Serum uric acid and its relationship with cardiovascular risk profile in Chinese patients with early-onset coronary artery disease

Objectives: Several studies have investigated the association between serum uric acid (SUA) and the risks of coronary artery disease (CAD) but have yielded inconsistent results. The aim of this study was to assess whether there is an independent association of SUA with all-cause and cardiovascular disease (CVD) mortality in Chinese patients with CAD. Methods: A prospective cohort study of 1,799 patients was conducted. Cox regression models were used to estimate the association of SUA with the risk of death. Results: During a median follow-up of 3.9 years, 177 deaths were recorded and 126 of these were due to CVD. Patients in the highest SUA quartile had a 2.43-fold risk of all-cause mortality and a 2.44-fold risk of CVD mortality compared with those in the lowest quartile. In the subpopulation analysis, the association between SUA and mortality remained similar when participants were stratified by age, gender, body mass index and type of CAD. In contrast, we found a significant interaction with estimated glomerular filtration rate (eGFR). There was a stronger association between SUA and the risk of all-cause and CVD mortality among patients with an eGFR ≥60 ml/min/1.73 m2, but no significant association was found in the population with an eGFR <60 ml/min/1.73 m2. Conclusions: Elevated SUA levels were positively associated with an increased risk of all-cause and CVD mortality among CAD patients.

Download Full-text

EFFECT OF ROSUVASTATIN ON CAROTID INTIMAMEDIA THICKNESS IN PATIENTS WITH CORONARY ARTERY DISEASE OF DIFFERENT GENDER AND CARDIOVASCULAR RISK PROFILE

Pharmacy & Pharmacology ◽

10.19163/2307-9266-2018-6-2-182-196 ◽

2018 ◽

Vol 6 (2) ◽

pp. 182-196

Author(s):

S. I. Kononov ◽

G. S. Mal

Keyword(s):

Coronary Artery Disease ◽

Cardiovascular Risk ◽

Coronary Artery ◽

Risk Profile ◽

Cardiovascular Risk Profile ◽

Artery Disease ◽

Carotid Intimamedia Thickness

Download Full-text

Khat chewing and cardiovascular risk profile in a cohort of Yemeni patients with angiographically documented coronary artery disease

Heart Asia ◽

10.1136/heartasia-2012-010205 ◽

2012 ◽

Vol 4 (1) ◽

pp. 164-167 ◽

Cited By ~ 2

Author(s):

Abdul-Kafi Shujaa ◽

Wail Nammas

Keyword(s):

Coronary Artery Disease ◽

Cardiovascular Risk ◽

Coronary Artery ◽

Risk Profile ◽

Cardiovascular Risk Profile ◽

Khat Chewing ◽

Artery Disease ◽

Documented Coronary Artery Disease

Download Full-text

Serum Uric Acid as an Independent Risk Factor for the Presence and Severity of Early-Onset Coronary Artery Disease: A Case-Control Study

Disease Markers ◽

10.1155/2018/1236837 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 9

Author(s):

Ting-Ting Tian ◽

Hui Li ◽

Sheng-Jie Chen ◽

Qing Wang ◽

Qing-Wu Tian ◽

...

Keyword(s):

Coronary Artery Disease ◽

Uric Acid ◽

Risk Factor ◽

Coronary Artery ◽

Serum Uric Acid ◽

Early Onset ◽

Independent Risk Factor ◽

Coronary Syndrome ◽

Vessel Disease ◽

Artery Disease

Serum uric acid (UA) is the final product of purine metabolism in humans. The present study is aimed at identifying the potential association between serum UA and early-onset coronary artery disease (EOCAD). The study population consisted of 1093 EOCAD patients aged ≤50 years, and 1117 age- and sex-matched apparently healthy people served as controls. The concentrations of UA were measured by uricase method. The severity of CAD was evaluated by Gensini score. The mean serum level of UA was 5.843 ± 1.479 mg/dl in EOCAD patients and 5.433 ± 1.529 mg/dl in controls. Serum UA levels were significantly higher in the EOCAD group than those in the control group (P<0.001) and was an independent risk factor for EOCAD (OR = 1.100, 95% CI: 1.022–1.185). The early-onset myocardial infarction patients with 3-vessel disease had higher serum UA levels than those with 1- or 2-vessel disease. The serum UA levels of EOCAD patients with acute coronary syndrome were significantly higher than those with chronic coronary artery disease. EOCAD patients with hyperuricemia had higher Gensini scores than those without hyperuricemia. In addition, the serum UA levels were affected by drinking (P<0.01) and were positively correlated with serum creatinine (r=0.323) and weight (r=0.327). Our results show that serum UA was an independent risk factor for EOCAD. The serum UA levels were associated with the presence and severity of EOCAD and suggested that UA may be involved in the progression of EOCAD.

Download Full-text

Genetically predicted serum uric acid levels and the risk of coronary artery disease in patients with diabetes: a Mendelian randomization study

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2021.03.007 ◽

2021 ◽

Author(s):

Songzan Chen ◽

Fangkun Yang ◽

Tian Xu ◽

Yao Wang ◽

Kaijie Zhang ◽

...

Keyword(s):

Coronary Artery Disease ◽

Uric Acid ◽

Coronary Artery ◽

Serum Uric Acid ◽

Mendelian Randomization ◽

Patients With Diabetes ◽

Artery Disease

Download Full-text

Serum Uric Acid Levels, but Not rs7442295 Polymorphism of SCL2A9 Gene, Predict Mortality in Clinically Stable Coronary Artery Disease

Current Problems in Cardiology ◽

10.1016/j.cpcardiol.2021.100798 ◽

2021 ◽

Vol 46 (5) ◽

pp. 100798

Author(s):

Chiara Mozzini ◽

Domenico Girelli ◽

Angela Setti ◽

Jacopo Croce ◽

Filippo Stefanoni ◽

...

Keyword(s):

Coronary Artery Disease ◽

Uric Acid ◽

Coronary Artery ◽

Serum Uric Acid ◽

Stable Coronary Artery Disease ◽

Artery Disease

Download Full-text

Abstract P049: Serum Uric Acid Levels Are Associated With Non-Calcified Coronary Plaque Independent of Traditional Cardiovascular Risk Factors in Patients With Psoriasis

Circulation ◽

10.1161/circ.137.suppl_1.p049 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Youssef A Elnabawi ◽

Amit K Dey ◽

Agastya D Belur ◽

Aditya Goyal ◽

Jacob W Groenendyk ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Uric Acid ◽

Coronary Artery ◽

Serum Uric Acid ◽

Coronary Plaque ◽

Chronic Inflammatory Disease ◽

Human Model ◽

Plaque Burden ◽

Artery Disease

Introduction: Serum uric acid (sUA), a known inflammosome-inducer, is associated with prospective risk of coronary artery disease in a dose-dependent fashion. Psoriasis (PSO), a chronic inflammatory disease associated with elevated burden of systemic inflammation and subclinical coronary artery disease, provides a reliable human model to study how sUA may relate to non-calcified coronary plaque burden (NCB) measured by computed coronary tomography angiography (CCTA). Hypothesis: We hypothesized that sUA would directly associate with NCB beyond traditional cardiovascular (CV) risk factors. Methods: 103 consecutive PSO patients and 47 healthy volunteers (HV) underwent CCTA (320 detector row, Toshiba) for coronary plaque burden quantification using QAngio (Medis). PSO severity was assessed by Psoriasis Area Severity Score (PASI) and divided into severe PSO (PASI>10) and mild-moderate PSO (PASI<10). All patients had fasting blood draws for the measurement of sUA at a certified clinical lab. Results: PSO patients were older than HV and had a higher CV risk by Framingham risk score (FRS) (Table 1). We observed a significant trend towards increase in sUA among severe PSO, mild-moderate PSO, and HV groups (mean 6.4, 5.9, 5.4 respectively, p=0.02 for trend). A positive association was observed between sUA and NCB, which was stronger in severe PSO after adjustment for traditional CV risk, alcohol, statins, and systemic/biologic PSO treatment (Severe PSO: β=0.27, p<0.001; Mild-moderate PSO: β=0.18, p=0.03), not significant in HV (β=0.18, p=0.12). Conclusions: sUA is independently associated with NCB in states of chronic inflammation such as PSO, and as such, may potentially serve as a biomarker for subclinical coronary atherosclerosis. However, larger prospective studies of CV outcomes in chronic inflammatory diseases are needed to confirm these results.

Download Full-text