scholarly journals Serum Uric Acid as an Independent Risk Factor for the Presence and Severity of Early-Onset Coronary Artery Disease: A Case-Control Study

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Ting-Ting Tian ◽  
Hui Li ◽  
Sheng-Jie Chen ◽  
Qing Wang ◽  
Qing-Wu Tian ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Uric Acid ◽  
Risk Factor ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Early Onset ◽  
Independent Risk Factor ◽  
Coronary Syndrome ◽  
Vessel Disease ◽  
Artery Disease

Serum uric acid (UA) is the final product of purine metabolism in humans. The present study is aimed at identifying the potential association between serum UA and early-onset coronary artery disease (EOCAD). The study population consisted of 1093 EOCAD patients aged ≤50 years, and 1117 age- and sex-matched apparently healthy people served as controls. The concentrations of UA were measured by uricase method. The severity of CAD was evaluated by Gensini score. The mean serum level of UA was 5.843 ± 1.479 mg/dl in EOCAD patients and 5.433 ± 1.529 mg/dl in controls. Serum UA levels were significantly higher in the EOCAD group than those in the control group (P<0.001) and was an independent risk factor for EOCAD (OR = 1.100, 95% CI: 1.022–1.185). The early-onset myocardial infarction patients with 3-vessel disease had higher serum UA levels than those with 1- or 2-vessel disease. The serum UA levels of EOCAD patients with acute coronary syndrome were significantly higher than those with chronic coronary artery disease. EOCAD patients with hyperuricemia had higher Gensini scores than those without hyperuricemia. In addition, the serum UA levels were affected by drinking (P<0.01) and were positively correlated with serum creatinine (r=0.323) and weight (r=0.327). Our results show that serum UA was an independent risk factor for EOCAD. The serum UA levels were associated with the presence and severity of EOCAD and suggested that UA may be involved in the progression of EOCAD.

scholarly journals Serum Uric Acid Is Not an Independent Risk Factor for Premature Coronary Artery Disease

2013 ◽  
Vol 3 (4) ◽  
pp. 246-253 ◽  
Author(s):  
Sara Zand ◽  
Akbar Shafiee ◽  
Mohammadali Boroumand ◽  
Arash Jalali ◽  
Younes Nozari
Keyword(s):  
Coronary Artery Disease ◽  
Uric Acid ◽  
Risk Factor ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Premature Coronary Artery Disease ◽  
Artery Disease

High Levels of Serum Uric Acid Predict Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome

Angiology ◽  
2011 ◽  
Vol 63 (6) ◽  
pp. 448-452 ◽  
Author(s):  
Mustafa Duran ◽  
Nihat Kalay ◽  
Mahmut Akpek ◽  
Ozcan Orscelik ◽  
Deniz Elcik ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Uric Acid ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Coronary Syndrome ◽  
Artery Disease

ID: 68: CORONARY ARTERY DISEASE AND ACUTE CORONARY SYNDROME IN PATIENTS ≤40 YEAR OLD

2016 ◽  
Vol 64 (4) ◽  
pp. 913.2-914
Author(s):  
H Alkhawam ◽  
R Sogomonian ◽  
N Vyas ◽  
A Al-khazraji ◽  
S Ahmed ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Premature Coronary Artery Disease ◽  
Modifiable Risk Factors ◽  
Coronary Syndrome ◽  
Vessel Disease ◽  
Single Vessel ◽  
Artery Disease

BackgroundCoronary artery disease (CAD) in the younger adult population has been commonly under-represented in clinical practice and research studies given its early latent asymptomatic course, in addition to the underestimation of this population's CHD lifetime risk by commonly used CHD risk predictors such as Framingham's score.ObjectiveTo assess the risk factor profile for premature coronary artery disease CAD and ACS presentation in younger adults.MethodsRetrospective chart analysis of 393 patient's ≤40 years old admitted from 2005 to 2014 for chest pain and underwent coronary angiography. The implication of modifiable risk factors and non-modifiable risk factors were evaluated in those with obstructive CAD (LM stenosis of ≥50% or stenosis of ≥70% in a major epicardial vessel), non-obstructive CAD (≥1 stenosis ≥20% but no stenosis ≥70%) and normal coronaries (no stenosis >20%). Additionally we evaluated the impact of the same risk factors on ACS presentation (NSTEMI vs STEMI) and the extent of CAD (single-vessel/multi vessel).ResultsOf 9012 patients who underwent cardiac catheterization, 393 (4.3%) patients were ≤40 years old.Out of 393, 212 (54%) had CAD (153 obstructive versus 59 non-obstructive) while 185 (46%) had normal coronaries.Fifty two (25%) patients presented with STEMI while 140 (66%) patients presented with NSTEMI.Of 153 patients with obstructive CAD, 87 (57%) patients had single vessel disease vs 66 (43%) multiple vessel disease.When compared to patients with normal coronaries patients with CAD were more likely to be smokers (p<0.0001), dyslipidemia (p<0.0001), Diabetic (p<0.0001) cocaine users (p 0.4) have a family history of premature CHD (<0.0001) and be males (p<0.0001) (figure=1).Smokers were more likely to present with acute coronary syndrome; 5 times more likely to present with STEMI (p<0.0001) and 1.7 with NSTEMI (p 0.0003) compared to the control group.When compared head to head, smokers were 2.2 times more likely to present with STEMI compared to NSTEMI (p<0.001).Smoking also, alone and with another risk factor increased the risk of obstructive versus no obstructive CAD (p=0.04 and 0.015, respectively).No significant difference was noted in the single vessel vs multi vessel CAD subgroups.Coronary artery disease was highest in South Asian population (38.4%), followed by Hispanic (13.7%), African-American (10%) and Caucasian (9%). The main in risk factors in African–American was Hyperlipidemia +/− Diabetes (47.8%) while the main risk factors in Hispanic and white were smoking alone (24.14% and 47.4% respectively). In East Asia population, Smoking with hyperlipidemia was the main risk factors (44%).ConclusionIn our population of young adults, smoking as a single risk factor was the most prevalent for earlier CAD. It was also associated with more STEMIs and obstructive CAD. Healthcare intervention in the general population through screening, counseling and education regarding smoking cessation is warranted to reduce premature coronary artery disease. Abstract ID: 68 Figure 1

The angiotensin converting enzyme D allele is an independent risk factor for early onset coronary artery disease

2010 ◽  
Vol 43 (15) ◽  
pp. 1189-1194 ◽  
Author(s):  
Asad Vaisi-Raygani ◽  
Hori Ghaneialvar ◽  
Zohreh Rahimi ◽  
Hamid Nomani ◽  
Mohmadreza Saidi ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Angiotensin Converting Enzyme ◽  
Early Onset ◽  
Independent Risk Factor ◽  
Converting Enzyme ◽  
Artery Disease
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