High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation

Objective. To investigate whether and how the working memory impairment induced by sleep deprivation (SD) could be recovered by using repetitive transcranial magnetic stimulation (rTMS), as well as to clarify the corresponding brain activity changes. Methods. Seventeen healthy adults received one session of 5.0 Hz rTMS over the left dorsolateral prefrontal cortex (DLPFC) following 24 hours of SD. Resting state functional magnetic resonance imaging (fMRI) and working memory test were performed during a rested waking period, after SD and rTMS. The amplitude of low-frequency fluctuations (ALFF) was used to detect the spontaneous neural activity changes after both SD and rTMS. The relationship between ALFF and the performance of working memory was also assessed by using correlation analysis. Results. After SD, the participants exhibited lower response accuracies and longer reaction times on the working memory tests of letters and numbers. The decreased response accuracy of numbers was significantly improved after rTMS similarly to the state of the rested waking period after a normal night of sleep. ALFF values decreased from the rested waking period state to the state of SD in the brain regions involving the frontal gyrus, precuneus, angular gyrus, and parietal lobe which showed significantly increased ALFF after rTMS. Furthermore, significantly positive correlations were observed between changes of response accuracy and the changes of ALFF value of the inferior frontal gyrus and supramarginal gyrus. Conclusion. These results indicate that high-frequency rTMS applied over left DLPFC may contribute to the recovery of the impaired working memory after SD by modulating the neural activity of related brain regions.

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The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls—A randomized placebo-controlled, double-blind fMRI study

Behavioural Brain Research ◽

10.1016/j.bbr.2012.09.034 ◽

2013 ◽

Vol 237 ◽

pp. 300-307 ◽

Cited By ~ 42

Author(s):

Birgit Guse ◽

Peter Falkai ◽

Oliver Gruber ◽

Heather Whalley ◽

Lydia Gibson ◽

...

Keyword(s):

Working Memory ◽

Transcranial Magnetic Stimulation ◽

High Frequency ◽

Magnetic Stimulation ◽

Repetitive Transcranial Magnetic Stimulation ◽

Healthy Controls ◽

Double Blind ◽

Fmri Study

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Neurostimulation in alcohol dependence: The effect of repetitive transcranial magnetic stimulation on brain function and craving

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.943 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S59-S59

Author(s):

J. Jansen ◽

O. van den Heuvel ◽

Y. van der Werf ◽

S. De Wit ◽

D. Veltman ◽

...

Keyword(s):

Emotion Regulation ◽

Transcranial Magnetic Stimulation ◽

Alcohol Dependence ◽

Neural Activity ◽

High Frequency ◽

Magnetic Stimulation ◽

Negative Emotion ◽

Repetitive Transcranial Magnetic Stimulation ◽

Anterior Cingulate ◽

Fmri Session

BackgroundAlcohol dependence has long been related to impaired processing and handling of negative emotions. This is the first study to compare emotion regulation (ER) at a behavioral and neural level in alcohol dependent patients (ADPs) and healthy controls (HCs). It also examines the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on ER abilities and related craving levels in ADPs.MethodThirty-six ADPs and 32 HCs matched on age, sex, and education, were included in a within-subject fixed-order study with one functional magnetic resonance imaging (fMRI) session and one rTMS plus fMRI session, with high-frequency (10 Hz) rTMS over the right dorsolateral prefrontal cortex (dlPFC). An fMRI emotion regulation task (ERT) was administered during both sessions and craving was measured before and after each ERT.ResultsADPs were impaired in the regulation of negative emotion and showed a higher activation of ER related brain areas compared to HCs. Furthermore, active rTMS improved ER abilities in both ADPs and HCs, but was accompanied by a decrease in anterior cingulate and left dlPFC activity only in ADPs. In addition, the ERT-induced increase in craving levels in ADPs was trend-significantly reduced by active rTMS, with a large effect size.ConclusionsADPs are impaired in the regulation of negative emotion and show enhanced neural activity in the ER brain circuit. High-frequency rTMS improves ER in ADPs and HCs and normalizes neural activity and tends to reduce craving in ADPs. Future studies are needed to test the long-term effects of (multiple session) rTMS on ER, craving, and drinking.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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The Effectiveness of the Repetitive Transcranial Magnetic Stimulation (rTMS)with high frequency (20 Hz) on Auditory Hallucinations, Inner Speech and Working Memory in Schizophrenic Patients

Yafteh Lorestan University of Medical Sciences ◽

10.32592/yafteh.2021.23.2.9 ◽

2021 ◽

pp. 111-124

Keyword(s):

Working Memory ◽

Transcranial Magnetic Stimulation ◽

High Frequency ◽

Magnetic Stimulation ◽

Repetitive Transcranial Magnetic Stimulation ◽

Auditory Hallucinations ◽

Inner Speech ◽

Control Group ◽

Schizophrenic Patients ◽

And Control

Background: The purpose of the present study was to investigate the effectiveness of high frequency transcranial magnetic stimulation (rTMS) treatment (20 Hz) on auditory hallucinations, inner speech and working memory in schizophrenic patients. Materials and Methods: This study was a pretest-posttest experimental design with control group. The statistical population of this study consisted of all schizophrenic patients referring to the outpatient department of Imam Hossein hospital in 2019, 12 of whom were selected by available sampling based on inclusion and exclusion criteria then were assigned randomly into two groups of 6 each. High frequency transcranial magnetic stimulation (r TMS) treatment (20 Hz) was used for experimental group but the control group received no intervention during the study. The instruments were the positive and negative syndrome scale in schizophrenia, the inner speech questionnaire, and the Daneman and Carpenter working memory questionnaire before and after the intervention. The data were analyzed by descriptive statistics, and one-way covariance analysis (ANCOVA) and multivariate covariance analysis (MANCOVA) were used to analyze the data. Results: The results showed that there were significant differences between experimental and control group (p<0.005). The rate of auditory hallucinations and inner speech significantly decreased in comparison with pretest and control group, but the rate of active memory increased. Conclusion: Repetitive transcranial magnetic stimulation (r TMS) treatment (20 Hz) significantly reduced auditory hallucinations, inner speech and improved active memory.

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High-frequency repetitive transcranial magnetic stimulation enhances layer II/III morphological dendritic plasticity in mouse primary motor cortex

Behavioural Brain Research ◽

10.1016/j.bbr.2021.113352 ◽

2021 ◽

pp. 113352

Author(s):

Marco Cambiaghi ◽

Laura Cherchi ◽

Laura Masin ◽

Carmenrita Infortuna ◽

Nicholas Briski ◽

...

Keyword(s):

Transcranial Magnetic Stimulation ◽

Motor Cortex ◽

High Frequency ◽

Magnetic Stimulation ◽

Primary Motor Cortex ◽

Repetitive Transcranial Magnetic Stimulation ◽

Dendritic Plasticity

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The effect of bilateral high frequency repetitive transcranial magnetic stimulation on cognitive functions in schizophrenia

Schizophrenia Research Cognition ◽

10.1016/j.scog.2020.100183 ◽

2020 ◽

Vol 22 ◽

pp. 100183

Author(s):

Mehmet Diyaddin Güleken ◽

Taner Akbaş ◽

Selime Çelik Erden ◽

Veysel Akansel ◽

Zeliha Cengiz Al ◽

...

Keyword(s):

Transcranial Magnetic Stimulation ◽

Cognitive Functions ◽

High Frequency ◽

Magnetic Stimulation ◽

Repetitive Transcranial Magnetic Stimulation

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The Role of the Parietal Lobe in Visual Extinction Studied with Transcranial Magnetic Stimulation

Journal of Cognitive Neuroscience ◽

10.1162/jocn.2008.21149 ◽

2009 ◽

Vol 21 (10) ◽

pp. 1946-1955 ◽

Cited By ~ 49

Author(s):

Lorella Battelli ◽

George A. Alvarez ◽

Thomas Carlson ◽

Alvaro Pascual-Leone

Keyword(s):

Transcranial Magnetic Stimulation ◽

Visual Tracking ◽

Magnetic Stimulation ◽

Posterior Parietal Cortex ◽

Parietal Lobe ◽

Repetitive Transcranial Magnetic Stimulation ◽

Visual Fields ◽

Brain Regions ◽

Visual Extinction ◽

Interhemispheric Competition

Interhemispheric competition between homologous areas in the human brain is believed to be involved in a wide variety of human behaviors from motor activity to visual perception and particularly attention. For example, patients with lesions in the posterior parietal cortex are unable to selectively track objects in the contralesional side of visual space when targets are simultaneously present in the ipsilesional visual field, a form of visual extinction. Visual extinction may arise due to an imbalance in the normal interhemispheric competition. To directly assess the issue of reciprocal inhibition, we used fMRI to localize those brain regions active during attention-based visual tracking and then applied low-frequency repetitive transcranial magnetic stimulation over identified areas in the left and right intraparietal sulcus to asses the behavioral effects on visual tracking. We induced a severe impairment in visual tracking that was selective for conditions of simultaneous tracking in both visual fields. Our data show that the parietal lobe is essential for visual tracking and that the two hemispheres compete for attentional resources during tracking. Our results provide a neuronal basis for visual extinction in patients with parietal lobe damage.

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