Sirolimus Ointment for Facial Angiofibromas in Individuals with Tuberous Sclerosis Complex

Background. Facial angiofibromas affect most patients with tuberous sclerosis complex. They tend to progress, can cause recurrent bleeding and facial disfigurement, and have significant psychological effects. We reviewed the effectiveness and safety of topical sirolimus ointment 0.1%. We also assessed the effect of treatment on quality of life. Methods. We report our experience in using sirolimus ointment in 14 patients with TSC (9 children and 5 adults). The impact of sirolimus ointment was monitored with digital photography, dermatological review using a validated Facial Angiofibroma Severity Index (FASI), and quality of life assessments using the questionnaires PedsQL for children and SF36 for adults. Results. The FASI scores were improved in 12/14 cases after six months’ treatment, and improvement was more likely in children (median FASI scores of improvement after treatment were 3 points for children and 1 for adults). Proxy-reported PedsQL scores for the total psychosocial domain improved significantly in the children in the cohort with treatment. Conclusions. Sirolimus ointment 0.1% administered once a day was effective in treating facial angiofibromas. It appears to be safe and well tolerated and to have a positive impact on patients’ quality of life. It appeared to be most beneficial when started in childhood.

Download Full-text

Strategic Role of Zakat in Multidimensional Quality of Life in Sijunjung, Indonesia

The Journal of Muamalat and Islamic Finance Research ◽

10.33102/jmifr.v15i1.101 ◽

2018 ◽

Vol 15 (1) ◽

pp. 55-72

Author(s):

Herlin Hamimi ◽

Abdul Ghafar Ismail ◽

Muhammad Hasbi Zaenal

Keyword(s):

Quality Of Life ◽

Positive Impact ◽

Wealth Distribution ◽

Absolute Poverty ◽

Before And After ◽

The Status ◽

Being There ◽

The Impact

Zakat is one of the five pillars of Islam which has a function of faith, social and economic functions. Muslims who can pay zakat are required to give at least 2.5 per cent of their wealth. The problem of poverty prevalent in disadvantaged regions because of the difficulty of access to information and communication led to a gap that is so high in wealth and resources. The instrument of zakat provides a paradigm in the achievement of equitable wealth distribution and healthy circulation. Zakat potentially offers a better life and improves the quality of human being. There is a human quality improvement not only in economic terms but also in spiritual terms such as improving religiousity. This study aims to examine the role of zakat to alleviate humanitarian issues in disadvantaged regions such as Sijunjung, one of zakat beneficiaries and impoverished areas in Indonesia. The researcher attempted a Cibest method to capture the impact of zakat beneficiaries before and after becoming a member of Zakat Community Development (ZCD) Program in material and spiritual value. The overall analysis shows that zakat has a positive impact on disadvantaged regions development and enhance the quality of life of the community. There is an improvement in the average of mustahik household incomes after becoming a member of ZCD Program. Cibest model demonstrates that material, spiritual, and absolute poverty index decreased by 10, 5, and 6 per cent. Meanwhile, the welfare index is increased by 21 per cent. These findings have significant implications for developing the quality of life in disadvantaged regions in Sijunjung. Therefore, zakat is one of the instruments to change the status of disadvantaged areas to be equivalent to other areas.

Download Full-text

Tinnitus Impact: Three Different Measurement Tools

Journal of the American Academy of Audiology ◽

10.1055/s-0040-1715725 ◽

2003 ◽

Vol 14 (04) ◽

pp. 181-187 ◽

Cited By ~ 8

Author(s):

Christopher D. Bauch ◽

Susan G. Lynn ◽

Donald E. Williams ◽

Michael W. Mellon ◽

Amy L. Weaver

Keyword(s):

Quality Of Life ◽

Severity Index ◽

Assessment Tools ◽

Symptom Checklist ◽

Tinnitus Handicap Inventory ◽

Measurement Tools ◽

Medical Population ◽

High Level ◽

The Impact

The impact of tinnitus and overall levels of distress were measured with three assessment tools for patients with tinnitus. The Tinnitus Handicap Inventory (THI), the Symptom Checklist-90-Revised (SCL-90-R) and an activities limitations questionnaire were administered to 53 audiology patients reporting tinnitus. Forty-three percent of these patients experienced either quality of life reductions associated with tinnitus, substantial perceived handicap, and/or a high level of distress. Results from the General Severity Index (GSI) of the SCL-90-R indicated that 25% of these patients displayed distress greater than that of the general medical population. The SCL-90-R can be a useful tool for audiologists working with tinnitus patients in assessing needs for referral for psychological or psychiatric counseling.

Download Full-text

Positive impact of cladribine on quality of life in people with relapsing multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458517726380 ◽

2017 ◽

Vol 24 (11) ◽

pp. 1461-1468 ◽

Cited By ~ 6

Author(s):

Dayo Afolabi ◽

Christo Albor ◽

Lukasz Zalewski ◽

Dan R Altmann ◽

David Baker ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Positive Impact ◽

Rank Correlation ◽

Phase Iii ◽

European Medicines Agency ◽

Total N ◽

The Impact ◽

Relapsing Multiple Sclerosis

Background: A number of elements of the pivotal ‘cladribine tablets treating multiple sclerosis orally’ (CLARITY) trial have remained unpublished. Objective: To report the impact of cladribine on health-related quality of life (QoL) in people with relapsing multiple sclerosis (pwRMS). Methods: QoL data from the phase III trial of two different doses (3.5 and 5.25 mg/kg) of oral cladribine in pwRMS were acquired from the European Medicines Agency through Freedom of Information. Spearman’s rank correlation was used to analyse the relationship between baseline QoL scores and baseline Expanded Disability Status Scale (EDSS) scores. Responses of the Euro Quality of Life 5 Dimensions (EQ-5D) and Multiple Sclerosis Quality of Life-54 (MSQOL-54) questionnaires were compared between treatment and control groups using univariate analyses of covariance. Results: In total, n = 5148 EQ-5D responses and n = 894 MSQOL-54 physical, mental health and dimension scores were extracted. Baseline EQ-5D indices correlated with EDSS scores. After 2 years, pwRMS taking 3.5 ( p = .001) and 5.25 mg/kg ( p = .022) reported significantly improved EQ-5D index scores compared with placebo. Positive, yet non-significant, differences were detected in MSQOL-54 scores between cladribine and placebo. Conclusion: Analysis of the CLARITY dataset suggests that, over and above its established clinical efficacy, cladribine leads to improved QoL over 96 weeks. ClinicalTrials.gov identifier: NCT00213135.

Download Full-text

Impact of low vision services on the quality of life of low vision patients in Ghana

African Vision and Eye Health ◽

10.4102/aveh.v75i1.19 ◽

2016 ◽

Vol 75 (1) ◽

Author(s):

Godwin O. Ovenseri-Ogbomo ◽

Harriette Osafo-Agyei ◽

Ralph E.U. Akpalaba ◽

James Addy ◽

Elizabeth O. Ovenseri

Keyword(s):

Quality Of Life ◽

Visual Acuity ◽

Positive Impact ◽

Low Vision ◽

Care Quality ◽

Eastern Region ◽

Post Intervention ◽

Low Vision Clinic ◽

The Impact

Patients’ perspectives on the impact of clinical interventions have been recognised as critical elements in patient care. Quality-of-life instruments are designed to measure these perspectives. We used the National Eye Institute’s 25-item Visual Function Questionnaire (NEI VFQ) to measure the impact of optical low vision devices on the quality of life of 22 low vision patients who obtained and were using low vision devices from a secondary low vision clinic in the Eastern Region, Ghana. The study employed a pre- and post-intervention technique. We found statistically significant improvements in measured visual acuity and NEI VFQ scores in 8 of the 10 domains evaluated. We conclude that optical low vision devices have a positive impact on the quality of life of low vision patients in Ghana.Keywords: low vision; quality of life; visual acuity; visual impairment; Ghana

Download Full-text

Perspectives of Entrepreneurial Orientation with the Quality of Life

Journal of Economics and Behavioral Studies ◽

10.22610/jebs.v3i6.295 ◽

2011 ◽

Vol 3 (6) ◽

pp. 388-394

Author(s):

Salima Hafeez ◽

Rashid Mehmood Chaudhry . ◽

Muhammad Aslam Khan . ◽

H.Mushtaq Ahmad . ◽

Kashif Ur Rehman .

Keyword(s):

Quality Of Life ◽

Entrepreneurial Orientation ◽

Third World ◽

Dynamic Capabilities ◽

Positive Impact ◽

Well Being ◽

Entrepreneurial Firms ◽

The Third World ◽

The Impact

The characteristics of entrepreneurial orientation is played important role in business. How do an entrepreneurial firms and individuals have taken the advantage in industry? This study explores the dynamic capabilities of the organization according to international performance. Our findings indicates the positive impact on dynamic capabilities of the business with perfectly use of this research framework. The main aspect of this paper is to analyse the impact of entrepreneurial orientation with the quality of life. Distinctive features of entrepreneurs and their contribution to the economy can make it possible for third world countries to grow their economies faster and provide financial means to enhance social, health, and environmental well-being (basic dimensions of quality of life), along with products and services that the poor need in these countries. Entrepreneurial orientation combined with organization learning and Quality of life (QOL) are enhanced the dynamic capability of the organization. Present conceptual research will provide the source of competitive advantage and mainstream line for further development of the business .We suggest that existing literature reconfiguring the different approaches for the entrepreneurial to capture the opportunities in world business. First, quality of life cannot possibly improve in inactive or weakening economic conditions; second, economic development in the third world countries cannot advance in a balanced and desirable manner without a major domestic entrepreneurship movement (Samli 2004, 2008a).

Download Full-text

How University Acts in the Development of “Smart Cities”

SHS Web of Conferences ◽

10.1051/shsconf/20197105011 ◽

2019 ◽

Vol 71 ◽

pp. 05011

Author(s):

M. Afanasiev ◽

M. Lysenkova

Keyword(s):

Quality Of Life ◽

Higher Education ◽

Smart City ◽

Positive Impact ◽

Smart Cities ◽

Territorial Development ◽

Higher Education System ◽

Impact Of Higher Education ◽

The Impact

“Smart city” is a new model of territorial development, taking into account the growing importance of information, innovation and human capital. One of the main elements of the “smart city” is a developed system of higher education. The aim of this work was to study the impact of higher education on "smart" and innovative cities. The objectives of this work were to obtain quantitative characteristics of the impact of the University on the smart city. Approach to solving this problem was to build indicators based on indicators that characterize the quality of life, and ratings to compare cities on their basis. The hypothesis of the study is that the higher education system has a positive impact on the development of smart and innovative cities. A theoretically justified method of constructing an indicator of a certain direction of socio-economic development is a component analysis of indicators characterizing this direction. As a result, the rankings of Russian and foreign cities based on the characteristics of quality of life, which prove that education is a key indicator of the development of "smart" and innovative cities.

Download Full-text

Quality of life in patients with Tuberous Sclerosis Complex (TSC)

European Journal of Paediatric Neurology ◽

10.1016/j.ejpn.2019.09.006 ◽

2019 ◽

Vol 23 (6) ◽

pp. 801-807 ◽

Cited By ~ 4

Author(s):

Sam Amin ◽

Andrew A. Mallick ◽

Andrew Lux ◽

Finbar O'Callaghan

Keyword(s):

Quality Of Life ◽

Tuberous Sclerosis ◽

Tuberous Sclerosis Complex

Download Full-text

The Impact of Routine Skin Care on the Quality of Life

Cosmetics ◽

10.3390/cosmetics7030059 ◽

2020 ◽

Vol 7 (3) ◽

pp. 59 ◽

Cited By ~ 2

Author(s):

Lixia Zhang ◽

Aldhel Adique ◽

Pradipta Sarkar ◽

Vinay Shenai ◽

Murali Sampath ◽

...

Keyword(s):

Quality Of Life ◽

Positive Impact ◽

Test Group ◽

Well Being ◽

Consumer Products ◽

Skin Care ◽

Main Study ◽

New Mothers ◽

The Impact

Importance: Consumers purchase a wide variety of consumer products and come into contact with these products on a daily basis. Manufacturers invest deeply in developing new products or improving existing products, in order to produce a positive impact on the lives of consumers. Objective: The goal of this study was to determine the impact of over-the-counter skin care products on the quality of life (QoL) of female consumers. Design and Measures: A QoL instrument developed for consumer products (the Farage QoL with an added Skin Care Module) was used to assess the impact of a 28-day facial skin care regimen using commercially available products formulated to improve elasticity, firmness and hydration, and to correct age- and sun-related skin color. Responses were collected prior to study commencement, at completion of the product usage stage, and after a period of withdrawal of the product with reversion to a basic skin care regimen. Participants: Two main study groups from Australia included 89 new mothers, i.e., women with children 2 years and under (mean age ± SD was 34 ± 4.8), and a national representative sample of 91 women (45 ± 12). An additional test group from China consisted of 40 younger cosmetic users (25 ± 4.3). The Skin Care Module was not included in the instrument for the third group. Results: After 28-days of usage, both test groups in the main study showed significant improvement in three of five items in the Skin Care Module (improved feelings of empowerment, happiness and self-esteem). Improvements persisted after 2 weeks of product withdrawal. In the main QoL instrument, the New Mothers group showed significant improvement in the Well-Being domain, driven by improvements in the Self-Image and Self Competence subdomains. The National Representative group showed improvements in the Energy and Vitality domain, driven by improvements in the Personal Pleasure, Physical State and Routine Activity subdomains. The additional group in the China study showed results similar to the New Mothers group. Conclusions and Relevance: A quality and efficacious skin care regimen can have a positive impact on the QoL of consumers. Differences in responses of the test groups were likely related to differences in the mean age and differences in time available to look after themselves.

Download Full-text