scholarly journals Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Nattawan Suwannakul ◽  
Ning Ma ◽  
Raynoo Thanan ◽  
Somchai Pinlaor ◽  
Piti Ungarreevittaya ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Fluke ◽  
Normal Liver ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Cd44 Isoforms ◽  
Cd44 Variant ◽  
Cox 2 ◽  
Liver Tissues

Various CD44 isoforms are expressed in several cancer stem cells during tumor progression and metastasis. In particular, CD44 variant 9 (CD44v9) is highly expressed in chronic inflammation-induced cancer. We investigated the expression of CD44v9 and assessed whether CD44v9 is a selective biomarker of human cholangiocarcinoma (CCA). The expression profile of CD44v9 was evaluated in human liver flukeOpisthorchis viverrini-related CCA (OV-CCA) tissues, human CCA (independent of OV infection, non-OV-CCA) tissues, and normal liver tissues. CD44v9 overexpression was detected by immunohistochemistry (IHC) in CCA tissues. There was a higher level of CD44v9 expression and IHC score in OV-CCA tissues than in non-OV-CCA tissues, and there was no CD44v9 staining in the bile duct cells of normal liver tissues. In addition, we observed significantly higher expression of inflammation-related markers, such as S100P and COX-2, in OV-CCA tissues compared to that in non-OV and normal liver tissues. Thus, these findings suggest that CD44v9 may be a novel candidate CCA stem cell marker and may be related to inflammation-associated cancer development.

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells

PROTEOMICS ◽  
2021 ◽  
pp. 2000098
Author(s):  
Annalisa L.E. Carli ◽  
Shoukat Afshar‐Sterle ◽  
Alin Rai ◽  
Haoyun Fang ◽  
Ryan O'Keefe ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Gastric Cancer Cells ◽  
Migratory Phenotype

CD44 as a cancer stem cell marker and its prognostic value in patients with ovarian carcinoma

2017 ◽  
Vol 38 (1) ◽  
pp. 110-114 ◽  
Author(s):  
Alena Bartakova ◽  
Kveta Michalova ◽  
Jiri Presl ◽  
Pavel Vlasak ◽  
Jan Kostun ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Ovarian Carcinoma ◽  
Prognostic Value ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals Epigenetic regulation of CD271, a potential cancer stem cell marker associated with chemoresistance and metastatic capacity

2014 ◽  
Vol 33 (1) ◽  
pp. 425-432 ◽  
Author(s):  
SULAN LI ◽  
DONGLI YUE ◽  
XINFENG CHEN ◽  
LIPING WANG ◽  
JIEYAO LI ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Epigenetic Regulation ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Metastatic Capacity ◽  
Potential Cancer

Role of cancer stem-cell marker doublecortin-like kinase 1 in head and neck squamous cell carcinoma

Oral Oncology ◽  
2017 ◽  
Vol 67 ◽  
pp. 109-118 ◽  
Author(s):  
Lorenz Kadletz ◽  
Dietmar Thurnher ◽  
Robert Wiebringhaus ◽  
Boban M. Erovic ◽  
Ulana Kotowski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals Expression of CD133 as a cancer stem cell marker in invasive gastric carcinoma

Pathologica ◽  
2019 ◽  
Vol 111 (1) ◽  
pp. 18-23
Author(s):  
S. Attia ◽  
N. Atwan ◽  
M. Arafa ◽  
R. A. Shahin
Keyword(s):  
Stem Cell ◽  
Gastric Carcinoma ◽  
Cancer Stem Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker
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