in schizophrenia. There was no association between serum vitamin D levels and the severity of schizophrenia using PANSS scores.


Author(s):  
Chandan Sharma

Background: Bronchial asthma is one of the most common chronic diseases. In India, bronchial asthma has 66% frequency of reported exacerbations. Vitamin D has action on pro-inflammatory mediators and smooth muscle function and proliferation, which has direct relevance for lung function in asthma.Methods: The cross sectional observational study was conducted in the Department of Medicine, Government Medical College Jammu for 10 months from January 2018-August 2018. 50 Patients of 18-60 years with diagnosis of bronchial asthma on the basis of clinical and radiological signs were included, while age matched 50 controls years free from any disease and morbidity were included and assessed for vitamin D levels.Results: The mean serum vitamin D level was significantly low at 26.13±4.91 ng/ml in patients, while 39.67±4.03 ng/ml was the mean vitamin D level of controls. The vitamin D levels of mild and moderate (persistent) asthma patients was seen lower than those of the controls.Conclusions: Vitamin D deficiency is highly prevalent in patients during exacerbations of bronchial asthma. It is also associated with lower lung functions and increased number of exacerbations. Thus improving vitamin D status may be effective in the prevention and treatment of bronchial asthma and exacerbations.


Author(s):  
Marzieh Shukohifar ◽  
Ali Dadbinpour ◽  
Zohre Sadat Mozafari ◽  
Mohadeseh Zarei Yazdeli

Introduction: Vitamin D is a hormonal precursor that in addition to known roles, may have an important effect on mental disorders such as depression. Therefore, this study was performed to determine the extent of vitamin D deficiency and depression and their relationship in thyroid patients referred to The clinic of Yazd Diabetes Center has been performed. Methods: The present study is a cross-sectional-analytical study that was performed on 150 thyroid patients referred to the Yazd Diabetes Center Clinic. Results: In this study, 150 thyroid patients including 55 men and 11. women with a mean age of 41.40± 7.61years participated. The mean score of Beck depression among these patients was 28.71± 8.34 .The mean level of vitamin D in these patients was 20.58 ± 7.21  ng / ml so that a total of 85% of thyroid patients were in the group of insufficient levels of vitamin D. A significant negative correlation was observed between depression score and serum vitamin D levels (r = -0.79 and p <0.001). Conclusion: The results of this study indicate a high prevalence of depression and vitamin D deficiency in thyroid patients. Another finding of this study was the relationship between vitamin D deficiency and depression, so that the less vitamin D in the body, the lower the rate of depression in The person becomes more. The use of vitamin D supplements in the treatment of thyroid patients with depression, as a clinical trial, can be a good solution in the treatment of patients.


2021 ◽  
Vol 16 (3) ◽  
Author(s):  
Seyed Jalal Eshagh Hosseini ◽  
Farzin Davoodi ◽  
Alireza Sharifi ◽  
Zahra Abbasi

Background: Recent studies have shown that insufficient vitamin D supply is correlated with increase in COVID-19 cases and its mortality. Potentially, it may play an important role in controlling virus proliferation. Objectives: This study aimed to evaluate the association between serum vitamin D levels and clinical findings, and mortality rate in patients with COVID-19. Methods: This cross-sectional study was conducted on 200 COVID-19 patients referred or admitted to Loghman-e-Hakim Hospital of Tehran, Iran, from February to June 2020. After patient selection, demographic information of all patients was recorded. Eventually, the relationship between basic demographic and clinical findings with vitamin D levels in all patients was evaluated. Results: The mean Vit-D levels in intubated and non-intubated patients were 22.95 ± 22.23 ng/mL and 21.64 ± 29.20 ng/mL, respectively (P = 0.018). In most of the outpatients (46.7%), Vit-D levels were between 21 - 30 ng/mL, and 47.6% of admitted patients had Vit-D ≤ 20 ng/mL. The mean Vit-D level in survived patients was significantly higher than patients who died (28.2 ± 21.18 ng/mL vs. 19.91 ± 14.18 ng/mL, respectively; P = 0.021). While 34.2% (55 cases) of survived patients had Vit-D level ≥ 31 ng/mL, about 70% of death cases had Vit-D ≤ 20 ng/mL (P < 0.001). Conclusions: According to our results, vitamin D supplementation could be beneficial in COVID-19 patients. However, further comprehensive clinical trials are needed to confirm these findings.


2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.


2017 ◽  
Vol 75 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Yara Dadalti Fragoso ◽  
Tarso Adoni ◽  
Soniza Vieira Alves-Leon ◽  
Samira L. Apostolos-Pereira ◽  
Walter Oleschko Arruda ◽  
...  

ABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26.07 ± 10.27 ng/mL for the control subjects, and 28.03 ± 12.19 ng/mL for patients with MS. No correlation was observed between vitamin D levels and the disability of patients over the disease duration. Conclusion: At least for the region around the Tropic of Capricorn, serum levels of vitamin D typically are within the range of 20 to 30 ng/mL for controls and patients with MS.


2021 ◽  
Vol 4 (1) ◽  
pp. 64-71
Author(s):  
Shasya Aniza Santoso ◽  
◽  
Tita Husnitawati Madjid ◽  
Anita Rachmawati

Objective: This study was aimed to determine the correlation between vitamin D and insulin resistance in women with PCOS. Method: This study was correlational analytic with cross-sectional approach to 34 women diagnosed with PCOS based on ultrasonography. Waist circumference and fasting blood glucose (FBG) represented insulin resistance. Women with hormonal therapy and vitamin D supplementation were not included to this study. This study used consecutive sampling method. Result: The average of age was 25.6±6.1 years old. Waist circumference and fasting blood glucose (FBG) represented insulin resistance. The average of waist circumference and FBG were 87.6±12.4 cm and 86.2±27.9 mg/dl, respectively. The mean of vitamin D levels was 11,5±3,6 ng/ml. According to Spearman’s correlation, vitamin D levels were weak negative correlated with waist circumference (r=-0.2; p>0.05) and FBG (r= -0,1; p>0,05), it statistically was not significant. Conclusion: There is weak negative correlation between vitamin D and metabolic syndrome in PCOS patients.


2021 ◽  
Vol 149 ◽  
Author(s):  
Aysegul Alpcan ◽  
Serkan Tursun ◽  
Yaşar Kandur

Abstract Several studies have demonstrated that higher levels of vitamin D are associated with better prognosis and outcomes in infectious diseases. We aimed to compare the vitamin D levels of paediatric patients with mild/moderate coronavirus disease 2019 (COVID-19) disease and a healthy control group. We retrospectively reviewed the medical records of patients who were hospitalised at our university hospital with the diagnosis of COVID-19 during the period between 25 May 2020 and 24 December 2020. The mean age of the COVID-19 patients was 10.7 ± 5.5 years (range 1–18 years); 43 (57.3%) COVID-19 patients were male. The mean serum vitamin D level was significantly lower in the COVID-19 group than the control group (21.5 ± 10.0 vs. 28.0 ± 11.0 IU, P < 0.001). The proportion of patients with vitamin D deficiency was significantly higher in the COVID-19 group than the control group (44% vs. 17.5%, P < 0.001). Patients with low vitamin D levels were older than the patients with normal vitamin D levels (11.6 ± 4.9 vs. 6.2 ± 1.8 years, P = 0.016). There was a significant male preponderance in the normal vitamin D group compared with the low vitamin D group (91.7% vs. 50.8%, P = 0.03). C-reactive protein level was higher in the low vitamin D group, although the difference did not reach statistical significance (9.6 ± 2.2 vs. 4.5 ± 1.6 mg/l, P = 0.074). Our study provides an insight into the relationship between vitamin D deficiency and COVID-19 for future studies. Empiric intervention with vitamin D can be justified by low serum vitamin D levels.


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