Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future
Keyword(s):
The Past
◽
The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated. Previous studies suggested that SMs have two major origins, namely, tissue-resident and monocyte-derived SMs. However, no systematic analysis to identify SM ontology in either physiological or pathological conditions has been available to date. In this review, we summarize relevant studies on the two main origins of SMs in rheumatoid arthritis (RA) and forecast the future research directions for this field. Furthermore, we discuss the current state of RA therapy that is based on targeting different SM subsets.
2020 ◽
Vol 27
(10)
◽
pp. 3309-3339
2017 ◽
Vol 21
◽
2021 ◽
Vol 18
(14)
◽
pp. 7567
2021 ◽
Vol 108
◽
pp. 103309
Keyword(s):