scholarly journals Autologous Fat Grafting in the Treatment of Facial Scleroderma

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Mehdi Gheisari ◽  
Arman Ahmadzadeh ◽  
Nilofar Nobari ◽  
Behzad Iranmanesh ◽  
Nikoo Mozafari
Keyword(s):  
Systemic Sclerosis ◽  
Treatment Options ◽  
Mouth Opening ◽  
Fat Grafting ◽  
Systemic Autoimmune Disease ◽  
P Value ◽  
Fat Injection ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Autologous Fat Transfer

Systemic sclerosis (SSc) is a rare systemic autoimmune disease, characterized by progressive cutaneous and internal organ fibrosis. Orofacial manifestations of systemic sclerosis are extremely disabling and treatment options are limited. In this study, we aimed to assess the safety and efficacy of autologous fat grafting in the face of patients with systemic sclerosis. We enrolled 16 SSc patients suffering from facial sclerosis and limited mouth opening capacity. Autologous fat injection ranging from 15 to 40 ml was administered per patient, based on their face morphology. The patients were evaluated at baseline and 3 months after fat injection. Evaluations included mouth opening capacity, mouth handicap in systemic sclerosis (MHISS), Rodnan skin sclerosis score, skin biophysical properties using a sensitive biometrologic device with the assessment of cutaneous resonance running time (CRRT), volumizing and aesthetic effects based on pre- and posttreatment photographs, possible side effects, and global patient satisfaction. Clinical assessment showed autologous fat transfer significantly improved mouth opening capacity and the MHISS and Rodnan score of patients with facial scleroderma (p value <.001). The aesthetic and/or functional results of fat injection were satisfying to about 80% of the patients. The changes in CRRT values were not significant. Our findings support the possible therapeutic role of autologous fat grafting in improving facial scleroderma both in aesthetic and in functional aspects. This trial is registered with IRCT20180209038677N1.

scholarly journals Oro-facial fibrosis in systemic sclerosis: a reconstructive journey

2020 ◽  
Vol 13 (10) ◽  
pp. e236663
Author(s):  
Faith Hyun Kyung Jeon ◽  
Michelle Griffin ◽  
Jajini Varghese ◽  
Peter Edward Michael Butler
Keyword(s):  
Systemic Sclerosis ◽  
Treatment Modality ◽  
Mouth Opening ◽  
Fat Grafting ◽  
Autologous Fat Grafting ◽  
Disease Manifestation ◽  
Lower Lip ◽  
Autologous Fat ◽  
Minimally Invasive Surgical Procedure ◽  
Minimally Invasive Surgical

Oro-facial fibrosis presents a significant disease burden in patients with systemic sclerosis, but there remains no established treatment modality. Autologous fat grafting is a minimally invasive surgical procedure that is now increasingly recognised for its regenerative capacity, propagating an expansion of heterogeneous indications beyond volume restoration, including fibrotic diseases such as systemic sclerosis. We present a 42-year-old woman with oro-facial involvement of systemic sclerosis leading to severe limitation in mouth opening and closure, with marked retraction of the lower lip and gingival display. We describe the reconstructive journey over a 12-year period, where the antifibrotic effect of autologous fat grafting served as the basis on which a series of surgical procedures were performed to achieve functional and aesthetic improvement. Autologous fat grafting provides a novel treatment modality for oro-facial skin fibrosis, previously considered a non-treatable disease manifestation of systemic sclerosis.

scholarly journals Treatment of “En Coupe De Sabre “ Linear Scleroderma. Soft Tissue Augmentation and Regeneration by Autologous Fat Transfer

2021 ◽  
pp. 30
Author(s):  
◽  
Keyword(s):  
Stem Cells ◽  
Soft Tissue ◽  
Fat Grafting ◽  
Soft Tissue Augmentation ◽  
Congenital Deformity ◽  
Autologous Fat Grafting ◽  
Fat Transfer ◽  
Autologous Fat ◽  
Autologous Fat Transfer ◽  
Linear Scleroderma

Aim: Frontal linear scleroderma, also known as ‘‘en coup de sabre,’’ is a congenital deformity characterized by atrophy and furrowing of the skin of the front parietal area above the level of the eyebrows. In most cases it occurs as a single paramedian line that may be associated with hypoplasia of underlying structures and facial hemiatrophy. In case of a wide lesion many reconstructive strategies have been proposed. The modern approach is aimed at augmentation of the tissue deficiency by using lipostructure and tissue regeneration. Autologous fat transfer (AFT) seems to be an effective strategy to restore the normal volume and contour of the face while providing a source of adipose-derived stem cells (ADSCs) with a multilineage differentiation potential. Methods: In this report, we present a rare case of linear scleroderma en coupe de sabre which was successfully managed with three stages of autologous fat grafting. Conclusion: The proposed uses for ADSCs in tissue repair and regeneration are quite impressive. Recent works on ADSCs would suggest that adult cells may prove to be an equally powerful regenerative tool in treating congenital and acquired maxillofacial disorders. More importantly, physicians, researchers and international associations need to cooperate in informing clinicians about what practices are based on evidence and to encourage support of additional research. There is increasing interest in a possible therapeutic effect of ADSCs from processed lipoaspirate for a wide spectrum of clinical applications in the facial and craniofacial area. AFT can be used in any facial area where soft tissue is lacking or where there is scarring, producing natural and long-lasting results. Mesenchymal stem cells represent a great tool in regenerative medicine. However, more definitive studies are needed to answer specific questions regarding the best technique to be used and the role of ADSCs. Autologous fat grafting provides a safe and easy approach for the treatment of linear scleroderma en coup de sabre, long-term clinically satisfactory results can be obtained.

scholarly journals Autologous Fat Grafting for the Oral and Digital Complications of Systemic Sclerosis: Results of a Prospective Study

2020 ◽  
Vol 44 (5) ◽  
pp. 1820-1832 ◽  
Author(s):  
Marco Pignatti ◽  
Amelia Spinella ◽  
Emanuele Cocchiara ◽  
Giulia Boscaini ◽  
Irene Laura Lusetti ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Prospective Study ◽  
Fat Grafting ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
A Prospective Study

Simultaneous Fat Injection for Nasal Contouring in Orthognathic Patients (Preprint)

2020 ◽  
Author(s):  
Daniel Lonic ◽  
Yen-Chang Hsiao ◽  
Jung-Ju Huang ◽  
Frank Chun-Shin Chang ◽  
Jyh-Ping Chen ◽  
...  
Keyword(s):  
Prospective Study ◽  
Orthognathic Surgery ◽  
Retention Rate ◽  
Asian Population ◽  
Fat Grafting ◽  
Fat Injection ◽  
Autologous Fat Grafting ◽  
Augmentation Rhinoplasty ◽  
Autologous Fat ◽  
Before And After

BACKGROUND Augmentation rhinoplasty with autologous fat grafting is a useful procedure to meet the demand for facial harmonization in the Asian population. We used this procedure during orthognathic surgery to address inadequate dorsum projection. OBJECTIVE This prospective study was conducted to determine the fat retention rate in patients with simultaneous autologous fat injection augmentation rhinoplasty and orthognathic surgery. METHODS Nineteen patients were treated with simultaneous bimaxillary orthognathic surgery and autologous fat grafting of the nasal dorsum and tip. The paired- t -test was used to compare the nasal volumes before and at least 6 months after surgery measured by 3D CT scans. All measurements were performed twice by the same evaluator at least 2 weeks apart for intra-rater consistency. RESULTS Seventeen patients completed the study. The volume means before and after surgery were 22.3 +/- 4.6 cm3 and 23.3 +/-4.7 cm3 respectively with a mean difference of 1.0 +/- 0.3 cm3 (p<0.001). The mean retention rate was calculated to be 50.5 +/- 7.0% (range 40.5% to 64.7%). Intra-rater consistency was high with a Cronbach α of 0.97 (P<0.001) and 0.98 (P<0.001) respectively. CONCLUSIONS To the best of our knowledge, this is the first prospective study that provides objective graft retention measurements based on computer tomography scans for orthognathic surgery combined with fat injection. All patients were satisfied with the results and no complications or additional morbidity was noted in the postoperative course. We consider this procedure to be a safe, reliable and powerful adjunct to improve the aesthetic results of orthognathic surgery.

scholarly journals Autologous Fat Grafting in the Treatment of Fibrotic Perioral Changes in Patients with Systemic Sclerosis

2015 ◽  
Vol 24 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Nicoletta Del Papa ◽  
Fabio Caviggioli ◽  
Domenico Sambataro ◽  
Eleonora Zaccara ◽  
Valeriano Vinci ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Fat Grafting ◽  
Autologous Fat Grafting ◽  
Autologous Fat

scholarly journals THU0349 AUTOLOGOUS FAT GRAFTING IN THE TREATMENT OF PATIENTS WITH SYSTEMIC SCLEROSIS: CURRENT EXPERIENCE AND FUTURE PROSPECTS

2019 ◽  
Author(s):  
Amelia Spinella ◽  
Marco Pignatti ◽  
Giorgia Citriniti ◽  
Federica Lumetti ◽  
Emanuele Cocchiara ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Fat Grafting ◽  
Future Prospects ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Current Experience
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