scholarly journals Vitamin D3 and Dental Caries in Children with Growth Hormone Deficiency

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Dorota Wójcik ◽  
Leszek Szalewski ◽  
Elżbieta Pietryka-Michałowska ◽  
Janusz Borowicz ◽  
Elżbieta Pels ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Vitamin D ◽  
Dental Caries ◽  
Growth Hormone Deficiency ◽  
Rural Areas ◽  
Urban Areas ◽  
Hormone Deficiency ◽  
Study Group ◽  
Paediatric Hospital ◽  
Dmft Index

Vitamin D deficiency is a common risk factor for multifactorial diseases, and it seems to be associated with growth hormone deficiency (GHD). Vitamin D could prevent dental caries. The goal of this study was to identify whether there is an association between hormonal therapy with growth hormone (GH), vitamin D3 supplementation, vitamin D3 levels, and the occurrence of caries among children affected by GHD. The study group consisted of patients from the Department of Endocrinology and Diabetology of the University Paediatric Hospital at the Medical University of Lublin treated with recombinant human GH for pituitary GHD. It was conducted between October 2014 and June 2015. The study group included 121 children and adolescents aged 6 to 18 years, with 56 children from rural areas and 65 from urban areas. The study group was stratified by the area of residence. We found the statistically significant impact of vitamin D3 concentration on the average value of the DMFT (decayed, missed, and filled teeth) index and its component—DT (decayed teeth), which was noted in subjects from rural areas. Among patients from urban areas, we found a statistically significant correlation between duration of therapy and the DMFT index. An increase in duration of GH therapy by 10 months leads to a mean increase in DMFT index by 0.70. Based on multiple regression analysis, we developed the following model: value of DT = 3.10 − 0.73∗category of vitamin D3 concentration − 0.07∗duration of supplementation (in months). In this model, variables with a significant impact on the value of DT in the group of patients from rural areas include time of vitamin D3 supplementation and category of vitamin D3 concentration. Greater emphasis should be placed on promoting vitamin D3 as a potentially effective agent reducing the number of dental caries, especially among patients with GHD.

scholarly journals Dental caries and vitamin D3 in children with growth hormone deficiency

Medicine ◽  
2018 ◽  
Vol 97 (8) ◽  
pp. e9811 ◽  
Author(s):  
Dorota Wójcik ◽  
Aleksandra Krzewska ◽  
Leszek Szalewski ◽  
Elżbieta Pietryka-Michałowska ◽  
Magdalena Szalewska ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Dental Caries ◽  
Growth Hormone Deficiency ◽  
Vitamin D3 ◽  
Hormone Deficiency

Vitamin D status and response to growth hormone treatment in prepubertal children with growth hormone deficiency

2020 ◽  
Vol 43 (10) ◽  
pp. 1485-1492
Author(s):  
T. Durá-Travé ◽  
F. Gallinas-Victoriano ◽  
P. Moreno-González ◽  
M. Urretavizcaya-Martinez ◽  
S. Berrade-Zubiri ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Vitamin D ◽  
Growth Hormone Deficiency ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Hormone Deficiency ◽  
Vitamin D Status ◽  
Prepubertal Children

Cardiovascular risk in adult hypopituitaric patients with growth hormone deficiency: is there a role for vitamin D?

Endocrine ◽  
2015 ◽  
Vol 52 (1) ◽  
pp. 111-119 ◽  
Author(s):  
Maria Cristina Savanelli ◽  
Elisabetta Scarano ◽  
Giovanna Muscogiuri ◽  
Luigi Barrea ◽  
Laura Vuolo ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Vitamin D ◽  
Cardiovascular Risk ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency

Vitamin D levels in primary growth hormone deficiency disorder Prader–Willi syndrome

Endocrine ◽  
2016 ◽  
Vol 53 (2) ◽  
pp. 619-620 ◽  
Author(s):  
Louise Purtell ◽  
Alexander Viardot ◽  
Lesley V. Campbell
Keyword(s):  
Growth Hormone ◽  
Vitamin D ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Prader Willi Syndrome ◽  
Primary Growth ◽  
Vitamin D Levels

scholarly journals Oral health in children with hearing and speech impairment in Banjaluka

2013 ◽  
Vol 60 (3) ◽  
pp. 139-146
Author(s):  
Aleksandra Djeri ◽  
Irena Kuzmanovic-Radman ◽  
Milkica Grabez ◽  
Zorislava Bajic ◽  
Alma Prtina ◽  
...  
Keyword(s):  
Oral Health ◽  
Dental Caries ◽  
Rural Areas ◽  
Urban Areas ◽  
World Health ◽  
Healthy Children ◽  
Speech Impairment ◽  
Cross Sectional ◽  
Significant Difference ◽  
Dmft Index

Introduction. Children with hearing impairment do not understand speech without specific instructions and cannot meet daily life requirements. Children with hearing and speech impairment have higher DMFT index and poorer oral hygiene than healthy children of the same age. The aim of this study was to determine oral health status and the prevalence of dental caries in children attending The Center for Education and Rehabilitation of Speech and Hearing in Banjaluka. Material and Methods. The study was conducted as a cross-sectional study and it included 66 children of both genders, age 3 to 18 years, with deciduous, mixed and permanent dentition. General information about the respondents, their socioeconomic status, dental hygiene habits and frequency of dental visits were obtained using a questionnaire. Dental examination was performed using a dental mirror, regular and proximal probe on the daylight, in accordance with World Health Organization guidelines. Oral examination included: number of present teeth, presence of caries, restorations, number of extracted teeth. These data was entered in each patient?s dental record. The DMFT index was used for the assessment of dental status. Results. Results showed that the mean DMFT value in the total sample was 7.79. There was no significant difference in the DMFT index between genders (p=0.19). The significant difference was not found between children who live with parents and those who live in foster families (p=0.15). It was observed that the respondents from rural areas had higher DMFT index (8.68) than respondents from urban areas (5.83). The DMFT index increased with age and school age (p<0.001). Examined patients were most affected with dental caries (6.62%) and least affected with extracted teeth (0.38%). It was revealed that 6% of respondents do not brush their teeth, and 25.8% of respondents had never visited dentist. Conclusion. Children with hearing and speech impairment from Banjaluka have low level of oral health. The DMFT index, as one of the most important parameters of oral health in these children was much higher compared to European countries and other countries in the region.

Vitamin D status in prepubertal children with isolated idiopathic growth hormone deficiency: effect of growth hormone therapy

2018 ◽  
Vol 66 (5) ◽  
pp. 1.2-8 ◽  
Author(s):  
Rasha Tarif Hamza ◽  
Amira I Hamed ◽  
Mahmoud T Sallam
Keyword(s):  
Growth Hormone ◽  
Vitamin D ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Vitamin D Status ◽  
Gh Therapy ◽  
Gh Treatment ◽  
Prepubertal Children ◽  
Idiopathic Growth Hormone Deficiency ◽  
Vitamin D Levels

Few studies, and with controversial results, analyzed vitamin D status in children before and after growth hormone (GH) treatment. Thus, we aimed to assess vitamin D status in prepubertal children with idiopathic growth hormone deficiency (GHD), and to evaluate the effect of GHD and GH treatment on vitamin D levels. Fifty prepubertal children with isolated GHD were compared with 50 controls. All were subjected to history, anthropometric assessment and measurement of 25 hydroxyvitamin D (25(OH)D), serum calcium, phosphorous, alkaline phosphatase and parathyroid hormone (PTH) at diagnosis and 1 year after GH therapy. Serum 25(OH)D levels <30 ng/mL and 20 ng/mL were defined as vitamin D insufficiency and deficiency, respectively. 25(OH)D was lower in cases than controls. Forty per cent of children with GHD were 25(OH)D insufficient and 44% deficient, while 16% were sufficient at baseline. There was a positive correlation between 25(OH)D and peak GH levels. Peak GH was a significant predictor of 25(OH)D levels. After 1 year of GH therapy, 25(OH)D increased (18.42±5.41 vs 34.5±10.1 ng/mL; P<0.001). Overall, 22% of cases remained insufficient and 24% deficient, with an increase in prevalence of children with normal levels (54%; P<0.001). 25(OH) correlated negatively with PTH (r=−0.71, P=0.01). In conclusion, hypovitaminosis D is prevalent in children with GHD and significantly improved 1 year after GH therapy. 25(OH)D should be assessed in children with GHD at diagnosis and during follow-up.

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