scholarly journals Myoepithelioma of the Parotid Gland: A Case Report with Review of the Literature and Classic Histopathology

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Mark Weitzel ◽  
Jason E. Cohn ◽  
Harvey Spector
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Benign Tumor ◽  
Clinical Presentation ◽  
Acinar Cells ◽  
Salivary Gland Neoplasm ◽  
Minor Salivary Glands ◽  
Review Of The Literature ◽  
Basal Plasma Membrane ◽  
Basal Plasma

Myoepithelioma is a rare salivary gland neoplasm. They most commonly affect the major and minor salivary glands with the parotid gland being the most common, approximately 40%. Only 1% of all salivary gland neoplasms are myoepitheliomas. Myoepithelioma is usually a benign tumor arising from neoplastic myoepithelial or basket cells which are found between the basement membrane and the basal plasma membrane of acinar cells. They also contain multiple cellular elements. We present a case of a 73-year-old female with myoepithelioma of the parotid gland, an extremely rare neoplasm. There have been approximately 42 cases reported through 1985 and fewer than 100 cases through 1993. We will discuss the clinical presentation, pathophysiology, diagnosis, and treatment of such neoplasms.

scholarly journals An analysis of Salivary Gland Neoplasms: A 12-Year, Single-Institution Experience in Turkey

2012 ◽  
Vol 91 (3) ◽  
pp. 125-129 ◽  
Author(s):  
Demet Etit ◽  
Nese Ekinci ◽  
Ayca Tan ◽  
Deniz Altinel ◽  
Filiz Dag
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Turkish Population ◽  
Salivary Gland Tumors ◽  
Salivary Gland Neoplasm ◽  
Malignant Neoplasms ◽  
Minor Salivary Glands ◽  
Single Institution ◽  
Common Malignancy

The epidemiology of salivary gland tumors worldwide is not very well defined. Although many studies on this subject have been undertaken, the data are generally focused on specific topics such as parotid gland neoplasms or tumors of the major salivary glands. We conducted a study to establish the prevalence and distribution of benign and malignant neoplasms of both the major and minor salivary glands at a single institution. We reviewed 244,204 cases that had come through our pathology department from January 1994 through December 2005 and found 235 cases of a salivary gland neoplasm (0.09%). The female-to-male ratio was 1.04:1, and the mean age of the patients was 47 years. Of the 235 neoplasms, 159 (67.66%) were located in the parotid gland, 34 (14.47%) in the submandibular gland, and 42 (17.87%) in the minor salivary glands. A total of 146 tumors (62.13%) were benign and 89 (37.87%) were malignant. Pleomorphic adenoma was the most common neoplasm, occurring in 98 cases (41.70%). The most common malignancy was mucoepidermoid carcinoma, with 27 cases (11.49%). Our data demonstrate that the characteristics of salivary gland tumors in a Turkish population at a single institution are similar to those reported in the literature worldwide.

scholarly journals Myoepithelial Carcinoma Arising in a Plasmacytoid Myoepithelioma of the Parotid Gland Synchronized with Melanoma: A Case Report and Review of the Literature

2021 ◽  
pp. 173-183
Author(s):  
Pamela Denisse Soberanis-Piña ◽  
Ricardo Fernández-Ferreira ◽  
Héctor Hugo Buerba-Vieregge ◽  
Edgar Varela-Santoyo ◽  
Jerónimo Rafael Rodriguez-Cid ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
English Language ◽  
De Novo ◽  
Complete Response ◽  
Salivary Gland Neoplasm ◽  
Myoepithelial Carcinoma ◽  
Review Of The Literature ◽  
Nodal Dissection ◽  
Language Literature

Myoepithelial carcinoma, also known as malignant myoepithelioma, is considered an extremely rare (0.45–1%) malignant salivary gland neoplasm. Approximately 100 cases have been reported in the English-language literature on myoepithelial carcinoma. The majority of the myoepitheliomas described in the literature have been benign, and the malignant counterpart is considered rare (<1%). Such a tumor may appear de novo or rarely develop from a preexisting pleomorphic adenoma (<20%), and in exceedingly rare cases (<0.5%), it has arisen from a benign myoepithelioma (i.e., plasmacytoid myoepithelioma). To our knowledge, no case of myoepithelial carcinoma of the parotid gland arising in a plasmacytoid myoepithelioma synchronized with melanoma has been reported to date. The treatment of myoepithelial carcinoma has been mainly surgical, including wide excision with free margins, with or without nodal dissection. The roles of chemotherapy and radiotherapy have not yet been established. We report a case of myoepithelial carcinoma of the parotid gland arising in a plasmacytoid myoepithelioma synchronized with melanoma in a 40-year-old woman. In our case, a complete response was achieved with surgery followed by adjuvant chemotherapy based on carboplatin and paclitaxel concurrent with radiotherapy.

scholarly journals Neurofibromin expression by normal salivary glands

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Eloá Borges Luna ◽  
Pâmella Pinho Montovani ◽  
Rafaela Elvira Rozza-de-Menezes ◽  
Karin Soares Cunha
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Acinar Cells ◽  
Staining Intensity ◽  
Neurofibromatosis 1 ◽  
Tissue Type ◽  
Sublingual Gland ◽  
Minor Salivary Glands ◽  
Expression Levels ◽  
Ductal Cells

AbstractIntroductionNeurofibromin, a protein encoded by theNF1gene, is mutated in neurofibromatosis 1, one of the most common genetic diseases. Oral manifestations are common and a high prevalence of hyposalivation was recently described in individuals with neurofibromatosis 1. Although neurofibromin is ubiquitously expressed, its expression levels vary depending on the tissue type and developmental stage of the organism. The role of neurofibromin in the development, morphology, and physiology of salivary glands is unknown and a detailed expression of neurofibromin in human normal salivary glands has never been investigated.AimTo investigate the expression levels and distribution of neurofibromin in acinar and ductal cells of major and minor salivary glands of adult individuals without NF1.Material and methodTen samples of morphologically normal major and minor salivary glands (three samples of each gland: parotid, submandibular and minor salivary; and one sample of sublingual gland) from individuals without neurofibromatosis 1 were selected to assess neurofibromin expression through immunohistochemistry. Immunoquantification was performed by a digital method.ResultsNeurofibromin was expressed in the cytoplasm of both serous and mucous acinar cells, as well as in ducts from all the samples of salivary glands. Staining intensity varied from mild to strong depending on the type of salivary gland and region (acini or ducts). Ducts had higher neurofibromin expression than acinar cells (p = 0.003). There was no statistical association between the expression of neurofibromin and the type of the salivary gland, considering acini (p = 0.09) or ducts (p = 0.50) of the four salivary glands (parotid, submandibular, minor salivary, and sublingual gland). Similar results were obtained comparing the acini (p = 0.35) and ducts (p = 0.50) of minor and major salivary glands. Besides, there was no correlation between the expression of neurofibromin and age (p = 0.08), and sex (p = 0.79) of the individuals, considering simultaneously the neurofibromin levels of acini and duct (n = 34).ConclusionNeurofibromin is expressed in the cytoplasm of serous and mucous acinar cells, and ductal cells of salivary glands, suggesting that this protein is important for salivary gland function.

Terminal duct adenocarcinomas of the parotid gland

1995 ◽  
Vol 109 (5) ◽  
pp. 466-468 ◽  
Author(s):  
Bonnie L. Kemp ◽  
John G. Batsakis ◽  
Adel K. El-Naggar ◽  
Sophia N. Kotliar ◽  
Mario A. Luna
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Minor Salivary Gland ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Biological Behaviour ◽  
Parotid Neoplasms ◽  
Clinicopathological Study

AbstractThe major salivary glands are considered to rarely be the sites of primary terminal duct adenocarcinomas, a neoplasm with a considerable predilection for origin from intraoral minor salivary glands. We present a clinicopathological study of 22 terminal duct adenocarcinomas of the parotid gland, the largest single series to date. A comparison between the parotid neoplasms and over 200 minor salivary gland terminal duct adenocarcinomas indicates there is little difference in biological behaviour and confirms the low-grade quality of the carcinomas, regardless of site of origin.

scholarly journals Tubular Type of Basal Cell Adenoma of Parotid Gland: A Rare Entity

2015 ◽  
Vol 5 (3) ◽  
pp. 184-187
Author(s):  
Pratik Dipak Shah ◽  
Srijon Mukherji
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Basal Cell ◽  
Myoepithelial Cell ◽  
Rare Case ◽  
Salivary Gland Neoplasm ◽  
Rare Entity ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Tubular Type

ABSTRACT Basal cell adenoma (BCA) is a significantly rare benign salivary gland neoplasm that includes isomorphic basaloid cells. Presence of myoepithelial cell is a characteristic of this tumor. Basal cell adenoma accounts for only 1 to 2% of all salivary gland epithelial tumors. The goal of the paper is to report a rare case of tubular type of BCA arising from parotid gland and discuss its management. How to cite this article Shah PD, Mukherji S. Tubular Type of Basal Cell Adenoma of Parotid Gland: A Rare Entity. J Contemp Dent 2015;5(3):184-187.

Basal cell adenocarcinoma of the parotid gland: a case report and review of the literature

1993 ◽  
Vol 107 (9) ◽  
pp. 862-864 ◽  
Author(s):  
Timo Atula ◽  
Pekka-Juhani Klemi ◽  
Karl Donath ◽  
Risto-Pekka Happonen ◽  
Heikki Joensuu ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Parotid Gland ◽  
Basal Cell ◽  
Mitotic Rate ◽  
Therapeutic Result ◽  
Review Of The Literature ◽  
Total Removal ◽  
Basal Cell Adenocarcinoma ◽  
Gland Tumour

AbstractBasal cell adenocarcinoma is a rare salivary gland tumour. A DNA diploid parotid gland basal cell adenocarcinoma, with a low mitotic rate, in a 78-year-old female patient is described. Total removal of the affected salivary gland without sacrificing the facial nerve gave a good therapeutic result.

Occult Primary Parotid Gland Acinic Cell Adenocarcinoma Presenting With Extensive Lung Metastasis

2007 ◽  
Vol 131 (6) ◽  
pp. 970-973
Author(s):  
Fabio Tavora ◽  
Negar Rassaei ◽  
Konstantin Shilo ◽  
Robert D. Foss ◽  
Jeffrey R. Galvin ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Clinical Evaluation ◽  
Distant Metastases ◽  
Salivary Gland Neoplasm ◽  
Regional Lymph Nodes ◽  
Acinic Cell ◽  
Parotid Carcinoma ◽  
Peripheral Lung ◽  
Gland Type

Abstract Acinic cell adenocarcinoma is a malignant salivary gland neoplasm with a relatively low rate of lymphangitic spread to regional lymph nodes. Distant metastases are rare and their occurrence typically indicates an unfavorable outcome. We encountered an unusual example of acinic cell adenocarcinoma that initially presented in the lung, whereas the primary parotid carcinoma, despite extensive clinical evaluation, only became apparent 1 year after initial diagnosis. The histologic, immunohistochemical, and ultrastructural features of the tumor in the parotid gland and lung were similar. The tumor displayed an aggressive behavior resulting in death within 2 years of the initial presentation. This presentation is unique, showing that peripheral lung tumors of salivary gland type are likely to be metastatic, and careful clinical evaluation is warranted in establishing their primary site of origin.

scholarly journals A Single Liver Metastasis From Adenoid Cystic Carcinoma of the Parotid Gland: Case Report

2019 ◽  
Vol 7 ◽  
pp. 232470961987963
Author(s):  
Ines Zemni ◽  
Nesrine Tounsi ◽  
Imene Bouraoui ◽  
Maher Slimene ◽  
Ghada Sahraoui ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Liver Metastasis ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Malignant Neoplasm ◽  
Salivary Gland Cancer ◽  
Review Of The Literature ◽  
Adenoid Cystic ◽  
Disease Free ◽  
Rare Situation

Adenoid cystic carcinoma is an uncommon malignant neoplasm of the salivary gland. Liver metastasis from salivary gland cancer is a rare situation. In this article, we report the case of a 29-year-old woman treated 5 years previously for adenoid cystic carcinoma of the parotid gland by surgery and radiotherapy, who presented for a large hypervascularized hepatic metastasis of 20 cm. After 3-cycle chemotherapy stability, hepatic surgery was successfully performed. The patient maintained disease-free period of 12 months after the surgical treatment. This rare case represents a therapeutic challenge for oncologists and surgeons. Through this case and a review of the literature, we try to better detail the management of this uncommon entity.

scholarly journals Nasopharyngeal Pleomorphic Adenoma: A Rare Case Report and Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Serdal Celik ◽  
Osman Kilic ◽  
Tulay Zenginkinet ◽  
M. Tayyar Kalcioglu
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Pleomorphic Adenoma ◽  
Relevant Literature ◽  
Minor Salivary Gland ◽  
Minor Salivary Glands ◽  
Review Of The Literature ◽  
Neck Tumors ◽  
Rare Case Report ◽  
Chondroid Metaplasia

Salivary gland tumors are rare among all head and neck tumors. Pleomorphic adenoma (PA) is the most commonly seen subtype, and 85% of the cases are located in the parotid gland. PA may very rarely be seen in minor salivary glands. Minor salivary gland PAs are mostly located in the hard and soft palates. Nasopharyngeal PA is very rare, and a total of 8 cases have been published to date. In this case report, a 51-year-old female patient who had nasopharyngeal PA with chondroid metaplasia is presented, and we review the relevant literature.

scholarly journals Salivary Duct Cyst: Histo-pathologic Correlation

2013 ◽  
Vol 3 ◽  
pp. 3 ◽  
Author(s):  
Divya Vinayachandran ◽  
Sathasivasubramanian Sankarapandian
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Minor Salivary Glands ◽  
Salivary Duct ◽  
Duct Cyst ◽  
Superficial Lobe ◽  
Salivary Duct Cyst ◽  
Left Parotid Gland ◽  
Histopathologic Features

Non-neoplastic cysts of the salivary glands are uncommon and represent 2-5% of all salivary gland lesions. They are mainly mucoceles or salivary duct cysts. Unlike a mucocele, which is surrounded by granulation tissue, the salivary duct cyst is lined by epithelium. Salivary duct cysts are more common in the oral minor salivary glands and rarely occur in the major salivary glands, show a marked predilection for the superficial lobe of the parotid, and represent 10% of all salivary gland cysts. Neoplastic differentiation of the lining of the salivary duct cyst has been reported. We report a case of a salivary duct cyst of the left parotid gland, with a review of radiographic and histopathologic features.

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