scholarly journals Biodegradable Magnesium Alloys Developed as Bone Repair Materials: A Review

Scanning ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Chen Liu ◽  
Zheng Ren ◽  
Yongdong Xu ◽  
Song Pang ◽  
Xinbing Zhao ◽  
...  
Keyword(s):  
Bone Repair ◽  
The Body ◽  
Mg Alloys ◽  
Repair Materials ◽  
Future Challenges ◽  
In Situ Degradation ◽  
Important Means ◽  
Human Bony ◽  
Biological Performance ◽  
Bone Repair Materials

Bone repair materials are rapidly becoming a hot topic in the field of biomedical materials due to being an important means of repairing human bony deficiencies and replacing hard tissue. Magnesium (Mg) alloys are potentially biocompatible, osteoconductive, and biodegradable metallic materials that can be used in bone repair due to their in situ degradation in the body, mechanical properties similar to those of bones, and ability to positively stimulate the formation of new bones. However, rapid degradation of these materials in physiological environments may lead to gas cavities, hemolysis, and osteolysis and thus, hinder their clinical orthopedic applications. This paper reviews recent work on the use of Mg alloy implants in bone repair. Research to date on alloy design, surface modification, and biological performance of Mg alloys is comprehensively summarized. Future challenges for and developments in biomedical Mg alloys for use in bone repair are also discussed.

scholarly journals A promising material for bone repair: PMMA bone cement modified by dopamine-coated strontium-doped calcium polyphosphate particles

2019 ◽  
Vol 6 (10) ◽  
pp. 191028 ◽  
Author(s):  
Xing Liu ◽  
Can Cheng ◽  
Xu Peng ◽  
Hong Xiao ◽  
Chengrui Guo ◽  
...  
Keyword(s):  
Bone Cement ◽  
Bone Repair ◽  
Bone Cements ◽  
The Novel ◽  
Calcium Polyphosphate ◽  
Pmma Bone Cement ◽  
Repair Materials ◽  
Biological Performance ◽  
Bone Repair Materials ◽  
Composite Bone

Polymethyl methacrylate (PMMA) bone cement has been widely used in clinics as bone repair materials for its excellent mechanical properties and good injection properties. However, it also has defects such as poor biological performance, high temperature, and the monomer has certain toxicity. Our study tried to modify the PMMA bone cement by doping with various particle weight fractions (5, 10 and 15%) of SCPP particles and polydopamine-coated SCPP particles (D/SCPP) to overcome its clinical application disadvantages. Our study showed that all results of physical properties of samples are in accordance with ISO 5833. The 15% D/SCPP/PMMA composite bone cement had much better biocompatibility compared with pure PMMA bone cement and SCPP/PMMA composite bone cement due to the best cell growth-promoting mineralization deposition on the surface of 15% D/SCPP/PMMA composite bone cements and Sr 2+ released from SCPP particles. Our research also revealed that the reaction temperature was found to be reduced with an increase in doped particles after incorporating the particles into composite bone cements. The novel PMMA bone cements modified by D/SCPP particles are promising materials for bone repair.

Peptide‐modified bone repair materials: Factors influencing osteogenic activity

2019 ◽  
Vol 107 (7) ◽  
pp. 1491-1512 ◽  
Author(s):  
Jie Liao ◽  
Shuai Wu ◽  
Kun Li ◽  
Yubo Fan ◽  
Nicholas Dunne ◽  
...  
Keyword(s):  
Bone Repair ◽  
Osteogenic Activity ◽  
Factors Influencing ◽  
Repair Materials ◽  
Bone Repair Materials

Self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system for bone repair materials

2017 ◽  
Vol 5 (12) ◽  
pp. 2245-2253 ◽  
Author(s):  
Yi-Xuan Chen ◽  
Rong Zhu ◽  
Zheng-liang Xu ◽  
Qin-Fei Ke ◽  
Chang-Qing Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Self Assembly ◽  
Bone Repair ◽  
Repair Materials ◽  
Double Hydroxide ◽  
First Time ◽  
Bone Repair Materials

The self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system was demonstrated for the first time to improve the cytocompatibility and enhance the osteoinductivity for the treatment of bone defects.

Study on osteointegrative properties of a functional gradient tumor bone repair materials in ulna bone defect model of rabbits

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S432
Author(s):  
Shihui Chen ◽  
Tao Tang ◽  
Zhong Liu ◽  
Poying Lau ◽  
Xinhui Xie ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Repair ◽  
Defect Model ◽  
Functional Gradient ◽  
Repair Materials ◽  
Bone Repair Materials

Study on the Preparation of Strontium-Doped Hydroxyapatite Whisker

2013 ◽  
Vol 738 ◽  
pp. 26-29 ◽  
Author(s):  
Ting Ting Yan ◽  
Yong Shun Cui ◽  
Qing Hua Chen
Keyword(s):  
Mechanical Property ◽  
Bone Repair ◽  
Calcium Nitrate ◽  
Xrd Analysis ◽  
Strontium Nitrate ◽  
X Ray Diffraction ◽  
X Ray ◽  
Repair Materials ◽  
Bone Repair Materials ◽  
Scanning Electron

Hydroxyapatite is well used as bone repair materials, due to its properties that can be combined with strontium to improve mechanical property and degradation property. In this article, hydroxyapatite whiskers with different amount of doped strontium were prepared with diammonium phosphate, calcium nitrate and strontium nitrate at 94 °C. Fourier transform infrared spectroscopy (FTIR) was used to identify the functional groups. X-ray diffraction (XRD) analysis was carried out to study the phase composition and crystallinity of the whisker. The morphology of the whiskers was characterized by scanning electron microscope (SEM). It was indicated that strontium can be doped in hydroxyapatite with proper process and then the strontium-doped hydroxyapatite whiskers were produced successfully.

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