scholarly journals Safe Administration of Ipilimumab, Pembrolizumab, and Nivolumab in a Patient with Metastatic Melanoma, Psoriasis, and a Previous Guillain–Barré Syndrome

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Alessio Cortellini ◽  
Alessandro Parisi ◽  
Maria Concetta Fargnoli ◽  
Katia Cannita ◽  
Azzurra Irelli ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Report ◽  
Metastatic Melanoma ◽  
Checkpoint Inhibitors ◽  
Guillain Barre Syndrome ◽  
Immune Disorders ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Sequential Treatments ◽  
Guillain Barré

Background. Patients with autoimmune diseases were not evaluated in clinical trials with immune checkpoint inhibitors (ICIs), since a history of immune disorders, such as Guillain–Barré syndrome (GBS) and psoriasis, is one of the major risk factors for the development of immune-related adverse events (irAEs). This risk cannot be defined; therefore, physicians are called to manage these patients in clinical practice. Case Report. We report the case of a 62-year-old male patient affected by metastatic melanoma, with a history of GBS and psoriasis, and treated with sequential ipilimumab, pembrolizumab, and nivolumab, without significant toxicities. Conclusion. This case report supports that although a history of immune disorders is one of the major risk factors for development of irAEs, in some patients, it could be possible to safely administer sequential treatments with ICIs. A proper decision should be made, considering therapeutic options, disease-related risks, and those related to a recurrence of preexisting autoimmune disorders.

scholarly journals Post-treatment Guillain-Barre Syndrome in a Patient with Brucellosis; A Case Report

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Navid Manouchheri ◽  
Omid Mirmosayyeb ◽  
Majid Ghasemi ◽  
Shervin Badihian ◽  
Vahid Shaygannejad ◽  
...  
Keyword(s):  
Case Report ◽  
Antimicrobial Treatment ◽  
Lower Limbs ◽  
Guillain Barre Syndrome ◽  
Case Presentation ◽  
Brucella Infection ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Guillain Barré ◽  
Uncommon Complication

Introduction: Guillain-Barre Syndrome is an uncommon complication during acute brucellosis. Case presentation: In this study, we present a case of Guillain-Barre Syndrome in a 22-year old male patient with complaints of weakness in his lower limbs. He had a history of acute Brucella infection for four months and received antimicrobial medication. Conclusion: the patients can be affected by GBS after antimicrobial treatment.

scholarly journals Risk factors for the severity of Guillain-Barré syndrome and predictors of short-term prognosis of severe Guillain-Barré syndrome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Puyuan Wen ◽  
Lisha Wang ◽  
Hong Liu ◽  
Li Gong ◽  
Han Ji ◽  
...  
Keyword(s):  
Risk Factors ◽  
Autonomic Dysfunction ◽  
Liver Enzymes ◽  
Guillain Barre Syndrome ◽  
Recent History ◽  
History Of Surgery ◽  
Short Term ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Guillain Barré

AbstractGuillain-Barré syndrome (GBS) is a neurological disorder characterized by paralysis. Identifying the severity, appropriate therapeutic method, and prognosis of GBS at an early stage is highly important. This study aimed to investigate the modifiable risk factors for the severity of GBS and consequent need for mechanical ventilation (MV) and to identify clinical predictive factors for poor short-term outcomes of severe GBS. 155 GBS patients who were admitted to the Affiliated Yantai Yuhuangding Hospital of Qingdao University during 2014–2020 were enrolled. Demographic, clinical, therapeutic and evolutionary data were collected and were then analyzed using univariate and multivariate regression analyses. Our analytic data demonstrated that the significant clinical predictors of severe GBS were recent history of surgery, older age, cranial nerve impairment, and elevated levels of liver enzymes (p < 0.05). Furthermore, autonomic dysfunction, lower Medical Research Council (MRC) score at nadir, and elevated levels of liver enzymes were significantly associated with MV for severe GBS (p < 0.05), and lower MRC score at nadir and autonomic dysfunction remained significant predictors of MV in severe GBS (p < 0.05). Lastly, recent history of surgery, lower MRC score at admission and at nadir, requirement for MV, and pneumonia during hospitalization were significantly associated with the short-term outcome of severe GBS and that lower MRC score at admission and need for MV were confirmed to be predictors of poor short-term prognosis (p < 0.05). Of note, this study suggested that recent history of surgery is a predictor of severity in GBS patients and is associated with the poor short-term prognosis of severe GBS.

scholarly journals A case report of Guillain Barré syndrome revealing underlying infective endocarditis due to Cardiobacterium hominis

Medicine ◽  
2019 ◽  
Vol 98 (15) ◽  
pp. e15014
Author(s):  
Kévin Diallo ◽  
Caroline Jacquet ◽  
Corentine Alauzet ◽  
Isabelle Beguinot ◽  
Thierry May ◽  
...  
Keyword(s):  
Case Report ◽  
Infective Endocarditis ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Co-Occurrence of Guillain-Barre Syndrome and Multiple Sclerosis: A Rare Case Report

2021 ◽  
pp. 1-5
Author(s):  
Amr Hassan ◽  
Alaa El-Mazny ◽  
Mohammed Saher ◽  
Ismail Ibrahim Ismail ◽  
Mohammed Almuqbil
Keyword(s):  
Multiple Sclerosis ◽  
Differential Diagnosis ◽  
Case Report ◽  
Rare Case ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Rare Case Report ◽  
Central Nervous Systems ◽  
Guillain Barré ◽  
Demyelinating Disorders

Guillain-Barre syndrome (GBS) and multiple sclerosis (MS) are autoimmune demyelinating disorders of the peripheral and central nervous systems, respectively. The co-occurrence of these 2 conditions is rare in the literature. Herein, we present a rare case of GBS and MS in a 19-year-old female who presented initially with GBS followed by MS, and we provide a literature review. Despite being rare, it should be kept in mind in the differential diagnosis of patients with atypical and usual presentation of both diseases.

P-PN018. The co-occurrence of myasthenia gravis and Guillain-Barré Syndrome: A case report

2021 ◽  
Vol 132 (8) ◽  
pp. e111
Author(s):  
R. Freshimona ◽  
A. Wijaya ◽  
Aryatama ◽  
S. Djojoatmodjo ◽  
J. Liman ◽  
...  
Keyword(s):  
Case Report ◽  
Myasthenia Gravis ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré
Sign in / Sign up

Export Citation Format

Share Document