scholarly journals Primary Cutaneous Follicle Centre Lymphoma with Hodgkin and Reed-Sternberg Like Cells: A Case Report and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Fatima A. Aldarweesh ◽  
Diana O. Treaba
Keyword(s):  
Dna Sequences ◽  
Fusion Transcript ◽  
Excisional Biopsy ◽  
Chain Gene ◽  
Left Forearm ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Ebv Dna ◽  
Follicle Centre Lymphoma

An elderly woman with a complex medical history presented with a left forearm mass that slowly developed for several months. The excisional biopsy of this skin mass was remarkable for involvement by a follicle centre cell derived lymphoma with a nodular and diffuse pattern associated with a subset of scattered Hodgkin and Reed-Sternberg like cells. Fluorescence in situ hybridization studies did not detect the presence of IgH-bcl2 fusion transcript, and molecular studies were negative for immunoglobulin heavy chain gene rearrangements and EBV DNA sequences. Hodgkin and Reed-Sternberg like cells are rarely reported in FLs, and the association with primary cutaneous follicle centre lymphoma is extremely rarely seen. To our knowledge, our case is the second case of primary cutaneous follicle centre lymphoma with Hodgkin and Reed-Sternberg like cells.

Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma

Cell ◽  
1986 ◽  
Vol 44 (1) ◽  
pp. 97-106 ◽  
Author(s):  
Michael L. Cleary ◽  
Timothy C. Meeker ◽  
Shoshana Levy ◽  
Elizabeth Lee ◽  
Martha Trela ◽  
...  
Keyword(s):  
B Cell ◽  
Heavy Chain ◽  
Somatic Mutations ◽  
Cell Lymphoma ◽  
Variable Region ◽  
B Cell Lymphoma ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Human B Cell

scholarly journals Primary Malignant Lymphoma of the Brain: Mutation Pattern of Rearranged Immunoglobulin Heavy Chain Gene

2002 ◽  
Vol 93 (12) ◽  
pp. 1308-1316 ◽  
Author(s):  
Sumio Endo ◽  
Shu-Jing Zhang ◽  
Takafumi Saito ◽  
Mitsuo Kouno ◽  
Toshihiko Kuroiwa ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Mutation Pattern ◽  
The Brain

scholarly journals Four new recurring translocations in non-Hodgkin lymphoma

Blood ◽  
1989 ◽  
Vol 74 (5) ◽  
pp. 1796-1800 ◽  
Author(s):  
EG Levine ◽  
DC Arthur ◽  
J Machnicki ◽  
G Frizzera ◽  
D Hurd ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Molecular Level ◽  
Chromosomal Translocations ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
B Cell Malignancies ◽  
Non Hodgkin Lymphoma ◽  
Karyotypic Abnormality ◽  
Extranodal Disease

The identification of recurring chromosomal translocations has provided clues to the gene regions important in lymphoma development. Among 157 patients with non-Hodgkin lymphoma studied by cytogenetic analysis, four new recurring translocations have been identified--t(8;9) (q24;p13), t(11;18)(q21;q21), t(14,15)(q32;q15), and an unbalanced translocation giving rise to der(22)t(17;22) (q11;p11). Each translocation appeared twice. The t(11;18) was the only karyotypic abnormality in the two patients with it, and the t(14;15) was the sole karyotypic abnormality in one patient. All translocations were found in B-cell malignancies and were associated with both nodal and extranodal disease. Among the regions affected, only the immunoglobulin heavy- chain gene MYC, and BCL2, have thus far been associated with lymphoma. The breakpoint sites identified by these translocations warrant further investigation at the molecular level.

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