Bone Mineral Density as a Predictor of Atherogenic Indexes of Cardiovascular Disease, Especially in Nonobese Adults

Purpose. This study is aimed at determining whether bone mineral density (BMD) values are related to atherogenic indexes (AIs) and could predict the risk of cardiovascular disease (CVD) in southern Taiwanese adults. Methods. Medical records of 3249 adults who underwent health examinations between June 2014 and February 2018 at a regional hospital in southern Taiwan were reviewed. Data collected included health history, anthropomorphic characteristics, exercise habits, diets (vegetarian or nonvegetarian), clinical laboratory results (lipid profile, systemic blood pressure (SBP), glucose level, creatinine (Cre) level, and hemoglobin (Hb) level), and bone mineral density (BMD), which were used to identify the associations of these parameters, especially BMD, with lipid profile and calculated AIs through simple and multiple linear regressions. Results. The mean age of the patients was 58.0 years, and 71.4% were male. Body mass index (BMI), SBP, glucose level, Cre level, Hb level, and all BMD values were positively correlated with triglyceride (TG) level and AIs and were negatively correlated with high-density lipoprotein cholesterol (HDL-C) level. The significant positive correlations of BMD at all the measured sites with AIs remained after adjusting for age, sex, SBP, glucose level, Cre level, Hb level, smoking, exercise habits, and vegetarian state. The expanded adjusting model for TG/HDL-C remained significant at all the BMD measured sites in nonobese men, at bilateral femoral neck and total hips in nonobese women, and at the bilateral total hips in obese women. Conclusions. AIs are predictive markers for CVD, and BMD values are predictors of AIs, especially the novel AI, i.e., TG/HDL-C ratio, in nonobese adult men and women after dividing the patients into subgroups to eliminate the effect of BMI as a confounding factor. Thus, BMD values could predict AIs of CVD, especially in nonobese adults.

Download Full-text

Prognostic value of lower bone mineral density in predicting adverse cardiovascular disease in Asian women

Heart ◽

10.1136/heartjnl-2020-318764 ◽

2021 ◽

pp. heartjnl-2020-318764

Author(s):

Jiesuck Park ◽

Yeonyee Elizabeth Yoon ◽

Kyoung Min Kim ◽

In-Chang Hwang ◽

Wonjae Lee ◽

...

Keyword(s):

Risk Factors ◽

Bone Mineral Density ◽

Cardiovascular Disease ◽

Clinical Diagnosis ◽

Bone Mineral ◽

Prognostic Value ◽

Clinical Risk Factors ◽

Mineral Density ◽

Clinical Risk ◽

Incremental Prognostic Value

ObjectiveWe investigated whether the evaluation of bone mineral density (BMD) provides independent and incremental prognostic value for predicting atherosclerotic cardiovascular disease (ASCVD) in women.MethodsA total of 12 681 women aged 50–80 years (mean, 63.0±7.8 years) who underwent dual-energy X-ray absorptiometry were retrospectively analysed. We assessed the hazard ratio (HR) for ASCVD events (ASCVD death, non-fatal myocardial infarction and ischaemic stroke) according to the BMD or a clinical diagnosis of osteopenia or osteoporosis, with adjustment for clinical risk factors, including age, body mass index, hypertension, type 2 diabetes, hyperlipidaemia, current smoking and previous fracture. We also evaluated whether the addition of BMD or a clinical diagnosis of osteopenia or osteoporosis to clinical risk factors improved the prediction for ASCVD events.ResultsIn total, 468 women (3.7%) experienced ASCVD events during follow-up (median, 9.2 years). Lower BMD at the lumbar spine, femur neck and total hip was independently associated with higher risk for ASCVD events (adjusted HR per 1-standard deviation decrease in BMD: 1.16, p<0.001; 1.29, p<0.001; 1.38, p<0.001; respectively). A clinical diagnosis of osteoporosis was also independently associated with higher risk for ASCVD events (adjusted HR: 1.79, p<0.001). The addition of BMD or a clinical diagnosis of osteopenia or osteoporosis to clinical risk factors demonstrated significant incremental value in discriminating ASCVD events (addition of total hip BMD, p for difference <0.001).ConclusionThe evaluation of BMD provides independent and incremental prognostic value for ASCVD in women and thus may improve risk stratification in women.

Download Full-text

Abstract #1003985: Correlation of Lipid Profile with Bone Mineral Density in Postmenopausal Women

Endocrine Practice ◽

10.1016/j.eprac.2021.04.626 ◽

2021 ◽

Vol 27 (6) ◽

pp. S74

Author(s):

sharikant sharma ◽

sunita Hemani ◽

jyoti D. jain

Keyword(s):

Bone Mineral Density ◽

Lipid Profile ◽

Postmenopausal Women ◽

Bone Mineral ◽

Mineral Density

Download Full-text

Clinical and subclinical cardiovascular disease in female SLE patients: Interplay between body mass index and bone mineral density

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2018.09.007 ◽

2019 ◽

Vol 29 (2) ◽

pp. 135-143 ◽

Cited By ~ 1

Author(s):

J. Rodríguez-Carrio ◽

A. Martínez-Zapico ◽

I. Cabezas-Rodríguez ◽

L. Benavente ◽

Á.I. Pérez-Álvarez ◽

...

Keyword(s):

Bone Mineral Density ◽

Cardiovascular Disease ◽

Body Mass Index ◽

Body Mass ◽

Bone Mineral ◽

Mineral Density ◽

Subclinical Cardiovascular Disease

Download Full-text

Correlation of the Lipid Profile, BMI and Bone Mineral Density in Postmenopausal Women

Materia Socio Medica ◽

10.5455/msm.2016.28.412-415 ◽

2016 ◽

Vol 28 (6) ◽

pp. 412 ◽

Cited By ~ 12

Author(s):

Radojka Bijelic ◽

Jagoda Balaban ◽

Snjezana Milicevic

Keyword(s):

Bone Mineral Density ◽

Lipid Profile ◽

Postmenopausal Women ◽

Bone Mineral ◽

Mineral Density

Download Full-text

Relationship between Serum Lipid Profile and Bone Mineral Density in Korean Men: The Fifth Korea Health and Nutrition Examination Survey (2010-2011)

Korean Journal of Family Practice ◽

10.21215/kjfp.2018.8.1.151 ◽

2018 ◽

Vol 8 (1) ◽

pp. 151-154

Author(s):

Oh-heon Kwon ◽

Hee-ju Kang ◽

Woo-cheol Lee ◽

Jung-ho Ko

Keyword(s):

Bone Mineral Density ◽

Lipid Profile ◽

Bone Mineral ◽

Serum Lipid ◽

Serum Lipid Profile ◽

Nutrition Examination Survey ◽

Mineral Density ◽

Health And Nutrition

Download Full-text

Causal link between lipid profile and bone mineral density: A Mendelian randomization study

Bone ◽

10.1016/j.bone.2019.05.037 ◽

2019 ◽

Vol 127 ◽

pp. 37-43 ◽

Cited By ~ 3

Author(s):

Xiao-Lin Yang ◽

Zhi-Zhen Cui ◽

Hong Zhang ◽

Xin-Tong Wei ◽

Gui-Juan Feng ◽

...

Keyword(s):

Bone Mineral Density ◽

Lipid Profile ◽

Bone Mineral ◽

Mendelian Randomization ◽

Causal Link ◽

Mineral Density

Download Full-text

Carotid plaque and lumbar bone mineral density status in post-menopausal women: An age-matched, analytical cross-sectional study

Post Reproductive Health ◽

10.1177/2053369119890746 ◽

2019 ◽

Vol 26 (1) ◽

pp. 9-18

Author(s):

Patraporn Sitthisombat ◽

Sukree Soontrapa ◽

Srinaree Kaewrudee ◽

Jen Sothornwit ◽

Nuntasiri Eamudomkarn ◽

...

Keyword(s):

Bone Mineral Density ◽

Cardiovascular Disease ◽

Lumbar Spine ◽

Bone Mineral ◽

Odds Ratio ◽

Carotid Plaque ◽

Spine Bone Mineral Density ◽

Mineral Density ◽

Menopausal Women ◽

Post Menopausal

Objective To explore the association between carotid plaque and lumbar spine osteoporosis in post-menopausal women. Study design Age-matched, cross-sectional study. Main outcome measures Carotid plaque and carotid intima media thickness were measured with B-mode ultrasound. Lumbar spine bone mineral density was measured with dual-energy X-ray absorptiometry. Prevalence odds ratios and the respective 95% confidence intervals (95%CI) were calculated to determine the association. Results Seventy-two post-menopausal women with lumbar spine osteoporosis and 72 post-menopausal women with normal lumbar spine bone mineral density were enrolled. The adjusted prevalence odds ratio of carotid plaque presence in post-menopausal women with lumbar spine osteoporosis was 1.73 (95%CI; 0.60 to 4.94) when compared to post-menopausal women with normal lumbar spine bone mineral density. The presence of vulnerable plaque was greater in post-menopausal women with lumbar spine osteoporosis; however, the difference was not statistically significant after adjusting for other risk factors of cardiovascular disease (odds ratio 1.31; 95%CI; 0.39 to 4.43). There was no significant difference in carotid intima media thickness between the two groups. Multiple logistic regression analysis with backward elimination in assessment of potential risk factors for the presence of carotid plaque showed that the year since menopause, family history of cardiovascular disease and systolic blood pressure were nominally significant associated factors with a respective adjusted odds ratio of 1.06 (95%CI; 1.01 to 1.12), 6.23 (95%CI; 1.65 to 23.46) and 1.03 (95%CI; 1.01 to 1.06). Conclusions The current study indicates that lumbar spine osteoporosis is not associated with the presence of carotid plaque, whereas year since menopause, family history of cardiovascular disease and systolic blood pressure are associated factors.

Download Full-text