scholarly journals Emulation with Organic Memristive Devices of Impairment of LTP Mechanism in Neurodegenerative Disease Pathology

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Silvia Battistoni ◽  
Victor Erokhin ◽  
Salvatore Iannotta

We explore and demonstrate the extension of the synapse-mimicking properties of memristive devices to a dysfunctional synapse as it occurs in the Alzheimer’s disease (AD) pathology. The ability of memristive devices to reproduce synapse properties such as LTP, LTD, and STDP has been already widely demonstrated, and moreover, they were used for developing artificial neuron networks (perceptrons) able to simulate the information transmission in a cell network. However, a major progress would be to extend the common sense of neuromorphic device even to the case of dysfunction of natural synapses. Can memristors efficiently simulate them? We provide here evidences of the ability of emulating the dysfunctional synaptic behavior typical of the AD pathology with organic memristive devices considering the effect of the disease not only on a single synapse but also in the case of a neural network, composed by numerous synapses.

Author(s):  
Carlos Sastre Jurado ◽  
P. Breul ◽  
Miguel Benz Navarette ◽  
C. Bacconnet

Conventional geotechnical soil classifications aim to classify soils into families with geotechnical characteristics and therefore similar behaviour, however, they require core samples and laboratory identification testing. Several empirical systems for estimating the nature of the soils have been developed on the basis of several in situ geotechnical tests. However, at present these systems remain empirical and they are often only used on an indicative basis. The objective of this article is, based on the analysis of dynamic penetrometric signals, to develop a methodology able to provide an estimate of the nature of the soil crossed. The methodology developed provide an automatic classification based on Artificial Neuron Networks (ANN) tools. Two types of ANN architectures were considered: Multilayer Feedforward Perceptron (MFP) and Probabilistic Neural Network (PNN). The learning of these two tools was achieved through a base carried out in the laboratory and in situ. The both classification models were then tested in blind conditions and showed a good efficiency for calibrated soils and promising results for in situ soils.


2019 ◽  
Vol 17 (1) ◽  
pp. 23-37
Author(s):  
Mark Boespflug
Keyword(s):  

The common sense that heavily informs the epistemology of Thomas Reid has been recently hailed as instructive with regard to some of the most fundamental issues in epistemology by a burgeoning segment of analytic epistemologists. These admirers of Reid may be called dogmatists. I highlight three ways in which Reid's approach has been a model to be imitated in the estimation of dogmatists. First, common sense propositions are taken to be the benchmarks of epistemology inasmuch as they constitute paradigm cases of knowledge. Second, dogmatists follow Reid in taking common sense propositions to provide boundaries for philosophical theorizing. Inasmuch as philosophical theorizing leads one to deny a common sense proposition, such theorizing is stepping outside of the bounds of what it can or should do. Third, dogmatists follow Reid in focusing heavily on the problem of skepticism and by responding to it by refusing to answer the demand for a meta-justification that the skeptic wants.


2016 ◽  
Vol 14 (1) ◽  
pp. 51-67 ◽  
Author(s):  
Manuel Barrantes ◽  
Juan M. Durán

We argue that there is no tension between Reid's description of science and his claim that science is based on the principles of common sense. For Reid, science is rooted in common sense since it is based on the (common sense) idea that fixed laws govern nature. This, however, does not contradict his view that the scientific notions of causation and explanation are fundamentally different from their common sense counterparts. After discussing these points, we dispute with Cobb's ( Cobb 2010 ) and Benbaji's ( Benbaji 2003 ) interpretations of Reid's views on causation and explanation. Finally, we present Reid's views from the perspective of the contemporary debate on scientific explanation.


1998 ◽  
Vol 4 (5-6) ◽  
pp. 62-66
Author(s):  
I.D. Gorbenko ◽  
◽  
Yu.V. Stasev ◽  
A.V. Pot ◽  
A.M. Tkachev ◽  
...  

2011 ◽  
Vol 42 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Sebastian Michalak

Motives of espionage against ones own country in the light of idiographic studies The money is perceived as the common denominator among people who have spied against their own country. This assumption is common sense and appears to be self-evident truth. But do we have any hard evidences to prove the validity of such a statement? What method could be applied to determine it? This article is a review of the motives behind one's resorting to spying activity which is a complex and multifarious process. I decided to present only the phenomenon of spying for another country. The studies on the motives behind taking up spying activity are idiographic in character. One of the basic methodological problems to be faced by the researchers of this problem is an inaccessibility of a control group.


2018 ◽  
Vol 4 (1) ◽  
Author(s):  
William Benzon

Sydney Lamb’s model focuses our attention on the physicality of language, of the signs themselves as objects in the external world and the neural systems the support them. By means of the metaphor of a cognitive dome, he demonstrates that there is no firm line between linguistic and cognitive structure. In this context, I offer physically grounded accounts of Jakobson’s metalingual and emotive functions. Drawing on Vygotsky’s account of language development, I point out that inner speech, corresponding to the common sense notion of thought, originates in a circuit that goes through the external world and is then internalized.


1993 ◽  
Vol 10 (2) ◽  
pp. 165-177
Author(s):  
Karen Harding

Ate appearances deceiving? Do objects behave the way they do becauseGod wills it? Ate objects impetmanent and do they only exist becausethey ate continuously created by God? According to a1 Ghazlli, theanswers to all of these questions ate yes. Objects that appear to bepermanent are not. Those relationships commonly tefemed to as causalare a result of God’s habits rather than because one event inevitably leadsto another. God creates everything in the universe continuously; if Heceased to create it, it would no longer exist.These ideas seem oddly naive and unscientific to people living in thetwentieth century. They seem at odds with the common conception of thephysical world. Common sense says that the universe is made of tealobjects that persist in time. Furthermore, the behavior of these objects isreasonable, logical, and predictable. The belief that the univetse is understandablevia logic and reason harkens back to Newton’s mechanical viewof the universe and has provided one of the basic underpinnings ofscience for centuries. Although most people believe that the world is accutatelydescribed by this sort of mechanical model, the appropriatenessof such a model has been called into question by recent scientificadvances, and in particular, by quantum theory. This theory implies thatthe physical world is actually very different from what a mechanicalmodel would predit.Quantum theory seeks to explain the nature of physical entities andthe way that they interact. It atose in the early part of the twentieth centuryin response to new scientific data that could not be incorporated successfullyinto the ptevailing mechanical view of the universe. Due largely ...


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