scholarly journals Pogonatherumol, a Novel Highly Oxygenated Norsesquiterpene with Flavone C-Glycosides from Pogonatherum crinitum

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Lin Ni ◽  
Wei Huang ◽  
He-shan Wang ◽  
Hui-you Xu
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Peritoneal Macrophage ◽  
Spectroscopic Data ◽  
Human Cancer ◽  
Mouse Peritoneal Macrophage ◽  
No Production ◽  
Human Cancer Cell ◽  
X Ray ◽  
Human Cancer Cell Lines

A novel highly oxygenated norsesquiterpene, pogonatherumol (1), with two known flavone C-glycosides (2-3), was isolated from Pogonatherum crinitum. The structure of the new compound was illuminated based on its spectroscopic data and X-ray analysis. Compounds 1 and 3 inhibited NO production in the mouse peritoneal macrophage (64.5 ± 7.2% and 61.6 ± 5.8%, respectively, at a concentration of 50 μM). The three compounds were inactive when tested against two human cancer cell lines (IC50 values > 50 μM).

scholarly journals Triangulene C, A New Cubitane-Based Diterpenoid from the Soft Coral Sinularia Triangula

2012 ◽  
Vol 7 (4) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Huey-Jen Su ◽  
Nai-Lun Lee ◽  
Mei-Chin Lu ◽  
Jui-Hsin Su
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Data ◽  
Soft Coral ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Hct 116

A new cubitane-based diterpenoid, triangulene C (1), was isolated from the soft coral Sinularia triangula and its structure was elucidated on the basis of spectroscopic data. Compound 1 was not cytotoxic (IC50 >20 μg/mL) toward the four human cancer cell lines tested (HL60, MDA-MB-231, HCT-116 and DLD-1).

scholarly journals Hopane-6α,16α,22-triol: A New Hopane Triterpenoid from the Lichen Parmotrema sancti-angelii

2019 ◽  
Vol 14 (6) ◽  
pp. 1934578X1985820 ◽  
Author(s):  
Jirapast Sichaem ◽  
Huu-Hung Nguyen ◽  
Thuc-Huy Duong
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Data ◽  
Human Cancer ◽  
In Vitro Cytotoxicity ◽  
Previous Literature ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Ergosterol Peroxide

A new compound, namely hopane-6 α,16 α,22-triol (1), along with 8 known compounds 2 to 9, leucotylin (2), 16 β-acetoxyhopane-6 α,22-diol (3), 6 α-acetoxyhopane-16 β,22-diol (4), zeorin (5), 6 α-acetoxyhopane-22-ol (6), ergosterol peroxide (7), brassicasterol (8), and atranorin (9), was isolated from the lichen Parmotrema sancti-angelii. The structures of all the isolated compounds 1 to 9 were fully characterized using spectroscopic data, as well as comparison with the previous literature data. Moreover, compounds 2 and 4 were assessed for their in vitro cytotoxicity against 3 human cancer cell lines.

Cytotoxic Thiophenes from the Root of Echinops grijisii Hance

2009 ◽  
Vol 64 (3-4) ◽  
pp. 193-196 ◽  
Author(s):  
Peng Zhang ◽  
Dong Liang ◽  
Wenrong Jin ◽  
Haibin Qu ◽  
Yiyu Cheng ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Data ◽  
Human Cancer ◽  
Ethanol Extract ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
First Time

A new thiophene, echinothiophenegenol (1), together with seven known thiophenes was isolated from the crude ethanol extract of roots of Echinops grijisii Hance. The structure of 1 was elucidated on the basis of spectroscopic data. Compounds 2 and 5, isolated from the plant for the first time, and compounds 1 - 7 were tested for their cytotoxicity against two human cancer cell lines, HL60 and K562. The thiophenes showed better activity than the bithiophenes

scholarly journals Glycoglycerolipids from Stellera Chamaejasme

2012 ◽  
Vol 7 (11) ◽  
pp. 1934578X1200701
Author(s):  
Liping Liu ◽  
Junqi Zhang ◽  
Xiaoyang Wang ◽  
Hongbing Wang
Keyword(s):  
Data Analysis ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Data ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Stellera Chamaejasme ◽  
New Compounds

Two new glycoglycerolipids (1 and 2), along with three known compounds (3-5) were isolated from Stellera chamaejasme. The structure of the new compounds was elucidated by chemical and spectroscopic data analysis. The cytotoxic activity of 1-3 was evaluated and showed no activity against the assayed human cancer cell lines.

scholarly journals Flavonoids from Twigs of Millettia pubinervis

2014 ◽  
Vol 9 (12) ◽  
pp. 1934578X1400901
Author(s):  
Zhi Na ◽  
Qi-Shi Song ◽  
Hua-Bin Hu
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Data ◽  
Human Cancer ◽  
Data Interpretation ◽  
2D Nmr ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Phytochemical Investigation ◽  
Mcf 7

A new flavone, 3-methoxy-5-hydroxy-[2”,3”:7,8] furanoflavone, pubinerone (1), was isolated from the twigs of Millettia pubinervis Kurz, together with ten known flavonoids, karanjin (2), kanjone (3), 3,6-dimethoxy-[2”,3”:7,8] furanoflavone (4), pongaglabrone (5), pongapin (6), pongaflavone (7), 3,6-dimethoxy-6”,6”-dimethylchromene-[2”,3”:7,8] flavone (8), pongachromene (9), 3,6-dimethoxy-3′,4′-methylenedioxy-6”,6”-dimethylchromene-[2”,3”:7,8] flavone (10) and demethoxykanugin (11). This is the first phytochemical investigation of this plant. The structure of compound 1 was elucidated on the basis of spectroscopic data interpretation, including 1D and 2D NMR and HREIMS analysis. The cytotoxicity of 1 against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7 and SW480, was evaluated, but it was inactive (IC50>40μM).

scholarly journals Synthesis, Structure and Cytotoxicity Testing of Novel 7-(4,5-Dihydro-1H-imidazol-2-yl)-2-aryl-6,7-dihydro-2H-imidazo[2,1-c][1,2,4]triazol-3(5H)-Imine Derivatives

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5924
Author(s):  
Łukasz Balewski ◽  
Franciszek Sączewski ◽  
Patrick J. Bednarski ◽  
Lisa Wolff ◽  
Anna Nadworska ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cell Lines ◽  
Spectroscopic Data ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
X Ray ◽  
Human Cancer Cell Lines ◽  
Ic50 Values

The appropriate 1-arylhydrazinecarbonitriles 1a–c are subjected to the reaction with 2-chloro-4,5-dihydro-1H-imidazole (2), yielding 7-(4,5-dihydro-1H-imidazol-2-yl)-2-aryl-6,7-dihydro-2H-imidazo[2,1-c][1,2,4]triazol-3(5H)-imines 3a–c, which are subsequently converted into the corresponding amides 4a–e, 8a–c, sulfonamides 5a–n, 9, ureas 6a–I, and thioureas 7a–d. The structures of the newly prepared derivatives 3a–c, 4a–e, 5a–n, 6a–i, 7a–d, 8a–c, and 9 are confirmed by IR, NMR spectroscopic data, as well as single-crystal X-ray analyses of 5e and 8c. The in vitro cytotoxic potency of these compounds is determined on a panel of human cancer cell lines, and the relationships between structure and antitumor activity are discussed. The most active 4-chloro-N-(2-(4-chlorophenyl)-7-(4,5-dihydro-1H-imidazol-2-yl)-6,7-dihydro-2H-imidazo[2,1-c][1,2,4]triazol-3(5H)-ylidene)benzamide (4e) and N-(7-(4,5-dihydro-1H-imidazol-2-yl)-2-(p-tolyl)-6,7-dihydro-2H-imidazo[2,1-c][1,2,4]triazol-3(5H)-ylidene)-[1,1′-biphenyl]-4-sulfonamide (5l) inhibits the growth of the cervical cancer SISO and bladder cancer RT-112 cell lines with IC50 values in the range of 2.38–3.77 μM. Moreover, N-(7-(4,5-dihydro-1H-imidazol-2-yl)-2-phenyl-6,7-dihydro-2H-imidazo[2,1-c][1,2,4]triazol-3(5H)-ylidene)-4-phenoxybenzenesulfonamide (5m) has the best selectivity towards the SISO cell line and induces apoptosis in this cell line.

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