scholarly journals Full Thickness Retinal Hole Formation after Nd:YAG Laser Hyaloidotomy in a Case with Valsalva Retinopathy

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Yasin Sakir Goker ◽  
Kemal Tekin ◽  
Cemile Ucgul Atilgan ◽  
Pinar Kosekahya ◽  
Pelin Yilmazbas
Keyword(s):  
Nd:Yag Laser ◽  
Pigment Epithelium ◽  
Care Center ◽  
Retinal Pigment ◽  
Full Thickness ◽  
Hole Formation ◽  
Inferior Margin ◽  
Valsalva Retinopathy ◽  
Vascular Arcade ◽  
Retinal Hole

A 27-year-old male was presented with a sudden onset of visual loss in his right eye. A secondary care center referred the patient with fundus photographs which were screened 4 days before and after the Nd: YAG laser hyaloidotomy treatment. Snellen acuity was 10/10 in both eyes. Fundus examinations revealed a retinal pigment epithelium (RPE) alteration at the margin of the inferior temporal arterial vascular arcade in the right eye and resolved preretinal and subretinal hemorrhages were seen in the macula. A diagnosis of Valsalva retinopathy was made based on the history and the treatment photographs of Nd:YAG laser hyaloidotomy. At 1st month examination all hemorrhages were resolved but RPE alterations were still at the margin of the inferior temporal arterial vascular arcade. The optical coherence tomography angiography (OCTA) images revealed 2 lesions. On en face OCT angiogram of OCTA full thickness retinal hole formation and ellipsoid zone damage at the superior and inferior margin of the inferior temporal arterial vascular arcade were seen. Superficial vascular plexus was also damaged at that region. The projection of the evacuation of blood from subhyaloid space and the full thickness retinal hole formation were the same, indicating that the partial and full thickness retinal holes were created by the laser treatment.

Full-thickness macular hole associated with congenital simple hamartoma of retinal pigment epithelium (CSHRPE)

2017 ◽  
Vol 38 (5) ◽  
pp. 2179-2182 ◽  
Author(s):  
Panagiotis Stavrakas ◽  
Athanasios Vachtsevanos ◽  
Efthymia Karakosta ◽  
Nikos Kozeis ◽  
Magdalini Triantafylla ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Macular Hole ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Full Thickness ◽  
Full Thickness Macular Hole

scholarly journals Longitudinal observation of OCT imaging is a valuable tool to monitor primary vitreoretinal lymphoma treated with intravitreal injections of methotrexate

2019 ◽  
Author(s):  
Huiying Zhao ◽  
Xiaona Wang ◽  
Yu Mao ◽  
Xiaoyan Peng
Keyword(s):  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Subretinal Fluid ◽  
Intravitreal Injections ◽  
Full Thickness ◽  
Vitreoretinal Lymphoma ◽  
Longitudinal Observation ◽  
Subretinal Fibrosis ◽  
Oct Imaging ◽  
Sd Oct

Abstract Background: Developing objective and repeatable indicators to evaluate the efficacy of PVRL treatment is important. The quantification of vitreous cells is a traditional criterion; however slight changes are difficult to ascertain. Spectral domain optical coherence tomography (SD-OCT) is objective, repeatable, and easily explained. The purpose of this study is to provide a longitudinal observation of OCT in PVRL treated with intravitreal injections of methotrexate (MTX) and to evaluate the utility of OCT in monitoringresponsiveness of PVRL to treatment. Methods: The medical records of patients with biopsy-positive PVRL attending our hospital between January 2016 and September 2017 who received intravitreal injections of MTX were included in this study. Pre- and posttreatment OCT images were reviewed independently by two researchers. Results: Of the 24 cases reviewed, 10 patients (18 eyes) were included. SD-OCT abnormalities at the initial visit included hyperreflective foci in the posterior vitreous (18/18), hyperreflective dots in the RPE (12/18), PEDs (detachment of retinal pigment epithelium) (9/18), hyperreflective band above the RPE (3/18), hyperreflectivity in the full thickness of the retina (8/18), and subretinal fluid (4/18). At one month after treatment, the subretinal fluid in cases with RD was absorbed, and subretinal fibrosis appeared. Other lesions were significantly reduced. At two months after treatment, the hyperreflective dots in the RPE, PEDs and subretinal fluid disappeared in 2 eyes, hyperreflectivity in the full thickness of the retina disappeared in 1 eye, and other abnormalities further improved. Additionally, retinal fibrosis was observed in 3 eyes. At nine months after treatment, all abnormalities observed at the first visit vanished. At the last visit, OCT showed subretinal fibrosis and in 3 eyes (16.7%), the disruption of outer retina in 9 eyes (50%) and thinning of the whole layer in 4 eyes (22.2%).Conclusions: Our observations reveal that characteristic OCT features in PVRL patients can reduce gradually and finally vanish with therapy. We propose that SD-OCT may be employed to monitor the responsiveness of PVRL to treatment, which may influence decision making in the management of this disease.

EFFECTS OF INDOCYANINE GREEN ON THE RETINA AND RETINAL PIGMENT EPITHELIUM IN A PORCINE MODEL OF RETINAL HOLE

Retina ◽  
2004 ◽  
Vol 24 (2) ◽  
pp. 275-282 ◽  
Author(s):  
MARCIN P. CZAJKA ◽  
BROOKS W. MCCUEN ◽  
THOMAS J. CUMMINGS ◽  
HOANG NGUYEN ◽  
SANDRA STINNETT ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Indocyanine Green ◽  
Porcine Model ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Retinal Hole

scholarly journals Vitrectomy for laser-induced full-thickness macular hole

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xin Wang ◽  
Ting Zhang ◽  
Rui Jiang ◽  
Gezhi Xu
Keyword(s):  
Visual Acuity ◽  
Yttrium Aluminum Garnet ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Internal Limiting Membrane ◽  
Rank Test ◽  
Retinal Layer ◽  
Full Thickness ◽  
Before And After ◽  
Signed Rank Test

Abstract Background To report the structure and visual outcomes of pars plana vitrectomy (PPV) for laser-induced full-thickness macular holes (MHs). Methods This retrospective study enrolled 10 patients who underwent vitrectomy for MHs caused by laser injury. Best corrected visual acuity (BCVA), macular spectral-domain optical coherence tomography (OCT) and OCT angiography (OCTA) were used for assessment. Results Four patients were injured by unexpected expose of an yttrium aluminum garnet (YAG) laser, and six patients were accidentally injured by a handheld laser. The MH minimum diameters (MDs) ranged from 55 to 966 μm (mean = 548.00 ± 286.10 μm), and BCVA ranged from 20/400 to 20/50 (mean = logMAR 0.87 ± 0.29) preoperatively. All 10 eyes underwent PPV, internal limiting membrane (ILM) peeling, and gas tamponade. All eyes demonstrated closure of the MH with different degrees of discontinuity of the outer layer of the retina, and four eyes exhibited serious retinal pigment epithelium (RPE) destruction. Postoperative BCVA values were significantly improved (mean = logMAR 0.55 ± 0.33; P = 0.032, t = 2.234). The mean BCVA of the destroyed RPE group was significantly worse than that of the non-destroyed RPE group both before and after surgery (P = 0.019; Wilcoxon signed rank test). Further, OCTA indicated choroidal ischemia in the laser-induced MHs. Conclusion Vitrectomy can be successful in closing laser-induced full-thickness MHs and improving visual acuity. However, If RPE/choroid is involved in laser damage in addition to the outer retinal layer, this may indicate poor visual prognosis.

Gliotic tissue simulating a macular neovascularization in full-thickness macular hole

2021 ◽  
pp. 112067212110295
Author(s):  
Chiara Vigano’ ◽  
Enrico Borrelli ◽  
Riccardo Sacconi ◽  
Maria Brambati ◽  
Francesco Bandello ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Pigment Epithelium ◽  
Macular Hole ◽  
Male Patient ◽  
Vascular Tissue ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Full Thickness ◽  
Macular Holes ◽  
Full Thickness Macular Hole

The authors report a case of a male patient affected by macular hole. In particular, a hyperreflective tissue was found on optical coherence tomography (OCT) examination in macular region, just above the retinal pigment epithelium (RPE). OCT angiography (OCTA) did not show the presence of vascular tissue, thus the hyperreflective material was ascribed to primary gliotic tissue. This case highlights the ability for Müller cells placed near macular holes to migrate up to the RPE and to produce gliotic tissue.

scholarly journals Advantages of robotic assistance over a manual approach in simulated subretinal injections and its relevance for gene therapy

Gene Therapy ◽  
2021 ◽  
Author(s):  
Reza Ladha ◽  
Thijs Meenink ◽  
Jorrit Smit ◽  
Marc D. de Smet
Keyword(s):  
Gene Therapy ◽  
Clinical Success ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Genetic Diseases ◽  
Cost Effective ◽  
Robotic Assistance ◽  
Injection Duration ◽  
Retinal Hole ◽  
Subretinal Injection

AbstractSubretinal injection is a method for gene delivery to treat genetic diseases of the photoreceptors and retinal pigment epithelium. A reflux-free subretinal injection is important to allow effective, safe, and cost-effective gene therapy to the retina. We report on a comparison between manual and robotic assistance in simulated subretinal injections using an artificial retina model. Nine surgeons carried out the procedure with and without the Preceyes Surgical System, using an OPMI Lumera 700 Zeiss surgical microscope equipped with intra-operative optical coherence tomography. Success in creating a bleb without reflux, injection duration, drift, tremor, and increase in the diameter of the puncture hole were analyzed. Robotic assistance improved drift (median 16 vs 212 µm), tremor (median 1 vs 18 µm), enlargement of the retinal hole, and allowed for prolonged injection times (median 52 vs 29 sec). Robotic assistance allowed higher rate of bleb formation (8/9 vs 4/9 attempts) with a moderate reduction in reflux (7/9 vs 8/9 attempts) in this artificial model. Robotic assistance can significantly contribute to subretinal injections and provide quantifiable parameters in assessing surgical and clinical success of novel retinal gene therapies.

scholarly journals Idiopathic Dural Optic Nerve Sheath Calcification Associated with Sclerochoroidal Calcification: Case Report and Review of Literatures

2021 ◽  
pp. 402-406
Author(s):  
Mohammad Sharifi ◽  
Bahar Tafaghodi Yousefi
Keyword(s):  
Optic Nerve ◽  
Pigment Epithelium ◽  
Outer Nuclear Layer ◽  
Retinal Pigment ◽  
Posterior Wall ◽  
Optic Nerve Sheath ◽  
Nerve Sheath ◽  
First Case ◽  
Brain Ultrasound ◽  
Vascular Arcade

We present a patient with idiopathic intracranial calcifications with simultaneous involvement of sclera, choroid, optic nerve, and trochlear apparatus. A 70-year-old woman with bilateral decreased vision was referred to our hospital. Ocular examinations revealed sclerochoroidal mass beneath superotemporal vascular arcade in macular area. Orbital CT scan shows bilateral calcification of dural optic nerve sheath and posterior wall of the globe as well as calcification in the trochlear apparatus and brain. Ultrasound showed highly reflective echogenic lesion with shadowing. OCT revealed rolling topography with thinning of the overlying choroid and outer nuclear layer as well as absence of the external limiting membrane and inner segment-outer segment junction. Slight irregular thickening of the retinal pigment epithelium is present. It is the first case of simultaneous bilateral dural optic nerve sheath and sclerochoroidal calcification.

Sign in / Sign up

Export Citation Format

Share Document