scholarly journals Associations of IDUA and PTCH1 with Bone Mineral Density, Bone Turnover Markers, and Fractures in Chinese Elderly Patients with Osteoporosis

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Qifei Wang ◽  
Chong Tang ◽  
Junxiu Jia ◽  
Guangwu Zhang ◽  
Zheng Liu
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Osteoporotic Fractures ◽  
The Elderly ◽  
Mineral Density ◽  
Chi Square ◽  
Genotype Frequencies ◽  
Elderly Chinese ◽  
Chi Square Test ◽  
Turnover Markers

Introduction. Osteoporosis (OP) is a common polygenic disorder in the aging population, and several single nucleotide polymorphisms (SNPs) in the alpha-L-iduronidase (IDUA) gene and patched homolog 1 (PTCH1) gene regulate bone metabolism and affect bone mass. The study aimed at investigating the relationships of rs3755955 and rs6831280 in the IDUA gene and rs28377268 in the PTCH1 gene with bone mineral density (BMD), bone turnover markers (BTMs), and fractures in the elderly Chinese subjects with OP. Materials and Methods. A cohort of 328 unrelated senile osteoporosis (SOP) patients with or without osteoporotic fractures was recruited. rs3755955, rs6831280, and rs28377268 polymorphisms were identified using SNaPshot technology. BTM levels were determined by electrochemiluminescence (ECL). Bone mineral densities (BMDs) at the lumbar spine (LS) and proximal femur sites were measured by dual-energy X-ray absorptiometry (DEXA) in all subjects. The Hardy-Weinberg equilibrium (HWE) test was performed. HWE P values and comparisons of genotype frequencies were estimated using the chi-square test. Analysis of covariance (ANCOVA) adjusted for confounding factors was performed to investigate associations of SNPs with BMDs and BTMs in subgroups. Results. The chi-square test indicated that genotype distributions in the control group conformed to HWE (P>0.05). The distributions of allele and genotype frequencies of rs6831280 between fracture and osteoporotic participants were significantly different (P-allele=0.002 and P-genotype=0.012, respectively). Concerning rs6831280, ANCOVA found BMDs at LS 2-4 (L2-4) and total hip (TH) among the study subjects suffering from SOP with GA genotype were lower than in those carrying GG or AA (P-L2-4=0.004 and P-TH=0.027, respectively). Conclusions. IDUA rs6831280 is associated with BMDs at L2-4 and TH in the elderly Chinese population with SOP and may serve as a marker for the genetic susceptibility to osteoporotic fractures.

scholarly journals Impact of physical activity on incidence of osteoporotic fractures - a review

2021 ◽  
Vol 11 (9) ◽  
pp. 196-207
Author(s):  
Paweł Oszczędłowski ◽  
Kacper Niewęgłowski ◽  
Barbara Madoń ◽  
Justyna Nowaczek ◽  
Adrian Giermasiński
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Weight Bearing ◽  
Osteoporotic Fractures ◽  
The Elderly ◽  
Protective Role ◽  
Mineral Density ◽  
Elderly Age ◽  
The Individual

Introduction and purpose: The purpose od this study is to describe influence of participating in sporting activities on health of the bones. Osteoporosis is a disease of elderly people in which bone mineral density lowers. Physical activity was reported to increase bone mineral density.A brief description of the state of knowledge: Better physical performance is a positive factor that lowers the possibility of fracturing the bones of the elderly. Another factor that plays protective role is lean body mass and development of muscles. Training in young age can help to increase the bone mineral density, but the effect ceases with the passing of time, being much lower after decades. Multiple genes have impact on bone mineral density of the individual. Professional athletes have usually higher bone mineral density, but accumulation of microdamage in their bones can result in stress fractures. Training in elderly age is proven to increase bone mineral density of an individual, especially performing weight-bearing sports.Conclusions: Physical activity has been proven to positively affect health in many ways. One of them is strengthening the bones by increasing bone mineral density. As it increases, the possibility to break the bone lowers, which makes it an effective way to support the fight against the osteoporosis. It is especially important for women, who are more susceptible to osteoporotic fractures in post-menopausal age.

scholarly journals Possible Association between Erectile Dysfunction and Osteoporosis in Men

2015 ◽  
Vol 116 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Murat Dursun ◽  
Emin Özbek ◽  
Alper Otunctemur ◽  
Suleyman Sami Cakir
Keyword(s):  
Bone Mineral Density ◽  
Erectile Dysfunction ◽  
Bone Mineral ◽  
Noninvasive Evaluation ◽  
Control Group ◽  
Mineral Density ◽  
Chi Square ◽  
Osteoporosis In Men ◽  
Chi Square Test

Sexual dysfunction in general and erectile dysfunction (ED) in particular significantly affect men’s quality of life. Some patients who have ED, also develop osteoporosis. So, in this study we investigated the relationship between erectile dysfunction and osteoporosis in men. 95 men with erectile dysfunction and 82 men with normal sexual function were included in the study. The men’s sexual functions were evaluated by International Index of Erectile Function-5 items (IIEF-5). All men received a Dual Energy X-ray Absorptiometry (DEXA; Hologic) scan to measure bone mineral density (BMD) for osteoporosis. Chi-square test was used for statistical analysis. Mean age was 53.5 (38–69) in ED group and 50.1 (31–69) in control group. In ED group the men have lower T score levels than those of the control group. In conclusion, the men who have erectile dysfunction were at more risk for osteoporosis. The results of the present study demonstrate that the men with erectile dysfunction have low bone mineral density and they are at higher risk for osteoporosis. Because of easy and noninvasive evaluation of osteoporosis, patients with ED should be checked for bone mineral density and osteoporotic male subjects should be evaluated for ED.

Bone mineral density and bone turnover markers in patients with thyroid cancer and L-T4 suppressive therapy after 25 years of follow-up

2014 ◽  
Author(s):  
Mingo Dominguez Maria Luisa de ◽  
Sonsoles Guadalix Iglesias ◽  
Maria Begona Lopez Alvarez ◽  
Guillermo Martinez Diaz-Guerra ◽  
Federico Hawkins Carranza
Keyword(s):  
Bone Mineral Density ◽  
Thyroid Cancer ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Suppressive Therapy ◽  
Mineral Density ◽  
Turnover Markers
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